-
1
-
-
0033528072
-
th century
-
Armstrong, G.L.; Conn, L.A.; Pinner, R.W. Trends in infectious disease mortality in the united states during the 20th century. JAMA 1999, 281, 61-66.
-
(1999)
JAMA
, vol.281
, pp. 61-66
-
-
Armstrong, G.L.1
Conn, L.A.2
Pinner, R.W.3
-
2
-
-
84922285353
-
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of plasmodium
-
Cross, R.M.; Flanigan, D.L.; Monastyrskyi, A.; LaCrue, A.N.; Saenz, F.E.; Maignan, J.R.; Mutka, T.S.; White, K.L.; Shackleford, D.M.; Bathurst, I. Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of plasmodium. J. Med. Chem. 2014, 57, 8860-8879.
-
(2014)
J. Med. Chem.
, vol.57
, pp. 8860-8879
-
-
Cross, R.M.1
Flanigan, D.L.2
Monastyrskyi, A.3
LaCrue, A.N.4
Saenz, F.E.5
Maignan, J.R.6
Mutka, T.S.7
White, K.L.8
Shackleford, D.M.9
Bathurst, I.10
-
3
-
-
84968545685
-
Multiple pathways of genome plasticity leading to development of antibiotic resistance
-
Baharoglu, Z.; Garriss, G.; Mazel, D. Multiple pathways of genome plasticity leading to development of antibiotic resistance. Antibiotics 2013, 2, 288-315.
-
(2013)
Antibiotics
, vol.2
, pp. 288-315
-
-
Baharoglu, Z.1
Garriss, G.2
Mazel, D.3
-
4
-
-
0345839252
-
Where will new antibiotics come from? Nat
-
Walsh, C. Where will new antibiotics come from? Nat. Rev. Microbiol. 2003, 1, 65-70.
-
(2003)
Rev. Microbiol
, vol.1
, pp. 65-70
-
-
Walsh, C.1
-
5
-
-
69949174478
-
Has the era of untreatable infections arrived? J
-
Livermore, D.M. Has the era of untreatable infections arrived? J. Antimicrob. Chemother. 2009, 64, i29-i36.
-
(2009)
Antimicrob. Chemother
, vol.64
, pp. i29-i36
-
-
Livermore, D.M.1
-
6
-
-
84929179822
-
3 )-H coupling
-
Hu, W.; Lin, J.-P.; Song, L.-R.; Long, Y.-Q. Direct synthesis of 2-aryl-4-quinolones via transition-metal-free intramolecular oxidative C (sp3)-H/C(sp3 )-H coupling. Org. Lett. 2015, 17, 1268-1271.
-
(2015)
Org. Lett.
, vol.17
, pp. 1268-1271
-
-
Hu, W.1
Lin, J.-P.2
Song, L.-R.3
Long, Y.-Q.4
-
7
-
-
0036472021
-
Quinolones: A comprehensive review
-
Oliphant, C.M.; Green, G.M. Quinolones: A comprehensive review. Am. Fam. Physician 2002, 65, 455-464.
-
(2002)
Am. Fam. Physician
, vol.65
, pp. 455-464
-
-
Oliphant, C.M.1
Green, G.M.2
-
8
-
-
33947476615
-
1,8-naphthyridine derivatives. A new class of chemotherapeutic agents
-
Lesher, G.Y.; Froelich, E.J.; Gruett, M.D.; Bailey, J.H.; Brundage, R.P. 1,8-naphthyridine derivatives. A new class of chemotherapeutic agents. J. Med. Chem. 1962, 5, 1063-1065.
-
(1962)
J. Med. Chem.
, vol.5
, pp. 1063-1065
-
-
Lesher, G.Y.1
Froelich, E.J.2
Gruett, M.D.3
Bailey, J.H.4
Brundage, R.P.5
-
9
-
-
84921389972
-
Practical route to 2-quinolinones via a pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade reaction
-
Wu, J.; Xiang, S.; Zeng, J.; Leow, M.; Liu, X.-W. Practical route to 2-quinolinones via a pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade reaction. Org. Lett. 2014, 17, 222-225.
-
(2014)
Org. Lett.
, vol.17
, pp. 222-225
-
-
Wu, J.1
Xiang, S.2
Zeng, J.3
Leow, M.4
Liu, X.W.5
-
11
-
-
21844443566
-
The quinolones: Past, present, and future
-
Andriole, V.T. The quinolones: Past, present, and future. Clin. Infect. Dis. 2005, 41, S113-S119.
-
(2005)
Clin. Infect. Dis
, vol.41
, pp. S113-S119
-
-
Andriole, V.T.1
-
12
-
-
84933074046
-
Origins of the quinolone class of antibacterials: An expanded discovery story
-
Bisacchi, G.S. Origins of the quinolone class of antibacterials: An expanded discovery story. J. Med. Chem. 2015, 58, 4874-4882.
-
(2015)
J. Med. Chem
, vol.58
, pp. 4874-4882
-
-
Bisacchi, G.S.1
-
13
-
-
14844347928
-
Bacterial topoisomerase inhibitors: Quinolone and pyridone antibacterial agents
-
Mitscher, L.A. Bacterial topoisomerase inhibitors: Quinolone and pyridone antibacterial agents. Chem. Rev. 2005, 105, 559-592.
-
(2005)
Chem. Rev
, vol.105
, pp. 559-592
-
-
Mitscher, L.A.1
-
14
-
-
0028316927
-
Structure-activity and structure-side-effect relationships for the quinolone antibacterials
-
Domagala, J.M. Structure-activity and structure-side-effect relationships for the quinolone antibacterials. J. Antimicrob. Chemother. 1994, 33, 685-706.
-
(1994)
J. Antimicrob. Chemother.
, vol.33
, pp. 685-706
-
-
Domagala, J.M.1
-
15
-
-
79953083475
-
Synthesis and in vitro antibacterial activity of 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl) fluoroquinolone derivatives
-
Guo, X.; Liu, M.L.; Guo, H.Y.; Wang, Y.C.; Wang, J.X. Synthesis and in vitro antibacterial activity of 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl) fluoroquinolone derivatives. Molecules 2011, 16, 2626-2635.
-
(2011)
Molecules
, vol.16
, pp. 2626-2635
-
-
Guo, X.1
Liu, M.L.2
Guo, H.Y.3
Wang, Y.C.4
Wang, J.X.5
-
16
-
-
84898948830
-
Mechanism of quinolone action and resistance
-
Aldred, K.J.; Kerns, R.J.; Osheroff, N. Mechanism of quinolone action and resistance. Biochemistry 2014, 53, 1565-1574.
-
(2014)
Biochemistry
, vol.53
, pp. 1565-1574
-
-
Aldred, K.J.1
Kerns, R.J.2
Osheroff, N.3
-
17
-
-
74949119366
-
Fluoroquinolone antibacterials: A review on chemistry, microbiology and therapeutic prospects
-
Sharma, P.C.; Jain, A.; Jain, S. Fluoroquinolone antibacterials: A review on chemistry, microbiology and therapeutic prospects. Acta. Pol. Pharm. 2009, 66, 587-604.
-
(2009)
Acta. Pol. Pharm
, vol.66
, pp. 587-604
-
-
Sharma, P.C.1
Jain, A.2
Jain, S.3
-
19
-
-
84868573252
-
Development of an improved method for trace analysis of quinolones in eggs of laying hens and wildlife species using molecularly imprinted polymers
-
Blasco, C.; PicoÌ, Y. Development of an improved method for trace analysis of quinolones in eggs of laying hens and wildlife species using molecularly imprinted polymers. J. Agric. Food Chem. 2012, 60, 11005-11014.
-
(2012)
J. Agric. Food Chem.
, vol.60
, pp. 11005-11014
-
-
Blasco, C.1
Picoì, Y.2
-
20
-
-
79960153362
-
Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships
-
Cross, R.M.; Maignan, J.R.; Mutka, T.S.; Luong, L.; Sargent, J.; Kyle, D.E.; Manetsch, R. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships. J. Med. Chem 2011, 54, 4399-4426.
-
(2011)
J. Med. Chem
, vol.54
, pp. 4399-4426
-
-
Cross, R.M.1
Maignan, J.R.2
Mutka, T.S.3
Luong, L.4
Sargent, J.5
Kyle, D.E.6
Manetsch, R.7
-
21
-
-
84876572176
-
Synthesis of 2 (1H)-quinolinones via Pd-catalyzed oxidative cyclocarbonylation of 2-vinylanilines
-
Ferguson, J.; Zeng, F.; Alwis, N.; Alper, H. Synthesis of 2 (1H)-quinolinones via Pd-catalyzed oxidative cyclocarbonylation of 2-vinylanilines. Org. Lett. 2013, 15, 1998-2001.
-
(2013)
Org. Lett.
, vol.15
, pp. 1998-2001
-
-
Ferguson, J.1
Zeng, F.2
Alwis, N.3
Alper, H.4
-
22
-
-
84928041937
-
Rh (III) and Ru (II)-catalyzed site-selective C-H alkynylation of quinolones
-
Kang, D.; Hong, S. Rh (III) and Ru (II)-catalyzed site-selective C-H alkynylation of quinolones. Org. Lett. 2015, 17, 1938-1941.
-
(2015)
Org. Lett.
, vol.17
, pp. 1938-1941
-
-
Kang, D.1
Hong, S.2
-
23
-
-
84935069605
-
Chiral phosphoric acid catalyzed asymmetric synthesis of 2-substituted 2, 3-dihydro-4-quinolones by a protecting-group-free approach
-
Saito, K.; Moriya, Y.; Akiyama, T. Chiral phosphoric acid catalyzed asymmetric synthesis of 2-substituted 2, 3-dihydro-4-quinolones by a protecting-group-free approach. Org. Lett. 2015, 17, 3202-3205.
-
(2015)
Org. Lett.
, vol.17
, pp. 3202-3205
-
-
Saito, K.1
Moriya, Y.2
Akiyama, T.3
-
24
-
-
84872505787
-
Pitchumani, K. Per-6-amino-β-cyclodextrin as a chiral base catalyst promoting one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones
-
Kanagaraj, K.; Pitchumani, K. Per-6-amino-β-cyclodextrin as a chiral base catalyst promoting one-pot asymmetric synthesis of 2-aryl-2,3-dihydro-4-quinolones. J. Org. Chem. 2013, 78, 744-751.
-
(2013)
J. Org. Chem.
, vol.78
, pp. 744-751
-
-
Kanagaraj, K.1
-
25
-
-
84922691261
-
Synthesis of 4-quinolones via a carbonylative Sonogashira cross-coupling using molybdenum hexacarbonyl as a CO source
-
Åkerbladh, L.; Nordeman, P.; Wejdemar, M.; Odell, L.R.; Larhed, M. Synthesis of 4-quinolones via a carbonylative Sonogashira cross-coupling using molybdenum hexacarbonyl as a CO source. J. Org. Chem. 2015, 80, 1464-1471.
-
(2015)
J. Org. Chem.
, vol.80
, pp. 1464-1471
-
-
Åkerbladh, L.1
Nordeman, P.2
Wejdemar, M.3
Odell, L.R.4
Larhed, M.5
-
26
-
-
84924325586
-
Metal-free arylation of ethyl acetoacetate with hypervalent diaryliodonium salts: An immediate access to diverse 3-aryl-4 (1H)-quinolones
-
Monastyrskyi, A.; Namelikonda, N.K.; Manetsch, R. Metal-free arylation of ethyl acetoacetate with hypervalent diaryliodonium salts: An immediate access to diverse 3-aryl-4 (1H)-quinolones. J. Org. Chem. 2015, 80, 2513-2520.
-
(2015)
J. Org. Chem.
, vol.80
, pp. 2513-2520
-
-
Monastyrskyi, A.1
Namelikonda, N.K.2
Manetsch, R.3
-
27
-
-
84924326510
-
Synthesis of quinolinones with palladium-catalyzed oxidative annulation between acrylamides and arynes
-
Wang, W.; Peng, X.; Qin, X.; Zhao, X.; Ma, C.; Tung, C.-H.; Xu, Z. Synthesis of quinolinones with palladium-catalyzed oxidative annulation between acrylamides and arynes. J. Org. Chem. 2015, 80, 2835-2841.
-
(2015)
J. Org. Chem.
, vol.80
, pp. 2835-2841
-
-
Wang, W.1
Peng, X.2
Qin, X.3
Zhao, X.4
Ma, C.5
Tung, C.-H.6
Xu, Z.7
-
28
-
-
84903746733
-
Ruthenium-catalyzed cyclization of anilides with substituted propiolates or acrylates: An efficient route to 2-quinolinones
-
Manikandan, R.; Jeganmohan, M. Ruthenium-catalyzed cyclization of anilides with substituted propiolates or acrylates: An efficient route to 2-quinolinones. Org. Lett. 2014, 16, 3568-3571.
-
(2014)
Org. Lett.
, vol.16
, pp. 3568-3571
-
-
Manikandan, R.1
Jeganmohan, M.2
-
29
-
-
84858034257
-
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH: Quinone oxidoreductase (PfNDH2)
-
Leung, S.C.; Gibbons, P.; Amewu, R.; Nixon, G.L.; Pidathala, C.; Hong, W.D.; Pacorel, B.; Berry, N.G.; Sharma, R.; Stocks, P.A.; et al. Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH: Quinone oxidoreductase (PfNDH2). J. Med. Chem. 2012, 55, 1844-1857.
-
(2012)
J. Med. Chem
, vol.55
, pp. 1844-1857
-
-
Leung, S.C.1
Gibbons, P.2
Amewu, R.3
Nixon, G.L.4
Pidathala, C.5
Hong, W.D.6
Pacorel, B.7
Berry, N.G.8
Sharma, R.9
Stocks, P.A.10
-
30
-
-
84866110858
-
Pyridoquinolones containing azetidinones: Synthesis and their biological evaluation
-
Patel, N.B.; Pathak, K.K. Pyridoquinolones containing azetidinones: Synthesis and their biological evaluation. Med. Chem. Res. 2011, 21, 2044-2055.
-
(2011)
Med. Chem. Res
, vol.21
, pp. 2044-2055
-
-
Patel, N.B.1
Pathak, K.K.2
-
31
-
-
33644671535
-
Chauhan, H. I. Novel pyridoquinolones of sulfonamides, thioureas and amines and their antimicrobial activity. Indian
-
Patel, N.B.; Chauhan, H.I. Novel pyridoquinolones of sulfonamides, thioureas and amines and their antimicrobial activity. Indian J. Heterocycl. Chem. 2005, 15, 39-42.
-
(2005)
J. Heterocycl. Chem.
, vol.15
, pp. 39-42
-
-
Patel, N.B.1
-
32
-
-
76049130213
-
Synthesis and antimicrobial activity of novel 6-hydroxy-4-oxo-pyrido[2,3-H] quinoline-3[(substituted aryl ureido/piperazinyl)carbonyl]
-
Patel, N.B.; Modi, S.H. Synthesis and antimicrobial activity of novel 6-hydroxy-4-oxo-pyrido[2,3-H] quinoline-3[(substituted aryl ureido/piperazinyl)carbonyl]. Indian J. Pharm. Educational Res. 2010, 44, 8-21.
-
(2010)
Indian J. Pharm. Educational Res.
, vol.44
, pp. 8-21
-
-
Patel, N.B.1
Modi, S.H.2
-
33
-
-
78650782033
-
Synthesis and antimicrobial study of fluoroquinolone based 4-thiozolidinones
-
Patel, N.B.; Patel, J.C. Synthesis and antimicrobial study of fluoroquinolone based 4-thiozolidinones. Med. Chem. Res. 2010, 19, 757-770.
-
(2010)
Med. Chem. Res
, vol.19
, pp. 757-770
-
-
Patel, N.B.1
Patel, J.C.2
-
34
-
-
80052030851
-
Synthesis and antimicrobial activities of 2-azetidinyl-4-quinazolinone derivatives of diclofenac analogue
-
Patel, N.B.; Patel, J.C. Synthesis and antimicrobial activities of 2-azetidinyl-4-quinazolinone derivatives of diclofenac analogue. Med. Chem. Res. 2011, 20, 511-521.
-
(2011)
Med. Chem. Res
, vol.20
, pp. 511-521
-
-
Patel, N.B.1
Patel, J.C.2
-
35
-
-
79951946488
-
Synthesis and antimicrobial activity of carbonyl pyridoquinolones containing urea and piperazine residue
-
Patel, N.B.; Patel, J.C.; Modi, S.H. Synthesis and antimicrobial activity of carbonyl pyridoquinolones containing urea and piperazine residue. J. Saudi Chem. Soc. 2010, 15, 167-176.
-
(2010)
J. Saudi Chem. Soc.
, vol.15
, pp. 167-176
-
-
Patel, N.B.1
Patel, J.C.2
Modi, S.H.3
-
36
-
-
80054717420
-
Synthesis and in vitro microbial activities of amides of pyridoquinolone
-
Patel, N.B.; Patel, S.D.; Chauhan, H.I. Synthesis and in vitro microbial activities of amides of pyridoquinolone. Med. Chem. Res. 2011, 20, 1054-1067.
-
(2011)
Med. Chem. Res
, vol.20
, pp. 1054-1067
-
-
Patel, N.B.1
Patel, S.D.2
Chauhan, H.I.3
-
37
-
-
84929311335
-
Phosphine derivatives of sparfloxacin-Synthesis, structures and in vitro activity
-
Komarnicka, U.K.; Starosta, R.; Guz-Regner, K.; Bugla-Płoskoñska, G.; Kyzioł, A.; Jżowska-Bojczuk, M. Phosphine derivatives of sparfloxacin-Synthesis, structures and in vitro activity. J. Mol. Struct. 2015, 1096, 55-63.
-
(2015)
J. Mol. Struct.
, vol.1096
, pp. 55-63
-
-
Komarnicka, U.K.1
Starosta, R.2
Guz-Regner, K.3
Bugla-Płoskoñska, G.4
Kyzioł, A.5
Jzowska-Bojczuk, M.6
-
38
-
-
84871689627
-
Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria
-
Plech, T.; Wujec, M.; Kosikowska, U.; Malm, A.; Rajtar, B.; Polz-Dacewicz, M. Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria. Eur. J. Med. Chem. 2013, 60, 128-134.
-
(2013)
Eur. J. Med. Chem.
, vol.60
, pp. 128-134
-
-
Plech, T.1
Wujec, M.2
Kosikowska, U.3
Malm, A.4
Rajtar, B.5
Polz-Dacewicz, M.6
-
39
-
-
84928922991
-
Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria
-
Parkinson, E.I.; Bair, J.S.; Nakamura, B.A.; Lee, H.Y.; Kuttab, H.I.; Southgate, E.H.; Lezmi, S.; Lau, G.W.; Hergenrother, P.J. Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nat. Commun. 2015, 6.
-
(2015)
Nat. Commun
, vol.6
-
-
Parkinson, E.I.1
Bair, J.S.2
Nakamura, B.A.3
Lee, H.Y.4
Kuttab, H.I.5
Southgate, E.H.6
Lezmi, S.7
Lau, G.W.8
Hergenrother, P.J.9
-
40
-
-
84939864397
-
Inhibition of Neisseria gonorrhoeae type II topoisomerases by the novel spiropyrimidinetrione azd0914
-
Kern, G. Inhibition of Neisseria gonorrhoeae type II topoisomerases by the novel spiropyrimidinetrione azd0914. J. Biol. Chem. 2015, 290, 20984-20994.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 20984-20994
-
-
Kern, G.1
-
41
-
-
84912097422
-
Fluoroquinolones: Chemistry & action-A review. Indo Global
-
Soni, K. Fluoroquinolones: Chemistry & action-A review. Indo Global J. Pharm. Sci. 2012, 2, 43-53.
-
(2012)
J. Pharm. Sci.
, vol.2
, pp. 43-53
-
-
Soni, K.1
-
42
-
-
84870429571
-
Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety
-
Mohammadhosseini, N.; Alipanahi, Z.; Alipour, E.; Emami, S.; Faramarzi, M.; Samadi, N.; Khoshnevis, N.; Shafiee, A.; Foroumadi, A. Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety. DARU J. Pharm. Sci. 2012, 20.
-
(2012)
DARU J. Pharm. Sci
, vol.20
-
-
Mohammadhosseini, N.1
Alipanahi, Z.2
Alipour, E.3
Emami, S.4
Faramarzi, M.5
Samadi, N.6
Khoshnevis, N.7
Shafiee, A.8
Foroumadi, A.9
-
43
-
-
84875429861
-
Binding of norfloxacin, enoxacin and enrofloxacin to calf thymus DNA
-
Vijan, L.E.; Giosanu, D. Binding of norfloxacin, enoxacin and enrofloxacin to calf thymus DNA. Rev. Roum. Chim. 2012, 57, 823-827.
-
(2012)
Rev. Roum. Chim.
, vol.57
, pp. 823-827
-
-
Vijan, L.E.1
Giosanu, D.2
-
44
-
-
34547112538
-
Mycobacterium tuberculosis DNA gyrase as a target for drug discovery
-
Mdluli, K.; Ma, Z. Mycobacterium tuberculosis DNA gyrase as a target for drug discovery. Infect. Disord. Drug Targets 2007, 7, 159-168.
-
(2007)
Infect. Disord. Drug Targets
, vol.7
, pp. 159-168
-
-
Mdluli, K.1
Ma, Z.2
-
45
-
-
77956304709
-
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II
-
Hawtin, R.E.; Stockett, D.E.; Byl, J.A.; McDowell, R.S.; Nguyen, T.; Arkin, M.R.; Conroy, A.; Yang, W.; Osheroff, N.; Fox, J.A. Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS ONE 2010, 5.
-
(2010)
PLoS ONE
, vol.5
-
-
Hawtin, R.E.1
Stockett, D.E.2
Byl, J.A.3
McDowell, R.S.4
Nguyen, T.5
Arkin, M.R.6
Conroy, A.7
Yang, W.8
Osheroff, N.9
Fox, J.A.10
-
46
-
-
80052975489
-
Development and validation of a microbiological agar assay for determination of orbifloxacin in pharmaceutical preparations
-
Cazedey, E.C.L.; Salgado, H.R. Development and validation of a microbiological agar assay for determination of orbifloxacin in pharmaceutical preparations. Pharmaceutics 2011, 3, 572-581.
-
(2011)
Pharmaceutics
, vol.3
, pp. 572-581
-
-
Cazedey, E.C.L.1
Salgado, H.R.2
-
47
-
-
85016785094
-
Beta-lactam antibiotics renaissance
-
Qin, W.; Panunzio, M.; Biondi, S. Beta-lactam antibiotics renaissance. Antibiotics 2014, 3, 193-215.
-
(2014)
Antibiotics
, vol.3
, pp. 193-215
-
-
Qin, W.1
Panunzio, M.2
Biondi, S.3
-
48
-
-
59849118937
-
Developing and optimizing an immunoaffinity cleanup technique for determination of quinolones from chicken muscle
-
Zhao, S.; Li, X.; Ra, Y.; Li, C.; Jiang, H.; Li, J.; Qu, Z.; Zhang, S.; He, F.; Wan, Y. Developing and optimizing an immunoaffinity cleanup technique for determination of quinolones from chicken muscle. J. Agric. Food Chem. 2009, 57, 365-371.
-
(2009)
J. Agric. Food Chem.
, vol.57
, pp. 365-371
-
-
Zhao, S.1
Li, X.2
Ra, Y.3
Li, C.4
Jiang, H.5
Li, J.6
Qu, Z.7
Zhang, S.8
He, F.9
Wan, Y.10
-
49
-
-
0033659828
-
Clinical use of the fluoroquinolones
-
Owens, R.C.; Ambrose, P.G. Clinical use of the fluoroquinolones. Med. Clin. N. Am. 2000, 84, 1447-1469.
-
(2000)
Med. Clin. N. Am
, vol.84
, pp. 1447-1469
-
-
Owens, R.C.1
Ambrose, P.G.2
-
50
-
-
84958110399
-
Anionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosa
-
Long, T.E.; Keding, L.C.; Lewis, D.D.; Anstead, M.I.; Ryan Withers, T.; Yu, H.D. Anionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosa. Bioorg. Med. Chem. Lett. 2016, 26, 1305-1309.
-
(2016)
Bioorg. Med. Chem. Lett.
, vol.26
, pp. 1305-1309
-
-
Long, T.E.1
Keding, L.C.2
Lewis, D.D.3
Anstead, M.I.4
Ryan Withers, T.5
Yu, H.D.6
-
51
-
-
80053477373
-
The use of systemic and topical fluoroquinolones
-
Bradley, J.; Jackson, M. The use of systemic and topical fluoroquinolones. Pediatrics 2011, 128, e1034-e1045.
-
(2011)
Pediatrics
, vol.128
, pp. e1034-e1045
-
-
Bradley, J.1
Jackson, M.2
-
52
-
-
81555211930
-
Current prospects for the fluoroquinolones as first-line tuberculosis therapy
-
Takiff, H.; Guerrero, E. Current prospects for the fluoroquinolones as first-line tuberculosis therapy. Antimicrob. Agents Chemother. 2011, 55, 5421-5429.
-
(2011)
Antimicrob. Agents Chemother
, vol.55
, pp. 5421-5429
-
-
Takiff, H.1
Guerrero, E.2
-
53
-
-
37549030092
-
Comparison of gyrA gene mutations between laboratory-selected ofloxacin-resistant Mycobacterium tuberculosis strains and clinical isolates. Int
-
Sun, Z.; Zhang, J.; Zhang, X.; Wang, S.; Zhang, Y.; Li, C. Comparison of gyrA gene mutations between laboratory-selected ofloxacin-resistant Mycobacterium tuberculosis strains and clinical isolates. Int. J. Antimicrob. Agents 2008, 31, 115-121.
-
(2008)
J. Antimicrob. Agents
, vol.31
, pp. 115-121
-
-
Sun, Z.1
Zhang, J.2
Zhang, X.3
Wang, S.4
Zhang, Y.5
Li, C.6
-
54
-
-
84929492224
-
Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: A systematic review
-
Avalos, E.; Catanzaro, D.; Catanzaro, A.; Ganiats, T.; Brodine, S.; Alcaraz, J.; Rodwell, T. Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: A systematic review. PLoS ONE 2015, 10, e0120470.
-
(2015)
PLoS ONE
, vol.10
, pp. e0120470
-
-
Avalos, E.1
Catanzaro, D.2
Catanzaro, A.3
Ganiats, T.4
Brodine, S.5
Alcaraz, J.6
Rodwell, T.7
-
55
-
-
84871111160
-
Bukatina, A. A.; Isaeva, Y. D.; Makarova, M. V.; Galkina, K. Y.; Moroz, A. M. Analysis of mutations in the gyrA and gyrB genes and their association with the resistance of Mycobacterium tuberculosis to levofloxacin, moxifloxacin and gatifloxacin
-
Nosova, E.Y.; Bukatina, A.A.; Isaeva, Y.D.; Makarova, M.V.; Galkina, K.Y.; Moroz, A.M. Analysis of mutations in the gyrA and gyrB genes and their association with the resistance of Mycobacterium tuberculosis to levofloxacin, moxifloxacin and gatifloxacin. J. Med. Microbiol. 2013, 62, 108-113.
-
(2013)
J. Med. Microbiol.
, vol.62
, pp. 108-113
-
-
Nosova, E.Y.1
-
56
-
-
84898057432
-
Mechanisms of fluoroquinolone monoresistance in mycobacterium tuberculosis
-
Lu, J.; Liu, M.; Wang, Y.; Pang, Y.; Zhao, Z. Mechanisms of fluoroquinolone monoresistance in mycobacterium tuberculosis. FEMS Microbiol. Lett. 2014, 353, 40-48.
-
(2014)
FEMS Microbiol. Lett.
, vol.353
, pp. 40-48
-
-
Lu, J.1
Liu, M.2
Wang, Y.3
Pang, Y.4
Zhao, Z.5
-
57
-
-
84891541286
-
Prevalence and molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis isolates in China
-
Zhang, Z.; Lu, J.; Wang, Y.; Pang, Y.; Zhao, Y. Prevalence and molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis isolates in china. Antimicrob. Agents Chemother. 2014, 58, 364-369.
-
(2014)
Antimicrob. Agents Chemother
, vol.58
, pp. 364-369
-
-
Zhang, Z.1
Lu, J.2
Wang, Y.3
Pang, Y.4
Zhao, Y.5
-
58
-
-
35448999349
-
Advances in the treatment of tuberculosis
-
Zhang, Y. Advances in the treatment of tuberculosis. Clin. Pharmacol. Ther. 2007, 82, 595-600.
-
(2007)
Clin. Pharmacol. Ther
, vol.82
, pp. 595-600
-
-
Zhang, Y.1
-
59
-
-
84862228470
-
Molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates from Shanghai
-
China
-
Zhu, C.; Zhang, Y.; Shen, Y.; Siu, G.K.H.; Wu, W.; Qian, X.; Deng, G.; Xu, Y.; Lau, R.; Fan, X.; et al. Molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates from Shanghai, China. Diagn. Microbiol. Infect. Dis. 2012, 73, 260-263.
-
(2012)
Diagn. Microbiol. Infect. Dis
, vol.73
, pp. 260-263
-
-
Zhu, C.1
Zhang, Y.2
Shen, Y.3
Siu, G.K.H.4
Wu, W.5
Qian, X.6
Deng, G.7
Xu, Y.8
Lau, R.9
Fan, X.10
-
60
-
-
33845583280
-
Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing
-
Shi, R.; Zhang, J.; Li, C.; Kazumi, Y.; Sugawara, I. Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from china as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing. J. Clin. Microbiol. 2006, 44, 4566-4568.
-
(2006)
J. Clin. Microbiol.
, vol.44
, pp. 4566-4568
-
-
Shi, R.1
Zhang, J.2
Li, C.3
Kazumi, Y.4
Sugawara, I.5
-
61
-
-
34447568191
-
Limited fluoroquinolone resistance among Mycobacterium tuberculosis isolates from Rwanda: Results of a national survey
-
Umubyeyi, A.N. Limited fluoroquinolone resistance among Mycobacterium tuberculosis isolates from rwanda: Results of a national survey. J. Antimicrob. Chemother. 2007, 59, 1031-1033.
-
(2007)
J. Antimicrob. Chemother.
, vol.59
, pp. 1031-1033
-
-
Umubyeyi, A.N.1
-
62
-
-
84924690319
-
Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3- A]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability
-
Hu, Q.; Yin, L.; Ali, A.; Cooke, A.J.; Bennett, J.; Ratcliffe, P.; Lo, M.M.-C.; Metzger, E.; Hoyt, S.; Hartmann, R.W. Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability. J. Med. Chem. 2015, 58, 2530-2537.
-
(2015)
J. Med. Chem.
, vol.58
, pp. 2530-2537
-
-
Hu, Q.1
Yin, L.2
Ali, A.3
Cooke, A.J.4
Bennett, J.5
Ratcliffe, P.6
Lo, M.M.-C.7
Metzger, E.8
Hoyt, S.9
Hartmann, R.W.10
-
63
-
-
84935877076
-
N-substituted quinolinonyl diketo acid derivatives as HIV integrase strand transfer inhibitors and their activity against RNase H function of reverse transcriptase
-
Pescatori, L.; Métifiot, M.; Chung, S.; Masoaka, T.; Cuzzucoli Crucitti, G.; Messore, A.; Pupo, G.; Madia, V.N.; Saccoliti, F.; Scipione, L.; et al. N-substituted quinolinonyl diketo acid derivatives as HIV integrase strand transfer inhibitors and their activity against RNase H function of reverse transcriptase. J. Med. Chem. 2015, 58, 4610-4623.
-
(2015)
J. Med. Chem.
, vol.58
, pp. 4610-4623
-
-
Pescatori, L.1
Métifiot, M.2
Chung, S.3
Masoaka, T.4
Cuzzucoli Crucitti, G.5
Messore, A.6
Pupo, G.7
Madia, V.N.8
Saccoliti, F.9
Scipione, L.10
-
64
-
-
33645405333
-
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: Design, synthesis, biological activities, and mechanism of action
-
Di Santo, R.C.R.; Roux, A.; Artico, M.; Lavecchia, A.; Marinelli, L.; Novellino, E.; Palmisano, L.; Andreotti, M.; Amici, R.; Galluzzo, C.M.; et al. Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: Design, synthesis, biological activities, and mechanism of action. J. Med. Chem. 2006, 49, 1939-1945.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1939-1945
-
-
Di Santo, R.C.R.1
Roux, A.2
Artico, M.3
Lavecchia, A.4
Marinelli, L.5
Novellino, E.6
Palmisano, L.7
Andreotti, M.8
Amici, R.9
Galluzzo, C.M.10
-
65
-
-
79961078738
-
Diketo acids derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain
-
Di Santo, R. Diketo acids derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. Curr. Med. Chem. 2011, 18, 3335-3342.
-
(2011)
Curr. Med. Chem
, vol.18
, pp. 3335-3342
-
-
Di Santo, R.1
-
66
-
-
84899554749
-
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase
-
Costi, R.M.M.; Chung, S.; Cuzzucoli Crucitti, G.; Maddali, K.; Pescatori, L.; Messore, A.; Madia, V.N.; Pupo, G.; Scipione, L.; Tortorella, S.; et al. Basic quinolinonyl diketo acid derivatives as inhibitors of hiv integrase and their activity against RNase H function of reverse transcriptase. J. Med. Chem. 2014, 57, 3223-3234.
-
(2014)
J. Med. Chem.
, vol.57
, pp. 3223-3234
-
-
Costi, R.M.M.1
Chung, S.2
Cuzzucoli Crucitti, G.3
Maddali, K.4
Pescatori, L.5
Messore, A.6
Madia, V.N.7
Pupo, G.8
Scipione, L.9
Tortorella, S.10
-
67
-
-
49449093292
-
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: Design, synthesis, and biological activities
-
Di Santo, R.C.R.; Roux, A.; Miele, G.; Cuzzucoli Crucitti, G.; Iacovo, A.; Rosi, F.; Lavecchia, A.; Marinelli, L.; Di Giovanni, C.; Novellino, E.; et al. Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: Design, synthesis, and biological activities. J. Med. Chem. 2008, 51, 4744-4750.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4744-4750
-
-
Di Santo, R.C.R.1
Roux, A.2
Miele, G.3
Cuzzucoli Crucitti, G.4
Iacovo, A.5
Rosi, F.6
Lavecchia, A.7
Marinelli, L.8
Di Giovanni, C.9
Novellino, E.10
-
68
-
-
84907220119
-
Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action. Int
-
Fu, Y.; Yang, Y.; Zhou, S.; Liu, Y.; Yuan, Y.; Li, S.; Li, C. Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action. Int. J. Oncol. 2014, 45, 2092-2100.
-
(2014)
J. Oncol.
, vol.45
, pp. 2092-2100
-
-
Fu, Y.1
Yang, Y.2
Zhou, S.3
Liu, Y.4
Yuan, Y.5
Li, S.6
Li, C.7
-
69
-
-
33845709540
-
Comparison of pharmacodynamics and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats
-
Boothe, D.; Boeckh, A.; Simpson, B.; Dubose, K. Comparison of pharmacodynamics and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats. J. Vet. Inter. Med. 2006, 20, 1297-1306.
-
(2006)
J. Vet. Inter. Med.
, vol.20
, pp. 1297-1306
-
-
Boothe, D.1
Boeckh, A.2
Simpson, B.3
Dubose, K.4
-
70
-
-
34247568862
-
Pradofloxacin in the treatment of canine deep pyoderma: A multicentred, blinded, randomized parallel trial
-
Mueller, R.S.; Stephan, B. Pradofloxacin in the treatment of canine deep pyoderma: A multicentred, blinded, randomized parallel trial. Vet. Dermatol. 2007, 18, 144-151.
-
(2007)
Vet. Dermatol
, vol.18
, pp. 144-151
-
-
Mueller, R.S.1
Stephan, B.2
-
71
-
-
0034923502
-
DNA topoisomerases: Structure, function, and mechanism
-
Champoux, J.J. DNA topoisomerases: Structure, function, and mechanism. Annu. Rev. Biochem. 2001, 70, 369-413.
-
(2001)
Annu. Rev. Biochem
, vol.70
, pp. 369-413
-
-
Champoux, J.J.1
-
72
-
-
84864196564
-
Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase
-
Dale, A.G.; Hinds, J.; Mann, J.; Taylor, P.W.; Neidle, S. Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase. Biochemistry 2012, 51, 5860-5871.
-
(2012)
Biochemistry
, vol.51
, pp. 5860-5871
-
-
Dale, A.G.1
Hinds, J.2
Mann, J.3
Taylor, P.W.4
Neidle, S.5
-
73
-
-
63349086953
-
The DNA cleavage reaction of topoisomerase II: Wolf in sheep's clothing
-
Deweese, J.E.; Osheroff, N. The DNA cleavage reaction of topoisomerase II: Wolf in sheep's clothing. Nucleic Acids Res. 2009, 37, 738-748.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 738-748
-
-
Deweese, J.E.1
Osheroff, N.2
-
74
-
-
2442611949
-
The c-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold
-
Corbett, K.D.; Shultzaberger, R.K.; Berger, J.M. The c-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc. Natl. Acad. Sci. USA 2004, 101, 7293-7298.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7293-7298
-
-
Corbett, K.D.1
Shultzaberger, R.K.2
Berger, J.M.3
-
75
-
-
0032189275
-
DNA gyrase and topoisomerase IV: Biochemical activities, physiological roles during chromosome replication, and drug sensitivities
-
Levine, C.; Hiasa, H.; Marians, K.J. DNA gyrase and topoisomerase IV: Biochemical activities, physiological roles during chromosome replication, and drug sensitivities. Biochim. Biophys. Acta 1998, 1400, 29-43.
-
(1998)
Biochim. Biophys. Acta
, vol.1400
, pp. 29-43
-
-
Levine, C.1
Hiasa, H.2
Marians, K.J.3
-
76
-
-
50649101663
-
DNA topoisomerases: Harnessing and constraining energy to govern chromosome topology
-
Schoeffler, A.J.; Berger, J.M. DNA topoisomerases: Harnessing and constraining energy to govern chromosome topology. Q. Rev. Biophys. 2008, 41, 41-101.
-
(2008)
Q. Rev. Biophys
, vol.41
, pp. 41-101
-
-
Schoeffler, A.J.1
Berger, J.M.2
-
77
-
-
0035042602
-
Type II topoisomerases as targets for quinolone antibacterials turning Dr Jekyll into Mr
-
Anderson, V.E.; Osheroff, N. Type II topoisomerases as targets for quinolone antibacterials turning Dr. Jekyll into Mr. Hyde. Curr. Pharm. Des. 2001, 7, 337-353.
-
(2001)
Hyde. Curr. Pharm. Des
, vol.7
, pp. 337-353
-
-
Anderson, V.E.1
Osheroff, N.2
-
78
-
-
28844455588
-
Recent advances in understanding structure-function relationships in the type II topoisomerase mechanism
-
Schoeffler, A.J.; Berger, J.M. Recent advances in understanding structure-function relationships in the type II topoisomerase mechanism. Biochem. Soc. Trans. 2005, 33, 1465-1470.
-
(2005)
Biochem. Soc. Trans
, vol.33
, pp. 1465-1470
-
-
Schoeffler, A.J.1
Berger, J.M.2
-
79
-
-
78649879246
-
A domain insertion in Escherichia coli gyrB adopts a novel fold that plays a critical role in gyrase function
-
Schoeffler, A.J.; May, A.P.; Berger, J.M. A domain insertion in Escherichia coli gyrB adopts a novel fold that plays a critical role in gyrase function. Nucleic Acids Res. 2010, 38, 7830-7844.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 7830-7844
-
-
Schoeffler, A.J.1
May, A.P.2
Berger, J.M.3
-
80
-
-
77953229439
-
A novel and unified two-metal mechanism for DNA cleavage by type II and Ia topoisomerases
-
Schmidt, B.H.; Burgin, A.B.; Deweese, J.E.; Osheroff, N.; Berger, J.M. A novel and unified two-metal mechanism for DNA cleavage by type II and Ia topoisomerases. Nature 2010, 465, 641-644.
-
(2010)
Nature
, vol.465
, pp. 641-644
-
-
Schmidt, B.H.1
Burgin, A.B.2
Deweese, J.E.3
Osheroff, N.4
Berger, J.M.5
-
81
-
-
79959425256
-
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV
-
Pitts, S.L.; Liou, G.F.; Mitchenall, L.A.; Burgin, A.B.; Maxwell, A.; Neuman, K.C.; Osheroff, N. Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Res. 2011, 39, 4808-4817.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 4808-4817
-
-
Pitts, S.L.1
Liou, G.F.2
Mitchenall, L.A.3
Burgin, A.B.4
Maxwell, A.5
Neuman, K.C.6
Osheroff, N.7
-
82
-
-
61449115991
-
DNA topology and topoisomerases
-
Deweese, J.E.; Osheroff, M.A.; Osheroff, N. DNA topology and topoisomerases. Biochem. Mol. Biol. Educ. 2009, 37, 2-10.
-
(2009)
Biochem. Mol. Biol. Educ
, vol.37
, pp. 2-10
-
-
Deweese, J.E.1
Osheroff, M.A.2
Osheroff, N.3
-
83
-
-
77955334540
-
Structural basis of gate-DNA breakage and resealing by type II topoisomerases
-
Laponogov, I.; Pan, X.-S.; Veselkov, D.A.; McAuley, K.E.; Fisher, L.M.; Sanderson, M.R. Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS ONE 2010, 5, e11338.
-
(2010)
PLoS ONE
, vol.5
, pp. e11338
-
-
Laponogov, I.1
Pan, X.-S.2
Veselkov, D.A.3
McAuley, K.E.4
Fisher, L.M.5
Sanderson, M.R.6
-
84
-
-
67349272340
-
Structural insight into the quinolone-DNA cleavage complex of type IIa topoisomerases
-
Laponogov, I.; Sohi, M.K.; Veselkov, D.; Pan, X.; Sawhney, R.; Thompson, A.; McAuley, K.; Fisher, L.; Sanderson, M. Structural insight into the quinolone-DNA cleavage complex of type IIa topoisomerases. Nat. Struct. Mol. Biol. 2009, 16, 667-669.
-
(2009)
Nat. Struct. Mol. Biol
, vol.16
, pp. 667-669
-
-
Laponogov, I.1
Sohi, M.K.2
Veselkov, D.3
Pan, X.4
Sawhney, R.5
Thompson, A.6
McAuley, K.7
Fisher, L.8
Sanderson, M.9
-
85
-
-
79551483068
-
Solution structures of DNA-bound gyrase
-
Baker, N.M.; Weigand, S.; Maar-Mathias, S.; Mondragon, A. Solution structures of DNA-bound gyrase. Nucleic Acids Res. 2011, 39, 755-766.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 755-766
-
-
Baker, N.M.1
Weigand, S.2
Maar-Mathias, S.3
Mondragon, A.4
-
86
-
-
84922680010
-
Activity of quinolone cp-115,955 against bacterial and human type II topoisomerases is mediated by different interactions
-
Aldred, K.J.; Schwanz, H.A.; Li, G.; Williamson, B.H.; McPherson, S.A.; Turnbough, C.L., Jr.; Kerns, R.J.; Osheroff, N. Activity of quinolone cp-115,955 against bacterial and human type II topoisomerases is mediated by different interactions. Biochemistry 2015, 54, 1278-1286.
-
(2015)
Biochemistry
, vol.54
, pp. 1278-1286
-
-
Aldred, K.J.1
Schwanz, H.A.2
Li, G.3
Williamson, B.H.4
McPherson, S.A.5
Turnbough, C.L.6
Kerns, R.J.7
Osheroff, N.8
-
87
-
-
0018628599
-
Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth
-
Kreuzer, K.N.; Cozzarelli, N.R. Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth. J. Bacteriol. 1979, 140, 424-435.
-
(1979)
J. Bacteriol.
, vol.140
, pp. 424-435
-
-
Kreuzer, K.N.1
Cozzarelli, N.R.2
-
88
-
-
0344328778
-
Mechanisms of Quinolone Resistance
-
rd ed.; ASM Press: Washington, DC, USA
-
Hooper, D.C. Mechanisms of Quinolone Resistance. In Quinolone Antimicrobial Agents, 3rd ed.; ASM Press: Washington, DC, USA, 2003; pp. 41-67.
-
(2003)
Quinolone Antimicrobial Agents
, pp. 41-67
-
-
Hooper, D.C.1
-
89
-
-
84945444280
-
Mechanisms of drug resistance: Quinolone resistance
-
Hooper, D.C.; Jacoby, G.A. Mechanisms of drug resistance: Quinolone resistance. Ann. N. Y. Acad. Sci. 2015, 1354, 12-31.
-
(2015)
Ann. N. Y. Acad. Sci.
, vol.1354
, pp. 12-31
-
-
Hooper, D.C.1
Jacoby, G.A.2
-
90
-
-
0033929893
-
SelectIVe targeting of topoisomerase IV and DNA gyrase in Staphylococcus aureus: Different patterns of quinolone-induced inhibition of DNA synthesis
-
Fournier, B.; Zhao, X.; Lu, T.; Drlica, K.; Hooper, D.C. Selective targeting of topoisomerase iv and DNA gyrase in Staphylococcus aureus: Different patterns of quinolone-induced inhibition of DNA synthesis. Antimicrob. Agents Chemother. 2000, 44, 2160-2165.
-
(2000)
Antimicrob. Agents Chemother
, vol.44
, pp. 2160-2165
-
-
Fournier, B.1
Zhao, X.2
Lu, T.3
Drlica, K.4
Hooper, D.C.5
-
91
-
-
0038650918
-
Vitro selection and characterization of Bacillus anthracis mutants with high-level resistance to ciprofloxacin
-
Price, L.B.; Vogler, A.; Pearson, T.; Busch, J.D.; Schupp, J.M.; Keim, P. In vitro selection and characterization of Bacillus anthracis mutants with high-level resistance to ciprofloxacin. Antimicrob. Agents Chemother. 2003, 47, 2362-2365.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 2362-2365
-
-
Price, L.B.1
Vogler, A.2
Pearson, T.3
Busch, J.D.4
Schupp, J.M.5
Keim, P.6
-
92
-
-
59749085790
-
Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates
-
Morgan-Linnell, S.K.; Boyd, L.B.; Steffen, D.; Zechiedrich, L. Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob. Agents Chemother. 2009, 53, 235-241.
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 235-241
-
-
Morgan-Linnell, S.K.1
Boyd, L.B.2
Steffen, D.3
Zechiedrich, L.4
-
93
-
-
0035800671
-
Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions
-
Sissi, C.; Perdona, E.; Domenici, E.; Feriani, A.; Howells, A.J.; Maxwell, A.; Palumbo, M. Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions. J. Mol. Biol. 2001, 311, 195-203.
-
(2001)
J. Mol. Biol.
, vol.311
, pp. 195-203
-
-
Sissi, C.1
Perdona, E.2
Domenici, E.3
Feriani, A.4
Howells, A.J.5
Maxwell, A.6
Palumbo, M.7
-
94
-
-
63349104786
-
Effects of magnesium and related divalent metal ions in topoisomerase structure and function
-
Sissi, C.; Palumbo, M. Effects of magnesium and related divalent metal ions in topoisomerase structure and function. Nucleic Acids Res. 2009, 37, 702-711.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 702-711
-
-
Sissi, C.1
Palumbo, M.2
-
95
-
-
0034959675
-
Interaction between DNA gyrase and quinolones: Effects of alanine mutations at gyrA subunit residues Ser83 and Asp87
-
Barnard, F.M.; Maxwell, A. Interaction between DNA gyrase and quinolones: Effects of alanine mutations at gyrA subunit residues Ser83 and Asp87. Antimicrob. Agents Chemother. 2001, 45, 1994-2000.
-
(2001)
Antimicrob. Agents Chemother
, vol.45
, pp. 1994-2000
-
-
Barnard, F.M.1
Maxwell, A.2
-
96
-
-
84949485120
-
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
-
Chan, P.F.; Srikannathasan, V.; Huang, J.; Cui, H.; Fosberry, A.P.; Gu, M.; Hann, M.M.; Hibbs, M.; Homes, P.; Ingraham, K.; et al. Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin. Nat. Commun. 2015, 6.
-
(2015)
Nat. Commun
, vol.6
-
-
Chan, P.F.1
Srikannathasan, V.2
Huang, J.3
Cui, H.4
Fosberry, A.P.5
Gu, M.6
Hann, M.M.7
Hibbs, M.8
Homes, P.9
Ingraham, K.10
-
97
-
-
77955917935
-
Type IIa topoisomerase inhibition by a new class of antibacterial agents
-
Bax, B.C.P.; Eggleston, D.; Fosberry, A.; Gentry, D.; Gorrec, F.; Giordano, I.; Hann, M.; Hennessy, A.; Hibbs, M.; Huang, J.; et al. Type IIa topoisomerase inhibition by a new class of antibacterial agents. Nature 2010, 466, 935-940.
-
(2010)
Nature
, vol.466
, pp. 935-940
-
-
Bax, B.C.P.1
Eggleston, D.2
Fosberry, A.3
Gentry, D.4
Gorrec, F.5
Giordano, I.6
Hann, M.7
Hennessy, A.8
Hibbs, M.9
Huang, J.10
-
98
-
-
84944215409
-
Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide
-
Srikannathasan, V.; Wohlkonig, A.; Shillings, A.; Singh, O.; Chan, P.F.; Huang, J.; Gwynn, M.N.; Fosberry, A.P.; Homes, P.; Hibbs, M.; et al. Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide. Acta Crystallogr. F Struct. Biol. Commun. 2015, 71, 1242-1246.
-
(2015)
Acta Crystallogr. F Struct. Biol. Commun
, vol.71
, pp. 1242-1246
-
-
Srikannathasan, V.1
Wohlkonig, A.2
Shillings, A.3
Singh, O.4
Chan, P.F.5
Huang, J.6
Gwynn, M.N.7
Fosberry, A.P.8
Homes, P.9
Hibbs, M.10
-
99
-
-
77956343814
-
Structural basis of quinolone inhibition of type IIa topoisomerases and target-mediated resistance
-
Wohlkonig, A. Structural basis of quinolone inhibition of type IIa topoisomerases and target-mediated resistance. Nat. Struct. Mol. Biol. 2010, 17, 1152-1153.
-
(2010)
Nat. Struct. Mol. Biol
, vol.17
, pp. 1152-1153
-
-
Wohlkonig, A.1
-
100
-
-
82355173219
-
Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives
-
Collin, F.; Karkare, S.; Maxwell, A. Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives. Appl. Microbiol. Biotechnol. 2011, 92, 479-497.
-
(2011)
Appl. Microbiol. Biotechnol
, vol.92
, pp. 479-497
-
-
Collin, F.1
Karkare, S.2
Maxwell, A.3
-
101
-
-
84906877854
-
Role of the water metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV
-
Aldred, K.J.; Breland, E.J.; Vlckova, V.; Strub, M.-P.; Neuman, K.C.; Kerns, R.J.; Osheroff, N. Role of the water metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV. Biochemistry 2014, 53, 5558-5567.
-
(2014)
Biochemistry
, vol.53
, pp. 5558-5567
-
-
Aldred, K.J.1
Breland, E.J.2
Vlckova, V.3
Strub, M.-P.4
Neuman, K.C.5
Kerns, R.J.6
Osheroff, N.7
-
102
-
-
84877257450
-
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: Mechanistic basis of quinolone resistance
-
Aldred, K.J.; McPherson, S.A.; Turnbough, C.L., Jr.; Kerns, R.J.; Osheroff, N. Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: Mechanistic basis of quinolone resistance. Nucleic Acids Res. 2013, 41, 4628-4639.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 4628-4639
-
-
Aldred, K.J.1
McPherson, S.A.2
Turnbough, C.L.3
Kerns, R.J.4
Osheroff, N.5
-
103
-
-
84863030593
-
Drug interactions with Bacillus anthracis topoisomerase IV: Biochemical basis for quinolone action and resistance
-
Aldred, K.J.; McPherson, S.A.; Wang, P.; Kerns, R.J.; Graves, D.E.; Turnbough, C.L., Jr.; Osheroff, N. Drug interactions with Bacillus anthracis topoisomerase IV: Biochemical basis for quinolone action and resistance. Biochemistry 2012, 51, 370-381.
-
(2012)
Biochemistry
, vol.51
, pp. 370-381
-
-
Aldred, K.J.1
McPherson, S.A.2
Wang, P.3
Kerns, R.J.4
Graves, D.E.5
Turnbough, C.L.6
Osheroff, N.7
-
104
-
-
84890834354
-
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions
-
Aldred, K.J.; Schwanz, H.A.; Li, G.; McPherson, S.A.; Turnbough, C.L., Jr.; Kerns, R.J.; Osheroff, N. Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. ACS Chem. Biol. 2013, 8, 2660-2668.
-
(2013)
ACS Chem. Biol
, vol.8
, pp. 2660-2668
-
-
Aldred, K.J.1
Schwanz, H.A.2
Li, G.3
McPherson, S.A.4
Turnbough, C.L.5
Kerns, R.J.6
Osheroff, N.7
-
105
-
-
22144473328
-
Etoposide, topoisomerase II and cancer
-
Baldwin, E.L.; Osheroff, N. Etoposide, topoisomerase ii and cancer. Curr. Med. Chem. Anticancer Agents 2005, 5, 363-372.
-
(2005)
Curr. Med. Chem. Anticancer Agents
, vol.5
, pp. 363-372
-
-
Baldwin, E.L.1
Osheroff, N.2
-
106
-
-
0029050909
-
A mutation in yeast top2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli GyrA alters sensitivity to eukaryotic topoisomerase inhibitors
-
Hsiung, Y.; Elsea, S.H.; Osheroff, N.; Nitiss, J.L. A mutation in yeast top2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli GyrA alters sensitivity to eukaryotic topoisomerase inhibitors. J. Biol. Chem. 1995, 270, 20359-20364.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20359-20364
-
-
Hsiung, Y.1
Elsea, S.H.2
Osheroff, N.3
Nitiss, J.L.4
-
107
-
-
84863168027
-
2+ -mediated dynamic bending of gate-DNA
-
USA
-
Lee, S.; Jung, S.-R.; Heo, K.; Byl, J.A.W.; Deweese, J.E.; Osheroff, N.; Hohng, S. DNA cleavage and opening reactions of human topoisomerase iiα are regulated via Mg2+ -mediated dynamic bending of gate-DNA. Proc. Natl. Acad. Sci. USA 2012, 109, 2925-2930.
-
(2012)
Proc. Natl. Acad. Sci.
, vol.109
, pp. 2925-2930
-
-
Lee, S.1
Jung, S.R.2
Heo, K.3
Byl, J.A.W.4
Deweese, J.E.5
Osheroff, N.6
Hohng, S.7
-
108
-
-
84869094439
-
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity
-
Schmidt, B.H.; Osheroff, N.; Berger, J.M. Structure of a topoisomerase ii-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat. Struct. Mol. Biol. 2012, 19, 1147-1154.
-
(2012)
Nat. Struct. Mol. Biol
, vol.19
, pp. 1147-1154
-
-
Schmidt, B.H.1
Osheroff, N.2
Berger, J.M.3
-
109
-
-
21844477302
-
Mechanisms of resistance to quinolones
-
Jacoby, G.A. Mechanisms of resistance to quinolones. Clin. Infect. Dis. 2005, 41, 120-126.
-
(2005)
Clin. Infect. Dis
, vol.41
, pp. 120-126
-
-
Jacoby, G.A.1
-
110
-
-
84905118923
-
Fluoroquinolone resistance: Mechanisms, impact on bacteria, and role in evolutionary success
-
Redgrave, L.S.; Sutton, S.B.; Webber, M.A.; Piddock, L.J. Fluoroquinolone resistance: Mechanisms, impact on bacteria, and role in evolutionary success. Trends Micobiol. 2014, 22, 438-445.
-
(2014)
Trends Micobiol
, vol.22
, pp. 438-445
-
-
Redgrave, L.S.1
Sutton, S.B.2
Webber, M.A.3
Piddock, L.J.4
-
111
-
-
70349126269
-
Probing the differential interactions of quinazolinedione pd 0305970 and quinolones with gyrase and topoisomerase IV
-
Pan, X.-S.; Gould, K.A.; Fisher, L.M. Probing the differential interactions of quinazolinedione pd 0305970 and quinolones with gyrase and topoisomerase IV. Antimicrob. Agents Chemother. 2009, 53, 3822-3831.
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 3822-3831
-
-
Pan, X.-S.1
Gould, K.A.2
Fisher, L.M.3
-
112
-
-
0036146667
-
Cleavable-complex formation by wild-type and quinolone-resistant streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones
-
Yague, G.; Morris, J.E.; Pan, X.-S.; Gould, K.A.; Fisher, L.M. Cleavable-complex formation by wild-type and quinolone-resistant streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones. Antimicrob. Agents Chemother. 2002, 46, 413-419.
-
(2002)
Antimicrob. Agents Chemother
, vol.46
, pp. 413-419
-
-
Yague, G.1
Morris, J.E.2
Pan, X.-S.3
Gould, K.A.4
Fisher, L.M.5
-
113
-
-
35948965576
-
Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action
-
Pfeiffer, E.S.; Hiasa, H. Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action. Antimicrob. Agents Chemother. 2007, 51, 3410-3412.
-
(2007)
Antimicrob. Agents Chemother
, vol.51
, pp. 3410-3412
-
-
Pfeiffer, E.S.1
Hiasa, H.2
-
114
-
-
74049088254
-
Quinolones: Action and resistance updated
-
Drlica, K.; Hiasa, H.; Kerns, R.; Malik, M.; Mustaev, A.; Zhao, X. Quinolones: Action and resistance updated. Curr. Top. Med. Chem. 2009, 9, 981-988.
-
(2009)
Curr. Top. Med. Chem
, vol.9
, pp. 981-988
-
-
Drlica, K.1
Hiasa, H.2
Kerns, R.3
Malik, M.4
Mustaev, A.5
Zhao, X.6
-
115
-
-
0038312025
-
Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai
-
China
-
Wang, M.; Tran, J.H.; Jacoby, G.A.; Zhang, Y.; Wang, F.; Hooper, D.C. Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from shanghai, china. Antimicrob. Agents Chemother. 2003, 47, 2242-2248.
-
(2003)
Antimicrob. Agents Chemother
, vol.47
, pp. 2242-2248
-
-
Wang, M.1
TranJ, H.2
Jacoby, G.A.3
Zhang, Y.4
Wang, F.5
Hooper, D.C.6
-
116
-
-
79955914895
-
Plasmid-mediated quinolone resistance: An update
-
Rodriguez-Martinez, J.M.; Cano, M.E.; Velasco, C.; Martinez-Martinez, L.; Pascual, A. Plasmid-mediated quinolone resistance: An update. J. Infect. Chemother. 2011, 17, 149-182.
-
(2011)
J. Infect. Chemother.
, vol.17
, pp. 149-182
-
-
Rodriguez-Martinez, J.M.1
Cano, M.E.2
Velasco, C.3
Martinez-Martinez, L.4
Pascual, A.5
-
117
-
-
0031728829
-
Alteration in the gyra subunit of DNA gyrase and the parc subunit of DNA topoisomerase IV in quinolone-resistant clinical isolates of Staphylococcus epidermidis
-
Li, Z.; Deguchi, T.; Yasuda, M.; Kawamura, T.; Kanematsu, E.; Nishino, Y.; Ishihara, S.; Kawada, Y. Alteration in the gyra subunit of DNA gyrase and the parc subunit of DNA topoisomerase IV in quinolone-resistant clinical isolates of Staphylococcus epidermidis. Antimicrob. Agents Chemother. 1998, 42, 3293-3295.
-
(1998)
Antimicrob. Agents Chemother
, vol.42
, pp. 3293-3295
-
-
Li, Z.1
Deguchi, T.2
Yasuda, M.3
Kawamura, T.4
Kanematsu, E.5
Nishino, Y.6
Ishihara, S.7
Kawada, Y.8
-
118
-
-
33748885240
-
The worldwide emergence of plasmid-mediated quinolone resistance
-
Robicsek, A.; Jacoby, G.A.; Hooper, D.C. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect. Dis. 2006, 6, 629-640.
-
(2006)
Lancet Infect. Dis
, vol.6
, pp. 629-640
-
-
Robicsek, A.1
Jacoby, G.A.2
Hooper, D.C.3
-
119
-
-
70449111402
-
Plasmid-mediated quinolone resistance: A multifaceted threat
-
Strahilevitz, J.; Jacoby, G.A.; Hooper, D.C.; Robicsek, A. Plasmid-mediated quinolone resistance: A multifaceted threat. Clin. Microbiol. Rev. 2009, 22, 664-689.
-
(2009)
Clin. Microbiol. Rev
, vol.22
, pp. 664-689
-
-
Strahilevitz, J.1
Jacoby, G.A.2
Hooper, D.C.3
Robicsek, A.4
-
120
-
-
0032515790
-
Quinolone resistance from a transferable plasmid
-
Martinez-Martinez, L.; Pascual, A.; Jacoby, G.A. Quinolone resistance from a transferable plasmid. Lancet 1998, 351, 797-799.
-
(1998)
Lancet
, vol.351
, pp. 797-799
-
-
Martinez-Martinez, L.1
Pascual, A.2
Jacoby, G.A.3
-
121
-
-
0037117605
-
Mechanism of plasmid-mediated quinolone resistance
-
Tran, J.H.; Jacoby, G.A. Mechanism of plasmid-mediated quinolone resistance. Proc. Natl. Acad. Sci. USA 2002, 99, 5638-5642.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5638-5642
-
-
Tran, J.H.1
Jacoby, G.A.2
-
122
-
-
79956033121
-
Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: Conserved surface loops direct the activity of a qnr protein from a gram-negative bacterium
-
Xiong, X.; Bromley, E.H.C.; Oelschlaeger, P.; Woolfson, D.N.; Spencer, J. Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: Conserved surface loops direct the activity of a qnr protein from a gram-negative bacterium. Nucleic Acids Res. 2011, 39, 3917-3927.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 3917-3927
-
-
Xiong, X.1
Bromley, E.H.C.2
Oelschlaeger, P.3
Woolfson, D.N.4
Spencer, J.5
-
123
-
-
84887481649
-
Ciprofloxacin treatment failure in a murine model of pyelonephritis due to an AAC (6')-Ib-cr-producing Escherichia coli strain susceptible to ciprofloxacin in vitro
-
Guillard, T.; Cambau, E.; Chau, F.; Massias, L.; de Champs, C.; Fantin, B. Ciprofloxacin treatment failure in a murine model of pyelonephritis due to an AAC (6')-Ib-cr-producing Escherichia coli strain susceptible to ciprofloxacin in vitro. Antimicrob. Agents Chemother. 2013, 57, 5830-5835.
-
(2013)
Antimicrob. Agents Chemother.
, Issue.57
, pp. 5830-5835
-
-
Guillard, T.1
Cambau, E.2
Chau, F.3
Massias, L.4
De Champs, C.5
Fantin, B.6
-
124
-
-
34247568394
-
Efflux pumps as antimicrobial resistance mechanisms
-
Poole, K. Efflux pumps as antimicrobial resistance mechanisms. Ann. Med. 2007, 39, 162-176.
-
(2007)
Ann. Med
, vol.39
, pp. 162-176
-
-
Poole, K.1
-
125
-
-
0029966719
-
Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones
-
Goldman, J.D.; White, D.G.; Levy, S.B. Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones. Antimicrob. Agents Chemother. 1996, 40, 1266-1269.
-
(1996)
Antimicrob. Agents Chemother
, vol.40
, pp. 1266-1269
-
-
Goldman, J.D.1
White, D.G.2
Levy, S.B.3
|