Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 51, 2012, Pages 21058-21063

  Park, Jiyoung ^a,b   Sarode, Venetia R ^b,c   Euhus, David ^b,c   Kittler, Ralf ^a,b,c   Scherer, Philipp E ^a,b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

FAIRE seq; Metabolic imprinting; PANIC ATTAC

Indexed keywords

CASPASE 8; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; HER3 RECEPTOR; LAPATINIB; MESSENGER RNA; NEU DIFFERENTIATION FACTOR; PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR CTCF; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY WEIGHT; BREAST CANCER; CANCER PATIENT; CELL GROWTH; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN; CONTROLLED STUDY; DIABETES MELLITUS; DNA SEQUENCE; FEMALE; HUMAN; HYPERGLYCEMIA; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHO CELLS; CRICETINAE; DIABETES MELLITUS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENOMIC IMPRINTING; HEK293 CELLS; HUMANS; HYPERGLYCEMIA; MICE; NEUREGULIN-1; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTOR, ERBB-3; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84871361983     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214400109     Document Type: Article

References (32)

1. Barone BB, et al. (2008) Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-analysis. JAMA 300(23):2754-2764.
2. Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R (2009) Diabetes and cancer. Endocr Relat Cancer 16(4):1103-1123.
3. Stattin P, et al. (2007) Prospective study of hyperglycemia and cancer risk. Diabetes Care 30(3):561-567.
4. Jee SH, et al. (2005) Fasting serum glucose level and cancer risk in Korean men and women. JAMA 293(2):194-202.
5. Wang ZV, et al. (2008) PANIC-ATTAC: A mouse model for inducible and reversible beta-cell ablation. Diabetes 57(8):2137-2148.
6. Guy CT, Cardiff RD, Muller WJ (1992) Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-961.
7. Heuson JC, Legros N (1972) Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction. Cancer Res 32(2):226-232.
8. Cocca C, et al. (2003) Suppression of mammary gland tumorigenesis in diabetic rats. Cancer Detect Prev 27(1):37-46.
9. Pollak M (2008) Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 8(12):915-928.
10. Pirola L, Balcerczyk A, Okabe J, El-Osta A (2010) Epigenetic phenomena linked to diabetic complications. Nat Rev Endocrinol 6(12):665-675.
11. Gaulton KJ, et al. (2010) A map of open chromatin in human pancreatic islets. Nat Genet 42(3):255-259.
12. Phillips JE, Corces VG (2009) CTCF: Master weaver of the genome. Cell 137(7):1194-1211.
13. Hynes NE, Lane HA (2005) ERBB receptors and cancer: The complexity of targeted inhibitors. Nat Rev Cancer 5(5):341-354.
14. Wilson TR, Lee DY, Berry L, Shames DS, Settleman J (2011) Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell 20(2):158-172.
15. Sheng Q, et al. (2010) An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell 17(3):298-310.
16. Falls DL (2003) Neuregulins: Functions, forms, and signaling strategies. Exp Cell Res 284(1):14-30.
17. Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science 256(5060):1205-1210.
18. Stove C, Bracke M (2004) Roles for neuregulins in human cancer. Clin Exp Metastasis 21(8):665-684.
19. Olayioye MA, Neve RM, Lane HA, Hynes NE (2000) The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 19(13):3159-3167.
20. Lee-Hoeflich ST, et al. (2008) A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy. Cancer Res 68(14):5878-5887.
21. Holbro T, et al. (2003) The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci USA 100(15):8933-8938.
22. Ritter CA, et al. (2007) Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network. Clin Cancer Res 13(16):4909-4919.
23. de Alava E, et al. (2007) Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer. J Clin Oncol 25(19):2656-2663.
24. Atlas E, et al. (2003) Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo. Mol Cancer Res 1(3):165-175.
25. Lin EY, et al. (2003) Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 163(5):2113-2126.
26. Medina PJ, Goodin S (2008) Lapatinib: A dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther 30(8):1426-1447.
27. Giresi PG, Kim J, McDaniell RM, Iyer VR, Lieb JD (2007) FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res 17(6):877-885.
28. Zhang Y, et al. (2008) Model-based analysis of ChIP-Seq (MACS). Genome Biol 9(9):R137.
29. Bailey TL, Williams N, Misleh C, Li WW (2006) MEME: Discovering and analyzing DNA and protein sequence motifs. Nucleic Acids Res 34(Web Server issue):W369-W373.
30. Sandelin A, Alkema W, Engström P, Wasserman WW, Lenhard B (2004) JASPAR: An open-access database for eukaryotic transcription factor binding profiles. Nucleic Acids Res 32(Database issue):D91-D94.
31. Wingender E, Dietze P, Karas H, Knüppel R (1996) TRANSFAC: A database on transcription factors and their DNA binding sites. Nucleic Acids Res 24(1):238-241.
32. Gupta S, Stamatoyannopoulos JA, Bailey TL, Noble WS (2007) Quantifying similarity between motifs. Genome Biol 8(2):R24.