메뉴 건너뛰기




Volumn 11, Issue , 2016, Pages 127-148

Genetics and Pathogenesis of Inflammatory Bowel Disease

Author keywords

Causative variants; Crohn's disease; Genome wide association study; Ulcerative colitis

Indexed keywords

INTERLEUKIN 10 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 84971251096     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-012615-044152     Document Type: Article
Times cited : (199)

References (121)
  • 3
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, et al. 2012. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491:119-24
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3    Duerr, R.H.4    McGovern, D.P.5
  • 4
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, et al. 2011. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat. Genet. 43:246-52
    • (2011) Nat. Genet. , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3    Franke, A.4    D'Amato, M.5
  • 5
    • 80054975975 scopus 로고    scopus 로고
    • Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
    • Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, et al. 2011. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat. Genet. 43:1066-73
    • (2011) Nat. Genet. , vol.43 , pp. 1066-1073
    • Rivas, M.A.1    Beaudoin, M.2    Gardet, A.3    Stevens, C.4    Sharma, Y.5
  • 6
    • 84880617946 scopus 로고    scopus 로고
    • Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
    • EllinghausD, Zhang H, Zeissig S, Lipinski S,Till A, et al. 2013. Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroenterology 145:339-47
    • (2013) Gastroenterology , vol.145 , pp. 339-347
    • Ellinghaus, D.1    Zhang, H.2    Zeissig, S.3    Lipinski, S.4    Till, A.5
  • 7
    • 84878764878 scopus 로고    scopus 로고
    • Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes
    • Christodoulou K, Wiskin AE, Gibson J, Tapper W, Willis C, et al. 2013. Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes. Gut 62:977-84
    • (2013) Gut , vol.62 , pp. 977-984
    • Christodoulou, K.1    Wiskin, A.E.2    Gibson, J.3    Tapper, W.4    Willis, C.5
  • 8
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor B, Gardet A, Xavier RJ. 2011. Genetics and pathogenesis of inflammatory bowel disease. Nature 474:307-17
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 9
    • 84881030701 scopus 로고    scopus 로고
    • From genetics of inflammatory bowel disease towards mechanistic insights
    • Graham DB,XavierRJ. 2013. From genetics of inflammatory bowel disease towards mechanistic insights. Trends Immunol. 34:371-78
    • (2013) Trends Immunol. , vol.34 , pp. 371-378
    • Graham, D.B.1    Xavier, R.J.2
  • 10
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
    • McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, et al. 2008. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet. 9:356-69
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 356-369
    • McCarthy, M.I.1    Abecasis, G.R.2    Cardon, L.R.3    Goldstein, D.B.4    Little, J.5
  • 12
    • 79955566359 scopus 로고    scopus 로고
    • Recent insights into the genetics of inflammatory bowel disease
    • Cho JH, Brant SR. 2011. Recent insights into the genetics of inflammatory bowel disease. Gastroenterology 140:1704-12
    • (2011) Gastroenterology , vol.140 , pp. 1704-1712
    • Cho, J.H.1    Brant, S.R.2
  • 13
    • 84904006087 scopus 로고    scopus 로고
    • Rare-variant association analysis: Study designs and statistical tests
    • Lee S, Abecasis GR, Boehnke M, Lin X. 2014. Rare-variant association analysis: study designs and statistical tests. Am. J. Hum. Genet. 95:5-23
    • (2014) Am. J. Hum. Genet. , vol.95 , pp. 5-23
    • Lee, S.1    Abecasis, G.R.2    Boehnke, M.3    Lin, X.4
  • 14
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, et al. 2006. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461-63
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5
  • 16
    • 84904036824 scopus 로고    scopus 로고
    • PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia
    • Stray-Pedersen A, Backe PH, Sorte HS, Morkrid L, Chokshi NY, et al. 2014. PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia. Am. J. Hum. Genet. 95:96-107
    • (2014) Am. J. Hum. Genet. , vol.95 , pp. 96-107
    • Stray-Pedersen, A.1    Backe, P.H.2    Sorte, H.S.3    Morkrid, L.4    Chokshi, N.Y.5
  • 17
    • 84908262165 scopus 로고    scopus 로고
    • The diagnostic approach to monogenic very early onset inflammatory bowel disease
    • Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, et al. 2014. The diagnostic approach to monogenic very early onset inflammatory bowel disease. Gastroenterology 147:990-1007.e3
    • (2014) Gastroenterology , vol.147 , pp. 990e3-1007e3
    • Uhlig, H.H.1    Schwerd, T.2    Koletzko, S.3    Shah, N.4    Kammermeier, J.5
  • 18
    • 80051494421 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis
    • Muise AM, Walters T, Xu W, Shen-Tu G, Guo CH, et al. 2011. Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. Gastroenterology 141:633-41
    • (2011) Gastroenterology , vol.141 , pp. 633-641
    • Muise, A.M.1    Walters, T.2    Xu, W.3    Shen-Tu, G.4    Guo, C.H.5
  • 19
    • 84861570833 scopus 로고    scopus 로고
    • NADPH oxidase complex and IBD candidate gene studies: Identification of a rare variant in NCF2 that results in reduced binding to RAC2
    • Muise AM, Xu W, Guo CH, Walters TD, Wolters VM, et al. 2012. NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut 61:1028-35
    • (2012) Gut , vol.61 , pp. 1028-1035
    • Muise, A.M.1    Xu, W.2    Guo, C.H.3    Walters, T.D.4    Wolters, V.M.5
  • 20
    • 84906541386 scopus 로고    scopus 로고
    • Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease
    • Dhillon SS, Fattouh R, Elkadri A, Xu W, Murchie R, et al. 2014. Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease. Gastroenterology 147:680-89.e2
    • (2014) Gastroenterology , vol.147 , pp. 680e2-689e2
    • Dhillon, S.S.1    Fattouh, R.2    Elkadri, A.3    Xu, W.4    Murchie, R.5
  • 21
    • 84873816901 scopus 로고    scopus 로고
    • Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair
    • LeoniG,Alam A, Neumann PA, Lambeth JD, ChengG, et al. 2013. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J. Clin. Investig. 123:443-54
    • (2013) J. Clin. Investig. , vol.123 , pp. 443-454
    • Leoni, G.1    Alam, A.2    Neumann, P.A.3    Lambeth, J.D.4    Cheng, G.5
  • 22
    • 84924066805 scopus 로고    scopus 로고
    • Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair
    • LeoniG,Neumann PA, Kamaly N, Quiros M, Nishio H, et al. 2015. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J. Clin. Investig. 125(3):1215-27
    • (2015) J. Clin. Investig. , vol.125 , Issue.3 , pp. 1215-1227
    • Leoni, G.1    Neumann, P.A.2    Kamaly, N.3    Quiros, M.4    Nishio, H.5
  • 23
    • 84896492362 scopus 로고    scopus 로고
    • Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease
    • Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, et al. 2014. Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology 146:1028-39
    • (2014) Gastroenterology , vol.146 , pp. 1028-1039
    • Avitzur, Y.1    Guo, C.2    Mastropaolo, L.A.3    Bahrami, E.4    Chen, H.5
  • 26
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schaffer AA, et al. 2009. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361:2033-45
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2033-2045
    • Glocker, E.O.1    Kotlarz, D.2    Boztug, K.3    Gertz, E.M.4    Schaffer, A.A.5
  • 27
    • 84864206050 scopus 로고    scopus 로고
    • Loss of interleukin-10 signaling and infantile inflammatory bowel disease: Implications for diagnosis and therapy
    • KotlarzD, Beier R, MuruganD,Diestelhorst J, JensenO, et al. 2012. Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology 143:347-55
    • (2012) Gastroenterology , vol.143 , pp. 347-355
    • Kotlarz, D.1    Beier, R.2    Murugan, D.3    Diestelhorst, J.4    Jensen, O.5
  • 28
    • 84901258872 scopus 로고    scopus 로고
    • Protective mucosal immunity mediated by epithelial CD1d and IL-10
    • Olszak T, Neves JF,DowdsCM,Baker K, Glickman J, et al. 2014. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509:497-502
    • (2014) Nature , vol.509 , pp. 497-502
    • Olszak, T.1    Neves, J.F.2    Dowds, C.M.3    Baker, K.4    Glickman, J.5
  • 29
    • 84900428511 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function
    • Shouval DS, Biswas A,Goettel JA, McCann K, Conaway E, et al. 2014. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity 40:706-19
    • (2014) Immunity , vol.40 , pp. 706-719
    • Shouval, D.S.1    Biswas, A.2    Goettel, J.A.3    McCann, K.4    Conaway, E.5
  • 30
    • 84900448316 scopus 로고    scopus 로고
    • Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
    • Zigmond E, Bernshtein B, Friedlander G, Walker CR, Yona S, et al. 2014. Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity 40:720-33
    • (2014) Immunity , vol.40 , pp. 720-733
    • Zigmond, E.1    Bernshtein, B.2    Friedlander, G.3    Walker, C.R.4    Yona, S.5
  • 31
    • 84922051718 scopus 로고    scopus 로고
    • Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection
    • MacDuff DA, Reese TA, Kimmey JM, Weiss LA, Song C, et al. 2015. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. eLife 4:e04494
    • (2015) ELife , vol.4 , pp. e04494
    • MacDuff, D.A.1    Reese, T.A.2    Kimmey, J.M.3    Weiss, L.A.4    Song, C.5
  • 32
    • 84917712273 scopus 로고    scopus 로고
    • Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins
    • Carmi S, Hui KY, Kochav E, Liu X, Xue J, et al. 2014. Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Nat. Commun. 5:4835
    • (2014) Nat. Commun. , vol.5 , pp. 4835
    • Carmi, S.1    Hui, K.Y.2    Kochav, E.3    Liu, X.4    Xue, J.5
  • 33
    • 84859253322 scopus 로고    scopus 로고
    • A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci
    • Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, et al. 2012. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLOS Genet. 8:e1002559
    • (2012) PLOS Genet. , vol.8 , pp. e1002559
    • Kenny, E.E.1    Pe'Er, I.2    Karban, A.3    Ozelius, L.4    Mitchell, A.A.5
  • 34
    • 84880923909 scopus 로고    scopus 로고
    • Extended haplotype association study in Crohn's disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3
    • Zhang W, Hui KY, Gusev A, Warner N, Ng SM, et al. 2013. Extended haplotype association study in Crohn's disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3. Genes Immun. 14:310-16
    • (2013) Genes Immun. , vol.14 , pp. 310-316
    • Zhang, W.1    Hui, K.Y.2    Gusev, A.3    Warner, N.4    Ng, S.M.5
  • 35
    • 84889680996 scopus 로고    scopus 로고
    • Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations
    • Yang SK, Hong M, Zhao W, Jung Y, Baek J, et al. 2014. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. Gut 63:80-87
    • (2014) Gut , vol.63 , pp. 80-87
    • Yang, S.K.1    Hong, M.2    Zhao, W.3    Jung, Y.4    Baek, J.5
  • 36
    • 84875234775 scopus 로고    scopus 로고
    • Agenome-wide association study identifies 2 susceptibility loci for Crohn's disease in a Japanese population
    • YamazakiK, Umeno J, TakahashiA,HiranoA, Johnson TA, et al. 2013.Agenome-wide association study identifies 2 susceptibility loci for Crohn's disease in a Japanese population. Gastroenterology 144:781-88
    • (2013) Gastroenterology , vol.144 , pp. 781-788
    • Yamazaki, K.1    Umeno, J.2    Takahashi, A.3    Hirano, A.4    Johnson, T.A.5
  • 37
    • 84876373775 scopus 로고    scopus 로고
    • Association study of 71 European Crohn's disease susceptibility loci in a Japanese population
    • Hirano A, Yamazaki K, Umeno J, Ashikawa K, Aoki M, et al. 2013. Association study of 71 European Crohn's disease susceptibility loci in a Japanese population. Inflamm. Bowel Dis. 19:526-33
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. 526-533
    • Hirano, A.1    Yamazaki, K.2    Umeno, J.3    Ashikawa, K.4    Aoki, M.5
  • 38
    • 84929589668 scopus 로고    scopus 로고
    • Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants
    • Hong SN, Park C, Park SJ, Lee CK, Ye BD, et al. 2015. Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants. Gut 65:788-96
    • (2015) Gut , vol.65 , pp. 788-796
    • Hong, S.N.1    Park, C.2    Park, S.J.3    Lee, C.K.4    Ye, B.D.5
  • 39
    • 84876361184 scopus 로고    scopus 로고
    • Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibilitywith Caucasians
    • Yang SK,HongM, ZhaoW, Jung Y, TayebiN, et al. 2013. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibilitywith Caucasians. Inflamm. Bowel Dis. 19:954-66
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. 954-966
    • Yang, S.K.1    Hong, M.2    Zhao, W.3    Jung, Y.4    Tayebi, N.5
  • 40
    • 84895778869 scopus 로고    scopus 로고
    • Differential effect of genetic burden on disease phenotypes in Crohn's disease and ulcerative colitis: Analysis of a North American cohort
    • Ananthakrishnan AN, Huang H, Nguyen DD, Sauk J, Yajnik V, Xavier RJ. 2014. Differential effect of genetic burden on disease phenotypes in Crohn's disease and ulcerative colitis: analysis of a North American cohort. Am. J. Gastroenterol. 109:395-400
    • (2014) Am. J. Gastroenterol. , vol.109 , pp. 395-400
    • Ananthakrishnan, A.N.1    Huang, H.2    Nguyen, D.D.3    Sauk, J.4    Yajnik, V.5    Xavier, R.J.6
  • 41
    • 80054746235 scopus 로고    scopus 로고
    • Understanding type 1 diabetes through genetics: Advances and prospects
    • Polychronakos C, Li Q. 2011. Understanding type 1 diabetes through genetics: advances and prospects. Nat. Rev. Genet. 12:781-92
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 781-792
    • Polychronakos, C.1    Li, Q.2
  • 42
    • 84923326765 scopus 로고    scopus 로고
    • Genetic and epigenetic fine mapping of causal autoimmune disease variants
    • Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, et al. 2014. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518:337-43
    • (2014) Nature , vol.518 , pp. 337-343
    • Farh, K.K.1    Marson, A.2    Zhu, J.3    Kleinewietfeld, M.4    Housley, W.J.5
  • 43
    • 84882449068 scopus 로고    scopus 로고
    • Genetic insights into common pathways and complex relationships among immune-mediated diseases
    • Parkes M, Cortes A, van Heel DA, Brown MA. 2013. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat. Rev. Genet. 14:661-73
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 661-673
    • Parkes, M.1    Cortes, A.2    Van Heel, D.A.3    Brown, M.A.4
  • 44
    • 84925779171 scopus 로고    scopus 로고
    • Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans
    • Yang SK, Hong M, Choi H, Zhao W, Jung Y, et al. 2014. Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. Inflamm. Bowel Dis. 21:1-7
    • (2014) Inflamm. Bowel Dis. , vol.21 , pp. 1-7
    • Yang, S.K.1    Hong, M.2    Choi, H.3    Zhao, W.4    Jung, Y.5
  • 45
    • 79960279940 scopus 로고    scopus 로고
    • Promise and pitfalls of the Immunochip
    • Cortes A, Brown MA. 2011. Promise and pitfalls of the Immunochip. Arthritis Res. Ther. 13:101
    • (2011) Arthritis Res. Ther. , vol.13 , pp. 101
    • Cortes, A.1    Brown, M.A.2
  • 46
    • 82255192188 scopus 로고    scopus 로고
    • Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
    • Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, et al. 2011. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat. Genet. 43:1193-201
    • (2011) Nat. Genet. , vol.43 , pp. 1193-1201
    • Trynka, G.1    Hunt, K.A.2    Bockett, N.A.3    Romanos, J.4    Mistry, V.5
  • 47
    • 84928612813 scopus 로고    scopus 로고
    • High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
    • Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, et al. 2015. High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat. Genet. 47:172-79
    • (2015) Nat. Genet. , vol.47 , pp. 172-179
    • Goyette, P.1    Boucher, G.2    Mallon, D.3    Ellinghaus, E.4    Jostins, L.5
  • 48
    • 84928560965 scopus 로고    scopus 로고
    • Super-enhancers delineate diseaseassociated regulatory nodes in T cells
    • Vahedi G, Kanno Y, Furumoto Y, Jiang K, Parker SC, et al. 2015. Super-enhancers delineate diseaseassociated regulatory nodes in T cells. Nature 520:558-62
    • (2015) Nature , vol.520 , pp. 558-562
    • Vahedi, G.1    Kanno, Y.2    Furumoto, Y.3    Jiang, K.4    Parker, S.C.5
  • 49
    • 84888015137 scopus 로고    scopus 로고
    • Super-enhancers in the control of cell identity and disease
    • Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-Andre V, et al. 2013. Super-enhancers in the control of cell identity and disease. Cell 155:934-47
    • (2013) Cell , vol.155 , pp. 934-947
    • Hnisz, D.1    Abraham, B.J.2    Lee, T.I.3    Lau, A.4    Saint-Andre, V.5
  • 50
    • 0035846326 scopus 로고    scopus 로고
    • Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent
    • Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, et al. 2001. Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent. N. Engl. J. Med. 345:1098-104
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1098-1104
    • Keane, J.1    Gershon, S.2    Wise, R.P.3    Mirabile-Levens, E.4    Kasznica, J.5
  • 51
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • SandbornWJ, Gasink C, Gao LL, Blank MA, Johanns J, et al. 2012. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N. Engl. J. Med. 367:1519-28
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3    Blank, M.A.4    Johanns, J.5
  • 52
    • 84883144028 scopus 로고    scopus 로고
    • Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice
    • Sokol H, Conway KL, ZhangM, ChoiM,Morin B, et al. 2013. Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Gastroenterology 145:591-601.e3
    • (2013) Gastroenterology , vol.145 , pp. 591e3-601e3
    • Sokol, H.1    Conway, K.L.2    Zhang, M.3    Choi, M.4    Morin, B.5
  • 53
    • 28444469783 scopus 로고    scopus 로고
    • Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
    • Vang T, Congia M, Macis MD, Musumeci L, Orru V, et al. 2005. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat. Genet. 37:1317-19
    • (2005) Nat. Genet. , vol.37 , pp. 1317-1319
    • Vang, T.1    Congia, M.2    Macis, M.D.3    Musumeci, L.4    Orru, V.5
  • 55
    • 84859891065 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
    • Rhee I, Veillette A. 2012. Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nat. Immunol. 13:439-47
    • (2012) Nat. Immunol. , vol.13 , pp. 439-447
    • Rhee, I.1    Veillette, A.2
  • 58
    • 4043128071 scopus 로고    scopus 로고
    • Genetic analysis of genome-wide variation in human gene expression
    • Morley M, Molony CM,Weber TM,Devlin JL, EwensKG, et al. 2004. Genetic analysis of genome-wide variation in human gene expression. Nature 430:743-47
    • (2004) Nature , vol.430 , pp. 743-747
    • Morley, M.1    Molony, C.M.2    Weber, T.M.3    Devlin, J.L.4    Ewens, K.G.5
  • 59
    • 34548805282 scopus 로고    scopus 로고
    • A genome-wide association study of global gene expression
    • Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, et al. 2007. A genome-wide association study of global gene expression. Nat. Genet. 39:1202-7
    • (2007) Nat. Genet. , vol.39 , pp. 1202-1207
    • Dixon, A.L.1    Liang, L.2    Moffatt, M.F.3    Chen, W.4    Heath, S.5
  • 60
    • 84896742056 scopus 로고    scopus 로고
    • Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
    • Fairfax BP, Humburg P,Makino S,Naranbhai V,WongD, et al. 2014. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 343:1246949
    • (2014) Science , vol.343 , pp. 1246949
    • Fairfax, B.P.1    Humburg, P.2    Makino, S.3    Naranbhai, V.4    Wong, D.5
  • 61
    • 84899630340 scopus 로고    scopus 로고
    • Gene-gene and gene-environment interactions in ulcerative colitis
    • Wang MH, Fiocchi C, Zhu X, Ripke S, Kamboh MI, et al. 2014. Gene-gene and gene-environment interactions in ulcerative colitis. Hum. Genet. 133:547-58
    • (2014) Hum. Genet. , vol.133 , pp. 547-558
    • Wang, M.H.1    Fiocchi, C.2    Zhu, X.3    Ripke, S.4    Kamboh, M.I.5
  • 62
    • 78149482162 scopus 로고    scopus 로고
    • Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort
    • Wagner J, Sim WH, Ellis JA, Ong EK, Catto-Smith AG, et al. 2010. Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort. PLOS ONE 5:e15376
    • (2010) PLOS ONE , vol.5 , pp. e15376
    • Wagner, J.1    Sim, W.H.2    Ellis, J.A.3    Ong, E.K.4    Catto-Smith, A.G.5
  • 63
    • 84900389558 scopus 로고    scopus 로고
    • Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele
    • Hedl M, Lahiri A, Ning K, Cho JH, Abraham C. 2014. Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele. Immunity 40:734-46
    • (2014) Immunity , vol.40 , pp. 734-746
    • Hedl, M.1    Lahiri, A.2    Ning, K.3    Cho, J.H.4    Abraham, C.5
  • 64
    • 84887621906 scopus 로고    scopus 로고
    • Paneth cells as a site of origin for intestinal inflammation
    • Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Bock J, et al. 2013. Paneth cells as a site of origin for intestinal inflammation. Nature 503:272-76
    • (2013) Nature , vol.503 , pp. 272-276
    • Adolph, T.E.1    Tomczak, M.F.2    Niederreiter, L.3    Ko, H.J.4    Bock, J.5
  • 65
    • 84924694448 scopus 로고    scopus 로고
    • Exposome in IBD: Recent insights in environmental factors that influence the onset and course of IBD
    • Rogler G, Vavricka S. 2014. Exposome in IBD: recent insights in environmental factors that influence the onset and course of IBD. Inflamm. Bowel Dis. 21:400-8
    • (2014) Inflamm. Bowel Dis. , vol.21 , pp. 400-408
    • Rogler, G.1    Vavricka, S.2
  • 66
    • 84874652518 scopus 로고    scopus 로고
    • Geographical variability and environmental risk factors in inflammatory bowel disease
    • Ng SC, Bernstein CN, Vatn MH, Lakatos PL, Loftus EV Jr, et al. 2013. Geographical variability and environmental risk factors in inflammatory bowel disease. Gut 62:630-49
    • (2013) Gut , vol.62 , pp. 630-649
    • Ng, S.C.1    Bernstein, C.N.2    Vatn, M.H.3    Lakatos, P.L.4    Loftus, E.V.5
  • 67
    • 79956078164 scopus 로고    scopus 로고
    • Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
    • Bloom SM, Bijanki VN, Nava GM, Sun L, Malvin NP, et al. 2011. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe 9:390-403
    • (2011) Cell Host Microbe , vol.9 , pp. 390-403
    • Bloom, S.M.1    Bijanki, V.N.2    Nava, G.M.3    Sun, L.4    Malvin, N.P.5
  • 68
    • 84934936350 scopus 로고    scopus 로고
    • Environmental risk factors in inflammatory bowel disease: A population-based case-control study in Asia-Pacific
    • Ng SC, Tang W, Leong RW, Chen M, Ko Y, et al. 2014. Environmental risk factors in inflammatory bowel disease: A population-based case-control study in Asia-Pacific. Gut 64:1063-71
    • (2014) Gut , vol.64 , pp. 1063-1071
    • Ng, S.C.1    Tang, W.2    Leong, R.W.3    Chen, M.4    Ko, Y.5
  • 69
    • 84902129948 scopus 로고    scopus 로고
    • Genetic polymorphisms in metabolizing enzymes modifying the association between smoking and inflammatory bowel diseases
    • Ananthakrishnan AN, Nguyen DD, Sauk J, YajnikV, Xavier RJ. 2014. Genetic polymorphisms in metabolizing enzymes modifying the association between smoking and inflammatory bowel diseases. Inflamm. Bowel Dis. 20:783-89
    • (2014) Inflamm. Bowel Dis. , vol.20 , pp. 783-789
    • Ananthakrishnan, A.N.1    Nguyen, D.D.2    Sauk, J.3    Yajnik, V.4    Xavier, R.J.5
  • 70
    • 84855961122 scopus 로고    scopus 로고
    • The effect of smoking on intestinal inflammation: What can be learned from animal models?
    • Verschuere S, De Smet R, Allais L, CuvelierCA. 2012. The effect of smoking on intestinal inflammation: What can be learned from animal models? J. Crohn's Colitis 6:1-12
    • (2012) J. Crohn's Colitis , vol.6 , pp. 1-12
    • Verschuere, S.1    De Smet, R.2    Allais, L.3    Cuvelier, C.A.4
  • 71
    • 84902136456 scopus 로고    scopus 로고
    • Opposing effects of smoking in ulcerative colitis and Crohn's disease may be explained by differential effects on dendritic cells
    • Ueno A, Jijon H, Traves S, Chan R, Ford K, et al. 2014. Opposing effects of smoking in ulcerative colitis and Crohn's disease may be explained by differential effects on dendritic cells. Inflamm. Bowel Dis. 20:800-10
    • (2014) Inflamm. Bowel Dis. , vol.20 , pp. 800-810
    • Ueno, A.1    Jijon, H.2    Traves, S.3    Chan, R.4    Ford, K.5
  • 72
    • 84928412757 scopus 로고    scopus 로고
    • Diet in the pathogenesis and treatment of inflammatory bowel diseases
    • Lee D, Albenberg L, Compher C, Baldassano R, Piccoli D, et al. 2015. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology 148:1087-106
    • (2015) Gastroenterology , vol.148 , pp. 1087-1106
    • Lee, D.1    Albenberg, L.2    Compher, C.3    Baldassano, R.4    Piccoli, D.5
  • 73
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, et al. 2015. Genetic studies of body mass index yield new insights for obesity biology. Nature 518:197-206
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1    Kahali, B.2    Berndt, S.I.3    Justice, A.E.4    Pers, T.H.5
  • 74
    • 84923169934 scopus 로고    scopus 로고
    • New genetic loci link adipose and insulin biology to body fat distribution
    • Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, et al. 2015. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518:187-96
    • (2015) Nature , vol.518 , pp. 187-196
    • Shungin, D.1    Winkler, T.W.2    Croteau-Chonka, D.C.3    Ferreira, T.4    Locke, A.E.5
  • 75
    • 84924301510 scopus 로고    scopus 로고
    • Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
    • Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, et al. 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519:92-96
    • (2015) Nature , vol.519 , pp. 92-96
    • Chassaing, B.1    Koren, O.2    Goodrich, J.K.3    Poole, A.C.4    Srinivasan, S.5
  • 76
    • 84889681706 scopus 로고    scopus 로고
    • Western diet induces dysbiosis with increased e coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
    • Martinez-MedinaM,Denizot J,Dreux N, Robin F, Billard E, et al. 2014. Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut 63:116-24
    • (2014) Gut , vol.63 , pp. 116-124
    • Martinez-Medina, M.1    Denizot, J.2    Dreux, N.3    Robin, F.4    Billard, E.5
  • 77
    • 84863436944 scopus 로고    scopus 로고
    • Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
    • Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, et al. 2012. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature 487:104-8
    • (2012) Nature , vol.487 , pp. 104-108
    • Devkota, S.1    Wang, Y.2    Musch, M.W.3    Leone, V.4    Fehlner-Peach, H.5
  • 78
    • 84856011484 scopus 로고    scopus 로고
    • Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease
    • Greenblum S, Turnbaugh PJ, Borenstein E. 2012. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. PNAS 109:594-99
    • (2012) PNAS , vol.109 , pp. 594-599
    • Greenblum, S.1    Turnbaugh, P.J.2    Borenstein, E.3
  • 79
    • 15944383403 scopus 로고    scopus 로고
    • Gene-environment interactions in human diseases
    • Hunter DJ. 2005. Gene-environment interactions in human diseases. Nat. Rev. Genet. 6:287-98
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 287-298
    • Hunter, D.J.1
  • 81
    • 84871135111 scopus 로고    scopus 로고
    • The Oslo definitions for coeliac disease and related terms
    • Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, et al. 2013. The Oslo definitions for coeliac disease and related terms. Gut 62:43-52
    • (2013) Gut , vol.62 , pp. 43-52
    • Ludvigsson, J.F.1    Leffler, D.A.2    Bai, J.C.3    Biagi, F.4    Fasano, A.5
  • 82
    • 0029787622 scopus 로고    scopus 로고
    • Nontraditional epidemiologic approaches in the analysis of geneenvironment interaction: Case-control studies with no controls! Am
    • Khoury MJ, Flanders WD. 1996. Nontraditional epidemiologic approaches in the analysis of geneenvironment interaction: case-control studies with no controls! Am. J. Epidemiol. 144:207-13
    • (1996) J. Epidemiol. , vol.144 , pp. 207-213
    • Khoury, M.J.1    Flanders, W.D.2
  • 83
    • 0021137170 scopus 로고
    • The design of case-control studies: The influence of confounding and interaction effects
    • Smith PG, Day NE. 1984. The design of case-control studies: The influence of confounding and interaction effects. Int. J. Epidemiol. 13:356-65
    • (1984) Int. J. Epidemiol. , vol.13 , pp. 356-365
    • Smith, P.G.1    Day, N.E.2
  • 84
    • 84897138296 scopus 로고    scopus 로고
    • Role of the microbiota in immunity and inflammation
    • Belkaid Y, Hand TW. 2014. Role of the microbiota in immunity and inflammation. Cell 157:121-41
    • (2014) Cell , vol.157 , pp. 121-141
    • Belkaid, Y.1    Hand, T.W.2
  • 86
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel disease: Current status and the future ahead
    • Kostic AD, Xavier RJ, Gevers D. 2014. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146:1489-99
    • (2014) Gastroenterology , vol.146 , pp. 1489-1499
    • Kostic, A.D.1    Xavier, R.J.2    Gevers, D.3
  • 87
    • 84884273778 scopus 로고    scopus 로고
    • Advances in inflammatory bowel disease pathogenesis: Linking host genetics and the microbiome
    • Knights D, Lassen KG, Xavier RJ. 2013. Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome. Gut 62:1505-10
    • (2013) Gut , vol.62 , pp. 1505-1510
    • Knights, D.1    Lassen, K.G.2    Xavier, R.J.3
  • 88
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • Willing BP, Dicksved J, Halfvarson J, Andersson AF, Lucio M, et al. 2010. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139:1844-54.e1
    • (2010) Gastroenterology , vol.139 , pp. 1844e1-1854e1
    • Willing, B.P.1    Dicksved, J.2    Halfvarson, J.3    Andersson, A.F.4    Lucio, M.5
  • 89
    • 79953748870 scopus 로고    scopus 로고
    • Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
    • JoossensM,Huys G, CnockaertM,DePreterV,Verbeke K, et al. 2011. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 60:631-37
    • (2011) Gut , vol.60 , pp. 631-637
    • Joossens, M.1    Huys, G.2    Cnockaert, M.3    DePreter, V.4    Verbeke, K.5
  • 91
    • 84941344904 scopus 로고    scopus 로고
    • The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients
    • Sadaghian SadabadM, Regeling A, deGoffauMC, Blokzijl T,Weersma RK, et al. 2015. The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients. Gut 64:1546-52
    • (2015) Gut , vol.64 , pp. 1546-1552
    • Sadaghian Sadabad, M.1    Regeling, A.2    DeGoffau, M.C.3    Blokzijl, T.4    Weersma, R.K.5
  • 93
    • 84904048875 scopus 로고    scopus 로고
    • A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
    • Machiels K, Joossens M, Sabino J, De Preter V, Arijs I, et al. 2014. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut 63:1275-83
    • (2014) Gut , vol.63 , pp. 1275-1283
    • Machiels, K.1    Joossens, M.2    Sabino, J.3    De Preter, V.4    Arijs, I.5
  • 94
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, et al. 2013. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:569-73
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3    Michaud, M.4    Gallini, C.A.5
  • 95
    • 80053462850 scopus 로고    scopus 로고
    • Metagenomics and personalized medicine
    • Virgin HW, Todd JA. 2011. Metagenomics and personalized medicine. Cell 147:44-56
    • (2011) Cell , vol.147 , pp. 44-56
    • Virgin, H.W.1    Todd, J.A.2
  • 96
    • 84860216630 scopus 로고    scopus 로고
    • Microbial exposure during early life has persistent effects on natural killer T cell function
    • Olszak T, An D, Zeissig S, Vera MP, Richter J, et al. 2012. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336:489-93
    • (2012) Science , vol.336 , pp. 489-493
    • Olszak, T.1    An, D.2    Zeissig, S.3    Vera, M.P.4    Richter, J.5
  • 98
    • 84922245262 scopus 로고    scopus 로고
    • Disease-specific alterations in the enteric virome in inflammatory bowel disease
    • Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, et al. 2015. Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell 160:447-60
    • (2015) Cell , vol.160 , pp. 447-460
    • Norman, J.M.1    Handley, S.A.2    Baldridge, M.T.3    Droit, L.4    Liu, C.Y.5
  • 99
    • 84907300008 scopus 로고    scopus 로고
    • Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease
    • Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, et al. 2014. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158:1000-10
    • (2014) Cell , vol.158 , pp. 1000-1010
    • Palm, N.W.1    De Zoete, M.R.2    Cullen, T.W.3    Barry, N.A.4    Stefanowski, J.5
  • 100
    • 84901660514 scopus 로고    scopus 로고
    • Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
    • Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, et al. 2014. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. PNAS 111:7741-46
    • (2014) PNAS , vol.111 , pp. 7741-7746
    • Lassen, K.G.1    Kuballa, P.2    Conway, K.L.3    Patel, K.K.4    Becker, C.E.5
  • 101
    • 84896730900 scopus 로고    scopus 로고
    • A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3
    • Murthy A, Li Y, Peng I, Reichelt M, Katakam AK, et al. 2014. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506:456-62
    • (2014) Nature , vol.506 , pp. 456-462
    • Murthy, A.1    Li, Y.2    Peng, I.3    Reichelt, M.4    Katakam, A.K.5
  • 102
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, et al. 2010. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 141:1135-45
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3    Liu, T.C.4    Ng, A.C.5
  • 103
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, MiyoshiH, Loh J, et al. 2008. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456:259-63
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3    Miyoshi, H.4    Loh, J.5
  • 104
    • 84890735514 scopus 로고    scopus 로고
    • Genetic variants synthesize to produce Paneth cell phenotypes that define subtypes of Crohn's disease
    • VanDussenKL, LiuTC, Li D, Towfic F,ModianoN, et al. 2014. Genetic variants synthesize to produce Paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology 146:200-9
    • (2014) Gastroenterology , vol.146 , pp. 200-209
    • VanDussen, K.L.1    Liu, T.C.2    Li, D.3    Towfic, F.4    Modiano, N.5
  • 105
    • 84882369710 scopus 로고    scopus 로고
    • A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection
    • Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, et al. 2013. A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Cell Host Microbe 14:216-24
    • (2013) Cell Host Microbe , vol.14 , pp. 216-224
    • Marchiando, A.M.1    Ramanan, D.2    Ding, Y.3    Gomez, L.E.4    Hubbard-Lucey, V.M.5
  • 106
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, et al. 2011. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745-57
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3    Henao-Mejia, J.4    Thaiss, C.A.5
  • 107
    • 84888223618 scopus 로고    scopus 로고
    • Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection
    • Conway KL,Kuballa P, Song JH, Patel KK, Castoreno AB, et al. 2013. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology 145:1347-57
    • (2013) Gastroenterology , vol.145 , pp. 1347-1357
    • Conway, K.L.1    Kuballa, P.2    Song, J.H.3    Patel, K.K.4    Castoreno, A.B.5
  • 108
    • 84921295403 scopus 로고    scopus 로고
    • Mouse genome engineering via CRISPR-Cas9 for study of immune function
    • Pelletier S, Gingras S, Green DR. 2015. Mouse genome engineering via CRISPR-Cas9 for study of immune function. Immunity 42:18-27
    • (2015) Immunity , vol.42 , pp. 18-27
    • Pelletier, S.1    Gingras, S.2    Green, D.R.3
  • 109
    • 17144383927 scopus 로고    scopus 로고
    • Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
    • Kim SC, Tonkonogy SL, Albright CA, Tsang J, Balish EJ, et al. 2005. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology 128:891-906
    • (2005) Gastroenterology , vol.128 , pp. 891-906
    • Kim, S.C.1    Tonkonogy, S.L.2    Albright, C.A.3    Tsang, J.4    Balish, E.J.5
  • 110
    • 80051486126 scopus 로고    scopus 로고
    • Antigen-presenting cell production of IL-10 inhibits T-helper 1 and 17 cell responses and suppresses colitis in mice
    • 662.e1-4
    • Liu B, Tonkonogy SL, Sartor RB. 2011. Antigen-presenting cell production of IL-10 inhibits T-helper 1 and 17 cell responses and suppresses colitis in mice. Gastroenterology 141:653-62, 662.e1-4
    • (2011) Gastroenterology , vol.141 , pp. 653-662
    • Liu, B.1    Tonkonogy, S.L.2    Sartor, R.B.3
  • 111
    • 84906553545 scopus 로고    scopus 로고
    • Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10-/- mice
    • Im E, Jung J, Pothoulakis C, Rhee SH. 2014. Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10-/- mice. Gastroenterology 147:667-79.e10
    • (2014) Gastroenterology , vol.147 , pp. 667e10-679e10
    • Im, E.1    Jung, J.2    Pothoulakis, C.3    Rhee, S.H.4
  • 112
    • 84934985095 scopus 로고    scopus 로고
    • Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays
    • VanDussenKL, Marinshaw JM, ShaikhN,Miyoshi H, Moon C, et al. 2015. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut 64:911-20
    • (2015) Gut , vol.64 , pp. 911-920
    • VanDussen, K.L.1    Marinshaw, J.M.2    Shaikh, N.3    Miyoshi, H.4    Moon, C.5
  • 113
    • 84928974420 scopus 로고    scopus 로고
    • Prospective derivation of a living organoid biobank of colorectal cancer patients
    • van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, et al. 2015. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161:933-45
    • (2015) Cell , vol.161 , pp. 933-945
    • Van De Wetering, M.1    Francies, H.E.2    Francis, J.M.3    Bounova, G.4    Iorio, F.5
  • 114
    • 84879217430 scopus 로고    scopus 로고
    • Combined serological, genetic, and inflammatory markers differentiate non-IBD, Crohn's disease, and ulcerative colitis patients
    • Plevy S, Silverberg MS, Lockton S, Stockfisch T, Croner L, et al. 2013. Combined serological, genetic, and inflammatory markers differentiate non-IBD, Crohn's disease, and ulcerative colitis patients. Inflamm. Bowel Dis. 19:1139-48
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. 1139-1148
    • Plevy, S.1    Silverberg, M.S.2    Lockton, S.3    Stockfisch, T.4    Croner, L.5
  • 115
    • 84875840665 scopus 로고    scopus 로고
    • Serological markers predict inflammatory bowel disease years before the diagnosis
    • van Schaik FD, Oldenburg B, Hart AR, Siersema PD, Lindgren S, et al. 2013. Serological markers predict inflammatory bowel disease years before the diagnosis. Gut 62:683-88
    • (2013) Gut , vol.62 , pp. 683-688
    • Van Schaik, F.D.1    Oldenburg, B.2    Hart, A.R.3    Siersema, P.D.4    Lindgren, S.5
  • 116
    • 84885575846 scopus 로고    scopus 로고
    • Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: Results from the IBDchip European Project
    • Cleynen I, Gonzalez JR, Figueroa C, Franke A, McGovern D, et al. 2013. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project. Gut 62:1556-65
    • (2013) Gut , vol.62 , pp. 1556-1565
    • Cleynen, I.1    Gonzalez, J.R.2    Figueroa, C.3    Franke, A.4    McGovern, D.5
  • 117
    • 84925357305 scopus 로고    scopus 로고
    • Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study
    • Alonso A, Domenech E, Julia A, Panes J, Garcia-Sanchez V, et al. 2015. Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study. Gastroenterology 148:794-805
    • (2015) Gastroenterology , vol.148 , pp. 794-805
    • Alonso, A.1    Domenech, E.2    Julia, A.3    Panes, J.4    Garcia-Sanchez, V.5
  • 119
    • 84879780190 scopus 로고    scopus 로고
    • Predicting complicated Crohn's disease and surgery: Phenotypes, genetics, serology and psychological characteristics of a populationbased cohort
    • Ryan JD, Silverberg MS, XuW, Graff LA, Targownik LE, et al. 2013. Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a populationbased cohort. Aliment. Pharmacol. Ther. 38:274-83
    • (2013) Aliment. Pharmacol. Ther. , vol.38 , pp. 274-283
    • Ryan, J.D.1    Silverberg, M.S.2    Xu, W.3    Graff, L.A.4    Targownik, L.E.5
  • 120
    • 84922393995 scopus 로고    scopus 로고
    • A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia
    • Yang SK, Hong M, Baek J, Choi H, Zhao W, et al. 2014. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. Nat. Genet. 46:1017-20
    • (2014) Nat. Genet. , vol.46 , pp. 1017-1020
    • Yang, S.K.1    Hong, M.2    Baek, J.3    Choi, H.4    Zhao, W.5
  • 121
    • 84896829795 scopus 로고    scopus 로고
    • A genotype-first approach to defining the subtypes of a complex disease
    • Stessman HA, Bernier R, Eichler EE. 2014. A genotype-first approach to defining the subtypes of a complex disease. Cell 156:872-77
    • (2014) Cell , vol.156 , pp. 872-877
    • Stessman, H.A.1    Bernier, R.2    Eichler, E.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.