Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38684-38691

  Sekine, Osamu ^a,c   Love, Dona C ^a   Rubenstein, David S ^b   Hanover, John A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BODY SIZES; CELL DYSFUNCTION; DROSOPHILA MELANOGASTER; EX-VIVO; FAT BODY; IN-VIVO; INSULIN RESISTANCE; INSULIN SIGNALING; NEUTRAL LIPID; O-LINKED; PERIPHERAL TISSUE; SIGNALING PATHWAYS; TRANSGENESIS;

ANTHROPOMETRY; BODY FLUIDS; CARBOHYDRATES; GLUCOSE; MAMMALS; MEDICAL PROBLEMS; PHOSPHORYLATION; PHYSIOLOGY; SIGNALING;

INSULIN;

BETA N ACETYLHEXOSAMINIDASE; DROSOPHILA INSULIN LIKE PEPTIDE 2; DROSOPHILA INSULIN LIKE PEPTIDE 3; DROSOPHILA INSULIN LIKE PEPTIDE 5; GLUCOSE; GLYCOSYLTRANSFERASE; INSULIN; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINE TRANSFERASE; PEPTIDE DERIVATIVE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY SIZE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME PHOSPHORYLATION; EX VIVO STUDY; HEMOLYMPH; HOMEOSTASIS; IN VIVO STUDY; LARVA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACETYLGLUCOSAMINE; ANIMALS; DROSOPHILA MELANOGASTER; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HOMEOSTASIS; INSULIN;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 78649640325     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.155192     Document Type: Article

References (47)

1. Hanover, J. A. (2001) FASEB J. 15, 1865-1876
2. Love, D. C., and Hanover, J. A. (2005) Sci. STKE re13
3. Lubas, W. A., Frank, D. W., Krause, M., and Hanover, J. A. (1997) J. Biol. Chem. 272, 9316-9324
4. Kreppel, L. K., Blomberg, M. A., and Hart, G. W. (1997) J. Biol. Chem. 272, 9308-9315
5. Hartweck, L. M., Scott, C. L., and Olszewski, N. E. (2002) Genetics 161, 1279-1291
6. Thornton, T. M., Swain, S. M., and Olszewski, N. E. (1999) Trends Plant Sci. 4, 424-428
7. Heckel, D., Comtesse, N., Brass, N., Blin, N., Zang, K. D., and Meese, E. (1998) Hum. Mol. Genet 7, 1859-1872
8. Toleman, C. A., Paterson, A. J., and Kudlow, J. E. (2006) J. Biol. Chem. 281, 3918-3925
9. Comtesse, N., Maldener, E., and Meese, E. (2001) Biochem. Biophys. Res. Commun. 283, 634-640
10. Toleman, C., Paterson, A. J., Whisenhunt, T. R., and Kudlow, J. E. (2004) J. Biol. Chem. 279, 53665-53673
11. Wells, L., Vosseller, K., and Hart, G. W. (2001) Science 291, 2376-2378
12. Vosseller, K., Wells, L., Lane, M. D., and Hart, G. W. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 5313-5318
13. McClain, D. A., Lubas, W. A., Cooksey, R. C., Hazel, M., Parker, G. J., Love, D. C., and Hanover, J. A. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 10695-10699
14. Lehman, D. M., Fu, D. J., Freeman, A. B., Hunt, K. J., Leach, R. J., Johnson-Pais, T., Hamlington, J., Dyer, T. D., Arya, R., Abboud, H., Göring, H. H., Duggirala, R., Blangero, J., Konrad, R. J., and Stern, M. P. (2005) Diabetes 54, 1214-1221
15. Hanover, J. A., Lai, Z., Lee, G., Lubas, W. A., and Sato, S. M. (1999) Arch Biochem. Biophys. 362, 38-45
16. Shafi, R., Iyer, S. P., Ellies, L. G., O'Donnell, N., Marek, K. W., Chui, D., Hart, G. W., and Marth, J. D. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 5735-5739
17. O'Donnell, N., Zachara, N. E., Hart, G. W., and Marth, J. D. (2004) Mol. Cell. Biol. 24, 1680-1690
18. Slawson, C., Zachara, N. E., Vosseller, K., Cheung, W. D., Lane, M. D., and Hart, G. W. (2005) J. Biol. Chem. 280, 32944-32956
19. Hanover, J. A., Forsythe, M. E., Hennessey, P. T., Brodigan, T. M., Love, D. C., Ashwell, G., and Krause, M. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 11266-11271
20. Forsythe, M. E., Love, D. C., Lazarus, B. D., Kim, E. J., Prinz, W. A., Ashwell, G., Krause, M. W., and Hanover, J. A. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 11952-11957
21. Kelly, W. G., and Hart, G. W. (1989) Cell 57, 243-251
22. Jínek, M., Rehwinkel, J., Lazarus, B. D., Izaurralde, E., Hanover, J. A., and Conti, E. (2004) Nat. Struct. Mol. Biol. 11, 1001-1007
23. Gambetta, M. C., Oktaba, K., and Müller, J. (2009) Science 325, 93-96
24. Sinclair, D. A., Syrzycka, M., Macauley, M. S., Rastgardani, T., Komljenovic, I., Vocadlo, D. J., Brock, H. W., and Honda, B. M. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 13427-13432
25. Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., and Hafen, E. (2001) Curr. Biol. 11, 213-221
26. Tatar, M., Bartke, A., and Antebi, A. (2003) Science 299, 1346-1351
27. Cao, C., and Brown, M. R. (2001) Cell Tissue Res. 304, 317-321
28. Rulifson, E. J., Kim, S. K., and Nusse, R. (2002) Science 296, 1118-1120
29. Broughton, S. J., Piper, M. D., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., and Partridge, L. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 3105-3110
30. Zhang, H., Liu, J., Li, C. R., Momen, B., Kohanski, R. A., and Pick, L. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 19617-19622
31. Giannakou, M. E., Goss, M., Jünger, M. A., Hafen, E., Leevers, S. J., and Partridge, L. (2004) Science 305, 361
32. Géminard, C., Rulifson, E. J., and Léopold, P. (2009) Cell Metab. 10, 199-207
33. Ikeya, T., Galic, M., Belawat, P., Nairz, K., and Hafen, E. (2002) Curr. Biol. 12, 1293-1300
34. Teleman, A. A. (2010) Biochem. J. 425, 13-26
35. Lizcano, J. M., Alrubaie, S., Kieloch, A., Deak, M., Leevers, S. J., and Alessi, D. R. (2003) Biochem. J. 374, 297-306
36. Rossetti, L., Giaccari, A., and DeFronzo, R. A. (1990) Diabetes Care 13, 610-630
37. Love, D. C., Ghosh, S., Mondoux, M. A., Fukushige, T., Wang, P., Wilson, M. A., Iser, W. B., Wolkow, C. A., Krause, M. W., and Hanover, J. A. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 7413-7418
38. Tang, J., Neidigh, J. L., Cooksey, R. C., and McClain, D. A. (2000) Diabetes 49, 1492-1499
39. Konrad, R. J., Janowski, K. M., and Kudlow, J. E. (2000) Biochem. Biophys. Res. Commun. 267, 26-32
40. Andrali, S. S., Qian, Q., and Ozcan, S. (2007) J. Biol. Chem. 282, 15589-15596
41. Goberdhan, D. C., Paricio, N., Goodman, E. C., Mlodzik, M., and Wilson, C. (1999) Genes Dev. 13, 3244-3258
42. Zierath, J. R., Krook, A., and Wallberg-Henriksson, H. (2000) Diabetologia 43, 821-835
43. Garvey, W. T., Maianu, L., Zhu, J. H., Brechtel-Hook, G., Wallace, P., and Baron, A. D. (1998) J. Clin. Invest. 101, 2377-2386
44. Del Prato, S., Leonetti, F., Simonson, D. C., Sheehan, P., Matsuda, M., and DeFronzo, R. A. (1994) Diabetologia 37, 1025-1035
45. Miles, P. D., Li, S., Hart, M., Romeo, O., Cheng, J., Cohen, A., Raafat, K., Moossa, A. R., and Olefsky, J. M. (1998) J. Clin. Invest. 101, 202-211
46. Pirola, L., Bonnafous, S., Johnston, A. M., Chaussade, C., Portis, F., and Van Obberghen, E. L. (2003) J. Biol. Chem. 278, 15641-15651
47. Egawa, K., Sharma, P. M., Nakashima, N., Huang, Y., Huver, E., Boss, G. R., and Olefsky, J. M. (1999) J. Biol. Chem. 274, 14306-14314