Analysis of mutations in the gyrA and gyrB genes and their association with the resistance of mycobacterium tuberculosis to levofloxacin, moxifloxacin and gatifloxacin

Journal of Medical Microbiology

Volumn 62, Issue PART1, 2013, Pages 108-113

  Nosova, Elena Yu ^a   Bukatina, Anastasia A ^a   Isaeva, Yulia D ^a   Makarova, Marina V ^a   Yu, Ksenia ^a   Moroz, Arkadyi M ^a  

^a Moscow Scientific and Clinical Antituberculosis Center   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARAGINE; ASPARTIC ACID; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) B; GATIFLOXACIN; HISTAMINE; ISONIAZID; LEVOFLOXACIN; MOXIFLOXACIN; OFLOXACIN; RIFAMPICIN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS RESISTANCE; DNA SEQUENCE; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; LUNG TUBERCULOSIS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANT TUBERCULOSIS; MUTATIONAL ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RUSSIAN FEDERATION; SEQUENCE ANALYSIS;

ANTITUBERCULAR AGENTS; AZA COMPOUNDS; DNA GYRASE; DRUG RESISTANCE, BACTERIAL; FLUOROQUINOLONES; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OFLOXACIN; QUINOLINES; RUSSIA; TUBERCULOSIS, PULMONARY;

EID: 84871111160     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.046821-0     Document Type: Article

References (29)

1. An, D. D., Hong Duyen, N. T., Lan, N. T. N., Hoa, D. V., Ha, D. T. M., Kiet, V. S., Thu, D. D. A., Van Vinh Chau, N., Dung, N. H. & other authors (2009). Beijing genotype of Mycobacterium tuberculosis is significantly associated with high-level fluoroquinolone resistance in Vietnam. Antimicrob Agents Chemother 53, 4835-4839.
2. Antonova, O. V., Gryadunov, D. A., Lapa, S. A., Kuz'min, A. V., Larionova, E. E., Smirnova, T. G., Nosova, E. Y., Skotnikova, O. I., Chernousova, L. N. & other authors (2008). Detection of mutations in Mycobacterium tuberculosis genome determining resistance to fluoroquinolones by hybridization on biological microchips. Bull Exp Biol Med 145, 108-113.
3. Cui, Z., Wang, J., Lu, J., Huang, X. & Hu, Z. (2011). Association of mutation patterns in gyrA/B genes and ofloxacin resistance levels in Mycobacterium tuberculosis isolates from East China in 2009. BMC Infect Dis 11, 78.
4. Delgado, M. B. & Telenti, A. (1996). Selected PCR Protocols for Emerging Infectious Diseases. Edited by D. H. Persing. Washington, DC: American Society for Microbiology.
5. El Sahly, H. M., Teeter, L. D., Jost, K. C., Jr, Dunbar, D., Lew, J. & Graviss, E. A. (2011). Incidence of moxifloxacin resistance in clinical Mycobacterium tuberculosis isolates in Houston, Texas. J Clin Microbiol 49, 2942-2945.
6. Feuerriegel, S., Cox, H. S., Zarkua, N., Karimovich, H. A., Braker, K., Rüsch-Gerdes, S. & Niemann, S. (2009). Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment. Antimicrob Agents Chemother 53, 3353-3356.
7. Ginsburg, A. S., Grosset, J. H. & Bishai, W. R. (2003). Fluoroquinolones, tuberculosis, and resistance. Lancet Infect Dis 3, 432-442.
8. Gryadunov, D., Dementieva, E., Mikhailovich, V., Nasedkina, T., Rubina, A., Savvateeva, E., Fesenko, E., Chudinov, A., Zimenkov, D. & other authors (2011). Gel-based microarrays in clinical diagnostics in Russia. Expert Rev Mol Diagn 11, 839-853.
9. Kam, K. M., Yip, C. W., Cheung, T. L., Tang, H. S., Leung, O. C. & Chan, M. Y. (2006). Stepwise decrease in moxifloxacin susceptibility amongst clinical isolates of multidrug-resistant Mycobacterium tuberculosis: correlation with ofloxacin susceptibility. Microb Drug Resist 12, 7-11.
10. Kim, H., Nakajima, C., Yokoyama, K., Rahim, Z., Kim, Y. U., Oguri, H. & Suzuki, Y. (2011). Impact of the E540V amino acid substitution in GyrB of Mycobacterium tuberculosis on quinolone resistance. Antimicrob Agents Chemother 55, 3661-3667.
11. Lau, R. W., Ho, P. L., Kao, R. Y., Yew, W. W., Lau, T. C., Cheng, V. C., Yuen, K. Y., Tsui, S. K., Chen, X. & Yam, W. C. (2011). Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74. Antimicrob Agents Chemother 55, 608-614.
12. Matrat, S., Veziris, N., Mayer, C., Jarlier, V., Truffot-Pernot, C., Camuset, J., Bouvet, E., Cambau, E. & Aubry, A. (2006). Functional analysis of DNA gyrase mutant enzymes carrying mutations at position 88 in the A subunit found in clinical strains of Mycobacterium tuberculosis resistant to fluoroquinolones. Antimicrob Agents Chemother 50, 4170-4173.
13. Merle, C. S., Sismanidis, C., Bah Sow, O., Gninafon, M., Horton, J., Lapujade, O., Lo, M. B., Mitchinson, D. A., Perronne, C. & other authors (2012). A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the gatifloxacin for TB (OFLOTUB) project. Trials 13, 61.
14. Mokrousov, I., Otten, T., Manicheva, O., Potapova, Y., Vishnevsky, B., Narvskaya, O. & Rastogi, N. (2008). Molecular characterization of ofloxacin-resistant Mycobacterium tuberculosis strains from Russia. Antimicrob Agents Chemother 52, 2937-2939.
15. Order of the Ministry of Health of the Russian Federation (2003). Improvement of tuberculosis-controlling measures in the Russian Federation under no. 109 on March 21 2003, In Russian; last accessed 5 April 2012. http://48rospotrebnadzor.ru/files.aspx?id=1bf0f4ed590545f3b2921079c2669ba8
16. Pantel, A., Petrella, S., Matrat, S., Brossier, F., Bastian, S., Reitter, D., Jarlier, V., Mayer, C. & Aubry, A. (2011). DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis. Antimicrob Agents Chemother 55, 4524-4529.
17. Pitaksajjakul, P., Wongwit, W., Punprasit, W., Eampokalap, B., Peacock, S. & Ramasoota, P. (2005). Mutations in the gyrA and gyrB genes of fluoroquinolone-resistant Mycobacterium tuberculosis from TB patients in Thailand. Southeast Asian J Trop Med Public Health 36 (Suppl. 4), 228-237.
18. Poissy, J., Aubry, A., Fernandez, C., Lott, M. C., Chauffour, A., Jarlier, V., Farinotti, R. & Veziris, N. (2010). Should moxifloxacin be used for the treatment of extensively drug-resistant tuberculosis? An answer from a murine model. Antimicrob Agents Chemother 54, 4765-4771.
19. Rodríguez, J. C., Ruiz, M., Lo ́pez, M. & Royo, G. (2002). In vitro activity of moxifloxacin, levofloxacin, gatifloxacin and linezolidagainst Mycobacterium tuberculosis. Int J Antimicrob Agents 20, 464-467.
20. Rüsch-Gerdes, S., Pfyffer, G. E., Casal, M., Chadwick, M. & Siddiqi, S. (2006). Multicenter laboratory validation of the BACTEC MGIT 960 technique for testing susceptibilities of Mycobacterium tuberculosis to classical second-line drugs and newer antimicrobials. J Clin Microbiol 44, 688-692.
21. Shi, R., Zhang, J., Li, C., Kazumi, Y. & Sugawara, I. (2006). Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing. J Clin Microbiol 44, 4566-4568.
22. Siddiqi, S. & Rusch-Gerdes, S. (2007). MGIT Procedure Manual. For BACTEC MGIT 960 TB System (Also applicable for Manual MGIT), Mycobacteria Growth Indicator Tube (MGIT), Culture and Drug Susceptibility Demonstration Projects. http://www.finddiagnostics.org/export/sites/default/resourcecentre/find_documentation/pdfs/mgit_manual_nov_2007.pdf
23. Takiff, H. E., Salazar, L., Guerrero, C., Philipp, W., Huang, W. M., Kreiswirth, B., Cole, S. T., Jacobs, W. R., Jr & Telenti, A. (1994). Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrob Agents Chemother 38, 773-780.
24. van Doorn, H. R., An, D. D., de Jong, M. D., Lan, N. T., Hoa, D. V., Quy, H. T., Chau, N. V., Duy, P. M., Tho, D. Q. & other authors (2008). Fluoroquinolone resistance detection in Mycobacterium tuberculosis with locked nucleic acid probe real-time PCR. Int J Tuberc Lung Dis 12, 736-742.
25. Von Groll, A., Martin, A., Jureen, P., Hoffner, S., Vandamme, P., Portaels, F., Palomino, J. C. & da Silva, P. A. (2009). Fluoroquinolone resistance in Mycobacterium tuberculosis and mutations in gyrA and gyrB. Antimicrob Agents Chemother 53, 4498-4500.
26. Wang, J. Y., Lee, L. N., Lai, H. C., Wang, S. K., Jan, I. S., Yu, C. J., Hsueh, P. R. & Yang, P. C. (2007). Fluoroquinolone resistance in Mycobacterium tuberculosis isolates: associated genetic mutations and relationship to antimicrobial exposure. J Antimicrob Chemother 59, 860-865.
27. Xu, P., Li, X., Zhao, M., Gui, X., DeRiemer, K., Gagneux, S., Mei, J. & Gao, Q. (2009). Prevalence of fluoroquinolone resistance among tuberculosis patients in Shanghai, China. Antimicrob Agents Chemother 53, 3170-3172.
28. Yin, X. & Yu, Z. (2010). Mutation characterization of gyrA and gyrB genes in levofloxacin-resistant Mycobacterium tuberculosis clinical isolates from Guangdong Province in China. J Infect 61, 150-154.
29. Zhao, B. Y., Pine, R., Domagala, J. & Drlica, K. (1999). Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages. Antimicrob Agents Chemother 43, 661-666.