Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis

Biochimica et Biophysica Acta - General Subjects

Volumn 1860, Issue 8, 2016, Pages 1688-1709

  Gray, C J ^a   Thomas, B ^a   Upton, R ^a   Migas, L G ^a   Eyers, C E ^b   Barran, P E ^a   Flitsch, S L ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Glycan analysis; Glycan sequencing; Glycoconjugates; Ion mobility spectrometry; Mass spectrometry; Stereochemical configuration

Indexed keywords

GLYCAN; GLYCOPEPTIDE; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; PEPTIDE DERIVATIVE; PROTEIN DERIVATIVE; POLYSACCHARIDE;

ARTICLE; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; ION MOBILITY MASS SPECTROMETRY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN GLYCOSYLATION; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; VALIDATION STUDY; ANIMAL; HUMAN; PROCEDURES;

ANIMALS; HUMANS; MASS SPECTROMETRY; POLYSACCHARIDES;

EID: 84973174769     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2016.02.003     Document Type: Article

References (235)

1. K. Ohtsubo, and J.D. Marth Glycosylation in cellular mechanisms of health and disease Cell 126 2006 855 867
2. T. Yoshida-Moriguchi, L.P. Yu, S.H. Stalnaker, S. Davis, S. Kunz, M. Madson, M.B.A. Oldstone, H. Schachter, L. Wells, and K.P. Campbell O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding Science 327 2010 88 92
3. M. Phillips, E. Nudelman, F. Gaeta, M. Perez, A. Singhal, S. Hakomori, and J. Paulson ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex Science 250 1990 1130 1132
4. L. Bode Human milk oligosaccharides: every baby needs a sugar mama Glycobiology 2012
5. M.B. Poulin, Y. Shi, C. Protsko, S.A. Dalrymple, D.A.R. Sanders, B.M. Pinto, and T.L. Lowary Specificity of a UDP-GalNAc pyranose-furanose mutase: a potential therapeutic target for Campylobacter jejuni infections Chembiochem 15 2014 47 56
6. T. Boren, P. Falk, K.A. Roth, G. Larson, and S. Normark Attachment of Helicobacter-pylori to human gastric epithelium mediated by blood-group antigens Science 262 1993 1892 1895
7. M. Sperandio, C.A. Gleissner, and K. Ley Glycosylation in immune cell trafficking Immunol. Rev. 230 2009 97 113
8. H.R. Morris, A. Dell, R.L. Easton, M. Panico, H. Koistinen, R. Koistinen, S. Oehninger, M.S. Patankar, M. Seppala, and G.F. Clark Gender-specific glycosylation of human glycodelin affects its contraceptive activity J. Biol. Chem. 271 1996 32159 32167
9. S. Benoff Carbohydrates and fertilization: an overview Mol. Hum. Reprod. 3 1997 599 637
10. S. Schröter, C. Osterhoff, W. McArdle, and R. Ivell The glycocalyx of the sperm surface Hum. Reprod. Update 5 1999 302 313
11. J. Bones, S. Mittermayr, N. O'Donoghue, A. Guttman, and P.M. Rudd Ultra performance liquid chromatographic profiling of serum N-glycans for fast and efficient identification of cancer associated alterations in glycosylation Anal. Chem. 82 2010 10208 10215
12. G. Lauc, J.E. Huffman, M. Pucic, L. Zgaga, B. Adamczyk, A. Muzinic, M. Novokmet, O. Polasek, O. Gornik, J. Kristic, T. Keser, V. Vitart, B. Scheijen, H.W. Uh, M. Molokhia, A.L. Patrick, P. McKeigue, I. Kolcic, I.K. Lukic, O. Swann, F.N. van Leeuwen, L.R. Ruhaak, J.J. Houwing-Duistermaat, P.E. Slagboom, M. Beekman, A.J.M. de Craen, A.M. Deelder, Q. Zeng, W. Wang, N.D. Hastie, U. Gyllensten, J.F. Wilson, M. Wuhrer, A.F. Wright, P.M. Rudd, C. Hayward, Y. Aulchenko, H. Campbell, and I. Rudan Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers PLoS Genet. 9 2013
13. T. Iskratsch, A. Braun, K. Paschinger, and I.B.H. Wilson Specificity analysis of lectins and antibodies using remodeled glycoproteins Anal. Biochem. 386 2009 133 146
14. S.R. Kumar, E.R. Sauter, T.P. Quinn, and S.L. Deutscher Thomsen-Friedenreich and Tn antigens in nipple fluid: carbohydrate biomarkers for breast cancer detection Clin. Cancer Res. 11 2005 6868 6871
15. R.M. Anthony, F. Nimmerjahn, D.J. Ashline, V.N. Reinhold, J.C. Paulson, and J.V. Ravetch Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc Science 320 2008 373 376
16. Y. Kanda, T. Yamada, K. Mori, A. Okazaki, M. Inoue, K. Kitajima-Miyama, R. Kuni-Kamochi, R. Nakano, K. Yano, S. Kakita, K. Shitara, and M. Satoh Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types Glycobiology 17 2007 104 118
17. G. Thanabalasingham, J.E. Huffman, J.J. Kattla, M. Novokmet, I. Rudan, A.L. Gloyn, C. Hayward, B. Adamczyk, R.M. Reynolds, A. Muzinic, N. Hassanali, M. Pucic, A.J. Bennett, A. Essafi, O. Polasek, S.A. Mughal, I. Redzic, D. Primorac, L. Zgaga, I. Kokic, T. Hansen, D. Gasperikova, E. Tjora, M.W.J. Strachan, T. Nielsen, J. Stanik, I. Klimes, O.B. Pedersen, P.R. Njolstad, S.H. Wild, U. Gyllensten, O. Gornik, J.F. Wilson, N.D. Hastie, H. Campbell, M.I. McCarthy, P.M. Rudd, K.R. Owen, G. Lauc, and A.F. Wright Mutations in HNF1A result in marked alterations of plasma glycan profile Diabetes 62 2013 1329 1337
18. H.F. Lodish, A. Berk, S. Zipursky, P. Matsudaira, D. Baltimore, and J. Darnell fourth ed. Molecular Cell Biology 2000 (New York)
19. M. Wuhrer, C.A.M. Koeleman, J.M. Fitzpatrick, K.F. Hoffmann, A.M. Deelder, and C.H. Hokke Gender-specific expression of complex-type N-glycans in schistosomes Glycobiology 16 2006 991 1006
20. F. Yamamoto ABO blood group system-ABH oligosaccharide antigens, anti-A and anti-B, A and B glycosyltransferases, and ABO genes Immunohematol./Am. Red Cross 20 2004 3 22
21. J. Krištić, F. Vučković, C. Menni, L. Klarić, T. Keser, I. Beceheli, M. Pučić-Baković, M. Novokmet, M. Mangino, K. Thaqi, P. Rudan, N. Novokmet, J. Šarac, S. Missoni, I. Kolčić, O. Polašek, I. Rudan, H. Campbell, C. Hayward, Y. Aulchenko, A. Valdes, J.F. Wilson, O. Gornik, D. Primorac, V. Zoldoš, T. Spector, and G. Lauc Glycans are a novel biomarker of chronological and biological ages J. Gerontol. Ser. A Biol. Med. Sci. 69 2014 779 789
22. I. Gudelj, T. Keser, F. Vuckovic, V. Skaro, S.S. Goreta, T. Pavic, J. Dumic, D. Primorac, G. Lauc, and O. Gornik Estimation of human age using N-glycan profiles from bloodstains Int. J. Legal Med. 129 2015 955 961
23. L. Krishnamoorthy, and L.K. Mahal Glycomic analysis: an array of technologies ACS Chem. Biol. 4 2009 715 732
24. O. Gornik, I. Gornik, V. Gasparovic, and G. Lauc Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis Clin. Biochem. 41 2008 504 510
25. I.T. Akmacic, N. Ventham, E. Theodoratou, F. Vuckovic, N. Kennedy, J. Kristic, E.R. Nimmo, R. Kalla, H. Drummond, J. Stambuk, M.G. Dunlop, M. Novokmet, Y. Aulchenko, O. Gornik, H. Campbell, M. Pucic-Bakovic, J. Satsangi, G. Lauc, and I.B. Consortium Inflammatory bowel disease associates with pro-inflammatory potential of the IgG glycome J. Crohn's Colitis 9 2015 S107-S107
26. D. Isailovic, R.T. Kurulugama, M.D. Plasencia, S.T. Stokes, Z. Kyselova, R. Goldman, Y. Mechref, M.V. Novotny, and D.E. Clemmer Profiling of human serum glycans associated with liver cancer and cirrhosis by IMS-MS J. Proteome Res. 7 2008 1109 1117
27. D. Isailovic, M.D. Plasencia, M.M. Gaye, S.T. Stokes, R.T. Kurulugama, V. Pungpapong, M. Zhang, Z. Kyselova, R. Goldman, Y. Mechref, M.V. Novotny, and D.E. Clemmer Delineating diseases by IMS-MS profiling of serum N-linked glycans J. Proteome Res. 11 2012 576 585
28. M.M. Gaye, S.J. Valentine, Y. Hu, N. Mirjankar, Z.T. Hammoud, Y. Mechref, B.K. Lavine, and D.E. Clemmer Ion mobility-mass spectrometry analysis of serum N-linked glycans from esophageal adenocarcinoma phenotypes J. Proteome Res. 11 2012 6102 6110
29. K. Ohtsubo, S. Takamatsu, M.T. Minowa, A. Yoshida, M. Takeuchi, and J.D. Marth Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes Cell 123 2005 1307 1321
30. C.R., A. Varki, Esko JD, and et al. Essentials of Glycobiology 2 ed. 2009 Cold Spring Harbor New York
31. L. Royle, A. Roos, D.J. Harvey, M.R. Wormald, D. Van Gijlswijk-Janssen, E.-R.M. Redwan, I.A. Wilson, M.R. Daha, R.A. Dwek, and P.M. Rudd Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems J. Biol. Chem. 278 2003 20140 20153
32. E. Gorelik, U. Galili, and A. Raz On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis Cancer Metastasis Rev. 20 2001 245 277
33. M.J. Paszek, C.C. DuFort, O. Rossier, R. Bainer, J.K. Mouw, K. Godula, J.E. Hudak, J.N. Lakins, A.C. Wijekoon, L. Cassereau, M.G. Rubashkin, M.J. Magbanua, K.S. Thorn, M.W. Davidson, H.S. Rugo, J.W. Park, D.A. Hammer, G. Giannone, C.R. Bertozzi, and V.M. Weaver The cancer glycocalyx mechanically primes integrin-mediated growth and survival Nature 511 2014 319 325
34. F. Jacob, D.R. Goldstein, N.V. Bovin, T. Pochechueva, M. Spengler, R. Caduff, D. Fink, M.I. Vuskovic, M.E. Huflejt, and V. Heinzelmann-Schwarz Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array Int. J. Cancer 130 2012 138 146
35. G.F. Springer T and Tn, general carcinoma auto-antigens Science 224 1984 1198 1206
36. Y.T. Chen, Y.M. Chong, C.W. Cheng, C.L. Ho, H.W. Tsai, F.H. Kasten, Y.L. Chen, and C.F. Chang Identification of novel tumor markers for oral squamous cell carcinoma using glycoproteomic analysis Clin. Chim. Acta 420 2013 45 53
37. D.M. Krasnewich, G.D. Holt, M. Brantly, F. Skovby, J. Redwine, and W.A. Gahl Abnormal synthesis of dolichol-linked oligosaccharides in carbohydrate-deficient glycoprotein syndrome Glycobiology 5 1995 503 510
38. F. Vuckovic, J. Kristic, I. Gudelj, M. Teruel, T. Keser, M. Pezer, M. Pucic-Bakovic, J. Stambuk, I. Trbojevic-Akmacic, C. Barrios, T. Pavic, C. Menni, Y.X. Wang, Y. Zhou, L.F. Cui, H.C. Song, Q. Zeng, X.H. Guo, B.A. Pons-Estel, P. McKeigue, A.L. Patrick, O. Gornik, T.D. Spector, M. Harjacek, M. Alarcon-Riquelme, M. Molokhia, W. Wang, and G. Lauc Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome Arthritis Rheumatol. 67 2015 2978 2989
39. A. Weidemann, G. König, D. Bunke, P. Fischer, J.M. Salbaum, C.L. Masters, and K. Beyreuther Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein Cell 57 1989 115 126
40. P. Pahlsson, and S.L. Spitalnik The role of glycosylation in synthesis and secretion of beta-amyloid precursor protein by Chinese hamster ovary cells Arch. Biochem. Biophys. 331 1996 177 186
41. J. Clardy, and C. Walsh Lessons from natural molecules Nature 432 2004 829 837
42. M. Dalziel, M. Crispin, C.N. Scanlan, N. Zitzmann, and R.A. Dwek Emerging principles for the therapeutic exploitation of glycosylation Science 343 2014
43. M.N. Thaker, and G.D. Wright Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity ACS Synth. Biol. 4 2015 195 206
44. L. Royle, M.P. Campbell, C.M. Radcliffe, D.M. White, D.J. Harvey, J.L. Abrahams, Y.G. Kim, G.W. Henry, N.A. Shadick, M.E. Weinblatt, D.M. Lee, P.M. Rudd, and R.A. Dwek HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software Anal. Biochem. 376 2008 1 12
45. M.P. Campbell, L. Royle, C.M. Radcliffe, R.A. Dwek, and P.M. Rudd GlycoBase and autoGU: tools for HPLC-based glycan analysis Bioinformatics 24 2008 1214 1216
46. S. Itoh, N. Kawasaki, M. Ohta, M. Hyuga, S. Hyuga, and T. Hayakawa Simultaneous microanalysis of N-linked oligosaccharides in a glycoprotein using microbore graphitized carbon column liquid chromatography-mass spectrometry J. Chromatogr. A 968 2002 89 100
47. M. Pičmanová, E.H. Neilson, M.S. Motawia, C.E. Olsen, N. Agerbirk, C.J. Gray, S. Flitsch, S. Meier, D. Silvestro, K. Jørgensen, R. Sánchez Pérez, B.L. Møller, and N. Bjarnholt A recycling pathway for cyanogenic glycosides evidenced by the comparative metabolic profiling in three cyanogenic plant species Biochem. J. 469 2015 375 389
48. L.R. Ruhaak, A.M. Deelder, and M. Wuhrer Oligosaccharide analysis by graphitized carbon liquid chromatography-mass spectrometry Anal. Bioanal. Chem. 394 2009 163 174
49. C.A. Cooper, E. Gasteiger, and N.H. Packer GlycoMod - a software tool for determining glycosylation compositions from mass spectrometric data Proteomics 1 2001 340 349
50. H.L. Zhang, S. Singh, and V.N. Reinhold Congruent strategies for carbohydrate sequencing. 2. FragLib: an MSn spectral library Anal. Chem. 77 2005 6263 6270
51. C.A. Cooper, M.J. Harrison, M.R. Wilkins, and N.H. Packer GlycoSuiteDB: a new curated relational database of glycoprotein glycan structures and their biological sources Nucleic Acids Res. 29 2001 332 335
52. O.M. Saad, and J.A. Leary Heparin sequencing using enzymatic digestion and ESI-MSn with HOST: A heparin/HS oligosaccharide sequencing tool Anal. Chem. 77 2005 5902 5911
53. E.P. Go, K.R. Rebecchi, D.S. Dalpathado, M.L. Bandu, Y. Zhang, and H. Desaire GlycoPep DB: a tool for glycopeptide analysis using a "smart search" Anal. Chem. 79 2007 1708 1713
54. C.A. Hayes, N.G. Karlsson, W.B. Struwe, F. Lisacek, P.M. Rudd, N.H. Packer, and M.P. Campbell UniCarb-DB: a database resource for glycomic discovery Bioinformatics 27 2011 1343 1344
55. M. Frank, T. Lutteke, and C.W. von der Lieth GlycoMapsDB: a database of the accessible conformational space of glycosidic linkages Nucleic Acids Res. 35 2007 D287 D290
56. M.P. Campbell, T. Nguyen-Khuong, C.A. Hayes, S.A. Flowers, K. Alagesan, D. Kolarich, N.H. Packer, and N.G. Karlsson Validation of the curation pipeline of UniCarb-DB: building a global glycan reference MS/MS repository BBA-Proteins Proteomics 1844 2014 108 116
57. C. Konda, F.A. Londry, B. Bendiak, and Y. Xia Assignment of the stereochemistry and anomeric configuration of sugars within oligosaccharides via overlapping disaccharide ladders using MSn J. Am. Soc. Mass Spectrom. 25 2014 1441 1450
58. B. Domon, and C.E. Costello A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates Glycoconj. J. 5 1988 397 409
59. C.S. Creaser, J.R. Griffiths, C.J. Bramwell, S. Noreen, C.A. Hill, and C.L.P. Thomas Ion mobility spectrometry: a review. Part 1. Structural analysis by mobility measurement Analyst 129 2004 984 994
60. F. Lanucara, S.W. Holman, C.J. Gray, and C.E. Eyers The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics Nat. Chem. 6 2014 281 294
61. C. Uetrecht, R.J. Rose, E. van Duijn, K. Lorenzen, and A.J.R. Heck Ion mobility mass spectrometry of proteins and protein assemblies Chem. Soc. Rev. 39 2010 1633 1655
62. A.B. Kanu, P. Dwivedi, M. Tam, L. Matz, and H.H. Hill Ion mobility-mass spectrometry J. Mass Spectrom. 43 2008 1 22
63. T. Wyttenbach, N.A. Pierson, D.E. Clemmer, and M.T. Bowers Ion mobility analysis of molecular dynamics M.A. Johnson, T.J. Martinez, Annual Review of Physical Chemistry 65 2014 175 196
64. V. D'Atri, M. Porrini, F. Rosu, and V. Gabelica Linking molecular models with ion mobility experiments. illustration with a rigid nucleic acid structure J. Mass Spectrom. 50 2015 711 726
65. E.A. Mason, and H.W. Schamp Mobility of gaseous ions in weak electric fields Ann. Phys. 4 1958 233 270
66. R.T. Kurulugama, E. Darland, F. Kuhlmann, G. Stafford, and J. Fjeldsted Evaluation of drift gas selection in complex sample analyses using a high performance drift tube ion mobility-QTOF mass spectrometer Analyst 140 2015 6834 6844
67. H.W. Ellis, R.Y. Pai, E.W. McDaniel, E.A. Mason, and L.A. Viehland Transport properties of gaseous ions over a wide energy range At. Data Nucl. Data Tables 17 1976 177 210
68. H.W. Ellis, E.W. McDaniel, D.L. Albritton, L.A. Viehland, S.L. Lin, and E.A. Mason Transport properties of gaseous ions over a wide energy range. Part II At. Data Nucl. Data Tables 22 1978 179 217
69. H.W. Ellis, M.G. Thackston, E.W. McDaniel, and E.A. Mason Transport-properties of gaseous-ions over a wide energy-range.3 At. Data Nucl. Data Tables 31 1984 113 151
70. L.A. Viehland, and E.A. Mason Transport-properties of gaseous-ions over a wide energy-range.4 At. Data Nucl. Data Tables 60 1995 37 95
71. J.C. May, C.R. Goodwin, N.M. Lareau, K.L. Leaptrot, C.B. Morris, R.T. Kurulugama, A. Mordehai, C. Klein, W. Barry, E. Darland, G. Overney, K. Imatani, G.C. Stafford, J.C. Fjeldsted, and J.A. McLean Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer Anal. Chem. 86 2014 2107 2116
72. K. Giles, S.D. Pringle, K.R. Worthington, D. Little, J.L. Wildgoose, and R.H. Bateman Applications of a travelling wave-based radio-frequency-only stacked ring ion guide Rapid Commun. Mass Spectrom. 18 2004 2401 2414
73. K. Giles, J.P. Williams, and I. Campuzano Enhancements in travelling wave ion mobility resolution Rapid Commun. Mass Spectrom. 25 2011 1559 1566
74. A.S. Gelb, R.E. Jarratt, Y.T. Huang, and E.D. Dodds A study of calibrant selection in measurement of carbohydrate and peptide ion-neutral collision cross sections by traveling wave ion mobility spectrometry Anal. Chem. 86 2014 11396 11402
75. J. Hofmann, W.B. Struwe, C.A. Scarff, J.H. Scrivens, D.J. Harvey, and K. Pagel Estimating collision cross sections of negatively charged N-glycans using traveling wave ion mobility-mass spectrometry Anal. Chem. 86 2014 10789 10795
76. C. Bleiholder, N.R. Johnson, S. Contreras, T. Wyttenbach, and M.T. Bowers Molecular structures and ion mobility cross sections: analysis of the effects of He and N-2 buffer gas Anal. Chem. 87 2015 7196 7203
77. M.F. Jarrold Helices and sheets in vacuo Phys. Chem. Chem. Phys. 9 2007 1659 1671
78. E.W. Robinson, and E.R. Williams Multidimensional separations of ubiquitin conformers in the gas phase: relating ion cross sections to H/D exchange measurements J. Am. Soc. Mass Spectrom. 16 2005 1427 1437
79. J.P. Williams, M. Grabenauer, R.J. Holland, C.J. Carpenter, M.R. Wormald, K. Giles, D.J. Harvey, R.H. Bateman, J.H. Scrivens, and M.T. Bowers Characterization of simple isomeric oligosaccharides and the rapid separation of glycan mixtures by ion mobility mass spectrometry Int. J. Mass Spectrom. 298 2010 119 127
80. A.M. Rashid, G. Saalbach, and S. Bornemann Discrimination of large maltooligosaccharides from isobaric dextran and pullulan using ion mobility mass spectrometry Rapid Commun. Mass Spectrom. 28 2014 191 199
81. L. Jin, P.E. Barran, J.A. Deakin, M. Lyon, and D. Uhrin Conformation of glycosaminoglycans by ion mobility mass spectrometry and molecular modelling Phys. Chem. Chem. Phys. 7 2005 3464 3471
82. Y.J. Seo, M.R. Schenauer, and J.A. Leary Biologically relevant metal-cation binding induces conformational changes in heparin oligosaccharides as measured by ion mobility mass spectrometry Int. J. Mass Spectrom. 303 2011 191 198
83. B.T. Ruotolo, K. Giles, I. Campuzano, A.M. Sandercock, R.H. Bateman, and C.V. Robinson Evidence for macromolecular protein rings in the absence of bulk water Science 310 2005 1658 1661
84. B.T. Ruotolo, J.L.P. Benesch, A.M. Sandercock, S.J. Hyung, and C.V. Robinson Ion mobility-mass spectrometry analysis of large protein complexes Nat. Protoc. 3 2008 1139 1152
85. R. Cumeras, E. Figueras, C.E. Davis, J.I. Baumbach, and I. Gracia Review on ion mobility spectrometry. Part 1: current instrumentation Analyst 140 2015 1376 1390
86. R.W. Purves, and R. Guevremont Electrospray ionization high-field asymmetric waveform ion mobility spectrometry-mass spectrometry Anal. Chem. 71 1999 2346 2357
87. A.A. Shvartsburg, T.A. Seim, W.F. Danielson, R. Norheim, R.J. Moore, G.A. Anderson, and R.D. Smith High-definition differential ion mobility spectrometry with resolving power up to 500 J. Am. Soc. Mass Spectrom. 24 2013 109 114
88. R. Guevremont High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry J. Chromatogr. A 1058 2004 3 19
89. A.A. Shvartsburg, Y.M. Ibrahim, and R.D. Smith Differential ion mobility separations in up to 100% helium using microchips J. Am. Soc. Mass Spectrom. 25 2014 480 489
90. F. Fernandez-Lima, D. Kaplan, J. Suetering, and M. Park Gas-phase separation using a trapped ion mobility spectrometer Int. J. Ion Mobil. Spectrom. 14 2011 93 98
91. K. Michelmann, J. Silveira, M. Ridgeway, and M. Park Fundamentals of trapped ion mobility spectrometry J. Am. Soc. Mass Spectrom. 26 2015 14 24
92. J.A. Silveira, M.E. Ridgeway, and M.A. Park High resolution trapped ion mobility spectrometery of peptides Anal. Chem. 86 2014 5624 5627
93. S. Koeniger, and D. Clemmer Resolution and structural transitions of elongated states of ubiquitin J. Am. Soc. Mass Spectrom. 18 2007 322 331
94. E. Mack Average cross-sectional areas of molecules by gaseous diffusion methods J. Am. Chem. Soc. 47 1925 2468 2482
95. G. Vonhelden, M.T. Hsu, N. Gotts, and M.T. Bowers Carbon cluster cations with up to 84 atoms - structures, formation mechanism, and reactivity J. Phys. Chem. 97 1993 8182 8192
96. M.F. Mesleh, J.M. Hunter, A.A. Shvartsburg, G.C. Schatz, and M.F. Jarrold Structural information from ion mobility measurements: effects of the long-range potential J. Phys. Chem. 100 1996 16082 16086
97. C. Bleiholder, T. Wyttenbach, and M.T. Bowers A novel projection approximation algorithm for the fast and accurate computation of molecular collision cross sections (I). Method Int. J. Mass Spectrom. 308 2011 1 10
98. S.E. Anderson, C. Bleiholder, E.R. Brocker, P.J. Stang, and M.T. Bowers A novel projection approximation algorithm for the fast and accurate computation of molecular collision cross sections (III): application to supramolecular coordination-driven assemblies with complex shapes Int. J. Mass Spectrom. 330 2012 78 84
99. C. Bleiholder, S. Contreras, and M.T. Bowers A novel projection approximation algorithm for the fast and accurate computation of molecular collision cross sections (IV). Application to polypeptides Int. J. Mass Spectrom. 354 2013 275 280
100. C. Bleiholder, S. Contreras, T.D. Do, and M.T. Bowers A novel projection approximation algorithm for the fast and accurate computation of molecular collision cross sections (II). Model parameterization and definition of empirical shape factors for proteins Int. J. Mass Spectrom. 345 2013 89 96
101. T. Wyttenbach, C. Bleiholder, S.E. Anderson, and M.T. Bowers A new algorithm to characterise the degree of concaveness of a molecular surface relevant in ion mobility spectrometry Mol. Phys. 113 2015 2344 2349
102. A.A. Shvartsburg, and M.F. Jarrold An exact hard-spheres scattering model for the mobilities of polyatomic ions Chem. Phys. Lett. 261 1996 86 91
103. A.A. Shvartsburg, S.V. Mashkevich, E.S. Baker, and R.D. Smith Optimization of algorithms for ion mobility calculations J. Phys. Chem. A 111 2007 2002 2010
104. C. Larriba-Andaluz, and C.J. Hogan Jr. Collision cross section calculations for polyatomic ions considering rotating diatomic/linear gas molecules J. Chem. Phys. 141 2014
105. I. Campuzano, M.F. Bush, C.V. Robinson, C. Beaumont, K. Richardson, H. Kim, and H.I. Kim Structural characterization of drug-like compounds by ion mobility mass spectrometry: comparison of theoretical and experimentally derived nitrogen collision cross sections Anal. Chem. 84 2012 1026 1033
106. L.S. Fenn, and J.A. McLean Enhanced carbohydrate structural selectivity in ion mobility-mass spectrometry analyses by boronic acid derivatization Chem. Commun. 5505-5507 2008
107. J. Hofmann, H.S. Hahm, P.H. Seeberger, and K. Pagel Identification of carbohydrate anomers using ion mobility-mass spectrometry Nature 526 2015 241 244
108. P. Dwivedi, B. Bendiak, B. Clowers, and H. Hill Rapid resolution of carbohydrate isomers by electrospray ionization ambient pressure ion mobility spectrometry-time-of-flight mass spectrometry (ESI-APIMS-TOFMS) J. Am. Soc. Mass Spectrom. 18 2007 1163 1175
109. W. Gabryelski, and K.L. Froese Rapid and sensitive differentiation of anomers, linkage, and position isomers of disaccharides using high-field asymmetric waveform ion mobility spectrometry (FAIMS) J. Am. Soc. Mass Spectrom. 14 2003 265 277
110. D.J. Harvey, C.A. Scarff, M. Crispin, C.N. Scanlan, C. Bonomelli, and J.H. Scrivens MALDI-MS/MS with traveling wave ion mobility for the structural analysis of N-linked glycans J. Am. Soc. Mass Spectrom. 23 2012 1955 1966
111. P.M. Lalli, Y.E. Corilo, M. Fasciotti, M.F. Riccio, G.F. de Sa, R.J. Daroda, G.H.M.F. Souza, M. McCullagh, M.D. Bartberger, M.N. Eberlin, and I.D.G. Campuzano Baseline resolution of isomers by traveling wave ion mobility mass spectrometry: investigating the effects of polarizable drift gases and ionic charge distribution J. Mass Spectrom. 48 2013 989 997
112. 2 as a drift gas J. Mass Spectrom. 50 2015 336 343
113. R.T. Kurulugama, F.M. Nachtigall, S. Lee, S.J. Valentine, and D.E. Clemmer Overtone mobility spectrometry: part 1. Experimental observations J. Am. Soc. Mass Spectrom. 20 2009 729 737
114. P. Both, A.P. Green, C.J. Gray, R. Šardzík, J. Voglmeir, C. Fontana, M. Austeri, M. Rejzek, D. Richardson, R.A. Field, G. Widmalm, S.L. Flitsch, and C.E. Eyers Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing Nat. Chem. 6 2014 65 74
115. 2 as drift gas J. Mass Spectrom. 47 2012 1643 1647
116. E.J. Davis, K.F. Grows, W.F. Siems, and H.H. Hill Improved ion mobility resolving power with increased buffer gas pressure Anal. Chem. 84 2012 4858 4865
117. J.C. May, J.N. Dodds, R.T. Kurulugama, G.C. Stafford, J.C. Fjeldsted, and J.A. McLean Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer Analyst 140 2015 6824 6833
118. L.S. Fenn, and J.A. McLean Structural resolution of carbohydrate positional and structural isomers based on gas-phase ion mobility-mass spectrometry Phys. Chem. Chem. Phys. 13 2011 2196 2205
119. S. Lee, T. Wyttenbach, and M.T. Bowers Gas phase structures of sodiated oligosaccharides by ion mobility/ion chromatography methods Int. J. Mass Spectrom. Ion Process. 167-168 1997 605 614
120. M.D. Leavell, S.P. Gaucher, J.A. Leary, J.A. Taraszka, and D.E. Clemmer Conformational studies of Zn-ligand-hexose diastereomers using ion mobility measurements and density functional theory calculations J. Am. Soc. Mass Spectrom. 13 2002 284 293
121. Y. Huang, and E.D. Dodds Ion mobility studies of carbohydrates as group I adducts: isomer specific collisional cross section dependence on metal ion radius Anal. Chem. 85 2013 9728 9735
122. D.J. Harvey, C.A. Scarff, M. Edgeworth, M. Crispin, C.N. Scanlan, F. Sobott, S. Allman, K. Baruah, L. Pritchard, and J.H. Scrivens Travelling wave ion mobility and negative ion fragmentation for the structural determination of N-linked glycans Electrophoresis 34 2013 2368 2378
123. S. Lee, S.J. Valentine, J.P. Reilly, and D.E. Clemmer Analyzing a mixture of disaccharides by IMS-VUVPD-MS Int. J. Mass Spectrom. 309 2012 161 167
124. W. Hoffmann, J. Hofmann, and K. Pagel Energy-resolved ion mobility-mass spectrometry - a concept to improve the separation of isomeric carbohydrates J. Am. Soc. Mass Spectrom. 1-9 2014
125. Y. Liu, and D.E. Clemmer Characterizing oligosaccharides using injected-ion mobility/mass spectrometry Anal. Chem. 69 1997 2504 2509
126. D.S. Lee, C. Wu, and H.H. Hill Detection of carbohydrates by electrospray ionization ion mobility spectrometry following microbore high-performance liquid chromatography J. Chromatogr. A 822 1998 1 9
127. H. Li, K. Giles, B. Bendiak, K. Kaplan, W.F. Siems, and H.H. Hill Resolving structural isomers of monosaccharide methyl glycosides using drift tube and traveling wave ion mobility mass spectrometry Anal. Chem. 84 2012 3231 3239
128. M. Zhu, B. Bendiak, B. Clowers, and H. Hill Jr. Ion mobility-mass spectrometry analysis of isomeric carbohydrate precursor ions Anal. Bioanal. Chem. 394 2009 1853 1867
129. H. Li, B. Bendiak, K. Kaplan, E. Davis, W.F. Siems, and H.H. Hill Jr. Evaluation of ion mobility-mass spectrometry for determining the isomeric heterogeneity of oligosaccharide-alditols derived from bovine submaxillary mucin Int. J. Mass Spectrom. 352 2013 9 18
130. H.L. Li, B. Bendiak, W.F. Siems, D.R. Gang, and H.H. Hill Determining the isomeric heterogeneity of neutral oligosaccharide-alditols of bovine submaxillary mucin using negative ion traveling wave ion mobility mass spectrometry Anal. Chem. 87 2015 2228 2235
131. O. Hernandez, S. Isenberg, V. Steinmetz, G.L. Glish, and P. Maitre Probing mobility-selected saccharide isomers: selective ion-molecule reactions and wavelength-specific IR activation J. Phys. Chem. A 119 2015 6057 6064
132. F. Zhu, S. Lee, S. Valentine, J. Reilly, and D. Clemmer Mannose7 glycan isomer characterization by IMS-MS/MS analysis J. Am. Soc. Mass Spectrom. 23 2012 2158 2166
133. T. Yamagaki, and A. Sato Isomeric oligosaccharides analyses using negative-ion electrospray ionization ion mobility spectrometry combined with collision-induced dissociation MS/MS Anal. Sci. 25 2009 985 988
134. S.Y. Vakhrushev, J. Langridge, I. Campuzano, C. Hughes, and J. Peter-Katlinic Ion mobility mass spectrometry analysis of human glycourinome Anal. Chem. 80 2008 2506 2513
135. H.L. Li, B. Bendiak, W.F. Siems, D.R. Gang, and H.H. Hill Ion mobility mass spectrometry analysis of isomeric disaccharide precursor, product and cluster ions Rapid Commun. Mass Spectrom. 27 2013 2699 2709
136. H. Li, B. Bendiak, W.F. Siems, D.R. Gang, and H.H. Hill Jr. Carbohydrate structure characterization by tandem ion mobility mass spectrometry (IMMS)2 Anal. Chem. 85 2013 2760 2769
137. M.E. Pettit, B. Harper, M.R. Brantley, and T. Solouki Collision-energy resolved ion mobility characterization of isomeric mixtures Analyst 14 2015 6886 6896
138. B. Clowers, P. Dwivedi, W. Steiner, H. Hill, and B. Bendiak Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry J. Am. Soc. Mass Spectrom. 16 2005 660 669
139. L.S. Fenn, and J.A. McLean Simultaneous glycoproteomics on the basis of structure using ion mobility-mass spectrometry Mol. BioSyst. 5 2009 1298 1302
140. K. Pagel, and D.J. Harvey Ion mobility-mass spectrometry of complex carbohydrates: collision cross sections of sodiated N-linked glycans Anal. Chem. 85 2013 5138 5145
141. Y.T. Huang, and E.D. Dodds Discrimination of isomeric carbohydrates as the electron transfer products of group II cation adducts by ion mobility spectrometry and tandem mass spectrometry Anal. Chem. 87 2015 5664 5668
142. A. Guerrero, and C.B. Lebrilla New strategies for resolving oligosaccharide isomers by exploiting mechanistic and thermochemical aspects of fragment ion formation Int. J. Mass Spectrom. 354-355 2013 19 25
143. L. Han, and C. Costello Electron transfer dissociation of milk oligosaccharides J. Am. Soc. Mass Spectrom. 22 2011 997 1013
144. M.M. Gaye, R. Kurulugama, and D.E. Clemmer Investigating carbohydrate isomers by IMS-CID-IMS-MS: precursor and fragment ion cross-sections Analyst 140 2015 6922 6932
145. N.M. Lareau, J.C. May, and J.A. McLean Non-derivatized glycan analysis by reverse phase liquid chromatography and ion mobility-mass spectrometry Analyst 140 2015 3335 3338
146. D.J. Harvey, F. Sobott, M. Crispin, A. Wrobel, C. Bonomelli, S. Vasiljevic, C.N. Scanlan, C.A. Scarff, K. Thalassinos, and J.H. Scrivens Ion mobility mass spectrometry for extracting spectra of N-glycans directly from incubation mixtures following glycan release: application to glycans from engineered glycoforms of intact, folded HIV gp120 J. Am. Soc. Mass Spectrom. 22 2011 568 581
147. M. Plasencia, D. Isailovic, S. Merenbloom, Y. Mechref, and D. Clemmer Resolving and assigning N-linked glycan structural isomers from ovalbumin by IMS-MS J. Am. Soc. Mass Spectrom. 19 2008 1706 1715
148. W.B. Struwe, J.L. Benesch, D.J. Harvey, and K. Pagel Collision cross sections of high-mannose N-glycans in commonly observed adduct states - identification of gas-phase conformers unique to M - H (-) ions Analyst 140 2015 6799 6803
149. I. Capila, and R.J. Linhardt Heparin-protein interactions Angew. Chem. Int. Ed. 41 2002 390 412
150. Merton Bernfield, and Martin Götte Pyong Woo Park, Ofer Reizes, Marilyn L. Fitzgerald, a. John Lincecum, M. Zako, functions of cell surface heparan sulfate proteoglycans Annu. Rev. Biochem. 68 1999 729 777
151. U. Lindahl, L. Thunberg, G. Bäckström, and J. Riesenfeld The antithrombin-binding sequence of heparin Biochem. Soc. Trans. 9 1981 499 501
152. Z. Hu, C. Wang, Y. Xiao, N. Sheng, Y. Chen, Y. Xu, L. Zhang, W. Mo, N. Jing, and G. Hu NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development J. Cell Sci. 122 2009 1145 1154
153. H. Zhou, S. Roy, E. Cochran, R. Zouaoui, C.L. Chu, J. Duffner, G. Zhao, S. Smith, Z. Galcheva-Gargova, J. Karlgren, N. Dussault, R.Y.Q. Kwan, E. Moy, M. Barnes, A. Long, C. Honan, Y.W. Qi, Z. Shriver, T. Ganguly, B. Schultes, G. Venkataraman, and T.K. Kishimoto M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis PLoS One 6 2011 e21106
154. N.S. Gandhi, and R.L. Mancera The structure of glycosaminoglycans and their interactions with proteins Chem. Biol. Drug Des. 72 2008 455 482
155. H. Lortat-Jacob, A. Grosdidier, and A. Imberty Structural diversity of heparan sulfate binding domains in chemokines Proc. Natl. Acad. Sci. 99 2002 1229 1234
156. P. Gupta, J. McCarthy, and C. Verfaillie Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells Blood 87 1996 3229 3236
157. L. Jin, J.P. Abrahams, R. Skinner, M. Petitou, R.N. Pike, and R.W. Carrell The anticoagulant activation of antithrombin by heparin Proc. Natl. Acad. Sci. 94 1997 14683 14688
158. A.K. Powell, E.A. Yates, D.G. Fernig, and J.E. Turnbull Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches Glycobiology 14 2004 17R 30R
159. D.L. Rabenstein Heparin and heparan sulfate: structure and function Nat. Prod. Rep. 19 2002 312 331
160. J.R. Bishop, M. Schuksz, and J.D. Esko Heparan sulphate proteoglycans fine-tune mammalian physiology Nature 446 2007 1030 1037
161. M. Ly, F.E. Leach, T.N. Laremore, T. Toida, I.J. Amster, and R.J. Linhardt The proteoglycan bikunin has a defined sequence Nat. Chem. Biol. 7 2011 827 833
162. S. Faham, R.E. Hileman, J.R. Fromm, R.J. Linhardt, and D.C. Rees Heparin structure and interactions with basic fibroblast growth factor Science 271 1996 1116 1120
163. E. Sisu, S. Tripathy, J.-M. Mallet, P.-A. Driguez, J.-P. Hérault, P. Sizun, J.-M. Herbert, M. Petitou, and P. Sinay Synthesis of new conformationally constrained pentasaccharides as molecular probes to investigate the biological activity of heparin Biochimie 85 2003 91 99
164. Y. Seo, M.R. Schenauer, and J.A. Leary Biologically relevant metal-cation binding induces conformational changes in heparin oligosaccharides as measured by ion mobility mass spectrometry Int. J. Mass Spectrom. 303 2011 191 198
165. S. Ricard-Blum, O. Féraud, H. Lortat-Jacob, A. Rencurosi, N. Fukai, F. Dkhissi, D. Vittet, A. Imberty, B.R. Olsen, and M. van der Rest Characterization of endostatin binding to heparin and heparan sulfate by surface plasmon resonance and molecular modeling: role of divalent cations J. Biol. Chem. 279 2004 2927 2936
166. B. Lages, and S.S. Stivala Interaction of the polyelectrolyte heparin with copper(II) and calcium Biopolymers 12 1973 127 143
167. 2 + binding site Eur. J. Org. Chem. 2002 2002 2367 2376
168. R. González-Iglesias, M.a.A. Pajares, C. Ocal, J. Carlos Espinosa, B. Oesch, and M.a. Gasset Prion protein interaction with glycosaminoglycan occurs with the formation of oligomeric complexes stabilized by Cu(II) bridges J. Mol. Biol. 319 2002 527 540
169. R.F. Parrish, and W.R. Fair Selective binding of zinc ions to heparin rather than to other glycosaminoglycans Biochem. J. 193 1981 407 410
170. 2 + Arch. Biochem. Biophys. 170 1975 334 340
171. 2 + interaction: the influence of the O-sulfation pattern on binding Carbohydr. Res. 339 2004 975 983
172. M.R. Schenauer, J.K. Meissen, Y. Seo, J.B. Ames, and J.A. Leary Heparan sulfate separation, sequencing, and isomeric differentiation: ion mobility spectrometry reveals specific iduronic and glucuronic acid-containing hexasaccharides Anal. Chem. 81 2009 10179 10185
173. R. Miller, W. Wei, R. Schwörer, O. Zubkova, P. Tyler, J. Turnbull, and J. Leary Composition, sequencing and ion mobility mass spectrometry of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid content Eur. J. Mass Spectrom. 21 2015 245 254
174. E. Gray, B. Mulloy, and T.W. Barrowcliffe Heparin and low-molecular-weight heparin Thromb. Haemost. 99 2008 807 818
175. D.R. Ferro, A. Provasoli, M. Ragazzi, B. Casu, G. Torri, V. Bossennec, B. Perly, P. Sinaÿ, M. Petitou, and J. Choay Conformer populations of l-iduronic acid residues in glycosaminoglycan sequences Carbohydr. Res. 195 1990 157 167
176. P.N. Sanderson, T.N. Huckerby, and I.A. Nieduszynski Conformational equilibria of α-L-iduronate residues in disaccharides derived from heparin Biochem. J. 243 1987 175 181
177. Y. Seo, A. Andaya, and J.A. Leary Preparation, separation, and conformational analysis of differentially sulfated heparin octasaccharide isomers using ion mobility mass spectrometry Anal. Chem. 84 2012 2416 2423
178. B. Mulloy, and M.J. Forster Conformation and dynamics of heparin and heparan sulfate Glycobiology 10 2000 1147 1156
179. M. Hermannová, A.-M. Iordache, K. Slováková, V. Havlíček, H. Pelantová, and K. Lemr Arrival time distributions of product ions reveal isomeric ratio of deprotonated molecules in ion mobility-mass spectrometry of hyaluronan-derived oligosaccharides J. Mass Spectrom. 50 2015 854 863
180. M. Kailemia, M. Park, D. Kaplan, A. Venot, G.-J. Boons, L. Li, R. Linhardt, and I.J. Amster High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation of isobaric mixtures of glycosaminoglycans J. Am. Soc. Mass Spectrom. 25 2014 258 268
181. J.J. Wolff, T.N. Laremore, F.E. Leach, R.J. Linhardt, and I.J. Amster Electron capture dissociation, electron detachment dissociation, and infrared multiphoton dissociation of sucrose octasulfate Eur. J. Mass Spectrom. 15 2009 275 281 (Chichester, England)
182. M.S. Motawia, I. Damager, C.E. Olsen, B.L. Møller, S.B. Engelsen, S. Hansen, L.H. Gendal, and R. Bauer Comparative study of small linear and branched α-glucans using size exclusion chromatography and static and dynamic light scattering Biomacromolecules 6 2005 143 151
183. V.G. Murphy, B. Zaslow, and A.D. French The structure of V amylose dehydrate: a combined X-ray and stereochemical approach Biopolymers 14 1975 1487 1501
184. K. Nishinari, K. Kohyama, P.A. Williams, G.O. Phillips, W. Burchard, and K. Ogino Solution properties of pullulan Macromolecules 24 1991 5590 5593
185. J.-H. Huang, E.J. Bakx, H. Gruppen, and H.A. Schols Characterisation of 3-aminoquinoline-derivatised isomeric oligogalacturonic acid by travelling-wave ion mobility mass spectrometry Rapid Commun. Mass Spectrom. 27 2013 2279 2285
186. K. Kaneshiro, Y. Fukuyama, S. Iwamoto, S. Sekiya, and K. Tanaka Highly sensitive MALDI analyses of glycans by a new aminoquinoline-labeling method using 3-aminoquinoline/α-cyano-4-hydroxycinnamic acid liquid matrix Anal. Chem. 83 2011 3663 3667
187. A.G.M. Leijdekkers, J.-H. Huang, E.J. Bakx, H. Gruppen, and H.A. Schols Identification of novel isomeric pectic oligosaccharides using hydrophilic interaction chromatography coupled to traveling-wave ion mobility mass spectrometry Carbohydr. Res. 404 2015 1 8
188. B. Plancot, G. Vanier, F. Maire, M. Bardor, P. Lerouge, J.M. Farrant, J. Moore, A. Driouich, M. Vicré-Gibouin, C. Afonso, and C. Loutelier-Bourhis Structural characterization of arabinoxylans from two African plant species Eragrostis nindensis and Eragrostis tef using various mass spectrometric methods Rapid Commun. Mass Spectrom. 28 2014 908 916
189. M.R. Schenauer, and J.A. Leary An ion mobility-mass spectrometry investigation of monocyte chemoattractant protein-1 Int. J. Mass Spectrom. 287 2009 70 76
190. Y. Seo, A. Andaya, C. Bleiholder, and J.A. Leary Differentiation of CC vs CXC chemokine dimers with GAG octasaccharide binding partners: an ion mobility mass spectrometry approach J. Am. Chem. Soc. 135 2013 4325 4332
191. Y. Tian, L. Han, A.C. Buckner, and B.T. Ruotolo Collision induced unfolding of intact antibodies: rapid characterization of disulfide bonding patterns, glycosylation, and structures Anal. Chem. 87 2015 11509 11515
192. B.J. McCullough, J.M. Kalapothakis, W. Chin, K. Taylor, D.J. Clarke, H. Eastwood, D. Campopiano, D. MacMillan, J. Dorin, and P.E. Barran Binding a heparin derived disaccharide to defensin inspired peptides: insights to antimicrobial inhibition from gas-phase measurements Phys. Chem. Chem. Phys. 12 2010 3589 3596
193. S.R. Harvey, C.E. MacPhee, B.F. Volkman, and P.E. Barran The association and aggregation of the metamorphic chemokine lymphotactin with fondaparinux: from nm molecular complexes to [small mu ]M molecular assemblies Chem. Commun. 2016
194. H. Li, B. Bendiak, W. Siems, D. Gang, and H. Hill Jr. Ion mobility-mass correlation trend line separation of glycoprotein digests without deglycosylation Int. J. Ion Mobil. Spectrom. 16 2013 105 115
195. A.J. Creese, and H.J. Cooper Separation and identification of isomeric glycopeptides by high field asymmetric waveform ion mobility spectrometry Anal. Chem. 84 2012 2597 2601
196. G.N. Ulasi, A.J. Creese, S.X. Hui, C.W. Penn, and H.J. Cooper Comprehensive mapping of O-glycosylation in flagellin from Campylobacter jejuni 11168: a multienzyme differential ion mobility mass spectrometry approach Proteomics 15 2015 2733 2745
197. K. Brandenburg, and O. Holst Glycolipids: Distribution and Biological Function, in: eLS 2001 John Wiley & Sons Ltd
198. J.B. Robbins, and R. Schneerson Evaluating the Haemophilus influenzae type b conjugate vaccine PRP-D N. Engl. J. Med. 323 1990 1415 1416
199. B.D. Gessner, and R.A. Adegbola The impact of vaccines on pneumonia: key lessons from Haemophilus influenzae type b conjugate vaccines, vaccine, 26 Supplement 2 2008 B3 B8
200. E. Miller, D. Salisbury, and M. Ramsay Planning, registration, and implementation of an immunisation campaign against meningococcal serogroup C disease in the UK: a success story, vaccine, 20 Supplement 1 2001 S58 S67
201. J.T. Poolman Pneumococcal vaccine development Expert Rev. Vaccines 3 2004 597 604
202. S.P. Lockhart, J.G. Hackell, and B. Fritzell Pneumococcal conjugate vaccines: emerging clinical information and its implications Expert Rev. Vaccines 5 2006 553 564
203. A.H. Merrill Jr., M.D. Wang, M. Park, and M.C. Sullards (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology Trends Biochem. Sci. 32 2007 457 468
204. A.H. Merrill, T.H. Stokes, A. Momin, H. Park, B.J. Portz, S. Kelly, E. Wang, M.C. Sullards, and M.D. Wang Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease J. Lipid Res. 50 2009 S97 S102
205. S. Sonnino, and V. Chigorno Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures Biochim. Biophys. Acta Rev. Biomembr. 1469 2000 63 77
206. R. Yu, Y.-T. Tsai, and T. Ariga Functional roles of gangliosides in neurodevelopment: an overview of recent advances Neurochem. Res. 37 2012 1230 1244
207. E. Posse de Chaves, S. Sipione, Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction, FEBS Lett., 584 1748-1759.
208. G. van Echten-Deckert, and J. Walter Sphingolipids: critical players in Alzheimer's disease Prog. Lipid Res. 51 2012 378 393
209. T. Ariga, M.P. McDonald, and R.K. Yu Thematic review series: sphingolipids. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease - a review J. Lipid Res. 49 2008 1157 1175
210. T. Kolter, and K. Sandhoff Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids Annu. Rev. Cell Dev. Biol. 21 2005 81 103
211. X. Zhang, and F.L. Kiechle Glycosphingolipids in health and disease Ann. Clin. Lab. Sci. 34 2004 3 13
212. M.R. Wenk The emerging field of lipidomics Nat. Rev. Drug Discov. 4 2005 594 610
213. J. Li, R.W. Purves, and J.C. Richards Coupling capillary electrophoresis and high-field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of complex lipopolysaccharides Anal. Chem. 76 2004 4676 4683
214. S.N. Jackson, M. Ugarov, T. Egan, J.D. Post, D. Langlais, J. Albert Schultz, and A.S. Woods MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue J. Mass Spectrom. 42 2007 1093 1098
215. S.N. Jackson, B. Colsch, T. Egan, E.K. Lewis, J.A. Schultz, and A.S. Woods Gangliosides' analysis by MALDI-ion mobility MS Analyst 136 2011 463 466
216. S.N. Jackson, D. Barbacci, T. Egan, E.K. Lewis, J.A. Schultz, and A.S. Woods MALDI-ion mobility mass spectrometry of lipids in negative ion mode Anal. Methods 6 2014 5001 5007
217. S. Jackson, M. Ugarov, J. Post, T. Egan, D. Langlais, J.A. Schultz, and A. Woods A study of phospholipids by ion mobility TOFMS J. Am. Soc. Mass Spectrom. 19 2008 1655 1662
218. Y. Mechref, Y. Hu, A. Garcia, and A. Hussein Identifying cancer biomarkers by mass spectrometry-based glycomics Electrophoresis 33 2012 1755 1767
219. H. Liu, N. Zhang, D. Wan, M. Cui, Z. Liu, and S. Liu Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery Clin. Proteomics 11 2014 1 9
220. D. Isailovic, R.T. Kurulugama, M.D. Plasencia, S.T. Stokes, Z. Kyselova, R. Goldman, Y. Mechref, M.V. Novotny, and D.E. Clemmer Profiling of human serum glycans associated with liver cancer and cirrhosis by IMS-MS J. Proteome Res. 7 2008 1109 1117
221. A.A. Shvartsburg, W.F. Danielson, and R.D. Smith High-resolution differential ion mobility separations using helium-rich gases Anal. Chem. 82 2010 2456 2462
222. S. Lee, M.A. Ewing, F.M. Nachtigall, R.T. Kurulugama, S.J. Valentine, and D.E. Clemmer Determination of cross sections by overtone mobility spectrometry: evidence for loss of unstable structures at higher overtones J. Phys. Chem. B 114 2010 12406 12415
223. S.J. Valentine, R.T. Kurulugama, and D.E. Clemmer Overtone mobility spectrometry: part 3. On the origin of peaks J. Am. Soc. Mass Spectrom. 22 2011 804 816
224. R.T. Kurulugama, F.M. Nachtigall, S.J. Valentine, and D.E. Clemmer Overtone mobility spectrometry: part 4. OMS-OMS analyses of complex mixtures J. Am. Soc. Mass Spectrom. 22 2011 2049 2060
225. M.A. Ewing, S.M. Zucker, S.J. Valentine, and D.E. Clemmer Overtone mobility spectrometry: part 5. Simulations and analytical expressions describing overtone limits J. Am. Soc. Mass Spectrom. 24 2013 615 621
226. M.A. Ewing, C.R.P. Conant, S.M. Zucker, K.J. Griffith, and D.E. Clemmer Selected overtone mobility spectrometry Anal. Chem. 87 2015 5132 5138
227. S. Valentine, S. Stokes, R. Kurulugama, F. Nachtigall, and D. Clemmer Overtone mobility spectrometry: part 2. Theoretical considerations of resolving power J. Am. Soc. Mass Spectrom. 20 2009 738 750
228. K. Giles, J. Wildgoose, S. Pringle, J. Garside, P. Carney, P. Nixon, and D. Langridge Design and utility of a multi-pass cyclic ion mobility separator 62nd ASMS Conference, Baltimore 2014
229. S.I. Merenbloom, R.S. Glaskin, Z.B. Henson, and D.E. Clemmer High-resolution ion cyclotron mobility spectrometry Anal. Chem. 81 2009 1482 1487
230. R.S. Glaskin, M.A. Ewing, and D.E. Clemmer Ion trapping for ion mobility spectrometry measurements in a cyclical drift tube Anal. Chem. 85 2013 7003 7008
231. L. Cipolla, F. Peri, and C. Airoldi Glycoconjugates in cancer therapy Anti Cancer Agents Med. Chem. 8 2008 92 121
232. C. Jones Vaccines based on the cell surface carbohydrates of pathogenic bacteria An. Acad. Bras. Cienc. 77 2005 293 324
233. J.R. Mascola, G. Stiegler, T.C. VanCott, H. Katinger, C.B. Carpenter, C.E. Hanson, H. Beary, D. Hayes, S.S. Frankel, D.L. Birx, and M.G. Lewis Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies Nat. Med. 6 2000 207 210
234. R.D. Astronomo, and D.R. Burton Carbohydrate vaccines: developing sweet solutions to sticky situations? Nat. Rev. Drug Discov. 9 2010 308 324
235. D.J. Harvey, M. Crispin, C. Bonomelli, and J.H. Scrivens Ion mobility mass spectrometry for ion recovery and clean-up of MS and MS/MS spectra obtained from low abundance viral samples J. Am. Soc. Mass Spectrom. 26 2015 1754 1767