Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

Nature Immunology

Volumn 17, Issue 1, 2016, Pages 95-103

  Zhao, Ende ^a,b   Maj, Tomasz ^a   Kryczek, Ilona ^a   Li, Wei ^a,b   Wu, Ke ^a,b   Zhao, Lili ^a   Wei, Shuang ^a   Crespo, Joel ^a   Wan, Shanshan ^a   Vatan, Linda ^a   Szeliga, Wojciech ^a   Shao, Irene ^a   Wang, Yin ^a   Liu, Yan ^a   Varambally, Sooryanarayana ^a,c   Chinnaiyan, Arul M ^a   Welling, Theodore H ^a   Marquez, Victor ^d   Kotarski, Jan ^e   Wang, Hongbo ^b   Wang, Zehua ^b   Zhang, Yi ^a   Liu, Rebecca ^f   Wang, Guobin ^b   Zou, Weiping ^a,f   more..

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c University of Alabama at Birmingham   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^f UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FBXW7 PROTEIN; GLUCOSE; HISTONE H3; MICRORNA; MICRORNA 101; MICRORNA 26A; NOTCH RECEPTOR; NUMB PROTEIN; PROTEIN BCL 2; REPRESSOR PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; EZH2 PROTEIN, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; GENE EXPRESSION; GLYCOLYSIS; HISTONE METHYLATION; HUMAN; HUMAN TISSUE; LYMPHOCYTE FUNCTION; METABOLIC INHIBITION; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR IMMUNITY; ANIMAL; C57BL MOUSE; CELL SEPARATION; CHROMATIN IMMUNOPRECIPITATION; EXPERIMENTAL MELANOMA; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; IMMUNOBLOTTING; IMMUNOLOGY; NEOPLASM; OVARY TUMOR; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TISSUE MICROARRAY; TUMOR ESCAPE;

ANIMALS; CELL SEPARATION; CHROMATIN IMMUNOPRECIPITATION; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HUMANS; IMMUNOBLOTTING; MELANOMA, EXPERIMENTAL; MICE, INBRED C57BL; MICRORNAS; NEOPLASMS; OVARIAN NEOPLASMS; POLYCOMB REPRESSIVE COMPLEX 2; REAL-TIME POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TISSUE ARRAY ANALYSIS; TRANSFECTION; TUMOR ESCAPE;

EID: 84951313126     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3313     Document Type: Article

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