메뉴 건너뛰기




Volumn 7, Issue 2, 2014, Pages 428-439

Highly prevalent colorectal cancer-infiltrating LAP + Foxp3 - T cells exhibit more potent immunosuppressive activity than Foxp3 + regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD103 ANTIGEN; CD39 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; LATENCY ASSOCIATED PEPTIDE; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84895168217     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2013.62     Document Type: Article
Times cited : (107)

References (55)
  • 1
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • Jemal, A. et al. Global cancer statistics. CA Cancer JClin 61, 69-90 (2011).
    • (2011) CA Cancer JClin , vol.61 , pp. 69-90
    • Jemal, A.1
  • 2
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber,R.D., Old, L.J. & Smyth, M.J. Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science 331, 1565-1570 (2011).
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 3
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964 (2006).
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1
  • 4
    • 84858793263 scopus 로고    scopus 로고
    • Ovarian cancer progression is controlled by phenotypic changes in dendritic cells
    • Scarlett, U.K. et al. Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J. Exp. Med. 203, 495-506 (2012).
    • (2012) J. Exp. Med. , vol.203 , pp. 495-506
    • Scarlett, U.K.1
  • 5
    • 77955594335 scopus 로고    scopus 로고
    • The family of IL-10-secretingCD4+ T cells
    • Fujio, K., Okamura, T. &Yamamoto,K. The family of IL-10-secretingCD4+ T cells. Adv. Immunol. 105, 99-130 (2010).
    • (2010) Adv. Immunol. , vol.105 , pp. 99-130
    • Fujio, K.1    Okamura, T.2    Yamamoto, K.3
  • 6
    • 34848857434 scopus 로고    scopus 로고
    • Transforming growth factor-beta and the immune response: Implications for anticancer therapy
    • Wrzesinski, S.H.,Wan, Y.Y. & Flavell, R.A. Transforming growth factor-beta and the immune response: Implications for anticancer therapy. Clin. Cancer Res. 13, 5262-5270 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 5262-5270
    • Wrzesinski, S.H.1    Wan, Y.Y.2    Flavell, R.A.3
  • 7
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis, L.M. & Hicklin, D.J. VEGF-targeted therapy: Mechanisms of anti-tumour activity. Nat. Rev. Cancer 8, 579-591 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 8
    • 34248173331 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and tumorinduced tolerance
    • Munn, D.H. & Mellor, A.L. Indoleamine 2,3-dioxygenase and tumorinduced tolerance. J. Clin. Invest. 117, 1147-1154 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 9
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    • Nagaraj, S. et al. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat. Med. 13, 828-835 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 828-835
    • Nagaraj, S.1
  • 10
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory Tcells in tumor immunity
    • Nishikawa, H. & Sakaguchi, S. Regulatory Tcells in tumor immunity. Int. J. Cancer 127, 759-767 (2010).
    • (2010) Int. J. Cancer , vol.127 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 11
    • 37849026029 scopus 로고    scopus 로고
    • Regulatory T cells and tumour immunity-observations in mice and men
    • Gallimore, A. & Godkin, A. Regulatory T cells and tumour immunity-observations in mice and men. Immunology 123, 157-163 (2008).
    • (2008) Immunology , vol.123 , pp. 157-163
    • Gallimore, A.1    Godkin, A.2
  • 12
    • 44449110691 scopus 로고    scopus 로고
    • Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
    • Liang, B. et al. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J. Immunol. 180, 5916-5926 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 5916-5926
    • Liang, B.1
  • 13
    • 82155171374 scopus 로고    scopus 로고
    • Biological functions of regulatory Tcells
    • Shevach, E.M. Biological functions of regulatory Tcells. Adv. Immunol. 112, 137-176 (2011).
    • (2011) Adv. Immunol. , vol.112 , pp. 137-176
    • Shevach, E.M.1
  • 15
    • 54949139152 scopus 로고    scopus 로고
    • Cd4+cd25+foxp3+ regulatory t cells suppress anti-tumor immune responses in patients with colorectal cancer
    • Clarke, S.L. et al. CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PLoS One 1, e129 (2006).
    • (2006) PLoS One , vol.1
    • Clarke, S.L.1
  • 16
    • 84863721491 scopus 로고    scopus 로고
    • Suppression of tumour-specific CD4+ Tcells by regulatory Tcells is associated with progression of human colorectal cancer
    • Betts, G. et al. Suppression of tumour-specific CD4+ Tcells by regulatory Tcells is associated with progression of human colorectal cancer. Gut 61, 1163-1171 (2012).
    • (2012) Gut , vol.61 , pp. 1163-1171
    • Betts, G.1
  • 17
    • 77951217044 scopus 로고    scopus 로고
    • High frequency of tumor-infiltrating foxp3(+) regulatory t cells predicts improved survival in mismatch repair-proficient colorectal cancer patients
    • Frey, D.M. et al. High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. Int. J. Cancer 126, 2635-2643 (2010).
    • (2010) Int. J. Cancer , vol.126 , pp. 2635-2643
    • Frey, D.M.1
  • 18
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating foxp3+ tregulatory cells show strong prognostic significance in colorectal cancer
    • Salama, P. et al. Tumor-infiltrating FOXP3+ Tregulatory cells show strong prognostic significance in colorectal cancer. J. Clin. Oncol. 27, 186-192 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 186-192
    • Salama, P.1
  • 19
    • 79551521901 scopus 로고    scopus 로고
    • Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors
    • Hindley, J.P. etal.Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Res. 71, 736-746 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 736-746
    • Hindley, J.P.1
  • 20
    • 77951638740 scopus 로고    scopus 로고
    • Expression of helios, an ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton, A.M. et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 184, 3433-3441 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 3433-3441
    • Thornton, A.M.1
  • 21
    • 84874232301 scopus 로고    scopus 로고
    • Helios+ and Helios-cells coexist within the natural FOXP3+ Tregulatory cell subset in humans
    • Himmel, M.E.,MacDonald, K.G., Garcia, R.V., Steiner, T.S. & Levings, M.K. Helios+ and Helios-cells coexist within the natural FOXP3+ Tregulatory cell subset in humans. J. Immunol. 190, 2001-2008 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 2001-2008
    • Himmel, M.E.1    Macdonald, K.G.2    Garcia, R.V.3    Steiner, T.S.4    Levings, M.K.5
  • 22
    • 80052287274 scopus 로고    scopus 로고
    • Helios expression is a marker of T cell activation and proliferation
    • Akimova, T., Beier, U.H., Wang, L., Levine, M.H. & Hancock, W.W. Helios expression is a marker of T cell activation and proliferation. PLoS One 6, e24226 (2011).
    • (2011) PLoS One , vol.6
    • Akimova, T.1    Beier, U.H.2    Wang, L.3    Levine, M.H.4    Hancock, W.W.5
  • 23
    • 59849093427 scopus 로고    scopus 로고
    • Levels of foxp3 in regulatory t cells reflect their functional status in transplantation
    • Chauhan, S.K., Saban, D.R., Lee, H.K. & Dana, R. Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J. Immunol. 182, 148-153 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 148-153
    • Chauhan, S.K.1    Saban, D.R.2    Lee, H.K.3    Dana, R.4
  • 24
    • 70049098536 scopus 로고    scopus 로고
    • Regulatory T cells reinforce intestinal homeostasis
    • Barnes, M.J. & Powrie, F. Regulatory T cells reinforce intestinal homeostasis. Immunity 31, 401-411 (2009).
    • (2009) Immunity , vol.31 , pp. 401-411
    • Barnes, M.J.1    Powrie, F.2
  • 25
    • 84867901322 scopus 로고    scopus 로고
    • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    • S1711-S1719
    • Yadav, M. et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J. Exp. Med. 209 (1713-1722), S1711-S1719 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1713-1722
    • Yadav, M.1
  • 26
    • 34447570588 scopus 로고    scopus 로고
    • The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells
    • Mahajan, S. et al. The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. Eur. J. Immunol. 37, 1796-1808 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1796-1808
    • Mahajan, S.1
  • 27
    • 49149125958 scopus 로고    scopus 로고
    • Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: Implications and impact on tumor-mediated immune suppression
    • Strauss, L. et al. Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: Implications and impact on tumor-mediated immune suppression. J. Immunol. 180, 2967-2980 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 2967-2980
    • Strauss, L.1
  • 28
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ Tcells expressing the FoxP3 transcription factor
    • Miyara, M. et al. Functional delineation and differentiation dynamics of human CD4+ Tcells expressing the FoxP3 transcription factor. Immunity 30, 899-911 (2009).
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1
  • 29
    • 71149084582 scopus 로고    scopus 로고
    • Human Tcells expressCD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function
    • Kmieciak, M. et al. Human Tcells expressCD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J. Transl. Med. 7, 89 (2009).
    • (2009) J. Transl. Med. , vol.7 , pp. 89
    • Kmieciak, M.1
  • 30
    • 33749038866 scopus 로고    scopus 로고
    • Reversal of the TCR stop signal by CTLA-4
    • Schneider, H. et al. Reversal of the TCR stop signal by CTLA-4. Science 313, 1972-1975 (2006).
    • (2006) Science , vol.313 , pp. 1972-1975
    • Schneider, H.1
  • 31
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio, S. et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1257-1265
    • Deaglio, S.1
  • 32
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory Tcells
    • Huang, C.T. et al. Role of LAG-3 in regulatory Tcells. Immunity 21, 503-513 (2004).
    • (2004) Immunity , vol.21 , pp. 503-513
    • Huang, C.T.1
  • 33
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo, S.R. et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 72, 917-927 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 917-927
    • Woo, S.R.1
  • 34
    • 84880275285 scopus 로고    scopus 로고
    • Coexpression ofCD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    • Gagliani, N. et al. Coexpression ofCD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med 19, 739-746 (2013).
    • (2013) Nat Med , vol.19 , pp. 739-746
    • Gagliani, N.1
  • 35
    • 0033151953 scopus 로고    scopus 로고
    • Mucosal T lymphocyte numbers are selectively reduced in integrin alpha e (CD103)-deficient mice
    • Schon, M.P. et al. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J. Immunol. 162, 6641-6649 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 6641-6649
    • Schon, M.P.1
  • 36
    • 0036791004 scopus 로고    scopus 로고
    • Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25-regulatory T cells
    • Lehmann, J. et al. Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25-regulatory T cells. Proc. Natl. Acad. Sci. USA 99, 13031-13036 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13031-13036
    • Lehmann, J.1
  • 37
    • 84856471270 scopus 로고    scopus 로고
    • Accumulation of CCR4CTLA-4 FOXP3CD25(hi) regulatory Tcells in colon adenocarcinomas correlate to reduced activation of conventional T cells
    • Svensson, H. et al. Accumulation of CCR4CTLA-4 FOXP3CD25(hi) regulatory Tcells in colon adenocarcinomas correlate to reduced activation of conventional T cells. PLoS One 7, e30695 (2012).
    • (2012) PLoS One , vol.7
    • Svensson, H.1
  • 38
    • 77953116038 scopus 로고    scopus 로고
    • Cutting edge: Human latency-associated peptide + T cells: A novel regulatory T cell subset
    • Gandhi, R. et al. Cutting edge: Human latency-associated peptide + T cells: A novel regulatory T cell subset. J. Immunol. 184, 4620-4624 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 4620-4624
    • Gandhi, R.1
  • 39
    • 84866916324 scopus 로고    scopus 로고
    • LAP+CD4+ Tcells are suppressors accumulated in the tumor sites and associated with progression of colorectal cancer
    • Mahalingam, J. et al. LAP+CD4+ Tcells are suppressors accumulated in the tumor sites and associated with progression of colorectal cancer. Clin Cancer Res. 18, 5224-5233 (2012).
    • (2012) Clin Cancer Res. , vol.18 , pp. 5224-5233
    • Mahalingam, J.1
  • 40
    • 0035853778 scopus 로고    scopus 로고
    • Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta
    • Saito, T. et al. Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta. J. Biol. Chem. 276, 11469-11472 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 11469-11472
    • Saito, T.1
  • 41
    • 34447580869 scopus 로고    scopus 로고
    • Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis
    • Min, B. et al. Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur. J. Immunol. 37, 1916-1923 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1916-1923
    • Min, B.1
  • 42
    • 33748296240 scopus 로고    scopus 로고
    • Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    • Vukmanovic-Stejic, M. et al. Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J. Clin. Invest. 116, 2423-2433 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2423-2433
    • Vukmanovic-Stejic, M.1
  • 43
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: Harnessing the T cell response
    • Restifo, N.P., Dudley,M.E. & Rosenberg, S.A. Adoptive immunotherapy for cancer: Harnessing the T cell response. Nat. Rev. Immunol. 12, 269-281 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 44
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel, T.J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10, 942-949 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 942-949
    • Curiel, T.J.1
  • 45
    • 79959742164 scopus 로고    scopus 로고
    • Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: The paradox of colorectal cancer
    • Ladoire, S., Martin, F. & Ghiringhelli, F. Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: The paradox of colorectal cancer. Cancer Immunol. Immunother. 60, 909-918 (2011).
    • (2011) Cancer Immunol. Immunother. , vol.60 , pp. 909-918
    • Ladoire, S.1    Martin, F.2    Ghiringhelli, F.3
  • 46
    • 19944369378 scopus 로고    scopus 로고
    • Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans
    • Morgan, M.E. et al. Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum. Immunol. 66, 13-20 (2005).
    • (2005) Hum. Immunol. , vol.66 , pp. 13-20
    • Morgan, M.E.1
  • 47
    • 33846340789 scopus 로고    scopus 로고
    • FOXP3: Not just for regulatory Tcells anymore
    • Ziegler, S.F. FOXP3: Not just for regulatory Tcells anymore. Eur. J. Immunol. 37, 21-23 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , pp. 21-23
    • Ziegler, S.F.1
  • 48
    • 36048963838 scopus 로고    scopus 로고
    • LAG-3 regulates CD8+ Tcell accumulation and effector function in murine self-and tumor-tolerance systems
    • Grosso, J.F. et al. LAG-3 regulates CD8+ Tcell accumulation and effector function in murine self-and tumor-tolerance systems. J. Clin. Invest. 117, 3383-3392 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3383-3392
    • Grosso, J.F.1
  • 49
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY-ESO-1-specific CD8+ Tcells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • Matsuzaki, J. et al. Tumor-infiltrating NY-ESO-1-specific CD8+ Tcells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc. Natl. Acad. Sci. USA 107, 7875-7880 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 7875-7880
    • Matsuzaki, J.1
  • 50
    • 33749127585 scopus 로고    scopus 로고
    • Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients
    • Gandhi, M.K. et al. Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. Blood 108, 2280-2289 (2006).
    • (2006) Blood , vol.108 , pp. 2280-2289
    • Gandhi, M.K.1
  • 51
    • 79960451984 scopus 로고    scopus 로고
    • Tcell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-beta1 cytokine
    • Donkor, M.K. et al. Tcell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-beta1 cytokine. Immunity 35, 123-134 (2011).
    • (2011) Immunity , vol.35 , pp. 123-134
    • Donkor, M.K.1
  • 53
    • 0022573876 scopus 로고
    • Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors. A comparison between velocity sedimentation and discontinuous density gradients
    • Whiteside, T.L., Miescher, S., MacDonald, H.R. & Von Fliedner, V. Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors. A comparison between velocity sedimentation and discontinuous density gradients. J. Immunol. Methods 90, 221-233 (1986).
    • (1986) J. Immunol. Methods , vol.90 , pp. 221-233
    • Whiteside, T.L.1    Miescher, S.2    Macdonald, H.R.3    Von Fliedner, V.4
  • 54
    • 84855233207 scopus 로고    scopus 로고
    • Suppression assays with human T regulatory cells: A technical guide
    • McMurchy, A.N. & Levings, M.K. Suppression assays with human T regulatory cells: A technical guide. Eur. J. Immunol. 42, 27-34 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , pp. 27-34
    • McMurchy, A.N.1    Levings, M.K.2
  • 55
    • 79251515158 scopus 로고    scopus 로고
    • Spice: Exploration and analysis of post-cytometric complex multivariate datasets
    • Roederer,M., Nozzi, J.L. & Nason, M.C. SPICE: Exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 79, 167-174 (2011).
    • (2011) Cytometry A , vol.79 , pp. 167-174
    • Roederer, M.1    Nozzi, J.L.2    Nason, M.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.