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Volumn 2, Issue 1, 2015, Pages

Current knowledge and future directions of TLR and NOD signaling in sepsis

Author keywords

Innate immunity; NOD signaling; Sepsis; TLR signaling

Indexed keywords


EID: 84973130397     PISSN: 20957467     EISSN: 20549369     Source Type: Journal    
DOI: 10.1186/s40779-014-0029-7     Document Type: Review
Times cited : (36)

References (120)
  • 2
    • 84873714375 scopus 로고    scopus 로고
    • Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    • Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Intensive Care Med. 2013;39:165-228.
    • (2013) Intensive Care Med , vol.39 , pp. 165-228
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3    Annane, D.4    Gerlach, H.5    Opal, S.M.6
  • 3
    • 0026874127 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864-874.
    • (1992) Crit Care Med , vol.20 , pp. 864-874
  • 5
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007;449:819-826.
    • (2007) Nature , vol.449 , pp. 819-826
    • Medzhitov, R.1
  • 6
    • 84863196654 scopus 로고    scopus 로고
    • Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes
    • Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther. 2012;10:701-706.
    • (2012) Expert Rev Anti Infect Ther , vol.10 , pp. 701-706
    • Martin, G.S.1
  • 7
    • 84859208479 scopus 로고    scopus 로고
    • Inpatient care for septicemia or sepsis: a challenge for patients and hospitals
    • Hall MJ, Williams SN, DeFrances CJ, Golosinskiy A. Inpatient care for septicemia or sepsis: a challenge for patients and hospitals. NCHS Data Brief. 2011;62:1-8.
    • (2011) NCHS Data Brief , vol.62 , pp. 1-8
    • Hall, M.J.1    Williams, S.N.2    DeFrances, C.J.3    Golosinskiy, A.4
  • 9
    • 84894506061 scopus 로고    scopus 로고
    • Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis
    • Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med. 2014;42:625-631.
    • (2014) Crit Care Med , vol.42 , pp. 625-631
    • Stevenson, E.K.1    Rubenstein, A.R.2    Radin, G.T.3    Wiener, R.S.4    Walkey, A.J.5
  • 11
    • 84876665421 scopus 로고    scopus 로고
    • Benchmarking the incidence and mortality of severe sepsis in the United States
    • Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013;41:1167-1174.
    • (2013) Crit Care Med , vol.41 , pp. 1167-1174
    • Gaieski, D.F.1    Edwards, J.M.2    Kallan, M.J.3    Carr, B.G.4
  • 12
    • 0037179680 scopus 로고    scopus 로고
    • An economic evaluation of activated protein C treatment for severe sepsis
    • Manns BJ, Lee H, Doig CJ, Johnson D, Donaldson C. An economic evaluation of activated protein C treatment for severe sepsis. N Engl J Med. 2002;347:993-1000.
    • (2002) N Engl J Med , vol.347 , pp. 993-1000
    • Manns, B.J.1    Lee, H.2    Doig, C.J.3    Johnson, D.4    Donaldson, C.5
  • 13
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care
    • Angus DC, Linde-Zwirbler WT, Lidicker J, Clermont G, Carcillo J, Pinksy MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care. Crit Care Med. 2001;29:1303-1310.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirbler, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinksy, M.R.6
  • 14
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-1554.
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 15
    • 31344461826 scopus 로고    scopus 로고
    • Sepsis Occurrence in Acutely III Patients Investigators: Sepsis in European intensive care units: Results of the SOAP study
    • Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis Occurrence in Acutely III Patients Investigators: Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med. 2006;34:344-353.
    • (2006) Crit Care Med , vol.34 , pp. 344-353
    • Vincent, J.L.1    Sakr, Y.2    Sprung, C.L.3    Ranieri, V.M.4    Reinhart, K.5    Gerlach, H.6
  • 16
    • 72249087115 scopus 로고    scopus 로고
    • EPIC II Group of Investigators: International study of the prevalence and outcomes of infection in intensive care units
    • Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. EPIC II Group of Investigators: International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302:2323-2329.
    • (2009) JAMA , vol.302 , pp. 2323-2329
    • Vincent, J.L.1    Rello, J.2    Marshall, J.3    Silva, E.4    Anzueto, A.5    Martin, C.D.6
  • 17
    • 0032433470 scopus 로고    scopus 로고
    • Has the mortality of septic shock changed with time
    • Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time. Crit Care Med. 1998;26:2078-2086.
    • (1998) Crit Care Med , vol.26 , pp. 2078-2086
    • Friedman, G.1    Silva, E.2    Vincent, J.L.3
  • 18
    • 0015506169 scopus 로고
    • Germs
    • Thomas L. Germs. N Engl J Med. 1972;287:553-555.
    • (1972) N Engl J Med , vol.287 , pp. 553-555
    • Thomas, L.1
  • 19
    • 78449269170 scopus 로고    scopus 로고
    • More things in heaven and earth: defining innate and adaptive immunity
    • Biron CA. More things in heaven and earth: defining innate and adaptive immunity. Nat Immunol. 2010;11:1080-1082.
    • (2010) Nat Immunol , vol.11 , pp. 1080-1082
    • Biron, C.A.1
  • 20
    • 44649132540 scopus 로고    scopus 로고
    • Host innate immune receptors and beyond: making sense of microbial infections
    • Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S. Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe. 2008;3:352-363.
    • (2008) Cell Host Microbe , vol.3 , pp. 352-363
    • Ishii, K.J.1    Koyama, S.2    Nakagawa, A.3    Coban, C.4    Akira, S.5
  • 21
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 22
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: all we need to know about danger
    • Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol. 2007;81:1-5.
    • (2007) J Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 23
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science. 2002;296:301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 24
    • 65449115788 scopus 로고    scopus 로고
    • Targeting of immune signalling networks by bacterial pathogens
    • Brodsky IE, Medzhitov R. Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol. 2009;11:521-526.
    • (2009) Nat Cell Biol , vol.11 , pp. 521-526
    • Brodsky, I.E.1    Medzhitov, R.2
  • 25
    • 0036159842 scopus 로고    scopus 로고
    • Endotoxin tolerance: a review
    • West MA, Heagy W. Endotoxin tolerance: a review. Crit Care Med. 2002;30:S64-S73.
    • (2002) Crit Care Med , vol.30 , pp. S64-S73
    • West, M.A.1    Heagy, W.2
  • 26
    • 0035424542 scopus 로고    scopus 로고
    • Immune responses to intracellular bacteria
    • Raupach B, Kaufmann SH. Immune responses to intracellular bacteria. Curr Opin Immunol. 2001;13:417-428.
    • (2001) Curr Opin Immunol , vol.13 , pp. 417-428
    • Raupach, B.1    Kaufmann, S.H.2
  • 27
    • 34548452349 scopus 로고    scopus 로고
    • Immunity to extracellular bacteria
    • Paul WE, editor. Fundamental Immunology. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins
    • Weiser JN, Nahm MH. Immunity to extracellular bacteria. In: Paul WE, editor. Fundamental Immunology. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008. p. 1182-1203.
    • (2008) , pp. 1182-1203
    • Weiser, J.N.1    Nahm, M.H.2
  • 28
    • 33746028777 scopus 로고    scopus 로고
    • Intracellular pattern recognition receptors in the host response
    • Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature. 2006;442:39-44.
    • (2006) Nature , vol.442 , pp. 39-44
    • Meylan, E.1    Tschopp, J.2    Karin, M.3
  • 29
    • 80052144513 scopus 로고    scopus 로고
    • Intracellular sensors of microbes and danger
    • Núñez G. Intracellular sensors of microbes and danger. Immunol Rev. 2011;243:5-8.
    • (2011) Immunol Rev , vol.243 , pp. 5-8
    • Núñez, G.1
  • 30
    • 0042405132 scopus 로고    scopus 로고
    • Recognition of microbial infection by Toll-like receptors
    • Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol. 2003;15:396-401.
    • (2003) Curr Opin Immunol , vol.15 , pp. 396-401
    • Kopp, E.1    Medzhitov, R.2
  • 31
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • Kanneganti TD, Lamkanfi M, Núñez G. Intracellular NOD-like receptors in host defense and disease. Immunity. 2007;27:549-559.
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Núñez, G.3
  • 32
    • 0033542396 scopus 로고    scopus 로고
    • The toll of innate immunity on microbial pathogens
    • Modlin RL, Brightbill HD, Godowski PJ. The toll of innate immunity on microbial pathogens. N Engl J Med. 1999;340:1834-1835.
    • (1999) N Engl J Med , vol.340 , pp. 1834-1835
    • Modlin, R.L.1    Brightbill, H.D.2    Godowski, P.J.3
  • 33
    • 66149086936 scopus 로고    scopus 로고
    • NOD-like receptors: role in innate immunity and inflammatory disease
    • Chen G, Shaw MH, Kim YG, Nunez G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol. 2009;4:365-398.
    • (2009) Annu Rev Pathol , vol.4 , pp. 365-398
    • Chen, G.1    Shaw, M.H.2    Kim, Y.G.3    Nunez, G.4
  • 34
    • 68849085894 scopus 로고    scopus 로고
    • A cell biological view of Toll-like receptor function: regulation through compartmentalization
    • Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol. 2009;9:535-542.
    • (2009) Nat Rev Immunol , vol.9 , pp. 535-542
    • Barton, G.M.1    Kagan, J.C.2
  • 35
    • 0029730738 scopus 로고    scopus 로고
    • A conserved signaling pathway: the Drosophila toll-dorsal pathway
    • Belvin MP, Anderson KV. A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rev Cell Dev Biol. 1996;12:393-416.
    • (1996) Annu Rev Cell Dev Biol , vol.12 , pp. 393-416
    • Belvin, M.P.1    Anderson, K.V.2
  • 36
    • 0033517989 scopus 로고    scopus 로고
    • Lipoproteins take their toll on the host
    • Janeway CA, Medzhitov R. Lipoproteins take their toll on the host. Curr Biol. 1999;9:R879-R882.
    • (1999) Curr Biol , vol.9 , pp. R879-R882
    • Janeway, C.A.1    Medzhitov, R.2
  • 37
    • 61849170035 scopus 로고    scopus 로고
    • TLRs and innate immunity
    • Beutler BA. TLRs and innate immunity. Blood. 2009;113:1399-1407.
    • (2009) Blood , vol.113 , pp. 1399-1407
    • Beutler, B.A.1
  • 39
    • 0033801461 scopus 로고    scopus 로고
    • Toll-like receptors: molecular mechanisms of the mammalian immune response
    • Brightbill HD, Modlin RL. Toll-like receptors: molecular mechanisms of the mammalian immune response. Immunology. 2000;101:1-10.
    • (2000) Immunology , vol.101 , pp. 1-10
    • Brightbill, H.D.1    Modlin, R.L.2
  • 40
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol. 1999;162:3749-3752.
    • (1999) J Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6
  • 41
    • 68849119321 scopus 로고    scopus 로고
    • Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection
    • Andonegui G, Zhou H, Bullard D, Kelly MM, Mullaly SC, McDonald B, et al. Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest. 2009;119:1921-1930.
    • (2009) J Clin Invest , vol.119 , pp. 1921-1930
    • Andonegui, G.1    Zhou, H.2    Bullard, D.3    Kelly, M.M.4    Mullaly, S.C.5    McDonald, B.6
  • 42
    • 0037947560 scopus 로고    scopus 로고
    • Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
    • Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, Levin M, et al. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A. 2003;100:6075-6080.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6075-6080
    • Smirnova, I.1    Mann, N.2    Dols, A.3    Derkx, H.H.4    Hibberd, M.L.5    Levin, M.6
  • 43
    • 84885018938 scopus 로고    scopus 로고
    • Toll-like receptor genetic variants are associated with gram-negative infections in VLBW infants
    • Sampath V, Mulrooney NP, Garland JS, He J, Patel AL, Cohen JD, et al. Toll-like receptor genetic variants are associated with gram-negative infections in VLBW infants. J Perinatol. 2013;33:772-777.
    • (2013) J Perinatol , vol.33 , pp. 772-777
    • Sampath, V.1    Mulrooney, N.P.2    Garland, J.S.3    He, J.4    Patel, A.L.5    Cohen, J.D.6
  • 44
    • 0033618630 scopus 로고    scopus 로고
    • Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    • Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 1999;285:736-739.
    • (1999) Science , vol.285 , pp. 736-739
    • Aliprantis, A.O.1    Yang, R.B.2    Mark, M.R.3    Suggett, S.4    Devaux, B.5    Radolf, J.D.6
  • 45
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan-and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan-and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem. 1999;274:17406-17409.
    • (1999) J Biol Chem , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 46
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. 2000;406:782-787.
    • (2000) Nature , vol.406 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 47
    • 0034669910 scopus 로고    scopus 로고
    • Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
    • Takeuchi O, Hoshino K, Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol. 2000;165:5392-5396.
    • (2000) J Immunol , vol.165 , pp. 5392-5396
    • Takeuchi, O.1    Hoshino, K.2    Akira, S.3
  • 48
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol. 2007;8:487-496.
    • (2007) Nat Immunol , vol.8 , pp. 487-496
    • Tian, J.1    Avalos, A.M.2    Mao, S.Y.3    Chen, B.4    Senthil, K.5    Wu, H.6
  • 49
    • 84878232476 scopus 로고    scopus 로고
    • The history of Toll-like receptors: redefining innate immunity
    • O'Neill LAJ, Golenbock D, Bowie AG. The history of Toll-like receptors: redefining innate immunity. Nat Rev Immunol. 2013;13:453-460.
    • (2013) Nat Rev Immunol , vol.13 , pp. 453-460
    • O'Neill, L.A.J.1    Golenbock, D.2    Bowie, A.G.3
  • 50
    • 0742324860 scopus 로고    scopus 로고
    • TLR signaling pathways
    • Takeda K, Akira S. TLR signaling pathways. Semin Immunol. 2004;16:3-9.
    • (2004) Semin Immunol , vol.16 , pp. 3-9
    • Takeda, K.1    Akira, S.2
  • 52
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003;301:640-643.
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3    Hoshino, K.4    Kaisho, T.5    Sanjo, H.6
  • 53
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol. 2010;11:373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 54
    • 48549102504 scopus 로고    scopus 로고
    • NOD-like receptors (NLRs): bona fide intracellular microbial sensors
    • Shaw MH, Reimer T, Kim YG. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol. 2008;20:377-382.
    • (2008) Curr Opin Immunol , vol.20 , pp. 377-382
    • Shaw, M.H.1    Reimer, T.2    Kim, Y.G.3
  • 55
    • 17644366913 scopus 로고    scopus 로고
    • NOD-LRR proteins: role in host-microbial interactions and inflammatory disease
    • Inohara N, Chamaillard M, McDonald C, Nunez G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem. 2005;74:355-383.
    • (2005) Annu Rev Biochem , vol.74 , pp. 355-383
    • Inohara, N.1    Chamaillard, M.2    McDonald, C.3    Nunez, G.4
  • 56
    • 17644396670 scopus 로고    scopus 로고
    • CATERPILLER: a novel gene family important in immunity, cell death, and diseases
    • Ting JP, Davis BK. CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol. 2005;23:387-414.
    • (2005) Annu Rev Immunol , vol.23 , pp. 387-414
    • Ting, J.P.1    Davis, B.K.2
  • 57
    • 69949105213 scopus 로고    scopus 로고
    • Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders
    • Fukata M, Vamadevan AS, Abreu MT. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders. Semin Immunol. 2009;21:242-253.
    • (2009) Semin Immunol , vol.21 , pp. 242-253
    • Fukata, M.1    Vamadevan, A.S.2    Abreu, M.T.3
  • 61
    • 0038824980 scopus 로고    scopus 로고
    • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
    • Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol. 2003;4:702-707.
    • (2003) Nat Immunol , vol.4 , pp. 702-707
    • Chamaillard, M.1    Hashimoto, M.2    Horie, Y.3    Masumoto, J.4    Qiu, S.5    Saab, L.6
  • 63
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem. 2003;278:5509-5512.
    • (2003) J Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3    Gutierrez, O.4    Pons, F.5    Crespo, J.6
  • 65
    • 0033591330 scopus 로고    scopus 로고
    • Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
    • Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem. 1999;274:14560-14567.
    • (1999) J Biol Chem , vol.274 , pp. 14560-14567
    • Inohara, N.1    Koseki, T.2    Peso, L.3    Hu, Y.4    Yee, C.5    Chen, S.6
  • 66
    • 0036828844 scopus 로고    scopus 로고
    • Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation
    • Gutierrez O, Pipaon C, Inohara N, Fontalba A, Ogura Y, Prosper F, et al. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation. J Biol Chem. 2002;277:41701-41705.
    • (2002) J Biol Chem , vol.277 , pp. 41701-41705
    • Gutierrez, O.1    Pipaon, C.2    Inohara, N.3    Fontalba, A.4    Ogura, Y.5    Prosper, F.6
  • 67
    • 38549084725 scopus 로고    scopus 로고
    • A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
    • Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Nuñez G, et al. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J. 2008;27:373-383.
    • (2008) EMBO J , vol.27 , pp. 373-383
    • Hasegawa, M.1    Fujimoto, Y.2    Lucas, P.C.3    Nakano, H.4    Fukase, K.5    Nuñez, G.6
  • 68
    • 17944380130 scopus 로고    scopus 로고
    • CARD4/Nod1 mediates NF-ΚB and JNK activation by invasive Shigella flexneri
    • Girardin SE, Tournebize R, Mavris M, Page AL, Li X, Stark GR, et al. CARD4/Nod1 mediates NF-ΚB and JNK activation by invasive Shigella flexneri. EMBO Rep. 2001;2:736-742.
    • (2001) EMBO Rep , vol.2 , pp. 736-742
    • Girardin, S.E.1    Tournebize, R.2    Mavris, M.3    Page, A.L.4    Li, X.5    Stark, G.R.6
  • 69
    • 4344699028 scopus 로고    scopus 로고
    • Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae
    • Opitz B, Püschel A, Schmeck B, Hocke AC, Rosseau S, Hammerschmidt S, et al. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem. 2004;279:36426-36432.
    • (2004) J Biol Chem , vol.279 , pp. 36426-36432
    • Opitz, B.1    Püschel, A.2    Schmeck, B.3    Hocke, A.C.4    Rosseau, S.5    Hammerschmidt, S.6
  • 70
    • 84900556543 scopus 로고    scopus 로고
    • Recognition of extracellular bacteria by NLRs and its role in the development of adaptive immunity
    • Ferrand J, Ferrero RL. Recognition of extracellular bacteria by NLRs and its role in the development of adaptive immunity. Front Immunol. 2013;4:344.
    • (2013) Front Immunol , vol.4 , pp. 344
    • Ferrand, J.1    Ferrero, R.L.2
  • 71
    • 9244245293 scopus 로고    scopus 로고
    • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    • Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol. 2004;5:1166-1174.
    • (2004) Nat Immunol , vol.5 , pp. 1166-1174
    • Viala, J.1    Chaput, C.2    Boneca, I.G.3    Cardona, A.4    Girardin, S.E.5    Moran, A.P.6
  • 72
    • 69149087051 scopus 로고    scopus 로고
    • NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation
    • Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, et al. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009;106:12873-12878.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12873-12878
    • Hruz, P.1    Zinkernagel, A.S.2    Jenikova, G.3    Botwin, G.J.4    Hugot, J.P.5    Karin, M.6
  • 74
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with increased susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with increased susceptibility to Crohn's disease. Nature. 2001;411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5    Ramos, R.6
  • 75
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • Strober W, Murray PJ, Kitani A, Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol. 2006;6:9-20.
    • (2006) Nat Rev Immunol , vol.6 , pp. 9-20
    • Strober, W.1    Murray, P.J.2    Kitani, A.3    Watanabe, T.4
  • 76
    • 79955129532 scopus 로고    scopus 로고
    • Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands
    • Magalhaes JG, Lee J, Geddes K, Rubino S, Philpott DJ, Girardin SE. Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol. 2011;41:1445-1455.
    • (2011) Eur J Immunol , vol.41 , pp. 1445-1455
    • Magalhaes, J.G.1    Lee, J.2    Geddes, K.3    Rubino, S.4    Philpott, D.J.5    Girardin, S.E.6
  • 77
    • 0037075549 scopus 로고    scopus 로고
    • Involvement of receptor-interacting protein 2 in innate and adaptive immune responses
    • Chin AI, Dempsey PW, Brun K, Miller JF, Xu Y, Cheng G. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002;416:190-194.
    • (2002) Nature , vol.416 , pp. 190-194
    • Chin, A.I.1    Dempsey, P.W.2    Brun, K.3    Miller, J.F.4    Xu, Y.5    Cheng, G.6
  • 79
    • 33748477504 scopus 로고    scopus 로고
    • Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    • Bafica A, Santiago HC, Goldszmid R, Ropert C, Gazzinelli RT, Sher A. Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. J Immunol. 2006;177:3515-3519.
    • (2006) J Immunol , vol.177 , pp. 3515-3519
    • Bafica, A.1    Santiago, H.C.2    Goldszmid, R.3    Ropert, C.4    Gazzinelli, R.T.5    Sher, A.6
  • 80
    • 33846898975 scopus 로고    scopus 로고
    • Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection
    • Albiger B, Dahlberg S, Sandgren A, Wartha F, Beiter K, Katsuragi H, et al. Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol. 2007;9:633-644.
    • (2007) Cell Microbiol , vol.9 , pp. 633-644
    • Albiger, B.1    Dahlberg, S.2    Sandgren, A.3    Wartha, F.4    Beiter, K.5    Katsuragi, H.6
  • 81
    • 2342525996 scopus 로고    scopus 로고
    • Regulation of phagosome maturation by signals from toll-like receptors
    • Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from toll-like receptors. Science. 2004;304:1014-1018.
    • (2004) Science , vol.304 , pp. 1014-1018
    • Blander, J.M.1    Medzhitov, R.2
  • 82
    • 23844521000 scopus 로고    scopus 로고
    • Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists
    • Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, et al. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol. 2005;35:2459-2470.
    • (2005) Eur J Immunol , vol.35 , pp. 2459-2470
    • Fritz, J.H.1    Girardin, S.E.2    Fitting, C.3    Werts, C.4    Mengin-Lecreulx, D.5    Caroff, M.6
  • 83
    • 14744299357 scopus 로고    scopus 로고
    • The RIP kinases: crucial integrators of cellular stress
    • Meylan E, Tschopp J. The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci. 2005;30:151-159.
    • (2005) Trends Biochem Sci , vol.30 , pp. 151-159
    • Meylan, E.1    Tschopp, J.2
  • 84
    • 66349097787 scopus 로고    scopus 로고
    • The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    • Shimada K, Chen S, Dempsey PW, Sorrentino R, Alsabeh R, Slepenkin AV, et al. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog. 2009;5:e1000379.
    • (2009) PLoS Pathog , vol.5 , pp. e1000379
    • Shimada, K.1    Chen, S.2    Dempsey, P.W.3    Sorrentino, R.4    Alsabeh, R.5    Slepenkin, A.V.6
  • 85
    • 5144228220 scopus 로고    scopus 로고
    • The role of Toll-like receptors and Nod proteins in bacterial infection
    • Philpott DJ, Girardin SE. The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol. 2004;41:1099-1108.
    • (2004) Mol Immunol , vol.41 , pp. 1099-1108
    • Philpott, D.J.1    Girardin, S.E.2
  • 86
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005;307:731-734.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3    Henegariu, O.4    Inohara, N.5    Nunez, G.6
  • 87
    • 1542275510 scopus 로고    scopus 로고
    • Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction
    • Traub S, Kubasch N, Morath S, Kresse M, Hartung T, Schmidt RR, et al. Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction. J Biol Chem. 2004;279:8694-8700.
    • (2004) J Biol Chem , vol.279 , pp. 8694-8700
    • Traub, S.1    Kubasch, N.2    Morath, S.3    Kresse, M.4    Hartung, T.5    Schmidt, R.R.6
  • 88
    • 84875233002 scopus 로고    scopus 로고
    • TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2
    • Schwarz H, Posselt G, Wurm P, Ulbing M, Duschl A, Horejs-Hoeck J. TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2. Immunobiology. 2013;218:533-542.
    • (2013) Immunobiology , vol.218 , pp. 533-542
    • Schwarz, H.1    Posselt, G.2    Wurm, P.3    Ulbing, M.4    Duschl, A.5    Horejs-Hoeck, J.6
  • 89
    • 0036453023 scopus 로고    scopus 로고
    • Enhancement of endotoxin activity by muramyldipeptide
    • Takada H, Yokoyama S, Yang S. Enhancement of endotoxin activity by muramyldipeptide. J Endotoxin Res. 2002;8:337-342.
    • (2002) J Endotoxin Res , vol.8 , pp. 337-342
    • Takada, H.1    Yokoyama, S.2    Yang, S.3
  • 90
    • 2942535858 scopus 로고    scopus 로고
    • Reciprocal cross-talk between Nod2 and TAK1 signaling pathways
    • Chen CM, Gong Y, Zhang M, Chen JJ. Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem. 2004;279:25876-25882.
    • (2004) J Biol Chem , vol.279 , pp. 25876-25882
    • Chen, C.M.1    Gong, Y.2    Zhang, M.3    Chen, J.J.4
  • 91
    • 79954592046 scopus 로고    scopus 로고
    • Dual roles of NOD2 in TLR4-mediated signal transduction and-induced inflammatory gene expression in macrophages
    • Tsai WH, Huang DY, Yu YH, Chen CY, Lin WW. Dual roles of NOD2 in TLR4-mediated signal transduction and-induced inflammatory gene expression in macrophages. Cell Microbiol. 2011;13:717-730.
    • (2011) Cell Microbiol , vol.13 , pp. 717-730
    • Tsai, W.H.1    Huang, D.Y.2    Yu, Y.H.3    Chen, C.Y.4    Lin, W.W.5
  • 92
    • 79953046719 scopus 로고    scopus 로고
    • The inflammasome NLRs in immunity, inflammation, and associated diseases
    • Davis BK, Wen H, Ting JPY. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol. 2011;29:707-735.
    • (2011) Annu Rev Immunol , vol.29 , pp. 707-735
    • Davis, B.K.1    Wen, H.2    Ting, J.P.Y.3
  • 93
    • 39149094587 scopus 로고    scopus 로고
    • The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    • Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Núñez G. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity. 2008;28:246-257.
    • (2008) Immunity , vol.28 , pp. 246-257
    • Kim, Y.G.1    Park, J.H.2    Shaw, M.H.3    Franchi, L.4    Inohara, N.5    Núñez, G.6
  • 94
    • 84869219130 scopus 로고    scopus 로고
    • Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components
    • Lee KH, Biswas A, Liu YJ, Kobayashi KS. Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components. J Biol Chem. 2012;287:39800-39811.
    • (2012) J Biol Chem , vol.287 , pp. 39800-39811
    • Lee, K.H.1    Biswas, A.2    Liu, Y.J.3    Kobayashi, K.S.4
  • 97
    • 33748760336 scopus 로고    scopus 로고
    • Anti-high mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis
    • Suda K, Kitagawa Y, Ozawa S, Saikawa Y, Ueda M, Ebina M, et al. Anti-high mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J Surg. 2006;30:1755-1762.
    • (2006) World J Surg , vol.30 , pp. 1755-1762
    • Suda, K.1    Kitagawa, Y.2    Ozawa, S.3    Saikawa, Y.4    Ueda, M.5    Ebina, M.6
  • 98
    • 84875124740 scopus 로고    scopus 로고
    • Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial
    • Opal SM, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP, et al. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA. 2013;309:1154-6210.
    • (2013) JAMA , vol.309 , pp. 1154-6210
    • Opal, S.M.1    Laterre, P.F.2    Francois, B.3    LaRosa, S.P.4    Angus, D.C.5    Mira, J.P.6
  • 100
    • 38449100254 scopus 로고    scopus 로고
    • TLR4/MD2 monoclonal antibody therapy affords protection in experimental models of septic shock
    • Daubeuf B, Mathison J, Spiller S, Hugues S, Herren S, Ferlin W, et al. TLR4/MD2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol. 2007;179:6107-6114.
    • (2007) J Immunol , vol.179 , pp. 6107-6114
    • Daubeuf, B.1    Mathison, J.2    Spiller, S.3    Hugues, S.4    Herren, S.5    Ferlin, W.6
  • 101
    • 84920042236 scopus 로고    scopus 로고
    • TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis
    • van Lieshout MH, van der Poll T, Van't Veer C. TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis. Inflamm Res. 2014;63:927-933.
    • (2014) Inflamm Res , vol.63 , pp. 927-933
    • Lieshout, M.H.1    Poll, T.2    Veer, C.3
  • 102
    • 80052396795 scopus 로고    scopus 로고
    • A small molecule that mimics the BB-loop in the Toll/IL-1 receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice
    • Kissner TL, Moisan L, Mann E, Alam S, Ruthel G, Ulrich RG, et al. A small molecule that mimics the BB-loop in the Toll/IL-1 receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice. J Biol Chem. 2011;286:31385-31390.
    • (2011) J Biol Chem , vol.286 , pp. 31385-31390
    • Kissner, T.L.1    Moisan, L.2    Mann, E.3    Alam, S.4    Ruthel, G.5    Ulrich, R.G.6
  • 103
    • 77951240589 scopus 로고    scopus 로고
    • Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
    • Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, Yu JW, et al. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010;285:9792-9802.
    • (2010) J Biol Chem , vol.285 , pp. 9792-9802
    • Juliana, C.1    Fernandes-Alnemri, T.2    Wu, J.3    Datta, P.4    Solorzano, L.5    Yu, J.W.6
  • 104
    • 78651300299 scopus 로고    scopus 로고
    • TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules
    • Matsunaga N, Tsuchimori N, Matsumoto T, Ii M. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Mol Pharmacol. 2011;79:34-41.
    • (2011) Mol Pharmacol , vol.79 , pp. 34-41
    • Matsunaga, N.1    Tsuchimori, N.2    Matsumoto, T.3    Ii, M.4
  • 105
    • 70350304545 scopus 로고    scopus 로고
    • Analysis of binding site for the novel small- molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model
    • Takashima K, Matsunaga N, Yoshimatsu M, Hazeki K, Kaisho T, Uekata M, et al. Analysis of binding site for the novel small- molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. Br J Pharmacol. 2009;157:1250-1262.
    • (2009) Br J Pharmacol , vol.157 , pp. 1250-1262
    • Takashima, K.1    Matsunaga, N.2    Yoshimatsu, M.3    Hazeki, K.4    Kaisho, T.5    Uekata, M.6
  • 106
    • 34548496023 scopus 로고    scopus 로고
    • Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
    • Sha T, Sunamoto M, Kitazaki T, Sato J, Ii M, Iizawa Y. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model. Eur J Pharmacol. 2007;571:231-239.
    • (2007) Eur J Pharmacol , vol.571 , pp. 231-239
    • Sha, T.1    Sunamoto, M.2    Kitazaki, T.3    Sato, J.4    Ii, M.5    Iizawa, Y.6
  • 107
    • 85027943411 scopus 로고    scopus 로고
    • Combination of Imipenem and Tak-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis
    • Sha T, Iizawa Y, Ii M. Combination of Imipenem and Tak-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis. Shock. 2011;35:205-209.
    • (2011) Shock , vol.35 , pp. 205-209
    • Sha, T.1    Iizawa, Y.2    Ii, M.3
  • 108
    • 84973146517 scopus 로고    scopus 로고
    • Takeda
    • Takeda [ http://www.takeda.com/news/2009/20090220_3678.html ]
  • 109
    • 77954953617 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
    • Rice T, Wheeler A, Bernard G, Vincent JL, Angus D, Aikawa N, et al. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med. 2010;38:1685-1694.
    • (2010) Crit Care Med , vol.38 , pp. 1685-1694
    • Rice, T.1    Wheeler, A.2    Bernard, G.3    Vincent, J.L.4    Angus, D.5    Aikawa, N.6
  • 110
    • 85047690873 scopus 로고    scopus 로고
    • Antagonistic antibody prevents Toll-like receptor 2-driven lethal shock-like syndromes
    • Meng G, Rutz M, Schiemann M, Metzger J, Grabiec A, Schwandner R, et al. Antagonistic antibody prevents Toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest. 2004;113:1473-1481.
    • (2004) J Clin Invest , vol.113 , pp. 1473-1481
    • Meng, G.1    Rutz, M.2    Schiemann, M.3    Metzger, J.4    Grabiec, A.5    Schwandner, R.6
  • 111
    • 49249138761 scopus 로고    scopus 로고
    • TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives gram-negative sepsis in mice
    • Spiller S, Elson G, Ferstl R, Dreher S, Mueller T, Freudenberg M, et al. TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives gram-negative sepsis in mice. J Exp Med. 2008;205:1747-1754.
    • (2008) J Exp Med , vol.205 , pp. 1747-1754
    • Spiller, S.1    Elson, G.2    Ferstl, R.3    Dreher, S.4    Mueller, T.5    Freudenberg, M.6
  • 112
    • 58149149839 scopus 로고    scopus 로고
    • TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
    • Cavassani KA, Ishii M, Wen H, Schaller MA, Lincoln PM, Lukacs NW, et al. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med. 2008;205:2609-2621.
    • (2008) J Exp Med , vol.205 , pp. 2609-2621
    • Cavassani, K.A.1    Ishii, M.2    Wen, H.3    Schaller, M.A.4    Lincoln, P.M.5    Lukacs, N.W.6
  • 113
    • 57649184660 scopus 로고    scopus 로고
    • Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis
    • Wardowska A, Dzierzbicka K, Szarynska M, Dabrowska-Szponar M, Wisniewska K, Mysliwski A, et al. Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis. Vaccine. 2009;27:369-374.
    • (2009) Vaccine , vol.27 , pp. 369-374
    • Wardowska, A.1    Dzierzbicka, K.2    Szarynska, M.3    Dabrowska-Szponar, M.4    Wisniewska, K.5    Mysliwski, A.6
  • 114
    • 0034787079 scopus 로고    scopus 로고
    • Clinical tolerance and profile of cytokine induction in healthy volunteers following the simultaneous administration of IFN-α and the synthetic immunomodulator murabutide
    • Darcissac ECA, Vidal V, Guillaume M, Thebault JJ, Bahr GM. Clinical tolerance and profile of cytokine induction in healthy volunteers following the simultaneous administration of IFN-α and the synthetic immunomodulator murabutide. J Interferon Cytokine Res. 2001;21:655-661.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 655-661
    • Darcissac, E.C.A.1    Vidal, V.2    Guillaume, M.3    Thebault, J.J.4    Bahr, G.M.5
  • 115
    • 0020595380 scopus 로고
    • Immunoactive peptides, FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice
    • Mine Y, Yokota Y, Wakai Y, Fukada S, Nishida M, Goto S, et al. Immunoactive peptides, FK-156 and FK-565. I. Enhancement of host resistance to microbial infection in mice. J Antibiot. 1983;36:1045-1050.
    • (1983) J Antibiot , vol.36 , pp. 1045-1050
    • Mine, Y.1    Yokota, Y.2    Wakai, Y.3    Fukada, S.4    Nishida, M.5    Goto, S.6
  • 116
    • 84973100589 scopus 로고    scopus 로고
    • Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders
    • 29 May 2012.
    • Hackam DJ, Gribar SC: Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders. US Patent No. 8188058. 29 May 2012.
    • Hackam, D.J.1    Gribar, S.C.2
  • 119
    • 76749104336 scopus 로고    scopus 로고
    • Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia
    • Ribes S, Ebert S, Regen T, Agarwal A, Tauber SC, Czesnik D, et al. Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. Infect Immun. 2010;78:865-871.
    • (2010) Infect Immun , vol.78 , pp. 865-871
    • Ribes, S.1    Ebert, S.2    Regen, T.3    Agarwal, A.4    Tauber, S.C.5    Czesnik, D.6
  • 120
    • 84890861186 scopus 로고    scopus 로고
    • Animal models of sepsis
    • Fink MP. Animal models of sepsis. Virulence. 2014;5:143-153.
    • (2014) Virulence , vol.5 , pp. 143-153
    • Fink, M.P.1


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