A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Nature Genetics

Volumn 46, Issue 9, 2014, Pages 1017-1020

  Yang, Suk Kyun ^a   Hong, Myunghee ^a   Baek, Jiwon ^a   Choi, Hyunchul ^a   Zhao, Wanting ^b   Jung, Yusun ^a   Haritunians, Talin ^c   Ye, Byong Duk ^a   Kim, Kyung Jo ^a   Park, Sang Hyoung ^a   Park, Soo Kyung ^a   Yang, Dong Hoon ^a   Dubinsky, Marla ^c   Lee, Inchul ^a   McGovern, Dermot P B ^c   Liu, Jianjun ^b   Song, Kyuyoung ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; THIOPURINE METHYLTRANSFERASE; METHYLTRANSFERASE;

ARTICLE; CROHN DISEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG INDUCED DISEASE; GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; KOREAN (PEOPLE); LEUKOPENIA; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NUDT15 GENE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHEMICALLY INDUCED; CHILD; ENZYMOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; MIDDLE AGED;

ADOLESCENT; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHILD; CROHN DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKOPENIA; MALE; METHYLTRANSFERASES; MIDDLE AGED; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84922393995     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3060     Document Type: Article

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