메뉴 건너뛰기




Volumn 19, Issue 8, 2013, Pages 1926-1932

Molecular pathways: Adiponectin and leptin signaling in cancer

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; GLITAZONE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR SUBSTRATE; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; METFORMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; RECOMBINANT LEPTIN; STAT3 PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

EID: 84877090947     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-0930     Document Type: Review
Times cited : (186)

References (98)
  • 1
    • 2342439732 scopus 로고    scopus 로고
    • Leptin signaling in the central nervous system and the periphery
    • Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004;59:305-31.
    • (2004) Recent Prog Horm Res , vol.59 , pp. 305-331
    • Bjorbaek, C.1    Kahn, B.B.2
  • 3
    • 30044448374 scopus 로고    scopus 로고
    • Direct metabolic regulation in skeletal muscle and fat tissue by leptin: Implications for glucose and fatty acids homeostasis
    • DOI 10.1038/sj.ijo.0803025, PII 0803025
    • Ceddia RB. Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. Int J Obes (Lond) 2005;29:1175-83. (Pubitemid 43080295)
    • (2005) International Journal of Obesity , vol.29 , Issue.10 , pp. 1175-1183
    • Ceddia, R.B.1
  • 4
    • 52949129178 scopus 로고    scopus 로고
    • Leptin resistance: A possible interface of inflammation and metabolism in obesity-related cardiovascular disease
    • Martin SS, Qasim A, Reilly MP. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008;52:1201-10.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1201-1210
    • Martin, S.S.1    Qasim, A.2    Reilly, M.P.3
  • 5
    • 84858066573 scopus 로고    scopus 로고
    • Modulation of leptin resistance by protein tyrosine phosphatases
    • St-Pierre J, Tremblay ML. Modulation of leptin resistance by protein tyrosine phosphatases. Cell Metab 2012;15:292-7.
    • (2012) Cell Metab , vol.15 , pp. 292-297
    • St-Pierre, J.1    Tremblay, M.L.2
  • 6
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • DOI 10.1210/er.2005-0005
    • Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005;26:439-51. (Pubitemid 40686653)
    • (2005) Endocrine Reviews , vol.26 , Issue.3 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 13
    • 77954828973 scopus 로고    scopus 로고
    • Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation
    • Kim AY, Lee YS, Kim KH, Lee JH, Lee HK, Jang SH, et al. Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation. Mol Endocrinol 2010;24:1441-52.
    • (2010) Mol Endocrinol , vol.24 , pp. 1441-1452
    • Kim, A.Y.1    Lee, Y.S.2    Kim, K.H.3    Lee, J.H.4    Lee, H.K.5    Jang, S.H.6
  • 14
    • 76049087581 scopus 로고    scopus 로고
    • Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling
    • Man K, Ng KT, Xu A, Cheng Q, Lo CM, Xiao JW, et al. Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling. Clin Cancer Res 2010;16:967-77.
    • (2010) Clin Cancer Res , vol.16 , pp. 967-977
    • Man, K.1    Ng, K.T.2    Xu, A.3    Cheng, Q.4    Lo, C.M.5    Xiao, J.W.6
  • 15
    • 33845806853 scopus 로고    scopus 로고
    • Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    • DOI 10.1158/0008-5472.CAN-06-1969
    • Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, et al. Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res 2006;66:11462-70. (Pubitemid 46009979)
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11462-11470
    • Wang, Y.1    Lam, J.B.2    Lam, K.S.L.3    Liu, J.4    Lam, M.C.5    Hoo, R.L.C.6    Wu, D.7    Cooper, G.J.S.8    Xu, A.9
  • 16
    • 34249880848 scopus 로고    scopus 로고
    • Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2
    • DOI 10.1111/j.1349-7006.2007.00486.x
    • Ishikawa M, Kitayama J, Yamauchi T, Kadowaki T, Maki T, Miyato H, et al. Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2. Cancer Sci 2007;98:1120-7. (Pubitemid 46865400)
    • (2007) Cancer Science , vol.98 , Issue.7 , pp. 1120-1127
    • Ishikawa, M.1    Kitayama, J.2    Yamauchi, T.3    Kadowaki, T.4    Maki, T.5    Miyato, H.6    Yamashita, H.7    Nagawa, H.8
  • 17
    • 70349978983 scopus 로고    scopus 로고
    • Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells
    • Chiu YC, Shieh DC, Tong KM, Chen CP, Huang KC, Chen PC, et al. Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells. Carcinogenesis 2009;30:1651-9.
    • (2009) Carcinogenesis , vol.30 , pp. 1651-1659
    • Chiu, Y.C.1    Shieh, D.C.2    Tong, K.M.3    Chen, C.P.4    Huang, K.C.5    Chen, P.C.6
  • 18
    • 84856592310 scopus 로고    scopus 로고
    • Leptin promotes human glioblastoma growth through activating Signal Transducers and Activators of Transcription 3 signaling
    • Han G, Wang L, Zhao R, Yue Z, Zhou X, Hu X, et al. Leptin promotes human glioblastoma growth through activating Signal Transducers and Activators of Transcription 3 signaling. Brain Res Bull 2012;87:274-9.
    • (2012) Brain Res Bull , vol.87 , pp. 274-279
    • Han, G.1    Wang, L.2    Zhao, R.3    Yue, Z.4    Zhou, X.5    Hu, X.6
  • 19
    • 80455167878 scopus 로고    scopus 로고
    • Leptin activates STAT3 and ERK1/2 pathways and induces endometrial cancer cell proliferation
    • Liu Y, Lv L, Xiao W, Gong C, Yin J, Wang D, et al. Leptin activates STAT3 and ERK1/2 pathways and induces endometrial cancer cell proliferation. J Huazhong Univ Sci Technolog Med Sci 2011;31:365-70.
    • (2011) J Huazhong Univ Sci Technolog Med Sci , vol.31 , pp. 365-370
    • Liu, Y.1    Lv, L.2    Xiao, W.3    Gong, C.4    Yin, J.5    Wang, D.6
  • 20
    • 80052580981 scopus 로고    scopus 로고
    • Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis
    • Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, et al. Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut 2011;60:1363-71.
    • (2011) Gut , vol.60 , pp. 1363-1371
    • Endo, H.1    Hosono, K.2    Uchiyama, T.3    Sakai, E.4    Sugiyama, M.5    Takahashi, H.6
  • 21
    • 34250315764 scopus 로고    scopus 로고
    • Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
    • DOI 10.1074/jbc.M609798200
    • Saxena NK, Vertino PM, Anania FA, Sharma D. Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J Biol Chem 2007;282:13316-25. (Pubitemid 47100545)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.18 , pp. 13316-13325
    • Saxena, N.K.1    Vertino, P.M.2    Anania, F.A.3    Sharma, D.4
  • 22
    • 80052158404 scopus 로고    scopus 로고
    • Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells
    • Knight BB, Oprea-Ilies GM, Nagalingam A, Yang L, Cohen C, Saxena NK, et al. Survivin upregulation, dependent on leptin-EGFR-Notch1 axis, is essential for leptin-induced migration of breast carcinoma cells. Endocr Relat Cancer 2011;18:413-28.
    • (2011) Endocr Relat Cancer , vol.18 , pp. 413-428
    • Knight, B.B.1    Oprea-Ilies, G.M.2    Nagalingam, A.3    Yang, L.4    Cohen, C.5    Saxena, N.K.6
  • 23
    • 66249136720 scopus 로고    scopus 로고
    • Leptin induces migration and invasion of glioma cells through MMP-13 production
    • Yeh WL, Lu DY, Lee MJ, Fu WM. Leptin induces migration and invasion of glioma cells through MMP-13 production. Glia 2009;57:454-64.
    • (2009) Glia , vol.57 , pp. 454-464
    • Yeh, W.L.1    Lu, D.Y.2    Lee, M.J.3    Fu, W.M.4
  • 25
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • DOI 10.1158/0008-5472.CAN-06-3075
    • Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D, et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 2007;67:2497-507. (Pubitemid 46548934)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3    Lin, S.4    Marra, F.5    Merlin, D.6    Anania, F.A.7
  • 27
    • 72549083315 scopus 로고    scopus 로고
    • Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention
    • Schol Ed
    • Cleary MP, Ray A, Rogozina OP, Dogan S, Grossmann ME. Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention. Front Biosci (Schol Ed) 2009;1:329-57.
    • (2009) Front Biosci , vol.1 , pp. 329-357
    • Cleary, M.P.1    Ray, A.2    Rogozina, O.P.3    Dogan, S.4    Grossmann, M.E.5
  • 28
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • DOI 10.1074/jbc.272.51.32686
    • Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997;272:32686-95. (Pubitemid 28011961)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.51 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    Da, S.B.3    Flier, J.S.4
  • 31
    • 69549088269 scopus 로고    scopus 로고
    • The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo
    • Zhang J, Scarpace PJ. The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo. Br J Pharmacol 2009;158:475-82.
    • (2009) Br J Pharmacol , vol.158 , pp. 475-482
    • Zhang, J.1    Scarpace, P.J.2
  • 33
    • 0033965899 scopus 로고    scopus 로고
    • Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity
    • DOI 10.1128/MCB.20.5.1526-1536.2000
    • Shi ZQ, Yu DH, Park M, Marshall M, Feng GS. Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Mol Cell Biol 2000;20:1526-36. (Pubitemid 30100172)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.5 , pp. 1526-1536
    • Shi, Z.-Q.1    Yu, D.-H.2    Park, M.3    Marshall, M.4    Feng, G.-S.5
  • 35
    • 13544270759 scopus 로고    scopus 로고
    • DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells
    • DOI 10.1074/jbc.M411035200
    • Ling Y, Maile LA, Badley-Clarke J, Clemmons DR. DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. J Biol Chem 2005;280:3151-8. (Pubitemid 40223776)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.5 , pp. 3151-3158
    • Ling, Y.1    Maile, L.A.2    Badley-Clarke, J.3    Clemmons, D.R.4
  • 37
    • 15444366416 scopus 로고    scopus 로고
    • 1138 of the leptin receptor and suppressor of cytokine signaling 3
    • DOI 10.1210/me.2004-0353
    • Dunn SL, Bjornholm M, Bates SH, Chen Z, Seifert M, Myers MG Jr. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol 2005;19:925-38. (Pubitemid 40397057)
    • (2005) Molecular Endocrinology , vol.19 , Issue.4 , pp. 925-938
    • Dunn, S.L.1    Bjornholm, M.2    Bates, S.H.3    Chen, Z.4    Seifert, M.5    Myers Jr., M.G.6
  • 38
    • 82455174787 scopus 로고    scopus 로고
    • Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis
    • Handy JA, Fu PP, Kumar P, Mells JE, Sharma S, Saxena NK, et al. Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. Biochem J 2011;440:385-95.
    • (2011) Biochem J , vol.440 , pp. 385-395
    • Handy, J.A.1    Fu, P.P.2    Kumar, P.3    Mells, J.E.4    Sharma, S.5    Saxena, N.K.6
  • 39
    • 33744972277 scopus 로고    scopus 로고
    • APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
    • Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006;8:516-23.
    • (2006) Nat Cell Biol , vol.8 , pp. 516-523
    • Mao, X.1    Kikani, C.K.2    Riojas, R.A.3    Langlais, P.4    Wang, L.5    Ramos, F.J.6
  • 41
    • 84865793242 scopus 로고    scopus 로고
    • AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
    • Lee CW, Wong LL, Tse EY, Liu HF, Leong VY, Lee JM, et al. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res 2012;72:4394-404.
    • (2012) Cancer Res , vol.72 , pp. 4394-4404
    • Lee, C.W.1    Wong, L.L.2    Tse, E.Y.3    Liu, H.F.4    Leong, V.Y.5    Lee, J.M.6
  • 42
    • 65949116390 scopus 로고    scopus 로고
    • Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation
    • Kim KY, Baek A, Hwang JE, Choi YA, Jeong J, Lee MS, et al. Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res 2009;69:4018-26.
    • (2009) Cancer Res , vol.69 , pp. 4018-4026
    • Kim, K.Y.1    Baek, A.2    Hwang, J.E.3    Choi, Y.A.4    Jeong, J.5    Lee, M.S.6
  • 43
    • 39149104038 scopus 로고    scopus 로고
    • Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway
    • DOI 10.1677/ERC-06-0091
    • Barb D, Neuwirth A, Mantzoros CS, Balk SP. Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway. Endocr Relat Cancer 2007;14:995-1005. (Pubitemid 351252431)
    • (2007) Endocrine-Related Cancer , vol.14 , Issue.4 , pp. 995-1005
    • Barb, D.1    Neuwirth, A.2    Mantzoros, C.S.3    Balk, S.P.4
  • 44
    • 70449377000 scopus 로고    scopus 로고
    • Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
    • Uddin S, Bu R, Ahmed M, Abubaker J, Al-Dayel F, Bavi P, et al. Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer. Mol Cancer 2009;8:74.
    • (2009) Mol Cancer , vol.8 , pp. 74
    • Uddin, S.1    Bu, R.2    Ahmed, M.3    Abubaker, J.4    Al-Dayel, F.5    Bavi, P.6
  • 45
    • 3042817487 scopus 로고    scopus 로고
    • Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    • DOI 10.1158/1078-0432.CCR-03-0749
    • Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004;10:4325-31. (Pubitemid 38878870)
    • (2004) Clinical Cancer Research , vol.10 , Issue.13 , pp. 4325-4331
    • Ishikawa, M.1    Kitayama, J.2    Nagawa, H.3
  • 47
    • 84863226348 scopus 로고    scopus 로고
    • Lentivirus-mediated RNA interference targeting the ObR gene in human breast cancer MCF-7 cells in a nude mouse xenograft model
    • Engl
    • Xue RQ, Gu JC, Du ST, Yu W, Wang Y, Zhang ZT, et al. Lentivirus-mediated RNA interference targeting the ObR gene in human breast cancer MCF-7 cells in a nude mouse xenograft model. Chin Med J (Engl) 2012;125:1563-70.
    • (2012) Chin Med J , vol.125 , pp. 1563-1570
    • Xue, R.Q.1    Gu, J.C.2    Du, S.T.3    Yu, W.4    Wang, Y.5    Zhang, Z.T.6
  • 48
    • 64349091286 scopus 로고    scopus 로고
    • Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor
    • Yang SN, Chen HT, Tsou HK, Huang CY, Yang WH, Su CM, et al. Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor. Carcinogenesis 2009;30:566-74.
    • (2009) Carcinogenesis , vol.30 , pp. 566-574
    • Yang, S.N.1    Chen, H.T.2    Tsou, H.K.3    Huang, C.Y.4    Yang, W.H.5    Su, C.M.6
  • 51
    • 84860453490 scopus 로고    scopus 로고
    • The significance of serum levels of adiponectin, leptin, and hyaluronic acid in hepatocellular carcinoma of cirrhotic and noncirrhotic patients
    • Sadik NA, Ahmed A, Ahmed S. The significance of serum levels of adiponectin, leptin, and hyaluronic acid in hepatocellular carcinoma of cirrhotic and noncirrhotic patients. Hum Exp Toxicol 2012;31:311-21.
    • (2012) Hum Exp Toxicol , vol.31 , pp. 311-321
    • Sadik, N.A.1    Ahmed, A.2    Ahmed, S.3
  • 55
    • 33644527562 scopus 로고    scopus 로고
    • High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels
    • Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, et al. High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer 2006;118:1414-9.
    • (2006) Int J Cancer , vol.118 , pp. 1414-1419
    • Miyoshi, Y.1    Funahashi, T.2    Tanaka, S.3    Taguchi, T.4    Tamaki, Y.5    Shimomura, I.6
  • 56
    • 67349139615 scopus 로고    scopus 로고
    • Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: A case-control study
    • Dalamaga M, Migdalis I, Fargnoli JL, Papadavid E, Bloom E, Mitsiades N, et al. Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. Cancer Causes Control 2009;20:625-33.
    • (2009) Cancer Causes Control , vol.20 , pp. 625-633
    • Dalamaga, M.1    Migdalis, I.2    Fargnoli, J.L.3    Papadavid, E.4    Bloom, E.5    Mitsiades, N.6
  • 57
    • 77954406095 scopus 로고    scopus 로고
    • Adipokines and cytokines in human pancreatic juice: Unraveling the local pancreatic inflammatory milieu
    • Dalbec KM, Max Schmidt C, Wade TE, Wang S, Swartz-Basile DA, Pitt HA, et al. Adipokines and cytokines in human pancreatic juice: unraveling the local pancreatic inflammatory milieu. Dig Dis Sci 2010;55:2108-12.
    • (2010) Dig Dis Sci , vol.55 , pp. 2108-2112
    • Dalbec, K.M.1    Max Schmidt, C.2    Wade, T.E.3    Wang, S.4    Swartz-Basile, D.A.5    Pitt, H.A.6
  • 59
    • 13144280875 scopus 로고    scopus 로고
    • Serum leptin concentration and advanced gastrointestinal cancers: A case controlled study
    • Bolukbas FF, Kilic H, Bolukbas C, Gumus M, Horoz M, Turhal NS, et al. Serum leptin concentration and advanced gastrointestinal cancers: a case controlled study. BMC Cancer 2004;4:29.
    • (2004) BMC Cancer , vol.4 , pp. 29
    • Bolukbas, F.F.1    Kilic, H.2    Bolukbas, C.3    Gumus, M.4    Horoz, M.5    Turhal, N.S.6
  • 60
    • 34547741589 scopus 로고    scopus 로고
    • Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
    • DOI 10.1677/ERC-06-0068
    • Vona-Davis L, Rose DP. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 2007;14:189-206. (Pubitemid 47242622)
    • (2007) Endocrine-Related Cancer , vol.14 , Issue.2 , pp. 189-206
    • Vona-Davis, L.1    Rose, D.P.2
  • 63
    • 79960561552 scopus 로고    scopus 로고
    • Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: Comparison with VEGF effects
    • Ferla R, Bonomi M, Otvos L Jr, Surmacz E. Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 2011;11:303.
    • (2011) BMC Cancer , vol.11 , pp. 303
    • Ferla, R.1    Bonomi, M.2    Otvos Jr., L.3    Surmacz, E.4
  • 65
    • 40349108448 scopus 로고    scopus 로고
    • Adiponectin in relation to malignancies: A review of existing basic research and clinical evidence
    • Barb D, Williams CJ, Neuwirth AK, Mantzoros CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 2007;86:s858-66.
    • (2007) Am J Clin Nutr , vol.86
    • Barb, D.1    Williams, C.J.2    Neuwirth, A.K.3    Mantzoros, C.S.4
  • 66
    • 54849159000 scopus 로고    scopus 로고
    • Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk
    • Kaklamani VG, Wisinski KB, Sadim M, Gulden C, Do A, Offit K, et al. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA 2008;300:1523-31.
    • (2008) JAMA , vol.300 , pp. 1523-1531
    • Kaklamani, V.G.1    Wisinski, K.B.2    Sadim, M.3    Gulden, C.4    Do, A.5    Offit, K.6
  • 67
    • 44849097842 scopus 로고    scopus 로고
    • Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk
    • Kaklamani VG, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, et al. Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Cancer Res 2008;68:3178-84.
    • (2008) Cancer Res , vol.68 , pp. 3178-3184
    • Kaklamani, V.G.1    Sadim, M.2    Hsi, A.3    Offit, K.4    Oddoux, C.5    Ostrer, H.6
  • 68
  • 70
    • 54349120590 scopus 로고    scopus 로고
    • Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition
    • Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, et al. Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut 2008;57:1531-8.
    • (2008) Gut , vol.57 , pp. 1531-1538
    • Fujisawa, T.1    Endo, H.2    Tomimoto, A.3    Sugiyama, M.4    Takahashi, H.5    Saito, S.6
  • 72
    • 66149179123 scopus 로고    scopus 로고
    • Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-Adipokine mT mouse model of mammary cancer
    • Denzel MS, Hebbard LW, Shostak G, Shapiro L, Cardiff RD, Ranscht B. Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-Adipokine mT mouse model of mammary cancer. Clin Cancer Res 2009;15:3256-64.
    • (2009) Clin Cancer Res , vol.15 , pp. 3256-3264
    • Denzel, M.S.1    Hebbard, L.W.2    Shostak, G.3    Shapiro, L.4    Cardiff, R.D.5    Ranscht, B.6
  • 75
    • 34047141622 scopus 로고    scopus 로고
    • Demonstration of Adiponectin Receptors 1 and 2 mRNA expression in human breast cancer cells
    • DOI 10.1016/j.canlet.2006.10.006, PII S030438350600560X
    • Takahata C, Miyoshi Y, Irahara N, Taguchi T, Tamaki Y, Noguchi S. Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells. Cancer Lett 2007;250:229-36. (Pubitemid 46529445)
    • (2007) Cancer Letters , vol.250 , Issue.2 , pp. 229-236
    • Takahata, C.1    Miyoshi, Y.2    Irahara, N.3    Taguchi, T.4    Tamaki, Y.5    Noguchi, S.6
  • 76
    • 68149099885 scopus 로고    scopus 로고
    • The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric carcinoma
    • Barresi V, Grosso M, Giuffre G, Tuccari G, Barresi G. The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric carcinoma. J Clin Pathol 2009;62:705-9.
    • (2009) J Clin Pathol , vol.62 , pp. 705-709
    • Barresi, V.1    Grosso, M.2    Giuffre, G.3    Tuccari, G.4    Barresi, G.5
  • 77
    • 34548020729 scopus 로고    scopus 로고
    • Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance
    • DOI 10.1111/j.1467-789X.2007.00348.x
    • Crimmins NA, Martin LJ. Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance. Obes Rev 2007;8:419-23. (Pubitemid 47283939)
    • (2007) Obesity Reviews , vol.8 , Issue.5 , pp. 419-423
    • Crimmins, N.A.1    Martin, L.J.2
  • 78
    • 79951689120 scopus 로고    scopus 로고
    • Leptin promotes melanoma tumor growth in mice related to increasing circulating endothelial progenitor cells numbers and plasma NO production
    • Amjadi F, Javanmard SH, Zarkesh-Esfahani H, Khazaei M, Narimani M. Leptin promotes melanoma tumor growth in mice related to increasing circulating endothelial progenitor cells numbers and plasma NO production. J Exp Clin Cancer Res 2011;30:21.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 21
    • Amjadi, F.1    Javanmard, S.H.2    Zarkesh-Esfahani, H.3    Khazaei, M.4    Narimani, M.5
  • 79
    • 79958835946 scopus 로고    scopus 로고
    • Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer
    • Otvos L Jr, Kovalszky I, Riolfi M, Ferla R, Olah J, Sztodola A, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer 2011;47:1578-84.
    • (2011) Eur J Cancer , vol.47 , pp. 1578-1584
    • Otvos Jr., L.1    Kovalszky, I.2    Riolfi, M.3    Ferla, R.4    Olah, J.5    Sztodola, A.6
  • 81
    • 0348141022 scopus 로고    scopus 로고
    • The soluble leptin receptor is crucial for leptin action: Evidence from clinical and experimental data
    • DOI 10.1038/sj.ijo.0802432
    • Zastrow O, Seidel B, Kiess W, Thiery J, Keller E, Böttner A, et al. The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int J Obes Relat Metab Disord 2003;27:1472-8. (Pubitemid 38019159)
    • (2003) International Journal of Obesity , vol.27 , Issue.12 , pp. 1472-1478
    • Zastrow, O.1    Seidel, B.2    Kiess, W.3    Thiery, J.4    Keller, E.5    Bottner, A.6    Kratzsch, J.7
  • 82
    • 33645746168 scopus 로고    scopus 로고
    • Induction of leptin resistance through direct interaction of C-reactive protein with leptin
    • Chen K, Li F, Li J, Cai H, Strom S, Bisello A, et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 2006;12:425-32.
    • (2006) Nat Med , vol.12 , pp. 425-432
    • Chen, K.1    Li, F.2    Li, J.3    Cai, H.4    Strom, S.5    Bisello, A.6
  • 85
    • 0347986520 scopus 로고    scopus 로고
    • Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR
    • DOI 10.1016/j.bbrc.2003.12.058
    • Chinetti G, Zawadski C, Fruchart JC, Staels B. Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. Biochem Biophys Res Commun 2004;314:151-8. (Pubitemid 38058382)
    • (2004) Biochemical and Biophysical Research Communications , vol.314 , Issue.1 , pp. 151-158
    • Chinetti, G.1    Zawadski, C.2    Fruchart, J.C.3    Staels, B.4
  • 87
    • 79959431773 scopus 로고    scopus 로고
    • Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes
    • Mittendorfer B, Horowitz JF, DePaoli AM, McCamish MA, Patterson BW, Klein S. Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes. Diabetes 2011;60:1474-7.
    • (2011) Diabetes , vol.60 , pp. 1474-1477
    • Mittendorfer, B.1    Horowitz, J.F.2    DePaoli, A.M.3    McCamish, M.A.4    Patterson, B.W.5    Klein, S.6
  • 88
    • 83555164657 scopus 로고    scopus 로고
    • Metformin and neoplasia: implications and indications
    • Aljada A, Mousa SA. Metformin and neoplasia: implications and indications. Pharmacol Ther 2012;133:108-15.
    • (2012) Pharmacol Ther , vol.133 , pp. 108-115
    • Aljada, A.1    Mousa, S.A.2
  • 89
    • 84859029647 scopus 로고    scopus 로고
    • Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival
    • Currie CJ, Poole CD, Jenkins-Jones S, Gale EA, Johnson JA, Morgan CL. Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care. 2012;35:299-304.
    • (2012) Diabetes Care , vol.35 , pp. 299-304
    • Currie, C.J.1    Poole, C.D.2    Jenkins-Jones, S.3    Gale, E.A.4    Johnson, J.A.5    Morgan, C.L.6
  • 90
    • 84864314304 scopus 로고    scopus 로고
    • Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer
    • He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Ann Oncol 2012;23:1771-80.
    • (2012) Ann Oncol , vol.23 , pp. 1771-1780
    • He, X.1    Esteva, F.J.2    Ensor, J.3    Hortobagyi, G.N.4    Lee, M.H.5    Yeung, S.C.6
  • 91
    • 80053504259 scopus 로고    scopus 로고
    • Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients
    • He XX, Tu SM, Lee MH, Yeung SC. Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients. Ann Oncol 2011;22:2640-5.
    • (2011) Ann Oncol , vol.22 , pp. 2640-2645
    • He, X.X.1    Tu, S.M.2    Lee, M.H.3    Yeung, S.C.4
  • 93
    • 84870685371 scopus 로고    scopus 로고
    • Thiazolidinedione use and cancer incidence in type 2 diabetes: A systematic review and meta-analysis
    • Colmers IN, Bowker SL, Johnson JA. Thiazolidinedione use and cancer incidence in type 2 diabetes: a systematic review and meta-analysis. Diabetes Metab 2012;38:475-84.
    • (2012) Diabetes Metab , vol.38 , pp. 475-484
    • Colmers, I.N.1    Bowker, S.L.2    Johnson, J.A.3
  • 94
    • 19944379835 scopus 로고    scopus 로고
    • Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia
    • DOI 10.2337/diacare.28.6.1419
    • Koh KK, Han SH, Quon MJ, Yeal Ahn J, Shin EK. Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia. Diabetes Care 2005;28:1419-24. (Pubitemid 40756707)
    • (2005) Diabetes Care , vol.28 , Issue.6 , pp. 1419-1424
    • Koh, K.K.1    Han, S.H.2    Quon, M.J.3    Ahn, J.Y.4    Shin, E.K.5
  • 95
    • 20844444135 scopus 로고    scopus 로고
    • Targeting Stat3 in cancer therapy
    • DOI 10.1097/00001813-200507000-00002
    • Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 2005;16:601-7. (Pubitemid 40863092)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.6 , pp. 601-607
    • Jing, N.1    Tweardy, D.J.2
  • 97
    • 84862902308 scopus 로고    scopus 로고
    • Novel small molecule Raf kinase inhibitors for targeted cancer therapeutics
    • Kim DH, Sim T. Novel small molecule Raf kinase inhibitors for targeted cancer therapeutics. Arch Pharm Res 2012;35:605-15.
    • (2012) Arch Pharm Res , vol.35 , pp. 605-615
    • Kim, D.H.1    Sim, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.