Endotoxin tolerance: A review

Critical Care Medicine

Volumn 30, Issue 1 SUPPL. B, 2002, Pages

  West, Michael A ^a   Heagy, Wyrta ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Animal; Cytokine; Human; Lipopolysaccharide; Macrophage; Monocyte; Priming; Rechallenge; Sepsis; Signal transduction

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; NITRATE; NITRITE; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; THROMBOXANE B2; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

CONFERENCE PAPER; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; SEPSIS; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 0036159842     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200201001-00009     Document Type: Conference Paper

References (138)

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5. Patterns of tolerance to endotoxin
6. Mechanisms of endotoxin tolerance with special reference to man
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8. Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery
9. Endotoxin tolerance from lipopolysaccharide pretreatment induces nuclear factor-kappaB alterations not present in C3H/HeJ mice
10. Signal transduction alterations in macrophage endotoxin tolerance: Abnormal protein kinase C-zeta activation
11. Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: Role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation
12. Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression
13. Impaired ex vivo lipopolysaccharide-stimulated whole blood tumor necrosis factor production may identify "septic" intensive care unit patients
14. Molecular mechanisms responsible for endotoxin tolerance
15. Minimally invasive surgery induces endotoxin-tolerance in the absence of detectable endotoxemia
16. Lipopolysaccharide pretreatment produces macrophage endotoxin tolerance via a serum-independent pathway
17. Molecular basis of endotoxin tolerance
18. The nonspecific nature of endotoxin tolerance
19. Mechanisms of endotoxin tolerance
20. The nature of endotoxin tolerance
21. Early endotoxin tolerance is associated with alterations in bone marrow-derived macrophage precursor pools
22. Induction of tolerance in mice and rats to the effect of endotoxin to decrease the hepatic microsomal mixed-function oxidase system: Evidence for a possible macrophage-derived factor in the endotoxin effect
23. Endotoxin tolerance is associated with reduced secretion of tumor necrosis factor
24. Endotoxin tolerance: Independent regulation of interleukin-1 and tumor necrosis factor expression
25. Interleukin 1 and its relationship to endotoxin tolerance
26. Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response
27. Administration of endotoxin associated with lipopolysaccharide tolerance protects mice against fungal infection
28. Endotoxin tolerance in rats: Expression of TNF-alpha, IL-6, IL-10, VCAM-1 and HSP 70 in lung and liver during endotoxin shock
29. Macrophage endotoxin tolerance: Effect of TNF or endotoxin pretreatment
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31. Discordant adaptation of human peritoneal macrophages to stimulation by lipopolysaccharide and synthestic lipid A analogue DSZ MRL 953
32. Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes
33. Endotoxin tolerance is not a LPS-specific phenomenon: Partial mimicry, with IL-1, IL-10 and TGFβ
34. Endotoxin tolerance is associated with altered GTP-binding protein function
35. Lipopolysaccharide (LPS) recognition in macrophages: Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages
36. LPS induces selective translocation of protein kinase C-β in LPS-responsive mouse macrophages, but not in LPS-nonresponsive mouse macrophages
37. Pre-exposure of macrophages to low doses of lipopolysaccharide inhibits the expression of tumor necrosis factor-α mRNA but not of IL-1β mRNA
38. Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro
39. Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells
40. Endotoxin pretreatment of human monocytes alters subsequent endotoxin-triggered release of inflammatory mediators
41. Pre-exposure to hypoxia or septic stimuli differentially regulates endotoxin release of tumor necrosis factor, interleukin-6, interleukin-1, prostaglandin E2, nitric oxide, and superoxide by macrophages
42. Lipopolysaccharide-induced selective priming effects on tumor necrosis factor-alpha and nitric oxide production in mouse peritoneal macrophages
43. mRNA and protein stability regulate the differential expression of pro- and anti-inflammatory genes in endotoxin-tolerant THP-1 cells
44. Endotoxin tolerance is associated with decreased prostaglandin H synthases-1 and -2
45. Differential desensitization of lipopolysaccharide-inducible chemokine gene expression in human monocytes and macrophages
46. Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-kappaB cascades, but not lipopolysaccharide-incorporation steps
47. Suppresion of TNF-α mRNA expression in LPS-primed macrophages occurs at the level of nuclear factor-κB activation, but not at the level of protein kinase C or CD14 expression
48. Coordinate regulation of TNF biosynthesis at the levels of transcription and translation: Patterns of TNF expression in vivo
49. Macrophage endotoxin tolerance: Tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment
50. Discordant reprogramming of LPS-stimulated cytokine gene transcription and secretion by macrophages after LPS pretreatment
51. Impaired antigen presentation by human monocytes during endotoxin tolerance
52. Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance
53. Interleukin 8 production in whole blood assays: Is interleukin 10 responsible for the down-regulation observed in sepsis?
54. LPS pretreatment reprograms macrophage LPS-stimulated TNF and IL-1 release without protein tyrosine kinase activation
55. Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers
56. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events
57. Endotoxin tolerance alters macrophage membrane regulatory G proteins
58. Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways
59. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and Toll-like receptor 2 and 4 gene expression
60. Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4
61. Signal transduction events in Chinese hamster ovary cells expressing human CD14: Effect of endotoxin desensitization
62. Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells
63. Macrophage TNF secretion in endotoxin tolerance: Role of SAPK, p38, and MAPK
64. Defective lipopolysaccharide-dependent ERK 1/2 activation in endotoxin tolerant murine macrophages is reversed by direct protein kinase C stimulation
65. Endotoxin activation of mitogen-activated protein kinase in THP-1 cells: Diminished activation following endotoxin desensitization
66. Protein kinase C regulates macrophage tumor necrosis factor secretion: Direct protein kinase C activation restores tumor necrosis factor production in endotoxin tolerance
67. Suppression of Cox-2 and TNF-alpha mRNA in endotoxin tolerance: Effect of cycloheximide, antinomycin D, and okadaic acid
68. NF-κB1 (p50) is upregulated in lipopolysacchride tolerance and can block tumor neecrosis factor gene expression
69. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
70. Inhibitory kappaBalpha control of nuclear factor-kappaB is dysregulated in endotoxin tolerant macrophages
71. NF-κB controls expression of inhibitor IκBα: Evidence for an inducible autoregulatory pathway
72. d phenotype
73. Tumor cell killing and cytostasis by C3H/HeJ macrophages activated in vitro by lipid A-associated protein and interferon gamma
74. Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis?
75. Macrophages derived from C3H/HeJ (Lps) mice respond to bacterial lipopolysaccharide by activating NF-κB
76. d) macrophages requires the presence of lipid A-associated proteins
77. d) macrophages
78. The lipid A moiety of Prophyromonas gingivalis lipopolysaccharide specifically mediates the activation of C3H/HeJ mice
79. Purification and characterization of the 65-kDa protein phosphorylated in murine macrophages by stimulation with bacterial lipopolysaccharide
80. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
81. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
82. In vitro macrophage endotoxin tolerance: Defective in vitro macrophage MAP kinase signal transduction after LPS pretreatment is not present in macrophages from C3H/HeJ endotoxin resistant mice
83. CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol
84. Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the Lps(d) C57BL/ 10ScCr mouse
85. Role of the hepatic function in the development of the pyrogenic tolerance to muramyl dipeptide
86. Differential tolerance induction by lipoarabinomannan and lipopolysaccharide in human macrophages
87. Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
88. 25-Hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages
89. Endotoxin induces a dose-dependent myocardial cross-tolerance to ischemia-reperfusion injury
90. Induction of tolerance against ischemia/reperfusion injury in the rat brain by preconditioning with the endotoxin analog diphosphoryl lipid A
91. Endotoxin cross tolerance: Another inflammatory preconditioning stimulus?
92. Induction of endotoxin tolerance in rat bone marrow cells by in vivo infusion of tumor necrosis factor
93. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
94. Comparison of SP-A and LPS effects on the THP-1 monocytic cell line
95. Lipoarabinomannan of Mycobacterium tuberculosis promotes protein tyrosine dephosphorylation and inhibition of mitogen activated protein kinase in human mononuclear phagocytes
96. Lipopolysacchride pretreatment induces endotoxin tolerance in human THP-1 monocytic cells via a CD14-independent pathway
97. Endotoxin signal transduction in macrophages
98. Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural synthetic bacterial products
99. Cytokine down-regulation in endotoxin tolerance
100. Different regulation of TNF alpha and IL-1 ra synthesis in LPS-tolerant human monocytes
101. In vivo endotoxin tolerance: Impaired LPS-stimulated TNF release of monocytes from patients with sepsis, but not SIRS
102. Impaired mitogen-activated protein kinase activation and altered cytokine secretion in endotoxin-tolerant human monocytes
103. Role of interleukin-10 on hyporesponsiveness of endotoxin during surgery
104. Role of interleukin-10 in monocyte hyporesponsiveness associated with septic shock
105. In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion
106. Flow cytometric analysis of human bone marrow III: Neutrophil maturation
107. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
108. TNF-alpha gene expression in macrophages: Regulation by NF-kappa B is independent of c-Jun or C/EBP beta
109. NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance
110. NF-kappaB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
111. Endotoxin inducible transcription is repressed in endotoxin tolerant cells
112. Dysregulation of in vitro cytokine production by monocytes during sepsis
113. Release of proinflammatory cytokines by mitogen-stimulated peripheral blood mononuclear cells from critically ill multiple-trauma victims
114. Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis
115. Selective cytokine release induced by serum and separated plasma from septic patients
116. Intravenous endotoxin supresses the cytokine response of peripheral blood mononuclear cells of healthy humans
117. Whole blood tumor necrosis factor-alpha production and its relation to systemic concentrations of interleukin 4, interleukin 10, and transforming growth factor-beta1 in multiply injured blunt trauma victims
118. Regulation of whole blood tumor necrosis factor production upon endotoxin stimulation after severe blunt trauma
119. Reduced tumor necrosis factor production in endotoxin-spiked whole blood after trauma: Experimental results and clinical correlation
120. Sex differences in posttraumatic cytokine release of endotoxin-stimulated whole blood: Relationship to the development of severe sepsis
121. Endotoxin tolerance after severe injury and its regulatory mechanisms
122. Sustained endotoxemia leads to marked down-regulation of early steps in the insulin-signaling cascade
123. Both inflammatory and endocrine mediators stimulate host responses in sepsis
124. Endotoxin tolerance: In vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level
125. Tolerance to lipopolysaccharide (LPS) regulates the endotoxin effects on Shiga toxin-2 lethality
126. Effect of endotoxin pretreatment on surgical lethality in animal experiments
127. Adaptation of bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages
128. Effects of in vivo endotoxin infusions on in vitro cellular immune responses in humans
129. Low dose LPS pretreatment of mouse macrophages modulates LPS-dependent IL-6 production in vitro
130. Increased nitric oxide synthesis during the development of endotoxin tolerance
131. Endotoxin tolerance: Effects on lethality and macrophage thromboxane and interleukin-6 production
132. The production of TNF alpha and IL-8 in whole blood assays are differently regulated upon activation by LPS
133. Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide
134. Involvement of p38 mitogen-activated protein kinase in the induction of tolerance to hemorrhagic and endotoxic shock
135. Molecular mechanism in tolerance to lipopolysaccharide
136. Induction of endotoxin tolerance depletes nuclear factor-kappaB and suppresses its activation in rat alveolar macrophages
137. The involvement of an LPS inducible I kappa B kinase in endotoxin tolerance
138. Increased levels of myocardial I kappa B-alpha protein promote tolerance to endotoxin