메뉴 건너뛰기




Volumn 19, Issue 6, 2013, Pages 1139-1148

Combined serological, genetic, and inflammatory markers differentiate Non-IBD, Crohn's disease, and ulcerative colitis patients

Author keywords

Crohn's disease; Genetics; Inflammation; Inflammatory bowel disease; Serology; Ulcerative colitis

Indexed keywords

A4 FLA2 ANTIBODY; ATG16L1 PROTEIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CBIR1 ANTIBODY; ECM1 PROTEIN; FLAX ANTIBODY; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1; NEUTROPHIL CYTOPLASMIC ANTIBODY; NKX2 3 PROTEIN; OUTER MEMBRANE PROTEIN C; SACCHAROMYCES CEREVISIAE ANTIBODY; SERUM AMYLOID A; STAT3 PROTEIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

EID: 84879217430     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e318280b19e     Document Type: Article
Times cited : (103)

References (41)
  • 1
    • 31844441031 scopus 로고    scopus 로고
    • Serologic markers in inflammatory bowel disease
    • Bossuyt X. Serologic markers in inflammatory bowel disease. Clin Chem. 2006;52:171-181.
    • (2006) Clin Chem. , vol.52 , pp. 171-181
    • Bossuyt, X.1
  • 2
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    • Targan SR, Landers CJ, Yang H, et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005;128:2020-2028.
    • (2005) Gastroenterology , vol.128 , pp. 2020-2028
    • Targan, S.R.1    Landers, C.J.2    Yang, H.3
  • 3
    • 0036726184 scopus 로고    scopus 로고
    • Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens
    • Landers CJ, Cohavy O, Misra R, et al. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology. 2002;123:689-699.
    • (2002) Gastroenterology , vol.123 , pp. 689-699
    • Landers, C.J.1    Cohavy, O.2    Misra, R.3
  • 4
    • 70449713617 scopus 로고    scopus 로고
    • Phenotypic associations of Crohn's disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort
    • Schoepfer AM, Schaffer T, Mueller S, et al. Phenotypic associations of Crohn's disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort. Inflamm Bowel Dis. 2009;15:1358-1367.
    • (2009) Inflamm Bowel Dis. , vol.15 , pp. 1358-1367
    • Schoepfer, A.M.1    Schaffer, T.2    Mueller, S.3
  • 5
    • 61949313980 scopus 로고    scopus 로고
    • Intestinal barrier dysfunction in inflammatory bowel diseases
    • McGuckin MA, Eri R, Simms LA, et al. Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm Bowel Dis. 2009;15:100-113.
    • (2009) Inflamm Bowel Dis. , vol.15 , pp. 100-113
    • McGuckin, M.A.1    Eri, R.2    Simms, L.A.3
  • 6
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474:307-317.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 8
    • 70449724721 scopus 로고    scopus 로고
    • Genetics of inflammatory bowel disease: Implications for disease pathogenesis and natural history
    • Lees CW, Satsangi J. Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history. Expert Rev Gastroenterol Hepatol. 2009;3:513-534.
    • (2009) Expert Rev Gastroenterol Hepatol. , vol.3 , pp. 513-534
    • Lees, C.W.1    Satsangi, J.2
  • 9
    • 0029025476 scopus 로고
    • Adhesion molecules in inflammatory bowel disease
    • Jones SC, Banks RE, Haidar A, et al. Adhesion molecules in inflammatory bowel disease. Gut. 1995;36:724-730.
    • (1995) Gut. , vol.36 , pp. 724-730
    • Jones, S.C.1    Banks, R.E.2    Haidar, A.3
  • 10
    • 0031978507 scopus 로고    scopus 로고
    • Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease
    • Panes J, Granger DN. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology. 1998;114:1066-1090.
    • (1998) Gastroenterology , vol.114 , pp. 1066-1090
    • Panes, J.1    Granger, D.N.2
  • 11
    • 0032912597 scopus 로고    scopus 로고
    • Elevated serum vascular endothelial growth factor in children and young adults with Crohn's disease
    • Bousvaros A, Leichtner A, Zurakowski D, et al. Elevated serum vascular endothelial growth factor in children and young adults with Crohn's disease. Dig Dis Sci. 1999;44:424-430.
    • (1999) Dig Dis Sci. , vol.44 , pp. 424-430
    • Bousvaros, A.1    Leichtner, A.2    Zurakowski, D.3
  • 12
    • 4644318578 scopus 로고    scopus 로고
    • Serum bFGF and VEGF correlate respectively with bowel wall thickness and intramural blood flow in Crohn's disease
    • Di SA, Ciccocioppo R, Armellini E, et al. Serum bFGF and VEGF correlate respectively with bowel wall thickness and intramural blood flow in Crohn's disease. Inflamm Bowel Dis. 2004;10:573-577.
    • (2004) Inflamm Bowel Dis. , vol.10 , pp. 573-577
    • Di, S.A.1    Ciccocioppo, R.2    Armellini, E.3
  • 13
    • 0035072493 scopus 로고    scopus 로고
    • VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: A novel mechanism of chronic intestinal inflammation
    • Kanazawa S, Tsunoda T, Onuma E, et al. VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol. 2001;96:822-828.
    • (2001) Am J Gastroenterol. , vol.96 , pp. 822-828
    • Kanazawa, S.1    Tsunoda, T.2    Onuma, E.3
  • 14
    • 38849104424 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohn's disease patients
    • Pousa ID, Mate J, Salcedo-Mora X, et al. Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohn's disease patients. Inflamm Bowel Dis. 2008;14:61-67.
    • (2008) Inflamm Bowel Dis. , vol.14 , pp. 61-67
    • Pousa, I.D.1    Mate, J.2    Salcedo-Mora, X.3
  • 15
    • 0037391756 scopus 로고    scopus 로고
    • Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    • Ye QH, Qin LX, Forgues M, et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med. 2003;9:416-423.
    • (2003) Nat Med. , vol.9 , pp. 416-423
    • Ye, Q.H.1    Qin, L.X.2    Forgues, M.3
  • 16
    • 0141738784 scopus 로고    scopus 로고
    • Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data
    • Wu B, Abbott T, Fishman D, et al. Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data. Bioinformatics. 2003;19:1636-1643.
    • (2003) Bioinformatics , vol.19 , pp. 1636-1643
    • Wu, B.1    Abbott, T.2    Fishman, D.3
  • 17
    • 0029883566 scopus 로고    scopus 로고
    • Specific antibody response to oligomannosidic epitopes in Crohn's disease
    • Sendid B, Colombel JF, Jacquinot PM, et al. Specific antibody response to oligomannosidic epitopes in Crohn's disease. Clin Diagn Lab Immunol. 1996;3:219-226.
    • (1996) Clin Diagn Lab Immunol. , vol.3 , pp. 219-226
    • Sendid, B.1    Colombel, J.F.2    Jacquinot, P.M.3
  • 18
    • 0033956320 scopus 로고    scopus 로고
    • Colonic bacteria express an ulcerative colitis pANCA-related protein epitope
    • Cohavy O, Bruckner D, Gordon LK, et al. Colonic bacteria express an ulcerative colitis pANCA-related protein epitope. Infect Immun. 2000;68: 1542-1548.
    • (2000) Infect Immun. , vol.68 , pp. 1542-1548
    • Cohavy, O.1    Bruckner, D.2    Gordon, L.K.3
  • 19
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn disease
    • Lodes MJ, Cong Y, Elson CO, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest. 2004;113:1296-1306.
    • (2004) J Clin Invest. , vol.113 , pp. 1296-1306
    • Lodes, M.J.1    Cong, Y.2    Elson, C.O.3
  • 20
    • 0028784646 scopus 로고
    • Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: Ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis
    • Vidrich A, Lee J, James E, et al. Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis. J Clin Immunol. 1995;15:293-299.
    • (1995) J Clin Immunol. , vol.15 , pp. 293-299
    • Vidrich, A.1    Lee, J.2    James, E.3
  • 21
    • 0035478854 scopus 로고    scopus 로고
    • Random forests
    • Breiman L. Random forests. Machine Learn. 2011;45:5-32.
    • (2011) Machine Learn. , vol.45 , pp. 5-32
    • Breiman, L.1
  • 22
    • 84894353884 scopus 로고    scopus 로고
    • Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
    • Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19(suppl A):5-36.
    • (2005) Can J Gastroenterol. , vol.19 , Issue.SUPPL. A , pp. 5-36
    • Silverberg, M.S.1    Satsangi, J.2    Ahmad, T.3
  • 23
    • 0019319257 scopus 로고
    • A simple index of Crohn's-disease activity
    • Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet. 1980;1:514.
    • (1980) Lancet. , vol.1 , pp. 514
    • Harvey, R.F.1    Bradshaw, J.M.2
  • 24
    • 59849104111 scopus 로고    scopus 로고
    • Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis
    • Lewis JD, Chuai S, Nessel L, et al. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008;14:1660-1666.
    • (2008) Inflamm Bowel Dis. , vol.14 , pp. 1660-1666
    • Lewis, J.D.1    Chuai, S.2    Nessel, L.3
  • 25
    • 33749181545 scopus 로고    scopus 로고
    • Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease
    • Reese GE, Constantinides VA, Simillis C, et al. Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease. Am J Gastroenterol. 2006;101:2410-2422.
    • (2006) Am J Gastroenterol. , vol.101 , pp. 2410-2422
    • Reese, G.E.1    Constantinides, V.A.2    Simillis, C.3
  • 26
    • 10744228695 scopus 로고    scopus 로고
    • Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease
    • Mow WS, Vasiliauskas EA, Lin YC, et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology. 2004;126:414-424.
    • (2004) Gastroenterology , vol.126 , pp. 414-424
    • Mow, W.S.1    Vasiliauskas, E.A.2    Lin, Y.C.3
  • 27
    • 8744262944 scopus 로고    scopus 로고
    • Serologic testing with AN-CA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: Diagnostic value and correlation with disease phenotype
    • Zholudev A, Zurakowski D, Young W, et al. Serologic testing with AN-CA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotype. Am J Gastroenterol. 2004;99:2235-2241.
    • (2004) Am J Gastroenterol. , vol.99 , pp. 2235-2241
    • Zholudev, A.1    Zurakowski, D.2    Young, W.3
  • 28
    • 38849194737 scopus 로고    scopus 로고
    • Discriminating IBD from IBS: Comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies
    • Schoepfer AM, Trummler M, Seeholzer P, et al. Discriminating IBD from IBS: comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies. Inflamm Bowel Dis. 2008;14: 32-39.
    • (2008) Inflamm Bowel Dis. , vol.14 , pp. 32-39
    • Schoepfer, A.M.1    Trummler, M.2    Seeholzer, P.3
  • 29
    • 0019958621 scopus 로고
    • Serum levels of C-reactive protein in Crohn's disease and ulcerative colitis
    • Fagan EA, Dyck RF, Maton PN, et al. Serum levels of C-reactive protein in Crohn's disease and ulcerative colitis. Eur J Clin Invest. 1982;12: 351-359.
    • (1982) Eur J Clin Invest. , vol.12 , pp. 351-359
    • Fagan, E.A.1    Dyck, R.F.2    Maton, P.N.3
  • 30
    • 54349117795 scopus 로고    scopus 로고
    • C-reactive protein: A predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study
    • Henriksen M, Jahnsen J, Lygren I, et al. C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study. Gut. 2008;57: 1518-1523.
    • (2008) Gut. , vol.57 , pp. 1518-1523
    • Henriksen, M.1    Jahnsen, J.2    Lygren, I.3
  • 31
    • 33644589943 scopus 로고    scopus 로고
    • Clinically active Crohn's disease in the presence of a low C-reactive protein
    • Florin TH, Paterson EW, Fowler EV, et al. Clinically active Crohn's disease in the presence of a low C-reactive protein. Scand J Gastroenterol. 2006;41:306-311.
    • (2006) Scand J Gastroenterol. , vol.41 , pp. 306-311
    • Florin, T.H.1    Paterson, E.W.2    Fowler, E.V.3
  • 32
    • 0029886548 scopus 로고    scopus 로고
    • Human serum amyloid A (SAA) protein: A prominent acute-phase reactant for clinical practice
    • Malle E, De Beer FC. Human serum amyloid A (SAA) protein: a prominent acute-phase reactant for clinical practice. Eur J Clin Invest. 1996;26: 427-435.
    • (1996) Eur J Clin Invest. , vol.26 , pp. 427-435
    • Malle, E.1    De Beer, F.C.2
  • 33
    • 0032918632 scopus 로고    scopus 로고
    • Serum amyloid A (SAA): A concise review of biology, assay methods and clinical usefulness
    • Yamada T. Serum amyloid A (SAA): a concise review of biology, assay methods and clinical usefulness. Clin Chem Lab Med. 1999;37: 381-388.
    • (1999) Clin Chem Lab Med. , vol.37 , pp. 381-388
    • Yamada, T.1
  • 34
    • 25444453244 scopus 로고    scopus 로고
    • Screening large-scale association study data: Exploiting interactions using random forests
    • Lunetta KL, Hayward LB, Segal J, et al. Screening large-scale association study data: exploiting interactions using random forests. BMC Genet. 2004;5:32.
    • (2004) BMC Genet. , vol.5 , pp. 32
    • Lunetta, K.L.1    Hayward, L.B.2    Segal, J.3
  • 35
    • 77950164076 scopus 로고    scopus 로고
    • T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: A meta-analysis
    • Cheng JF, Ning YJ, Zhang W, et al. T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis. World J Gastroenterol. 2010;16:1258-1266.
    • (2010) World J Gastroenterol. , vol.16 , pp. 1258-1266
    • Cheng, J.F.1    Ning, Y.J.2    Zhang, W.3
  • 36
    • 34548163868 scopus 로고    scopus 로고
    • Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene
    • Cummings JR, Cooney R, Pathan S, et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis. 2007;13:941-946.
    • (2007) Inflamm Bowel Dis. , vol.13 , pp. 941-946
    • Cummings, J.R.1    Cooney, R.2    Pathan, S.3
  • 37
    • 44349136821 scopus 로고    scopus 로고
    • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    • Fisher SA, Tremelling M, Anderson CA, et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet. 2008;40:710-712.
    • (2008) Nat Genet. , vol.40 , pp. 710-712
    • Fisher, S.A.1    Tremelling, M.2    Anderson, C.A.3
  • 38
    • 78649395791 scopus 로고    scopus 로고
    • NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients
    • Meggyesi N, Kiss LS, Koszarska M, et al. NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients. World J Gastroenterol. 2010;16:5233-5240.
    • (2010) World J Gastroenterol. , vol.16 , pp. 5233-5240
    • Meggyesi, N.1    Kiss, L.S.2    Koszarska, M.3
  • 39
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008;40:955-962.
    • (2008) Nat Genet. , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 40
    • 77951498680 scopus 로고    scopus 로고
    • STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility
    • Cenit MC, Alcina A, Marquez A, et al. STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility. Genes Immun. 2010; 11:264-268.
    • (2010) Genes Immun. , vol.11 , pp. 264-268
    • Cenit, M.C.1    Alcina, A.2    Marquez, A.3
  • 41
    • 34249047618 scopus 로고    scopus 로고
    • Utility of serological markers in inflammatory bowel diseases: Gadget or magic?
    • Papp M, Norman GL, Altorjay I, et al. Utility of serological markers in inflammatory bowel diseases: gadget or magic? World J Gastroenterol. 2007;13:2028-2036.
    • (2007) World J Gastroenterol. , vol.13 , pp. 2028-2036
    • Papp, M.1    Norman, G.L.2    Altorjay, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.