A small molecule that mimics the B-loop in the toll interleukin-1 (IL-1) receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice

Journal of Biological Chemistry

Volumn 286, Issue 36, 2011, Pages 31385-31396

  Kissner, Teri L ^a   Moisan, Lionel ^b   Mann, Enrique ^b   Alam, Shahabuddin ^a   Ruthel, Gordon ^a   Ulrich, Robert G ^a   Rebek, Mitra ^b   Rebek Jr , Julius ^b   Saikh, Kamal U ^a,b  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL-BASED; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; CYTOKINE SIGNALING; ENTEROTOXIN; ESSENTIAL COMPONENT; GENE SILENCING; HUMAN CELLS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MIMETICS; MONONUCLEAR CELLS; PRIMARY CELLS; PROINFLAMMATORY CYTOKINES; RECEPTOR DOMAINS; REPORTER ASSAY; SIGNALING COMPONENTS; SMALL MOLECULES; T CELLS; TOXIC SHOCKS; TRANSCRIPTIONAL ACTIVATIONS;

BODY FLUIDS; GENES; GENETIC ENGINEERING; MAMMALS; SIGNALING; SYNTHESIS (CHEMICAL); TOXICITY;

CELLS;

ADAPTOR PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; SMALL INTERFERING RNA; STAPHYLOCOCCUS ENTEROTOXIN B; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1;

ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG SYNTHESIS; GENE SILENCING; HUMAN; HUMAN CELL; MONOCYTE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TOXIC SHOCK SYNDROME; TRANSCRIPTION INITIATION;

ANIMALS; CELLS, CULTURED; CYTOKINES; ENTEROTOXINS; HUMANS; INFLAMMATION; MICE; MICE, KNOCKOUT; MOLECULAR MIMICRY; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDES; RECEPTORS, INTERLEUKIN-1; SHOCK, SEPTIC;

MURINAE; MUS;

EID: 80052396795     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.204982     Document Type: Article

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