Sepsis, severe sepsis and septic shock: Changes in incidence, pathogens and outcomes

Expert Review of Anti-Infective Therapy

Volumn 10, Issue 6, 2012, Pages 701-706

  Martin, Greg S ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

critical illness; infection; intensive care unit; sepsis

Indexed keywords

ANTIBIOTIC AGENT;

ANTIMICROBIAL THERAPY; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIGH RISK PATIENT; HUMAN; INCIDENCE; INFECTION RISK; MOLECULAR EVOLUTION; MOLECULAR PATHOLOGY; MORTALITY; NONHUMAN; OUTCOME ASSESSMENT; PREDICTION; RACE DIFFERENCE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEPTIC SHOCK; SYNDROME DELINEATION;

FUNGI; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INCIDENCE; MYCOSES; SEPSIS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC;

EID: 84863196654     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.12.50     Document Type: Review

References (41)

1. Riedemann NC, Guo RF, Ward PA. The enigma of sepsis. J. Clin. Invest. 112(4), 460-467 (2003). (Pubitemid 38056327)
2. Thomas L. Germs. N. Engl. J. Med. 287(11), 553-555 (1972).
3. Abraham E, Matthay MA, Dinarello CA et al. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit. Care Med. 28(1), 232-235 (2000). (Pubitemid 30091059)
4. Vincent JL. Procalcitonin: the marker of sepsis? Crit. Care Med. 28(4), 1226-1228 (2000).
5. No authors listed. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 20(6), 864-874 (1992).
6. Levy MM, Fink MP, Marshall JC et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit. Care Med. 31(4), 1250-1256 (2003). (Pubitemid 36444440)
7. Howell MD, Talmor D, Schuetz P, Hunziker S, Jones AE, Shapiro NI. Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit. Care Med. 39(2), 322-327 (2011).
8. Vincent JL, Sakr Y, Sprung CL et al. Sepsis in European intensive care units: results of the SOAP study. Crit. Care Med. 34(2), 344-353 (2006). (Pubitemid 43145611)
9. Vincent JL, Rello J, Marshall J et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 302(21), 2323-2329 (2009).
10. Danai P, Martin GS. Epidemiology of sepsis: recent advances. Curr. Infect. Dis. Rep. 7(5), 329-334 (2005). (Pubitemid 41419366)
11. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348(16), 1546-1554 (2003). (Pubitemid 36437931)
12. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Facing the challenge: decreasing case fatality rates in severe sepsis despite increasing hospitalizations. Crit. Care Med. 33(11), 2555-2562 (2005). (Pubitemid 41682108)
13. Sundararajan V, Macisaac CM, Presneill JJ, Cade JF, Visvanathan K. Epidemiology of sepsis in Victoria, Australia. Crit. Care Med. 33(1), 71-80 (2005). (Pubitemid 40116539)
14. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit. Care Med. 35(5), 1244-1250 (2007). (Pubitemid 46642649)
15. Finfer S, Bellomo R, Lipman J, French C, Dobb G, Myburgh J. Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. 30(4), 589-596 (2004). (Pubitemid 38530093)
16. Harrison DA, Welch CA, Eddleston JM. The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC case mix programme database. Crit. Care 10(2), R42 (2006).
17. Degoricija V, Sharma M, Legac A, Gradiser M, Sefer S, Vucicevic Z. Survival analysis of 314 episodes of sepsis in medical intensive care unit in university hospital: impact of intensive care unit performance and antimicrobial therapy. Croat. Med. J. 47(3), 385-397 (2006).
18. Adhikari NK, Fowler RA, Bhagwanjee S, Rubenfeld GD. Critical care and the global burden of critical illness in adults. Lancet 376(9749), 1339-1346 (2010).
19. Berkley JA, Maitland K, Mwangi I et al. Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study. BMJ 330(7498), 995 (2005).
20. Danai PA, Moss M, Mannino DM, Martin GS. The epidemiology of sepsis in patients with malignancy. Chest 129(6), 1432-1440 (2006). (Pubitemid 43894970)
21. Esper AM, Moss M, Lewis CA, Nisbet R, Mannino DM, Martin GS. The role of infection and comorbidity: factors that influence disparities in sepsis. Crit. Care Med. 34(10), 2576-2582 (2006). (Pubitemid 44413055)
22. Mayr FB, Yende S, Linde-Zwirble WT et al. Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA 303(24), 2495-2503 (2010).
23. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Occurrence and outcomes of sepsis: influence of race. Crit. Care Med. 35(3), 763-768 (2007). (Pubitemid 46407788)
24. Parrillo JE, Parker MM, Natanson C et al. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann. Intern. Med. 113(3), 227-242 (1990). (Pubitemid 20242299)
25. Sands KE, Bates DW, Lanken PN et al. Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA 278(3), 234-240 (1997). (Pubitemid 27339591)
26. Pittet D, Wenzel RP. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch. Intern. Med. 155(11), 1177-1184 (1995).
27. Trick WE, Jarvis WR. Epidemiology of nosocomial fungal infection in the 1990s. Rev. Iberoam. Micol. 15(1), 2-6 (1998). (Pubitemid 128534049)
28. Danai PA, Sinha S, Moss M, Haber MJ, Martin GS. Seasonal variation in the epidemiology of sepsis. Crit. Care Med. 35(2), 410-415 (2007). (Pubitemid 46148529)
29. Houck PM, Bratzler DW, Nsa W, Ma A, Bartlett JG. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch. Intern. Med. 164(6), 637-644 (2004). (Pubitemid 38392978)
30. Kumar A, Roberts D, Wood KE et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 34(6), 1589-1596 (2006). (Pubitemid 43810035)
31. Harbarth S, Garbino J, Pugin J, Romand JA, Lew D, Pittet D. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am. J. Med. 115(7), 529-535 (2003). (Pubitemid 37352798)
32. Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit. Care Med. 31(12), 2742-2751 (2003). (Pubitemid 38010630)
33. Kumar A, Zarychanski R, Light B et al. Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit. Care Med. 38(9), 1773-1785 (2010).
34. Dellinger RP, Carlet JM, Masur H et al. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit. Care Med. 32(3), 858-873 (2004). (Pubitemid 38344143)
35. Marshall JC, Maier RV, Jimenez M, Dellinger EP. Source control in the management of severe sepsis and septic shock: an evidence-based review. Crit. Care Med. 32(Suppl. 11), S513-S526 (2004). (Pubitemid 39489024)
36. Edbrooke DL, Hibbert CL, Kingsley JM, Smith S, Bright NM, Quinn JM. The patient-related costs of care for sepsis patients in a United Kingdom adult general intensive care unit. Crit. Care Med. 27(9), 1760-1767 (1999). (Pubitemid 29455101)
37. Schmid A, Schneider H, Adlof A et al. Economic burden of illness imposed by severe sepsis in Austria. Wien. Klin. Wochenschr. 114(15-16), 697-701 (2002). (Pubitemid 35033592)
38. Brun-Buisson C, Roudot-Thoraval F, Girou E, Grenier-Sennelier C, Durand-Zaleski I. The costs of septic syndromes in the intensive care unit and influence of hospital-acquired sepsis. Intensive Care Med. 29(9), 1464-1471 (2003). (Pubitemid 37153590)
39. Schmid A, Pugin J, Chevrolet JC et al. Burden of illness imposed by severe sepsis in Switzerland. Swiss. Med. Wkly 134(7-8), 97-102 (2004). (Pubitemid 38268825)
40. Moerer O, Plock E, Mgbor U et al. A German national prevalence study on the cost of intensive care: an evaluation from 51 intensive care units. Crit. Care 11(3), R69 (2007).
41. Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time. Crit. Care Med. 26(12), 2078-2086 (1998). (Pubitemid 29016694)