Optimization of 1,2,3,4-tetrahydroacridin-9(10 H)-ones as antimalarials utilizing structure-activity and structure-property relationships

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4399-4426

  Cross, R Matthew ^a   Maignan, Jordany R ^a   Mutka, Tina S ^b   Luong, Lisa ^a   Sargent, Justin ^a   Kyle, Dennis E ^b   Manetsch, Roman ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 2,2 DIMETHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 3 HEPTYL 7 METHOXY 2 METHYL 4 QUINOLINOL; 3 METHOXY 6,7,8,9,10,11 HEXAHYDROCYCLOOCTA[B]QUINOLIN 12(5H)ONE; 3 METHOXY 7,8,9,10 TETRAHYDRO 5H CYCLOHEPTA[B]QUINOLIN 11(6H)ONE; 3 PHENYL 4(1H)QUINOLONE; 3 TRIFLUOROMETHYL 6,7,8,9,10,11 HEXAHYDROCYCLOOCTA[B]QUINOLIN 12(5H)ONE; 3 TRIFLUOROMETHYL 7,8,9,10 TETRAHYDRO 5H CYCLOHEPTA[B]QUINOLIN 11(6H)ONE; 5 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 5 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 5 METHOXY 2,2 DIMETHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 5 METHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 6 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 6 METHOXY 2,2 DIMETHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 6 METHOXY 2,3 DIHYDRO 1H CYCLOPENTA[B]QUINOLIN 9(4H)ONE; 6 METHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 6 TRIFLUOROMETHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 6 TRIFLUOROMETHYL 2,3 DIHYDRO 1H CYCLOPENTA[B]QUINOLIN 9(4H)ONE; 7 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 7 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 7 METHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 8 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 8 METHOXY 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; 8 METHYL 1,2,3,4 TETRAHYDROACRIDIN 9(10H)ONE; ANTIMALARIAL AGENT; FLOXACRINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WR 243246; WR 243251;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ACRIDINES; ANIMALS; ANTIMALARIALS; CELL LINE; DRUG RESISTANCE; ERYTHROCYTES; HUMANS; MICE; MICROSOMES, LIVER; PLASMODIUM FALCIPARUM; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960153362     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200015a     Document Type: Article

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