-
1
-
-
0034775153
-
Toll-like receptors control activation of adaptive immune responses
-
Schnare M., Barton G.M., Holt A.C., Takeda K., Akira S., Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol. 2:2001;947-950.
-
(2001)
Nat Immunol
, vol.2
, pp. 947-950
-
-
Schnare, M.1
Barton, G.M.2
Holt, A.C.3
Takeda, K.4
Akira, S.5
Medzhitov, R.6
-
2
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 1:2001;135-145.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
4
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
This paper demonstrates that engagement of TLR9 on B cells by chromatin-containing immune complexes can lead to the activation of autoreactive B cells
-
Leadbetter E.A., Rifkin I.R., Hohlbaum A.M., Beaudette B.C., Shlomchik M.J., Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:2002;603-607 This paper demonstrates that engagement of TLR9 on B cells by chromatin-containing immune complexes can lead to the activation of autoreactive B cells.
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
Rifkin, I.R.2
Hohlbaum, A.M.3
Beaudette, B.C.4
Shlomchik, M.J.5
Marshak-Rothstein, A.6
-
5
-
-
0036839577
-
Endogenous ligands of Toll-like receptors: Implications for regulating inflammatory and immune responses
-
Beg A.A. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. 23:2002;509-512.
-
(2002)
Trends Immunol
, vol.23
, pp. 509-512
-
-
Beg, A.A.1
-
6
-
-
0036829687
-
Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
-
Biragyn A., Ruffini P.A., Leifer C.A., Klyushnenkova E., Shakhov A., Chertov O., Shirakawa A.K., Farber J.M., Segal D.M., Oppenheim J.J.et al. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science. 298:2002;1025-1029.
-
(2002)
Science
, vol.298
, pp. 1025-1029
-
-
Biragyn, A.1
Ruffini, P.A.2
Leifer, C.A.3
Klyushnenkova, E.4
Shakhov, A.5
Chertov, O.6
Shirakawa, A.K.7
Farber, J.M.8
Segal, D.M.9
Oppenheim, J.J.10
-
7
-
-
0037414787
-
Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages
-
Gao B., Tsan M.F. Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages. J Biol Chem. 278:2003;174-179.
-
(2003)
J Biol Chem
, vol.278
, pp. 174-179
-
-
Gao, B.1
Tsan, M.F.2
-
8
-
-
0035877013
-
An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells
-
Li M., Carpio D.F., Zheng Y., Bruzzo P., Singh V., Ouaaz F., Medzhitov R.M., Beg A.A. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol. 166:2001;7128-7135.
-
(2001)
J Immunol
, vol.166
, pp. 7128-7135
-
-
Li, M.1
Carpio, D.F.2
Zheng, Y.3
Bruzzo, P.4
Singh, V.5
Ouaaz, F.6
Medzhitov, R.M.7
Beg, A.A.8
-
9
-
-
0034795208
-
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability
-
Randow F., Seed B. Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat Cell Biol. 3:2001;891-896.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 891-896
-
-
Randow, F.1
Seed, B.2
-
10
-
-
0034927975
-
Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
-
Kaisho T., Akira S. Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol. 22:2001;78-83.
-
(2001)
Trends Immunol
, vol.22
, pp. 78-83
-
-
Kaisho, T.1
Akira, S.2
-
11
-
-
0037436119
-
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
-
Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 299:2003;1033-1036.
-
(2003)
Science
, vol.299
, pp. 1033-1036
-
-
Pasare, C.1
Medzhitov, R.2
-
12
-
-
0029865142
-
IRAK: A kinase associated with the interleukin-1 receptor
-
Cao Z., Henzel W.J., Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science. 271:1996;1128-1131.
-
(1996)
Science
, vol.271
, pp. 1128-1131
-
-
Cao, Z.1
Henzel, W.J.2
Gao, X.3
-
13
-
-
0037117543
-
IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase
-
Li S., Strelow A., Fontana E.J., Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci USA. 99:2002;5567-5572.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5567-5572
-
-
Li, S.1
Strelow, A.2
Fontana, E.J.3
Wesche, H.4
-
14
-
-
0030694108
-
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
-
Muzio M., Ni J., Feng P., Dixit V.M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 278:1997;1612-1615.
-
(1997)
Science
, vol.278
, pp. 1612-1615
-
-
Muzio, M.1
Ni, J.2
Feng, P.3
Dixit, V.M.4
-
15
-
-
0033516561
-
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
-
Wesche H., Gao X., Li X., Kirschning C.J., Stark G.R., Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 274:1999;19403-19410.
-
(1999)
J Biol Chem
, vol.274
, pp. 19403-19410
-
-
Wesche, H.1
Gao, X.2
Li, X.3
Kirschning, C.J.4
Stark, G.R.5
Cao, Z.6
-
16
-
-
0037178785
-
IRAK-M is a negative regulator of Toll-like receptor signaling
-
IRAK-M is a kinase-inactive IRAK family member expressed in monocytes and macrophages, and is induced upon TLR stimulation. Surprisingly, this IRAK inhibits cytokine production resulting from TLR signaling. IRAK-M-deficient mice have enhanced inflammatory responses to bacterial infection, indicating that IRAK-M dampens this response
-
Kobayashi K., Hernandez L.D., Galan J.E., Janeway C.A. Jr., Medzhitov R., Flavell R.A. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110:2002;191-202 IRAK-M is a kinase-inactive IRAK family member expressed in monocytes and macrophages, and is induced upon TLR stimulation. Surprisingly, this IRAK inhibits cytokine production resulting from TLR signaling. IRAK-M-deficient mice have enhanced inflammatory responses to bacterial infection, indicating that IRAK-M dampens this response.
-
(2002)
Cell
, vol.110
, pp. 191-202
-
-
Kobayashi, K.1
Hernandez, L.D.2
Galan, J.E.3
Janeway C.A., Jr.4
Medzhitov, R.5
Flavell, R.A.6
-
17
-
-
0037129212
-
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
-
In this paper, the authors generate and analyze IRAK-4 knockout mice, revealing an essential role for IRAK-4 in TLR signaling. These mice have striking impairments in the ability to produce cytokines (IL-1, TNF and IL-6) both in vitro and in vivo as a result of IL-1 or TLR stimulation. The animals are also resistant to lethal septic shock (a TLR4 response) and are dramatically more susceptible to bacterial and viral infections than wild-type animals
-
Suzuki N., Suzuki S., Duncan G.S., Millar D.G., Wada T., Mirtsos C., Takada H., Wakeham A., Itie A., Li S.et al. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416:2002;750-756 In this paper, the authors generate and analyze IRAK-4 knockout mice, revealing an essential role for IRAK-4 in TLR signaling. These mice have striking impairments in the ability to produce cytokines (IL-1, TNF and IL-6) both in vitro and in vivo as a result of IL-1 or TLR stimulation. The animals are also resistant to lethal septic shock (a TLR4 response) and are dramatically more susceptible to bacterial and viral infections than wild-type animals.
-
(2002)
Nature
, vol.416
, pp. 750-756
-
-
Suzuki, N.1
Suzuki, S.2
Duncan, G.S.3
Millar, D.G.4
Wada, T.5
Mirtsos, C.6
Takada, H.7
Wakeham, A.8
Itie, A.9
Li, S.10
-
18
-
-
0032127279
-
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
-
Adachi O., Kawai T., Takeda K., Matsumoto M., Tsutsui H., Sakagami M., Nakanishi K., Akira S. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 9:1998;143-150.
-
(1998)
Immunity
, vol.9
, pp. 143-150
-
-
Adachi, O.1
Kawai, T.2
Takeda, K.3
Matsumoto, M.4
Tsutsui, H.5
Sakagami, M.6
Nakanishi, K.7
Akira, S.8
-
19
-
-
0035339861
-
Endotoxin-induced maturation of MyD88-deficient dendritic cells
-
Kaisho T., Takeuchi O., Kawai T., Hoshino K., Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol. 166:2001;5688-5694.
-
(2001)
J Immunol
, vol.166
, pp. 5688-5694
-
-
Kaisho, T.1
Takeuchi, O.2
Kawai, T.3
Hoshino, K.4
Akira, S.5
-
20
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai T., Adachi O., Ogawa T., Takeda K., Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity. 11:1999;115-122.
-
(1999)
Immunity
, vol.11
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
21
-
-
0034650420
-
Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
-
Takeuchi O., Kaufmann A., Grote K., Kawai T., Hoshino K., Morr M., Muhlradt P.F., Akira S. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol. 164:2000;554-557.
-
(2000)
J Immunol
, vol.164
, pp. 554-557
-
-
Takeuchi, O.1
Kaufmann, A.2
Grote, K.3
Kawai, T.4
Hoshino, K.5
Morr, M.6
Muhlradt, P.F.7
Akira, S.8
-
22
-
-
0034699340
-
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
-
Schnare M., Holt A.C., Takeda K., Akira S., Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol. 10:2000;1139-1142.
-
(2000)
Curr Biol
, vol.10
, pp. 1139-1142
-
-
Schnare, M.1
Holt, A.C.2
Takeda, K.3
Akira, S.4
Medzhitov, R.5
-
23
-
-
0035889228
-
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
-
Kawai T., Takeuchi O., Fujita T., Inoue J., Muhlradt P.F., Sato S., Hoshino K., Akira S. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol. 167:2001;5887-5894.
-
(2001)
J Immunol
, vol.167
, pp. 5887-5894
-
-
Kawai, T.1
Takeuchi, O.2
Fujita, T.3
Inoue, J.4
Muhlradt, P.F.5
Sato, S.6
Hoshino, K.7
Akira, S.8
-
24
-
-
0035555301
-
TIRAP: An adapter molecule in the Toll signaling pathway
-
Horng T., Barton G.M., Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol. 2:2001;835-841.
-
(2001)
Nat Immunol
, vol.2
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
25
-
-
0035817925
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald K.A., Palsson-McDermott E.M., Bowie A.G., Jefferies C.A., Mansell A.S., Brady G., Brint E., Dunne A., Gray P., Harte M.T.et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 413:2001;78-83.
-
(2001)
Nature
, vol.413
, pp. 78-83
-
-
Fitzgerald, K.A.1
Palsson-McDermott, E.M.2
Bowie, A.G.3
Jefferies, C.A.4
Mansell, A.S.5
Brady, G.6
Brint, E.7
Dunne, A.8
Gray, P.9
Harte, M.T.10
-
26
-
-
0037153191
-
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
-
•]
-
•].
-
(2002)
Nature
, vol.420
, pp. 324-329
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Sanjo, H.4
Uematsu, S.5
Kaisho, T.6
Hoshino, K.7
Takeuchi, O.8
Kobayashi, M.9
Fujita, T.10
-
27
-
-
0037153130
-
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
-
•] describe the phenotype of TIRAP deficient mice. These mice have impaired B-cell proliferation and cytokine production in response to stimulation with TLR2 and TLR4 ligands but not with other TLR ligands, indicating differences in the signal transduction pathways among TLRs
-
•] describe the phenotype of TIRAP deficient mice. These mice have impaired B-cell proliferation and cytokine production in response to stimulation with TLR2 and TLR4 ligands but not with other TLR ligands, indicating differences in the signal transduction pathways among TLRs.
-
(2002)
Nature
, vol.420
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
Medzhitov, R.4
-
29
-
-
0037114185
-
Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling
-
•] describe a novel adaptor protein that links TLR activation with the induction of IRF3. Because IRF3 is involved in IFN-β production, TLRs utilizing this adapter could potentially stimulate an antiviral response. TRIF/TICAM appears to operate downstream of a only a subset of TLRS. Both papers demonstrate that TRIF/TICAM can interact directly with TLR3 and can activate the IFN-β promoter
-
•] describe a novel adaptor protein that links TLR activation with the induction of IRF3. Because IRF3 is involved in IFN-β production, TLRs utilizing this adapter could potentially stimulate an antiviral response. TRIF/TICAM appears to operate downstream of a only a subset of TLRS. Both papers demonstrate that TRIF/TICAM can interact directly with TLR3 and can activate the IFN-β promoter.
-
(2002)
J Immunol
, vol.169
, pp. 6668-6672
-
-
Yamamoto, M.1
Sato, S.2
Mori, K.3
Hoshino, K.4
Takeuchi, O.5
Takeda, K.6
Akira, S.7
-
30
-
-
0036785557
-
MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: No role for either in macrophage listericidal activity
-
Edelson B.T., Unanue E.R. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol. 169:2002;3869-3875.
-
(2002)
J Immunol
, vol.169
, pp. 3869-3875
-
-
Edelson, B.T.1
Unanue, E.R.2
-
31
-
-
0036785630
-
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice
-
Seki E., Tsutsui H., Tsuji N.M., Hayashi N., Adachi K., Nakano H., Futatsugi-Yumikura S., Takeuchi O., Hoshino K., Akira S.et al. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol. 169:2002;3863-3868.
-
(2002)
J Immunol
, vol.169
, pp. 3863-3868
-
-
Seki, E.1
Tsutsui, H.2
Tsuji, N.M.3
Hayashi, N.4
Adachi, K.5
Nakano, H.6
Futatsugi-Yumikura, S.7
Takeuchi, O.8
Hoshino, K.9
Akira, S.10
-
32
-
-
0034669910
-
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
-
Takeuchi O., Hoshino K., Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol. 165:2000;5392-5396.
-
(2000)
J Immunol
, vol.165
, pp. 5392-5396
-
-
Takeuchi, O.1
Hoshino, K.2
Akira, S.3
-
33
-
-
0037097795
-
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
-
Scanga C.A., Aliberti J., Jankovic D., Tilloy F., Bennouna S., Denkers E.Y., Medzhitov R., Sher A. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol. 168:2002;5997-6001.
-
(2002)
J Immunol
, vol.168
, pp. 5997-6001
-
-
Scanga, C.A.1
Aliberti, J.2
Jankovic, D.3
Tilloy, F.4
Bennouna, S.5
Denkers, E.Y.6
Medzhitov, R.7
Sher, A.8
-
34
-
-
0037105727
-
Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation
-
Echchannaoui H., Frei K., Schnell C., Leib S.L., Zimmerli W., Landmann R. Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J Infect Dis. 186:2002;798-806.
-
(2002)
J Infect Dis
, vol.186
, pp. 798-806
-
-
Echchannaoui, H.1
Frei, K.2
Schnell, C.3
Leib, S.L.4
Zimmerli, W.5
Landmann, R.6
-
35
-
-
0037220060
-
Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis
-
Koedel U., Angele B., Rupprecht T., Wagner H., Roggenkamp A., Pfister H.W., Kirschning C.J. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol. 170:2003;438-444.
-
(2003)
J Immunol
, vol.170
, pp. 438-444
-
-
Koedel, U.1
Angele, B.2
Rupprecht, T.3
Wagner, H.4
Roggenkamp, A.5
Pfister, H.W.6
Kirschning, C.J.7
-
36
-
-
0036784614
-
Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
-
Reiling N., Holscher C., Fehrenbach A., Kroger S., Kirschning C.J., Goyert S., Ehlers S. Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol. 169:2002;3480-3484.
-
(2002)
J Immunol
, vol.169
, pp. 3480-3484
-
-
Reiling, N.1
Holscher, C.2
Fehrenbach, A.3
Kroger, S.4
Kirschning, C.J.5
Goyert, S.6
Ehlers, S.7
-
37
-
-
0034891984
-
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients
-
Kang T.J., Chae G.T. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol. 31:2001;53-58.
-
(2001)
FEMS Immunol Med Microbiol
, vol.31
, pp. 53-58
-
-
Kang, T.J.1
Chae, G.T.2
-
38
-
-
0036344106
-
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
-
Alexopoulou L., Thomas V., Schnare M., Lobet Y., Anguita J., Schoen R.T., Medzhitov R., Fikrig E., Flavell R.A. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 8:2002;878-884.
-
(2002)
Nat Med
, vol.8
, pp. 878-884
-
-
Alexopoulou, L.1
Thomas, V.2
Schnare, M.3
Lobet, Y.4
Anguita, J.5
Schoen, R.T.6
Medzhitov, R.7
Fikrig, E.8
Flavell, R.A.9
-
39
-
-
0036134858
-
Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi
-
Wooten R.M., Ma Y., Yoder R.A., Brown J.P., Weis J.H., Zachary J.F., Kirschning C.J., Weis J.J. Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J Immunol. 168:2002;348-355.
-
(2002)
J Immunol
, vol.168
, pp. 348-355
-
-
Wooten, R.M.1
Ma, Y.2
Yoder, R.A.3
Brown, J.P.4
Weis, J.H.5
Zachary, J.F.6
Kirschning, C.J.7
Weis, J.J.8
-
40
-
-
0037080210
-
Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung
-
Wang X., Moser C., Louboutin J.-P., Lysenko E.S., Weiner D.J., Weiser J.N., Wilson J.M. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol. 168:2002;810-815.
-
(2002)
J Immunol
, vol.168
, pp. 810-815
-
-
Wang, X.1
Moser, C.2
Louboutin, J.-P.3
Lysenko, E.S.4
Weiner, D.J.5
Weiser, J.N.6
Wilson, J.M.7
-
41
-
-
0035674724
-
LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection
-
Bernheiden M., Heinrich J.M., Minigo G., Schutt C., Stelter F., Freeman M., Golenbock D., Jack R.S. LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection. J Endotoxin Res. 7:2001;447-450.
-
(2001)
J Endotoxin Res
, vol.7
, pp. 447-450
-
-
Bernheiden, M.1
Heinrich, J.M.2
Minigo, G.3
Schutt, C.4
Stelter, F.5
Freeman, M.6
Golenbock, D.7
Jack, R.S.8
-
42
-
-
0037105425
-
Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice
-
Abel B., Thieblemont N., Quesniaux V.J., Brown N., Mpagi J., Miyake K., Bihl F., Ryffel B. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol. 169:2002;3155-3162.
-
(2002)
J Immunol
, vol.169
, pp. 3155-3162
-
-
Abel, B.1
Thieblemont, N.2
Quesniaux, V.J.3
Brown, N.4
Mpagi, J.5
Miyake, K.6
Bihl, F.7
Ryffel, B.8
-
43
-
-
0037094116
-
The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis
-
Netea M.G., Van Der Graaf C.A., Vonk A.G., Verschueren I., Van Der Meer J.W., Kullberg B.J. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis. 185:2002;1483-1489.
-
(2002)
J Infect Dis
, vol.185
, pp. 1483-1489
-
-
Netea, M.G.1
Van Der Graaf, C.A.2
Vonk, A.G.3
Verschueren, I.4
Van Der Meer, J.W.5
Kullberg, B.J.6
-
44
-
-
5944261457
-
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
-
Kurt-Jones E.A., Popova L., Kwinn L., Haynes L.M., Jones L.P., Tripp R.A., Walsh E.E., Freeman M.W., Golenbock D.T., Anderson L.J.et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 1:2000;398-401.
-
(2000)
Nat Immunol
, vol.1
, pp. 398-401
-
-
Kurt-Jones, E.A.1
Popova, L.2
Kwinn, L.3
Haynes, L.M.4
Jones, L.P.5
Tripp, R.A.6
Walsh, E.E.7
Freeman, M.W.8
Golenbock, D.T.9
Anderson, L.J.10
-
45
-
-
0034768425
-
Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus
-
Haynes L.M., Moore D.D., Kurt-Jones E.A., Finberg R.W., Anderson L.J., Tripp R.A. Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol. 75:2001;10730-10737.
-
(2001)
J Virol
, vol.75
, pp. 10730-10737
-
-
Haynes, L.M.1
Moore, D.D.2
Kurt-Jones, E.A.3
Finberg, R.W.4
Anderson, L.J.5
Tripp, R.A.6
-
46
-
-
0036838764
-
Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways
-
Haeberle H.A., Takizawa R., Casola A., Brasier A.R., Dieterich H.J., Van Rooijen N., Gatalica Z., Garofalo R.P. Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect Dis. 186:2002;1199-1206.
-
(2002)
J Infect Dis
, vol.186
, pp. 1199-1206
-
-
Haeberle, H.A.1
Takizawa, R.2
Casola, A.3
Brasier, A.R.4
Dieterich, H.J.5
Van Rooijen, N.6
Gatalica, Z.7
Garofalo, R.P.8
-
47
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., Horiuchi T., Tomizawa H., Takeda K., Akira S. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 3:2002;196-200.
-
(2002)
Nat Immunol
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
48
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
-
Jurk M., Heil F., Vollmer J., Schetter C., Krieg A.M., Wagner H., Lipford G., Bauer S. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol. 3:2002;499.
-
(2002)
Nat Immunol
, vol.3
, pp. 499
-
-
Jurk, M.1
Heil, F.2
Vollmer, J.3
Schetter, C.4
Krieg, A.M.5
Wagner, H.6
Lipford, G.7
Bauer, S.8
-
49
-
-
18644376284
-
IRF3 mediates a TLR3/TLR4-specific antiviral gene program
-
••]
-
••].
-
(2002)
Immunity
, vol.17
, pp. 251-263
-
-
Doyle, S.1
Vaidya, S.2
O'Connell, R.3
Dadgostar, H.4
Dempsey, P.5
Wu, T.6
Rao, G.7
Sun, R.8
Haberland, M.9
Modlin, R.10
-
50
-
-
0036222241
-
TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages
-
••] identified that antiviral genes are induced by TLR3 and TLR4, but not by TLR2 or TLR9. By utilizing gene chip analysis, the authors discovered a broad set of genes dependent on NF-κB that are induced by apparently all four of these TLRs, and a subset of genes that are dependent on IRF3 that are induced by only TLR3 and TLR4
-
••] identified that antiviral genes are induced by TLR3 and TLR4, but not by TLR2 or TLR9. By utilizing gene chip analysis, the authors discovered a broad set of genes dependent on NF-κB that are induced by apparently all four of these TLRs, and a subset of genes that are dependent on IRF3 that are induced by only TLR3 and TLR4.
-
(2002)
Nat Immunol
, vol.3
, pp. 392-398
-
-
Toshchakov, V.1
Jones, B.W.2
Perera, P.Y.3
Thomas, K.4
Cody, M.J.5
Zhang, S.6
Williams, B.R.7
Major, J.8
Hamilton, T.A.9
Fenton, M.J.10
-
51
-
-
0037471003
-
Pyogenic bacterial infections in humans with IRAK-4 deficiency
-
Picard C., Puel A., Bonnet M., Ku C.L., Bustamante J., Yang K., Soudais C., Dupuis S., Feinberg J., Fieschi C.et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science. 299:2003;2076-2079.
-
(2003)
Science
, vol.299
, pp. 2076-2079
-
-
Picard, C.1
Puel, A.2
Bonnet, M.3
Ku, C.L.4
Bustamante, J.5
Yang, K.6
Soudais, C.7
Dupuis, S.8
Feinberg, J.9
Fieschi, C.10
|