Genome-wide association study of ulcerative colitis in koreans suggests extensive overlapping of genetic susceptibility with caucasians

Inflammatory Bowel Diseases

Volumn 19, Issue 5, 2013, Pages 954-966

  Yang, Suk Kyun ^a   Hong, Myunghee ^b   Zhao, Wanting ^c   Jung, Yusun ^b   Tayebi, Naeimeh ^c   Ye, Byong Duk ^a   Kim, Kyung Jo ^a   Park, Sang Hyoung ^a   Lee, Inchul ^b   Shin, Hyoung Doo ^d   Cheong, Hyun Sub ^e   Kim, Lyoung Hyo ^e   Kim, Hyo Jong ^f   Jung, Sung Ae ^g   Kang, Daehee ^h   Youn, Hee Shang ⁱ   Liu, Jianjun ^c   Song, Kyuyoung ^a  

^a Asan Medical Center   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c GENOME INSTITUTE OF SINGAPORE   (Singapore)

^d Sogang University   (South Korea)

^e SNP Genetics Inc   (South Korea)

^f Kyung Hee University Hospital   (South Korea)

^g Ewha Womans University School of Medicine   (South Korea)

^h Seoul National University   (South Korea)

ⁱ Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Genetics; Korean; Ulcerative colitis

Indexed keywords

ARTICLE; CAUCASIAN; CHROMOSOME 13; CHROMOSOME 1P; CHROMOSOME 21Q; CONTROLLED STUDY; CROHN DISEASE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; COLITIS, ULCERATIVE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84876361184     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e3182802ab6     Document Type: Article

References (40)

1. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448:427-434.
2. Yang H, McElree C, Roth MP, et al. Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut. 1993;34:517-524.
3. Park JB, Yang SK, Byeon JS, et al. Familial occurrence of inflammatory bowel disease in Korea. Inflamm Bowel Dis. 2006;12:1146-1151.
4. Tysk C, Lindberg E, Jarnerot G, et al. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut. 1988;29: 990-996.
5. Hugot J-P, Chamaillard M, Zouali H, et al. Association of NOD2 leucinerich repeat variants with susceptibility to Crohn's disease. Nature. 2001; 411:599-603.
6. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411: 603-606.
7. Yamazaki K, McGovern D, Ragoussis J, et al. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet. 2005;14:3499-3506.
8. Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006; 314:1461-1463.
9. Rioux JD, Xavier RJ, Taylor KD, et al. Genome-wide association study identifies new susceptibility loci for Crohn's disease and implicates autophage in disease pathogenesis. Nat Genet. 2007;39:596-604.
10. Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn's disease in ATG16L1. Nat Genet. 2007;39:207-211.
11. The Wellcome Trust Case Control Consortium. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature. 2007;447:661-678.
12. Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophage gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet. 2007;39:830-832.
13. Franke A, Balschun T, Karlsen TH, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 2008;40:1319-1323.
14. Fisher SA, Tremelling M, Anderson CA, et al. Genetic determinats of ulcerative colitis include the ECM locus and five loci implicated in Crohn's disease. Nat Genet. 2008;40:710-712.
15. Silverberg MS, Cho JH, Rioux JD, et al. Ulcerative colitis-risk loci on chromosome 1p36 and 12q15 found by genome-wide association study. Nat Genet. 2009;41:216-220.
16. Barrett JC, Lee JC, Lees CW, et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet. 2009;41:1330-1334.
17. Asano K, Matsushita T, Umeno J, et al. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet. 2009;41:1325-1329.
18. McGovern D, Gardet A, Törkvist L, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010; 42:332-337.
19. Franke A, Balschun T, Sina C, et al. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet. 2010; 42:292-294.
20. Franke A, McGovern D, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42;1118-1125.
21. Anderson CA, Boucher G, Lees CW, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011;43:246-252.
22. Thompson AI, Lees CW. Genetics of ulcerative colitis. Inflamm Bowel Dis. 2011;17:831-848.
23. Inoue N, Tamura K, Kinouchi Y, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology. 2002;123: 86-91.
24. Leong RW, Armuzzi A, Ahmad T, et al. NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population. Aliment Pharmacol Ther. 2003;17:1465-1470.
25. Croucher PJ, Mascheretti S, Hampe J, et al. Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations. Eur J Hum Genet. 2003;11:6-16.
26. Yamazaki K, Takazoe M, Tanaka T, et al. Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease. J Hum Genet. 2004;49:664-668.
27. Yamazaki K, Onouchi Y, Takazoe M, et al. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet. 2007;52:575-583.
28. Yamazaki K, Takahashi A, Takazoe M, et al. Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. Gut. 2009;58:228-232.
29. Yang SK, Park M, Lim J, et al. Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans. Inflamm Bowel Dis. 2009;15: 1385-1390.
30. Picornell Y, Mei L, Taylor K, et al. TNFSF15 is an ethnic-specific IBD gene. Inflamm Bowel Dis. 2007;13:1333-1338.
31. Kakuta Y, Kinouchi Y, Negoro K, et al. Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease. Gut. 2006;55:1527-1528.
32. Yang SK, Lim J, Chang HS, et al. Association of TNFSF15 with Crohn's disease in Koreans. Am J Gastroenterol. 2008;103:1437-1442.
33. Yang SK, Jung Y, Hong M, et al. No association of TNFSF15 and IL23R with ulcerative colitis in Koreans. J Hum Genet. 2011; 56:200-204.
34. Yang SK, Jung Y, Kim H, et al. Association of FCGR2A, JAK2 or HNF4A variants with UC in Koreans. Dig Liver Dis. 2011;43:856- 861.
35. Ng SC, Tsoi KK, Kamm MA, et al. Genetics of inflammatory bowel disease in Asia: systematic review and meta-analysis. Inflamm Bowel Dis. 2012;18:1164-1176.
36. Stokkers PC, Reitsma PH, Tytgat GN, et al. HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta analysis. Gut. 1999;45: 395-401.
37. Okada Y, Yamazaki K, Umeno J, et al. HLA-Cw*1202-B*5201- DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. Gastroenterology. 2011;141:864-871.
38. Wagner EF. Bone development and inflammatory disease is regulated by AP-1(Fos/Jun). Ann Rheum Dis. 2010;69:i86-i88.
39. Ray N, Kuwahara M, Takada Y, et al. c-Fos suppresses systemic inflammation response to endotoxin. Int Immunol. 2006;18:671-677.
40. Takada Y, Ray N, Ikeda E, et al. Fos protein suppress dextran sulfate sodium-induce colitis through inhibition of NF-kappaB. J Immunol. 2010; 184:1014-1021.