NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 31, 2009, Pages 12873-12878

  Hruz, Petr ^a   Zinkernagel, Annelies S ^b   Jenikova, Gabriela ^a   Botwin, Gregory J ^a   Hugot, Jean Pierre ^c   Karin, Michael ^d   Nizet, Victor ^b,e   Eckmann, Lars ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c INSERM   (France)

^d San Diego   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Innate immunity; Interleukin 1; Interleukin 6; Microbial pathogenesis

Indexed keywords

ALPHA TOXIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 6; PEPTIDOGLYCAN; PORE FORMING CYTOTOXIC PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; BACTERIAL TOXIN; CARD15 PROTEIN, MOUSE; HEMOLYSIN; INTERLEUKIN 8; STAPHYLOCOCCAL ALPHA-TOXIN; STAPHYLOCOCCUS ALPHA TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BACTERIUM DETECTION; CONTROLLED STUDY; CYTOPLASM; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; OLIGOMERIZATION; PATHOGENESIS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; IMMUNOLOGY; LEUKOCYTE ACTIVATION; MICROBIOLOGY; PHYSIOLOGY; SKIN;

BACTERIA (MICROORGANISMS); MUS; STAPHYLOCOCCUS AUREUS;

ANIMALS; BACTERIAL TOXINS; HEMOLYSIN PROTEINS; IMMUNITY, INNATE; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MICE; MICE, INBRED C57BL; NEUTROPHIL ACTIVATION; NOD2 SIGNALING ADAPTOR PROTEIN; SKIN; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 69149087051     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904958106     Document Type: Article

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