A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3

Nature

Volumn 506, Issue 7489, 2014, Pages 456-462

  Murthy, Aditya ^a   Li, Yun ^a   Peng, Ivan ^a   Reichelt, Mike ^a   Katakam, Anand Kumar ^a   Noubade, Rajkumar ^a   Roose Girma, Merone ^a   Devoss, Jason ^a   Diehl, Lauri ^a   Graham, Robert R ^a   Van Lookeren Campagne, Menno ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CASPASE 3; DEATH RECEPTOR;

ALLELE; AMINO ACID; APOPTOSIS; BACTERIUM; DEGRADATION; DIGESTIVE SYSTEM DISORDER; MOLECULAR ANALYSIS; PATHOGEN; POLYMORPHISM; RODENT;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATG16L1 GENE; AUTOPHAGY; BACTERIAL CLEARANCE; CELL STRESS; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE RESPONSE; DEGRADATION; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; GENE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MACROPHAGE; METABOLIC STRESS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGEN CLEARANCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SENSITIZATION; SITE DIRECTED MUTAGENESIS; STARVATION; XENOPHAGY; YERSINIA ENTEROCOLITICA;

AMINO ACID MOTIFS; ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CASPASE 3; CELL LINE; CELLS, CULTURED; CROHN DISEASE; CYTOKINES; ENZYME ACTIVATION; FEMALE; FOOD DEPRIVATION; HUMANS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEOLYSIS; STRESS, PHYSIOLOGICAL; YERSINIA ENTEROCOLITICA;

MURINAE; MUS; YERSINIA ENTEROCOLITICA;

EID: 84896730900     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13044     Document Type: Article

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