High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Nature Genetics

Volumn 47, Issue 2, 2015, Pages 172-179

  Goyette, Philippe ^a   Boucher, Gabrielle ^a   Mallon, Dermot ^b,c   Ellinghaus, Eva ^d   Jostins, Luke ^e,f   Huang, Hailiang ^g,h   Ripke, Stephan ^g,h   Gusareva, Elena S ⁱ   Annese, Vito ^j,k   Hauser, Stephen L ^l   Oksenberg, Jorge R ^l   Thomsen, Ingo ^d   Leslie, Stephen ^m,n   Daly, Mark J ^g,h   Van Steen, Kristel ⁱ   Duerr, Richard H ^o,p   Barrett, Jeffrey C ^q   McGovern, Dermot P B ^r   Schumm, L Philip ^s   Traherne, James A ^b,t   Carrington, Mary N ^u,v   Kosmoliaptsis, Vasilis ^b,c   Karlsen, Tom H ^w,x,y   Franke, Andre ^d   Rioux, John D ^a,z   Abraham, Clara ^aa   Achkar, Jean Paul ^ab   Ahmad, Tariq ^ac   Amininejad, Leila ^ad,ae   Ananthakrishnan, Ashwin N ^g,af   Andersen, Vibeke ^ag,ah   Anderson, Carl A ^r   Andrews, Jane M ^ai   Aumais, Guy ^x,aj   Baidoo, Leonard ^o   Baldassano, Robert N ^ak   Balschun, Tobias ^d   Bampton, Peter A ^al   Barclay, Murray ^am   Bayless, Theodore M ^an   Bethge, Johannes ^d   Bis, Joshua C ^ao   Bitton, Alain ^ap   Brand, Stephan ^aq   Brant, Steven R ^an   Buning, Carsten ^ar   Chew, Angela ^as,at   Cho, Judy H ^aa   Cleynen, Isabelle ^au   Cohain, Ariella ^av   Croft, Anthony ^aw   D'Amato, Mauro ^ax   Danese, Silvio ^ay   De Jong, Dirk ^az   De Vos, Martine ^ba   Denapiene, Goda ^bb   Denson, Lee A ^bc   Devaney, Kathy L ^g   Dewit, Olivier ^bd   D'Inca, Renata ^be   Dubinsky, Marla ^r   Edwards, Cathryn ^bf   Ellinghaus, David ^g   Essers, Jonah ^g,af   Ferguson, Lynnette R ^bg   Festen, Eleonora A ^bh   Fleshner, Philip ^r   Florin, Tim ^bi   Franchimont, Denis ^ad,ae   Fransen, Karin ^bh   Gearry, Richard ^am,bj   Georges, Michel ⁱ   Gieger, Christian ^bk   Glas, Jurgen ^ap   Green, Todd ^g,h   Griffiths, Anne M ^bl   Guthery, Stephen L ^bm   Hakonarson, Hakon ^ak   Halfvarson, Jonas ^bn,bo   Hanigan, Katherine ^aw   Haritunians, Talin ^r   Hart, Ailsa ^bp   Hawkey, Chris ^bq   Hayward, Nicholas K ^aw   Hedl, Matija ^aa   Henderson, Paul ^br,bs   Hu, Xinli ^bt   Hui, Ken Y ^aa   Imielinski, Marcin ^ak   Ippoliti, Andrew ^r   Jonaitis, Laimas ^bu   Kennedy, Nicholas A ^bs   Khan, Mohammed Azam ^bv,bw   Kiudelis, Gediminas ^bu   Kugathasan, Subra ^bx   Kupcinskas, Limas ^by   Latiano, Anna ^j   Laukens, Debby ^ba   Lawrance, Ian C ^at   Lee, James C ^bz   Lees, Charlie W ^bs   Leja, Marcis ^ca   Van Limbergen, Johan ^bl   Lionetti, Paolo ^cb   Liu, Jimmy Z ^q   Louis, Edouard ^cc   Mahy, Gillian ^cd   Mansfield, John ^ce   Massey, Dunecan ^bz   Mathew, Christopher G ^cf   Milgrom, Raquel ^cg   Mitrovic, Mitja ^bh,ch   Montgomery, Grant ^aw   Mowat, Craig ^ci   Newman, Wwilliam ^bv,bw   Ng, Aylwin ^g   Ng, Siew C ^cj   Evelyn Ng, Sok Meng ^aa   Nikolaus, Susanna ^d   Ning, Kaida ^aa   Nothen, Markus ^ck   Oikonomou, Ioannis ^aa   Palmieri, Orazio ^j   Parkes, Miles ^bz   Phillips, Anne ^ci   Ponsioen, Cyriel Y ^cl   Potocnik, Uros ^ch   Prescott, Natalie J ^cf   Proctor, Deborah D ^aa   Radford Smith, Graham ^aw,cm   Rahier, Jean Francois ^cn   Raychaudhur, Soumya ^bt   Regueiro, Miguel ^o   Rieder, Florian ^ab   Roberts, Rebecca ^am   Russell, Richard K ^br   Sanderson, Jeremy D ^co   Sans, Miquel ^cp   Satsangi, Jack ^bs   Schadt, Eric E ^av   Schreiber, Stefan ^d   Scott, Regan ^o   Seielstad, Mark ^cq,cr   Sharma, Yashoda ^aa   Silverberg, Mark S ^cg   Simms, Lisa A ^aw   Skieceviciene, Jurgita ^bu   Spain, Sarah L ^cf   Steinhart, A Hillary ^cg   Stempak, Joanne M ^cg   Stronati, Laura ^cs   Sventoraityte, Jurgita ^by   Targan, Stephan R ^r   Taylor, Kirstin M ^co   Ter Velde, Anje ^cl   Theatre, Emilie ⁱ   Torkvist, Leif ^ax   Tremelling, Mark ^ct   Van Der Meulen, Andrea ^cu   Van Sommeren, Suzanne ^bh   Vasiliauskas, Eric ^r   Vermeire, Severine ^au,cv   Verspaget, Hein W ^cu   Walters, Thomas ^bl,cw   Wwang, Kai ^ak   Wwang, Ming Hsi ^ab,an   Wweersma, Rinse K ^bh   Wei, Zhi ^cx   Whiteman, David ^aw   Wijmenga, Cisca ^bh   Wilson, David C ^br,bs   Winkelmann, Juliane ^cy   Xavier, Ramnik J ^g,h   Zeissig, Sebastian ^d   Zhang, Bin ^av   Zhang, Clarence K ^cz   Zhang, Hu ^da,db   Zhang, Wwei ^aa   Zhao, Hongyu ^cz   Zhao, Zhen Z ^aw   more..

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c National Institute for Health Research ^*  (United Kingdom)

^d UNIVERSITY OF KIEL   (Germany)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f CHRIST CHURCH   (United Kingdom)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁱ UNIVERSITY OF LIÈGE   (Belgium)

^j CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^k CAREGGI UNIVERSITY HOSPITAL   (Italy)

^l UNIVERSITY OF CALIFORNIA   (United States)

^m MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

ⁿ UNIVERSITY OF MELBOURNE   (Australia)

^o UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^p UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^q WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^r CEDARS SINAI MEDICAL CENTER   (United States)

^s UNIVERSITY OF CHICAGO   (United States)

^t UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^u FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^v MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^w OSLO UNIVERSITY HOSPITAL   (Norway)

^x Divisions of Surgery and Cancer Medicine   (Norway)

^y UNIVERSITY OF OSLO   (Norway)

^z UNIVERSITÉ DE MONTRÉAL   (Canada)

^aa YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ab LERNER RESEARCH INSTITUTE   (United States)

^ac PLYMOUTH UNIVERSITY PENINSULA SCHOOLS OF MEDICINE AND DENTISTRY   (United Kingdom)

^ad ERASME HOSPITAL   (Belgium)

^ae FREE UNIVERSITY OF BRUSSELS   (Belgium)

^af HARVARD MEDICAL SCHOOL   (United States)

^ag VIBORG HOSPITAL   (Denmark)

^ah Hospital of Southern Jutland   (Denmark)

^ai ROYAL ADELAIDE HOSPITAL   (Australia)

^aj MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^ak CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^al FLINDERS UNIVERSITY   (Australia)

^am UNIVERSITY OF OTAGO   (New Zealand)

^an JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ao UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^ap ROYAL VICTORIA HOSPITAL   (Canada)

^aq LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^ar CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^as FREMANTLE HOSPITAL   (Australia)

^at UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^au UNIVERSITY OF LEUVEN   (Belgium)

^av MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^aw QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^ax KAROLINSKA INSTITUTE   (Sweden)

^ay HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^az RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^ba GHENT UNIVERSITY HOSPITAL   (Belgium)

^bb VILNIUS UNIVERSITY   (Lithuania)

^bc CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^bd CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^be UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^bf TORBAY HOSPITAL   (United Kingdom)

^bg UNIVERSITY OF AUCKLAND   (New Zealand)

^bh UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^bi MATER HOSPITAL   (Australia)

^bj CHRISTCHURCH HOSPITAL   (New Zealand)

^bk INSTITUTE OF EPIDEMIOLOGY   (Germany)

^bl HOSPITAL FOR SICK CHILDREN   (Canada)

^bm UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^bn ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^bo ÖREBRO UNIVERSITY   (Sweden)

^bp ST MARK S HOSPITAL   (United Kingdom)

^bq QUEEN S MEDICAL CENTRE   (United Kingdom)

^br ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^bs UNIVERSITY OF EDINBURGH   (United Kingdom)

^bt BRIGHAM AND WOMEN S HOSPITAL   (United States)

^bu LITHUANIAN UNIVERSITY OF HEALTH SCIENCES   (Lithuania)

^bv UNIVERSITY OF MANCHESTER   (United Kingdom)

^bw UNIVERSITY OF MANCHESTER   (United Kingdom)

^bx EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^by KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

^bz ADDENBROOKE S HOSPITAL   (United Kingdom)

^ca UNIVERSITY OF LATVIA   (Latvia)

^cb UNIVERSITY OF FLORENCE   (Italy)

^cc UNIVERSITY OF LIÈGE   (Belgium)

^cd TOWNSVILLE HOSPITAL   (Australia)

^ce NEWCASTLE UNIVERSITY   (United Kingdom)

^cf GUY S HOSPITAL   (United Kingdom)

^cg MOUNT SINAI HOSPITAL   (Canada)

^ch UNIVERSITY OF MARIBOR   (Slovenia)

^ci UNIVERSITY OF DUNDEE   (United Kingdom)

^cj CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^ck UNIVERSITY HOSPITAL BONN   (Germany)

^cl ACADEMIC MEDICAL CENTER   (Netherlands)

^cm ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^cn UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^co ST THOMAS HOSPITAL   (United Kingdom)

^cp HOSPITAL QUIRÓN   (Spain)

^cq GENOME INSTITUTE OF SINGAPORE   (Singapore)

^cr UNIVERSITY OF CALIFORNIA   (United States)

^cs ENEA   (Italy)

^ct NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^cu LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^cv UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^cw UNIVERSITY OF TORONTO   (Canada)

^cx University Heights   (United States)

^cy TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^cz YALE UNIVERSITY   (United States)

^da SICHUAN UNIVERSITY   (China)

^db SICHUAN UNIVERSITY   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DRB1 ANTIGEN; HLA-DRB1*01 ANTIGEN;

ADAPTIVE IMMUNITY; ALLELE; ARTICLE; CROHN DISEASE; DENSITY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOTE ADVANTAGE; HUMAN; INFLAMMATORY BOWEL DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS; CHROMOSOME MAP; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; GENOTYPING TECHNIQUE; HETEROZYGOTE; PHENOTYPE; PROCEDURES;

ALLELES; CHROMOSOME MAPPING; COLITIS, ULCERATIVE; CROHN DISEASE; GENETIC LINKAGE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GENOTYPING TECHNIQUES; HETEROZYGOTE; HLA-DRB1 CHAINS; HUMANS; INFLAMMATORY BOWEL DISEASES; MAJOR HISTOCOMPATIBILITY COMPLEX; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84928612813     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3176     Document Type: Article

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