Thomsen-Friedenreich and Tn antigens in nipple fluid: Carbohydrate biomarkers for breast cancer detection

Clinical Cancer Research

Volumn 11, Issue 19 I, 2005, Pages 6868-6871

  Kumar, Senthil R ^a   Sauter, Edward R ^a   Quinn, Thomas P ^a   Deutscher, Susan L ^a,b  

^a University of Missouri   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CELL SURFACE PROTEIN; GLYCOLIPID; MONOCLONAL ANTIBODY; TN ANTIGEN; TUMOR ANTIGEN;

ADULT; AGED; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; ASPIRATION; BODY FLUID; BREAST CANCER; CANCER DIAGNOSIS; CANCER SCREENING; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; EARLY DIAGNOSIS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MAMMOGRAPHY; NIPPLE; PRIORITY JOURNAL; RISK ASSESSMENT; SAMPLING;

ADULT; AGED; ANTIGENS, NEOPLASM; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BIOPSY, NEEDLE; BODY FLUIDS; BREAST; BREAST NEOPLASMS; CARBOHYDRATES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOSYLATION; HUMANS; IMMUNOASSAY; MASS SCREENING; MIDDLE AGED; POSTMENOPAUSE; PREMENOPAUSE; RECURRENCE; TUMOR MARKERS, BIOLOGICAL;

EID: 26444452697     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-0146     Document Type: Article

References (19)

1. Sauter ER, Ross E, Daly M, et al. Nipple aspirate fluid: a promising non-invasive method to identify cellular markers of breast cancer risk. Br J Cancer 1997; 76:494-501.
2. Gruenke LD, Wrensch MR, Petrakis NL, Miike R, Ernster VL, Craig JC. Breast fluid cholesterol and cholesterol epoxides: relationships to breast cancer risk factors and other characteristics. Cancer Res 1987; 47:5843-87.
3. Liu Y, Wang JL, Chang H, Barsky SH, Nguyen M. Breast-cancer diagnosis with nipple fluid bFGF. Lancet 2000;356:567.
4. Sauter ER, Lininger J, Magklara A, Hewett JE, Diamandis EP. Association of kallikrein expression in nipple aspirate fluid with breast cancer risk. Int J Cancer 2004;108:588-91.
5. Hsiung R, Zhu W, Klein G, et al. High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer. Cancer J 2002;8:303-10.
6. Springer JF. T and Tn, general carcinoma autoantigens. Science 1984;224:1198-206.
7. Baldus SE, Zirbes TK, Hanisch FG, et al. Thomsen Friedenreich antigen presents as a prognostic factor in colorectal carcinoma: a clinicopathologic study of 264 patients. Cancer 2000;88:1536-43.
8. Springer GF, Desai PR, Bantatwala I. Blood group MN antigens and precursors in normal and malignant breast glandular tissue. J Natl Cancer Inst 1975;54: 335-9.
9. Itzkowitz SH, Yuan M, Montgomery CK, et al. Expression of Tn, Sialosyl Tn, and T antigens in human colon cancer. Cancer Res 1989;49:197-204.
10. Osinaga E, Pancino G, Porchet N, et al. Analysis of a heterogeneous group of human breast carcinoma associated glycoproteins bearing the Tn determinant. Breast Cancer Res Treat 1994;32:139-52.
11. Glinsky VV, Glinsky GV, Olson RK, et al. The role of Thomsen Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium. Cancer Res 2001;61:4851-7.
12. Freire T, Medeiros A, Reis CA, Real FX, Osinaga E. Biochemical characterization of soluble Tn glycoproteins from malignant effusions of patients with carcinomas. Oncol Rep 2003;10:1577-85.
13. Chagpar A, Evelegh M, Fritsche HA, Jr., Krishnamurthy S, Hunt KK, Kuerer HM. Prospective evaluation of a novel approach for the use of a quantitative galactose oxidase-Schiff reaction in ductal fluid samples from women with breast carcinoma. Cancer 2004;100:2549-54.
14. Krepinsky JJ, Kandel GP, Yeung KS. From T-antigen to plasmalogen-derived aldehydes: the identification of a marker of colorectal cancer in human rectal mucous. Can J Chem 2003;81:109-17.
15. Foretova L, Garber JE, Sadowsky NL, et al. Carcinoembryonic antigen in breast nipple aspirate fluid. Cancer Epidemiol Biomarkers Prev 1998;7: 195-8.
16. Zhao Y, Verselis SJ, Klar N, et al. Nipple fluid carcinoembryonic antigen and prostate-specific antigen in cancer-bearing and tumor-free breasts. J Clin Oncol 2001;19:3160.
17. Landon LA, Peletskaya EN, Glinsky VV, Karasseva N, Quinn TP, Deutscher SL. Combinatorial evolution of high-affinity peptides that bind to the Thomsen-Friedenreich carcinoma antigen. J Protein Chem 2003; 22:193-204.
18. Imai J, Ghazizadeh M, Naito Z, Asano G. Immunohistochemical expression of T, Tn and sialyl-Tn antigens and clinical outcome in human breast carcinoma. Anticancer Res 2001;21:1327-34.
19. Springer GF, Cheingsong-Popov R, Schirrmacher V, Desai PR, Tegtmeyer H. Proposed molecular basis of murine tumor cell-hepatocyte interaction. J Biol Chem 1983;258:5702-6.