-
2
-
-
0037448353
-
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
-
Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, RegnaniG, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 2003;348:203-13.
-
(2003)
N Engl J Med
, vol.348
, pp. 203-213
-
-
Zhang, L.1
Conejo-Garcia, J.R.2
Katsaros, D.3
Gimotty, P.A.4
Massobrio, M.5
Regnani, G.6
-
3
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006;313: 1960-4.
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
Kirilovsky, A.4
Mlecnik, B.5
Lagorce-Pages, C.6
-
4
-
-
84864059882
-
Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma
-
Azimi F, Scolyer RA, Rumcheva P, Moncrieff M, Murali R, McCarthy SW, et al. Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. J Clin Oncol 2012;30: 2678-83.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2678-2683
-
-
Azimi, F.1
Scolyer, R.A.2
Rumcheva, P.3
Moncrieff, M.4
Murali, R.5
McCarthy, S.W.6
-
5
-
-
27144500671
-
Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8 T cells in patients with melanoma
-
Rosenberg SA, Sherry RM, Morton KE, Scharfman WJ, Yang JC, Topalian SL, et al. Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8 T cells in patients with melanoma. J Immunol 2005;175:6169-76.
-
(2005)
J Immunol
, vol.175
, pp. 6169-6176
-
-
Rosenberg, S.A.1
Sherry, R.M.2
Morton, K.E.3
Scharfman, W.J.4
Yang, J.C.5
Topalian, S.L.6
-
6
-
-
0032416085
-
Viral immune evasion due to persistence of activated T cells without effector function
-
Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, Altman JD, et al. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 1998;188:2205-13.
-
(1998)
J Exp Med
, vol.188
, pp. 2205-2213
-
-
Zajac, A.J.1
Blattman, J.N.2
Murali-Krishna, K.3
Sourdive, D.J.4
Suresh, M.5
Altman, J.D.6
-
7
-
-
70349569569
-
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
-
Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009; 114:1537-44.
-
(2009)
Blood
, vol.114
, pp. 1537-1544
-
-
Ahmadzadeh, M.1
Johnson, L.A.2
Heemskerk, B.3
Wunderlich, J.R.4
Dudley, M.E.5
White, D.E.6
-
8
-
-
66949111877
-
PD-1 is a regulator of NY-ESO-1-specific CD8 T cell expansion in melanoma patients
-
Fourcade J, Kudela P, Sun Z, Shen H, Land SR, Lenzner D, et al. PD-1 is a regulator of NY-ESO-1-specific CD8 T cell expansion in melanoma patients. J Immunol 2009;182:5240-9.
-
(2009)
J Immunol
, vol.182
, pp. 5240-5249
-
-
Fourcade, J.1
Kudela, P.2
Sun, Z.3
Shen, H.4
Land, S.R.5
Lenzner, D.6
-
9
-
-
57849168934
-
Coregulation of CD8 T cell exhaustion by multiple inhibitory receptors during chronic viral infection
-
Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, et al. Coregulation of CD8 T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 2009;10: 29-37.
-
(2009)
Nat Immunol
, vol.10
, pp. 29-37
-
-
Blackburn, S.D.1
Shin, H.2
Haining, W.N.3
Zou, T.4
Workman, C.J.5
Polley, A.6
-
10
-
-
0037383592
-
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
-
Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003;77: 4911-27.
-
(2003)
J Virol
, vol.77
, pp. 4911-4927
-
-
Wherry, E.J.1
Blattman, J.N.2
Murali-Krishna, K.3
Van Der Most, R.4
Ahmed, R.5
-
11
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006;443:350-4.
-
(2006)
Nature
, vol.443
, pp. 350-354
-
-
Day, C.L.1
Kaufmann, D.E.2
Kiepiela, P.3
Brown, J.A.4
Moodley, E.S.5
Reddy, S.6
-
12
-
-
35349014587
-
Molecular signature of CD8 T cell exhaustion during chronic viral infection
-
Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, et al. Molecular signature of CD8 T cell exhaustion during chronic viral infection. Immunity 2007;27:670-84.
-
(2007)
Immunity
, vol.27
, pp. 670-684
-
-
Wherry, E.J.1
Ha, S.J.2
Kaech, S.M.3
Haining, W.N.4
Sarkar, S.5
Kalia, V.6
-
13
-
-
84929000784
-
TIGIT and PD-1 impair tumor antigen-specific CD8 T cells in melanoma patients
-
Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sander C, et al. TIGIT and PD-1 impair tumor antigen-specific CD8 T cells in melanoma patients. J Clin Invest 2015;125:2046-58.
-
(2015)
J Clin Invest
, vol.125
, pp. 2046-2058
-
-
Chauvin, J.M.1
Pagliano, O.2
Fourcade, J.3
Sun, Z.4
Wang, H.5
Sander, C.6
-
14
-
-
84863115998
-
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate Tcell function to promote tumoral immune escape
-
Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate Tcell function to promote tumoral immune escape. Cancer Res 2012; 72:917-27.
-
(2012)
Cancer Res
, vol.72
, pp. 917-927
-
-
Woo, S.R.1
Turnis, M.E.2
Goldberg, M.V.3
Bankoti, J.4
Selby, M.5
Nirschl, C.J.6
-
15
-
-
84919494669
-
The immunoreceptor TIGIT regulates antitumor and antiviral CD8() T cell effector function
-
Johnston RJ, Comps-Agrar L, Hackney J, Yu X, HuseniM, Yang Y, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8() T cell effector function. Cancer Cell 2014;26:923-37.
-
(2014)
Cancer Cell
, vol.26
, pp. 923-937
-
-
Johnston, R.J.1
Comps-Agrar, L.2
Hackney, J.3
Yu, X.4
Huseni, M.5
Yang, Y.6
-
16
-
-
77957723967
-
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8 T cell dysfunction in melanoma patients
-
Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8 T cell dysfunction in melanoma patients. J Exp Med 2010;207:2175-86.
-
(2010)
J Exp Med
, vol.207
, pp. 2175-2186
-
-
Fourcade, J.1
Sun, Z.2
Benallaoua, M.3
Guillaume, P.4
Luescher, I.F.5
Sander, C.6
-
17
-
-
84863393290
-
CD8() T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
-
Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, et al. CD8() T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res 2012;72:887-96.
-
(2012)
Cancer Res
, vol.72
, pp. 887-896
-
-
Fourcade, J.1
Sun, Z.2
Pagliano, O.3
Guillaume, P.4
Luescher, I.F.5
Sander, C.6
-
18
-
-
84899748384
-
PD-1 identifies the patient-specific CD8() tumor-reactive repertoire infiltrating human tumors
-
Gros A, Robbins PF, Yao X, Li YF, Turcotte S, Tran E, et al. PD-1 identifies the patient-specific CD8() tumor-reactive repertoire infiltrating human tumors. J Clin Invest 2014;124:2246-59.
-
(2014)
J Clin Invest
, vol.124
, pp. 2246-2259
-
-
Gros, A.1
Robbins, P.F.2
Yao, X.3
Li, Y.F.4
Turcotte, S.5
Tran, E.6
-
19
-
-
79955005750
-
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults
-
Duraiswamy J, Ibegbu CC, Masopust D, Miller JD, Araki K, Doho GH, et al. Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. J Immunol 2011;186: 4200-12.
-
(2011)
J Immunol
, vol.186
, pp. 4200-4212
-
-
Duraiswamy, J.1
Ibegbu, C.C.2
Masopust, D.3
Miller, J.D.4
Araki, K.5
Doho, G.H.6
-
20
-
-
58149191881
-
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
-
Kinter AL, Godbout EJ, McNally JP, Sereti I, Roby GA, O'Shea MA, et al. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. J Immunol 2008;181:6738-46.
-
(2008)
J Immunol
, vol.181
, pp. 6738-6746
-
-
Kinter, A.L.1
Godbout, E.J.2
McNally, J.P.3
Sereti, I.4
Roby, G.A.5
O'Shea, M.A.6
-
21
-
-
84860330727
-
Antigenindependent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway
-
Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, et al. Antigenindependent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J Immunol 2012;188:3745-56.
-
(2012)
J Immunol
, vol.188
, pp. 3745-3756
-
-
Mujib, S.1
Jones, R.B.2
Lo, C.3
Aidarus, N.4
Clayton, K.5
Sakhdari, A.6
-
22
-
-
84922713971
-
VEGF-A modulates expression of inhibitory checkpoints on CD8 T cells in tumors
-
Voron T, Colussi O, Marcheteau E, Pernot S, Nizard M, Pointet AL, et al. VEGF-A modulates expression of inhibitory checkpoints on CD8 T cells in tumors. J Exp Med 2015;212:139-48.
-
(2015)
J Exp Med
, vol.212
, pp. 139-148
-
-
Voron, T.1
Colussi, O.2
Marcheteau, E.3
Pernot, S.4
Nizard, M.5
Pointet, A.L.6
-
23
-
-
84894266990
-
PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8() T cells induced by melanoma vaccines
-
Fourcade J, Sun Z, Pagliano O, Chauvin JM, Sander C, Janjic B, et al. PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8() T cells induced by melanoma vaccines. Cancer Res 2014;74:1045-55.
-
(2014)
Cancer Res
, vol.74
, pp. 1045-1055
-
-
Fourcade, J.1
Sun, Z.2
Pagliano, O.3
Chauvin, J.M.4
Sander, C.5
Janjic, B.6
-
24
-
-
84922394653
-
T cell differentiation in chronic infection and cancer: Functional adaptation or exhaustion
-
Speiser DE, Utzschneider DT, Oberle SG, Munz C, Romero P, Zehn D. T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion>Nat Rev Immunol 2014;14:768-74.
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 768-774
-
-
Speiser, D.E.1
Utzschneider, D.T.2
Oberle, S.G.3
Munz, C.4
Romero, P.5
Zehn, D.6
-
25
-
-
79957925314
-
Exhaustion of tumor-specific CD8() T cells in metastases from melanoma patients
-
Baitsch L, Baumgaertner P, Devevre E, Raghav SK, Legat A, Barba L, et al. Exhaustion of tumor-specific CD8() T cells in metastases from melanoma patients. J Clin Invest 2011;121:2350-60.
-
(2011)
J Clin Invest
, vol.121
, pp. 2350-2360
-
-
Baitsch, L.1
Baumgaertner, P.2
Devevre, E.3
Raghav, S.K.4
Legat, A.5
Barba, L.6
-
26
-
-
84893711428
-
Tolerance and exhaustion: Defining mechanisms of T cell dysfunction
-
Schietinger A, Greenberg PD. Tolerance and exhaustion: defining mechanisms of T cell dysfunction. Trends Immunol 2014;35:51-60.
-
(2014)
Trends Immunol
, vol.35
, pp. 51-60
-
-
Schietinger, A.1
Greenberg, P.D.2
-
27
-
-
0036172220
-
Cytotoxic T lymphocyte antigen-4 accumulation in theimmunological synapse is regulated by TCR signal strength
-
Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in theimmunological synapse is regulated by TCR signal strength. Immunity 2002;16:23-35.
-
(2002)
Immunity
, vol.16
, pp. 23-35
-
-
Egen, J.G.1
Allison, J.P.2
-
28
-
-
84864324543
-
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
-
Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med 2012;209:1201-17.
-
(2012)
J Exp Med
, vol.209
, pp. 1201-1217
-
-
Yokosuka, T.1
Takamatsu, M.2
Kobayashi-Imanishi, W.3
Hashimoto-Tane, A.4
Azuma, M.5
Saito, T.6
-
29
-
-
77957781776
-
Transcriptional analysis of HIV-specific CD8 T cells shows that PD-1 inhibits T cell function by upregulating BATF
-
Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, et al. Transcriptional analysis of HIV-specific CD8 T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med 2010;16: 1147-51.
-
(2010)
Nat Med
, vol.16
, pp. 1147-1151
-
-
Quigley, M.1
Pereyra, F.2
Nilsson, B.3
Porichis, F.4
Fonseca, C.5
Eichbaum, Q.6
-
30
-
-
57849101994
-
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
-
Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 2009;10:48-57.
-
(2009)
Nat Immunol
, vol.10
, pp. 48-57
-
-
Yu, X.1
Harden, K.2
Gonzalez, L.C.3
Francesco, M.4
Chiang, E.5
Irving, B.6
-
31
-
-
84937837169
-
Molecular and cellular insights into T cell exhaustion
-
Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol 2015;15:486-99.
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 486-499
-
-
Wherry, E.J.1
Kurachi, M.2
-
32
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T andmyeloid cells within B16 melanoma tumors
-
Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T andmyeloid cells within B16 melanoma tumors. Proc Natl Acad Sci US A 2010;107:4275-80.
-
(2010)
Proc Natl Acad Sci US A
, vol.107
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
33
-
-
84870230232
-
Progenitor and terminal subsets of CD8 T cells cooperate to contain chronic viral infection
-
Paley MA, Kroy DC, Odorizzi PM, Johnnidis JB, Dolfi DV, Barnett BE, et al. Progenitor and terminal subsets of CD8 T cells cooperate to contain chronic viral infection. Science 2012;338:1220-5.
-
(2012)
Science
, vol.338
, pp. 1220-1225
-
-
Paley, M.A.1
Kroy, D.C.2
Odorizzi, P.M.3
Johnnidis, J.B.4
Dolfi, D.V.5
Barnett, B.E.6
-
34
-
-
84948430497
-
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8 T cells
-
Odorizzi PM, Pauken KE, Paley MA, Sharpe A, Wherry EJ. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8 T cells. J Exp Med 2015;212:1125-37.
-
(2015)
J Exp Med
, vol.212
, pp. 1125-1137
-
-
Odorizzi, P.M.1
Pauken, K.E.2
Paley, M.A.3
Sharpe, A.4
Wherry, E.J.5
-
35
-
-
84859128199
-
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
-
Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37.
-
(2012)
Sci Transl Med
, vol.4
, pp. 127ra37
-
-
Taube, J.M.1
Anders, R.A.2
Young, G.D.3
Xu, H.4
Sharma, R.5
McMiller, T.L.6
-
36
-
-
84921449533
-
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
-
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, et al. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 2015;517:386-90.
-
(2015)
Nature
, vol.517
, pp. 386-390
-
-
Huang, Y.H.1
Zhu, C.2
Kondo, Y.3
Anderson, A.C.4
Gandhi, A.5
Russell, A.6
-
37
-
-
30044434075
-
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
-
Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 2005;6:1245-52.
-
(2005)
Nat Immunol
, vol.6
, pp. 1245-1252
-
-
Zhu, C.1
Anderson, A.C.2
Schubart, A.3
Xiong, H.4
Imitola, J.5
Khoury, S.J.6
-
38
-
-
84865422909
-
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
-
Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol 2012;13:832-42.
-
(2012)
Nat Immunol
, vol.13
, pp. 832-842
-
-
Chiba, S.1
Baghdadi, M.2
Akiba, H.3
Yoshiyama, H.4
Kinoshita, I.5
Dosaka-Akita, H.6
-
39
-
-
77951673268
-
TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
-
Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH. TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 2010;235:172-89.
-
(2010)
Immunol Rev
, vol.235
, pp. 172-189
-
-
Freeman, G.J.1
Casasnovas, J.M.2
Umetsu, D.T.3
DeKruyff, R.H.4
-
40
-
-
84897445677
-
VISTA is an immune checkpoint molecule for human T cells
-
Lines JL, Pantazi E, Mak J, Sempere LF, Wang L, O'Connell S, et al. VISTA is an immune checkpoint molecule for human T cells. Cancer Res 2014;74:1924-32.
-
(2014)
Cancer Res
, vol.74
, pp. 1924-1932
-
-
Lines, J.L.1
Pantazi, E.2
Mak, J.3
Sempere, L.F.4
Wang, L.5
O'Connell, S.6
-
41
-
-
0028675006
-
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
-
Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994; 1:793-801.
-
(1994)
Immunity
, vol.1
, pp. 793-801
-
-
Linsley, P.S.1
Greene, J.L.2
Brady, W.3
Bajorath, J.4
Ledbetter, J.A.5
Peach, R.6
-
42
-
-
0042922822
-
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
-
Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, et al. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 2003;198:557-67.
-
(2003)
J Exp Med
, vol.198
, pp. 557-567
-
-
Bottino, C.1
Castriconi, R.2
Pende, D.3
Rivera, P.4
Nanni, M.5
Carnemolla, B.6
-
43
-
-
79251572651
-
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions
-
Joller N, Hafler JP, Brynedal B, KassamN, Spoerl S, Levin SD, et al. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol 2011;186: 1338-42.
-
(2011)
J Immunol
, vol.186
, pp. 1338-1342
-
-
Joller, N.1
Hafler, J.P.2
Brynedal, B.3
Kassam, N.4
Spoerl, S.5
Levin, S.D.6
-
45
-
-
0028347925
-
Production of IL-10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma
-
Chen Q, Daniel V, Maher DW, Hersey P. Production of IL-10 by melanoma cells: examination of its role in immunosuppression mediated by melanoma. Int J Cancer 1994;56:755-60.
-
(1994)
Int J Cancer
, vol.56
, pp. 755-760
-
-
Chen, Q.1
Daniel, V.2
Maher, D.W.3
Hersey, P.4
-
46
-
-
0032709778
-
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function
-
Sharma S, Stolina M, Lin Y, Gardner B, Miller PW, Kronenberg M, et al. T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function. J Immunol 1999;163:5020-8.
-
(1999)
J Immunol
, vol.163
, pp. 5020-5028
-
-
Sharma, S.1
Stolina, M.2
Lin, Y.3
Gardner, B.4
Miller, P.W.5
Kronenberg, M.6
-
47
-
-
84942887332
-
Differential expression of immune-regulatory genes associated with PDL1 display in melanoma: Implications for PD-1 pathway blockade
-
Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, et al. Differential expression of immune-regulatory genes associated with PDL1 display in melanoma: implications for PD-1 pathway blockade. Clin Cancer Res 2015;21:3969-76.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3969-3976
-
-
Taube, J.M.1
Young, G.D.2
McMiller, T.L.3
Chen, S.4
Salas, J.T.5
Pritchard, T.S.6
-
48
-
-
0037136303
-
Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody
-
Vicari AP, Chiodoni C, Vaure C, Ait-Yahia S, Dercamp C, Matsos F, et al. Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody. J Exp Med 2002;196:541-9.
-
(2002)
J Exp Med
, vol.196
, pp. 541-549
-
-
Vicari, A.P.1
Chiodoni, C.2
Vaure, C.3
Ait-Yahia, S.4
Dercamp, C.5
Matsos, F.6
-
49
-
-
83455173552
-
IL-10 elicits IFNgamma-dependent tumor immune surveillance
-
MummJB, Emmerich J, Zhang X, Chan I, Wu L, Mauze S, et al. IL-10 elicits IFNgamma-dependent tumor immune surveillance. Cancer Cell 2011; 20:781-96.
-
(2011)
Cancer Cell
, vol.20
, pp. 781-796
-
-
Mumm, J.B.1
Emmerich, J.2
Zhang, X.3
Chan, I.4
Wu, L.5
Mauze, S.6
-
50
-
-
0035496946
-
Interleukin-10 promotes the maintenance of antitumor CD8() T-cell effector function in situ
-
Fujii S, Shimizu K, Shimizu T, Lotze MT. Interleukin-10 promotes the maintenance of antitumor CD8() T-cell effector function in situ. Blood 2001;98:2143-51.
-
(2001)
Blood
, vol.98
, pp. 2143-2151
-
-
Fujii, S.1
Shimizu, K.2
Shimizu, T.3
Lotze, M.T.4
-
51
-
-
33748357735
-
A2A adenosine receptor protects tumors from antitumor T cells
-
Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, WongMK, et al. A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad Sci U S A 2006;103:13132-7.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13132-13137
-
-
Ohta, A.1
Gorelik, E.2
Prasad, S.J.3
Ronchese, F.4
Lukashev, D.5
Wong, M.K.6
-
52
-
-
34250884676
-
Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8 and CD4 T lymphocytes by adenosine-protein kinase A type i signaling
-
Raskovalova T, Lokshin A, Huang X, Su Y, Mandic M, Zarour HM, et al. Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8 and CD4 T lymphocytes by adenosine-protein kinase A type I signaling. Cancer Res 2007;67: 5949-56.
-
(2007)
Cancer Res
, vol.67
, pp. 5949-5956
-
-
Raskovalova, T.1
Lokshin, A.2
Huang, X.3
Su, Y.4
Mandic, M.5
Zarour, H.M.6
-
53
-
-
84905657094
-
Extracellular adenosine-mediated modulation of regulatory T cells
-
Ohta A, Sitkovsky M. Extracellular adenosine-mediated modulation of regulatory T cells. Front Immunol 2014;5:304.
-
(2014)
Front Immunol
, vol.5
, pp. 304
-
-
Ohta, A.1
Sitkovsky, M.2
-
54
-
-
84883422236
-
Blockade of A2A receptors potently suppresses the metastasis of CD73 tumors
-
Beavis PA, Divisekera U, Paget C, Chow MT, John LB, Devaud C, et al. Blockade of A2A receptors potently suppresses the metastasis of CD73 tumors. Proc Natl Acad Sci U S A 2013;110:14711-6.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 14711-14716
-
-
Beavis, P.A.1
Divisekera, U.2
Paget, C.3
Chow, M.T.4
John, L.B.5
Devaud, C.6
-
55
-
-
84904254163
-
Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor
-
Mittal D, Young A, Stannard K, Yong M, Teng MW, Allard B, et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Res 2014;74:3652-8.
-
(2014)
Cancer Res
, vol.74
, pp. 3652-3658
-
-
Mittal, D.1
Young, A.2
Stannard, K.3
Yong, M.4
Teng, M.W.5
Allard, B.6
-
56
-
-
0142137237
-
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase
-
Uyttenhove C, Pilotte L, Theate I, Stroobant V, Colau D, Parmentier N, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase. Nat Med 2003;9:1269-74.
-
(2003)
Nat Med
, vol.9
, pp. 1269-1274
-
-
Uyttenhove, C.1
Pilotte, L.2
Theate, I.3
Stroobant, V.4
Colau, D.5
Parmentier, N.6
-
57
-
-
34848915783
-
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2, 3-dioxygenase
-
Sharma MD, Baban B, Chandler P, Hou DY, Singh N, Yagita H, et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2, 3-dioxygenase. J Clin Invest 2007;117:2570-82.
-
(2007)
J Clin Invest
, vol.117
, pp. 2570-2582
-
-
Sharma, M.D.1
Baban, B.2
Chandler, P.3
Hou, D.Y.4
Singh, N.5
Yagita, H.6
-
58
-
-
84883863501
-
Upregulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8() T cells
-
Spranger S, Spaapen RM, Zha Y, Williams J, Meng Y, Ha TT, et al. Upregulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8() T cells. Sci Transl Med 2013;5: 200ra116.
-
(2013)
Sci Transl Med
, vol.5
, pp. 200ra116
-
-
Spranger, S.1
Spaapen, R.M.2
Zha, Y.3
Williams, J.4
Meng, Y.5
Ha, T.T.6
-
59
-
-
34248173331
-
Indoleamine 2, 3-dioxygenase and tumor-induced tolerance
-
Munn DH, Mellor AL. Indoleamine 2, 3-dioxygenase and tumor-induced tolerance. J Clin Invest 2007;117:1147-54.
-
(2007)
J Clin Invest
, vol.117
, pp. 1147-1154
-
-
Munn, D.H.1
Mellor, A.L.2
-
60
-
-
84880664259
-
Indoleamine 2, 3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
-
Holmgaard RB, Zamarin D, Munn DH, Wolchok JD, Allison JP. Indoleamine 2, 3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J Exp Med 2013; 210:1389-402.
-
(2013)
J Exp Med
, vol.210
, pp. 1389-1402
-
-
Holmgaard, R.B.1
Zamarin, D.2
Munn, D.H.3
Wolchok, J.D.4
Allison, J.P.5
-
61
-
-
84977161108
-
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8 () T cells directly within the tumor microenvironment
-
Spranger S, Koblish HK, Horton B, Scherle PA, Newton R, Gajewski TF. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8 () T cells directly within the tumor microenvironment. J Immunother Cancer 2014;2:3.
-
(2014)
J Immunother Cancer
, vol.2
, pp. 3
-
-
Spranger, S.1
Koblish, H.K.2
Horton, B.3
Scherle, P.A.4
Newton, R.5
Gajewski, T.F.6
-
62
-
-
84968911182
-
Preliminary results from a phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers [abstract]
-
Nov 6-8; National Harbour, MD. Milwaukee (WI): Society for Immunotherapy of Cancer; 2015. Abstract nr O7
-
Gangadhar TC, Hamid O, Smith DC, Bauer TM, Wasser J, Luke J, et al. Preliminary results from a phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers [abstract]. In: Proceedings of the 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015); 2015 Nov 6-8; National Harbour, MD. Milwaukee (WI): Society for Immunotherapy of Cancer; 2015. Abstract nr O7.
-
(2015)
Proceedings of the 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015)
-
-
Gangadhar, T.C.1
Hamid, O.2
Smith, D.C.3
Bauer, T.M.4
Wasser, J.5
Luke, J.6
-
63
-
-
84872593848
-
VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer
-
Terme M, Pernot S, Marcheteau E, Sandoval F, BenhamoudaN, Colussi O, et al. VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. Cancer Res 2013; 73:539-49.
-
(2013)
Cancer Res
, vol.73
, pp. 539-549
-
-
Terme, M.1
Pernot, S.2
Marcheteau, E.3
Sandoval, F.4
Benhamouda, N.5
Colussi, O.6
-
64
-
-
0029842830
-
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
-
Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 1996;2:1096-103.
-
(1996)
Nat Med
, vol.2
, pp. 1096-1103
-
-
Gabrilovich, D.I.1
Chen, H.L.2
Girgis, K.R.3
Cunningham, H.T.4
Meny, G.M.5
Nadaf, S.6
-
65
-
-
84876311772
-
Persistent LCMV infection is controlled by blockade of type i interferon signaling
-
Teijaro JR, Ng C, Lee AM, Sullivan BM, Sheehan KC, Welch M, et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 2013;340:207-11.
-
(2013)
Science
, vol.340
, pp. 207-211
-
-
Teijaro, J.R.1
Ng, C.2
Lee, A.M.3
Sullivan, B.M.4
Sheehan, K.C.5
Welch, M.6
-
66
-
-
79952767536
-
IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
-
Terawaki S, Chikuma S, Shibayama S, Hayashi T, Yoshida T, Okazaki T, et al. IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. J Immunol 2011;186:2772-9.
-
(2011)
J Immunol
, vol.186
, pp. 2772-2779
-
-
Terawaki, S.1
Chikuma, S.2
Shibayama, S.3
Hayashi, T.4
Yoshida, T.5
Okazaki, T.6
-
67
-
-
84939431542
-
PKCs sweeten cell metabolism by phosphorylation of Glut1
-
Siska PJ, Rathmell JC. PKCs sweeten cell metabolism by phosphorylation of Glut1. Mol Cell 2015;58:711-2.
-
(2015)
Mol Cell
, vol.58
, pp. 711-712
-
-
Siska, P.J.1
Rathmell, J.C.2
-
68
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 2015;162:1229-41.
-
(2015)
Cell
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
Qiu, J.2
O'Sullivan, D.3
Buck, M.D.4
Noguchi, T.5
Curtis, J.D.6
-
69
-
-
84941366350
-
Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
-
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell 2015;162:1217-28.
-
(2015)
Cell
, vol.162
, pp. 1217-1228
-
-
Ho, P.C.1
Bihuniak, J.D.2
Macintyre, A.N.3
Staron, M.4
Liu, X.5
Amezquita, R.6
-
70
-
-
84951313126
-
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
-
Zhao E, Maj T, Kryczek I, Li W, WuK, Zhao L, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol 2016;17:95-103.
-
(2016)
Nat Immunol
, vol.17
, pp. 95-103
-
-
Zhao, E.1
Maj, T.2
Kryczek, I.3
Li, W.4
Wu, K.5
Zhao, L.6
-
71
-
-
84899753178
-
PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
-
Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, et al. PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med 2014;211:781-90.
-
(2014)
J Exp Med
, vol.211
, pp. 781-790
-
-
Noman, M.Z.1
Desantis, G.2
Janji, B.3
Hasmim, M.4
Karray, S.5
Dessen, P.6
-
72
-
-
84891876304
-
Regulatory T cell subsets in human cancer: Are they regulating for or against tumor progression>
-
Whiteside TL. Regulatory T cell subsets in human cancer: Are they regulating for or against tumor progression>Cancer Immunol Immunother 2014;63:67-72.
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 67-72
-
-
Whiteside, T.L.1
-
73
-
-
84906536054
-
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
-
Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, et al. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med 2014;211:1905-18.
-
(2014)
J Exp Med
, vol.211
, pp. 1905-1918
-
-
Penaloza-MacMaster, P.1
Kamphorst, A.O.2
Wieland, A.3
Araki, K.4
Iyer, S.S.5
West, E.E.6
-
74
-
-
84902184973
-
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction
-
Bauer CA, Kim EY, Marangoni F, Carrizosa E, Claudio NM, Mempel TR. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest 2014;124:2425-40.
-
(2014)
J Clin Invest
, vol.124
, pp. 2425-2440
-
-
Bauer, C.A.1
Kim, E.Y.2
Marangoni, F.3
Carrizosa, E.4
Claudio, N.M.5
Mempel, T.R.6
-
75
-
-
77953747963
-
The PD-1 pathway in tolerance and autoimmunity
-
Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010;236:219-42.
-
(2010)
Immunol Rev
, vol.236
, pp. 219-242
-
-
Francisco, L.M.1
Sage, P.T.2
Sharpe, A.H.3
-
76
-
-
84898681799
-
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
-
Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 2014;40:569-81.
-
(2014)
Immunity
, vol.40
, pp. 569-581
-
-
Joller, N.1
Lozano, E.2
Burkett, P.R.3
Patel, B.4
Xiao, S.5
Zhu, C.6
-
77
-
-
84946771300
-
TIGIT predominantly regulates the immune response via regulatory T cells
-
Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, et al. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest 2015;125:4053-62.
-
(2015)
J Clin Invest
, vol.125
, pp. 4053-4062
-
-
Kurtulus, S.1
Sakuishi, K.2
Ngiow, S.F.3
Joller, N.4
Tan, D.J.5
Teng, M.W.6
-
78
-
-
4644342928
-
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
-
Turk MJ, Guevara-Patino JA, Rizzuto GA, Engelhorn ME, Sakaguchi S, Houghton AN. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med 2004;200: 771-82.
-
(2004)
J Exp Med
, vol.200
, pp. 771-782
-
-
Turk, M.J.1
Guevara-Patino, J.A.2
Rizzuto, G.A.3
Engelhorn, M.E.4
Sakaguchi, S.5
Houghton, A.N.6
-
79
-
-
84904038862
-
OX40 engagement depletes intratumoral Tregs via activating FcgammaRs, leading to antitumor efficacy
-
Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS, Brogdon JL. OX40 engagement depletes intratumoral Tregs via activating FcgammaRs, leading to antitumor efficacy. Immunol Cell Biol 2014;92:475-80.
-
(2014)
Immunol Cell Biol
, vol.92
, pp. 475-480
-
-
Bulliard, Y.1
Jolicoeur, R.2
Zhang, J.3
Dranoff, G.4
Wilson, N.S.5
Brogdon, J.L.6
-
80
-
-
84887081136
-
Anti-CCR4 mAb selectively depletes effector-type FoxP3CD4 regulatory T cells, evoking antitumor immune responses in humans
-
Sugiyama D, NishikawaH, Maeda Y, Nishioka M, Tanemura A, Katayama I, et al. Anti-CCR4 mAb selectively depletes effector-type FoxP3CD4 regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci U S A 2013;110:17945-50.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 17945-17950
-
-
Sugiyama, D.1
Nishikawa, H.2
Maeda, Y.3
Nishioka, M.4
Tanemura, A.5
Katayama, I.6
-
81
-
-
84884271914
-
Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma
-
Simpson TR, Li F, Montalvo-Ortiz W, Sepulveda MA, Bergerhoff K, Arce F, et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013;210:1695-710.
-
(2013)
J Exp Med
, vol.210
, pp. 1695-1710
-
-
Simpson, T.R.1
Li, F.2
Montalvo-Ortiz, W.3
Sepulveda, M.A.4
Bergerhoff, K.5
Arce, F.6
-
82
-
-
84884229186
-
Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
-
Bulliard Y, Jolicoeur R, Windman M, Rue SM, Ettenberg S, Knee DA, et al. Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med 2013;210: 1685-93.
-
(2013)
J Exp Med
, vol.210
, pp. 1685-1693
-
-
Bulliard, Y.1
Jolicoeur, R.2
Windman, M.3
Rue, S.M.4
Ettenberg, S.5
Knee, D.A.6
-
83
-
-
77951258918
-
Myeloid-derived suppressor cell heterogeneity and subset definition
-
Peranzoni E, Zilio S, Marigo I, Dolcetti L, Zanovello P, Mandruzzato S, et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr Opin Immunol 2010;22:238-44.
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 238-244
-
-
Peranzoni, E.1
Zilio, S.2
Marigo, I.3
Dolcetti, L.4
Zanovello, P.5
Mandruzzato, S.6
-
84
-
-
77950944395
-
Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
-
Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-7.
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 231-237
-
-
Mantovani, A.1
Sica, A.2
-
85
-
-
84944045501
-
Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner
-
Holmgaard RB, Zamarin D, Li Y, Gasmi B, Munn DH, Allison JP, et al. Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner. Cell Rep 2015;13:412-24.
-
(2015)
Cell Rep
, vol.13
, pp. 412-424
-
-
Holmgaard, R.B.1
Zamarin, D.2
Li, Y.3
Gasmi, B.4
Munn, D.H.5
Allison, J.P.6
-
86
-
-
84907484156
-
CSF1/ CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
-
Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, West BL, Luo J, et al. CSF1/ CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res 2014;74:5057-69.
-
(2014)
Cancer Res
, vol.74
, pp. 5057-5069
-
-
Zhu, Y.1
Knolhoff, B.L.2
Meyer, M.A.3
Nywening, T.M.4
West, B.L.5
Luo, J.6
-
87
-
-
68649096424
-
A role for the transcriptional repressor Blimp-1 in CD8() T cell exhaustion during chronic viral infection
-
Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, et al. A role for the transcriptional repressor Blimp-1 in CD8() T cell exhaustion during chronic viral infection. Immunity 2009;31: 309-20.
-
(2009)
Immunity
, vol.31
, pp. 309-320
-
-
Shin, H.1
Blackburn, S.D.2
Intlekofer, A.M.3
Kao, C.4
Angelosanto, J.M.5
Reiner, S.L.6
-
88
-
-
79959375167
-
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8 T cell responses during chronic infection
-
Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, et al. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8 T cell responses during chronic infection. Nat Immunol 2011;12:663-71.
-
(2011)
Nat Immunol
, vol.12
, pp. 663-671
-
-
Kao, C.1
Oestreich, K.J.2
Paley, M.A.3
Crawford, A.4
Angelosanto, J.M.5
Ali, M.A.6
-
89
-
-
34248399247
-
Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8 T cell functions during chronic viral infection
-
Agnellini P, Wolint P, Rehr M, Cahenzli J, Karrer U, Oxenius A. Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8 T cell functions during chronic viral infection. Proc Natl Acad Sci U S A 2007;104:4565-70.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4565-4570
-
-
Agnellini, P.1
Wolint, P.2
Rehr, M.3
Cahenzli, J.4
Karrer, U.5
Oxenius, A.6
-
90
-
-
84938739934
-
Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion
-
Giordano M, Henin C, Maurizio J, Imbratta C, Bourdely P, Buferne M, et al. Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion. EMBO J 2015; 34:2042-58.
-
(2015)
EMBO J
, vol.34
, pp. 2042-2058
-
-
Giordano, M.1
Henin, C.2
Maurizio, J.3
Imbratta, C.4
Bourdely, P.5
Buferne, M.6
-
91
-
-
84880119204
-
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells
-
Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, et al. Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. J Immunol 2013;191:540-4.
-
(2013)
J Immunol
, vol.191
, pp. 540-544
-
-
Youngblood, B.1
Noto, A.2
Porichis, F.3
Akondy, R.S.4
Ndhlovu, Z.M.5
Austin, J.W.6
-
92
-
-
84890130945
-
Alterations of immune response of non-small cell lung cancer with azacytidine
-
Wrangle J, Wang W, Koch A, Easwaran H, Mohammad HP, Vendetti F, et al. Alterations of immune response of non-small cell lung cancer with azacytidine. Oncotarget 2013;4:2067-79.
-
(2013)
Oncotarget
, vol.4
, pp. 2067-2079
-
-
Wrangle, J.1
Wang, W.2
Koch, A.3
Easwaran, H.4
Mohammad, H.P.5
Vendetti, F.6
-
93
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. NEngl J Med 2013;369:134-44.
-
(2013)
NEngl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
-
94
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le DT, Uram JN, WangH, Bartlett BR, KemberlingH, Eyring AD, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015;372:2509-20.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
-
95
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
-
96
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015;348:124-8.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
-
97
-
-
84922369377
-
The vigorous immunemicroenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints
-
Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, et al. The vigorous immunemicroenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov 2015;5:43-51.
-
(2015)
Cancer Discov
, vol.5
, pp. 43-51
-
-
Llosa, N.J.1
Cruise, M.2
Tam, A.3
Wicks, E.C.4
Hechenbleikner, E.M.5
Taube, J.M.6
-
98
-
-
84966862666
-
Dendritic cell-based immunotherapy: State of the art and beyond
-
Bol KF, Schreibelt G, Gerritsen WR, de Vries IJM, Figdor CG. Dendritic cell-based immunotherapy: state of the art and beyond. Clin Cancer Res 2016;22:1897-906.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1897-1906
-
-
Bol, K.F.1
Schreibelt, G.2
Gerritsen, W.R.3
De Vries, I.J.M.4
Figdor, C.G.5
-
99
-
-
84966769739
-
Targeting the heterogeneity of cancer with individualized neoepitope vaccines
-
Tureci O, Vormehr M, Diken M, Kreiter S, Huber C, Sahin U. Targeting the heterogeneity of cancer with individualized neoepitope vaccines. Clin Cancer Res 2016;22:1885-96.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1885-1896
-
-
Tureci, O.1
Vormehr, M.2
Diken, M.3
Kreiter, S.4
Huber, C.5
Sahin, U.6
-
100
-
-
84967145937
-
Making better chimeric antigen receptors for adoptive T-cell therapy
-
Maus MV, June CH. Making better chimeric antigen receptors for adoptive T-cell therapy. Clin Cancer Res 2016;22:1875-84.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1875-1884
-
-
Maus, M.V.1
June, C.H.2
-
101
-
-
84940372582
-
The next hurdle in cancer immunotherapy: Overcoming the non-T-cell-inflamed tumor microenvironment
-
Gajewski TF. The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor microenvironment. Semin Oncol 2015;42: 663-71.
-
(2015)
Semin Oncol
, vol.42
, pp. 663-671
-
-
Gajewski, T.F.1
-
102
-
-
84957093642
-
Loss of PTEN promotes resistance to T cell-mediated immunotherapy
-
Peng W, Chen JQ, Liu C, Malu S, Creasy C, Tetzlaff MT, et al. Loss of PTEN promotes resistance to T cell-mediated immunotherapy. Cancer Discov 2015;6:202-16.
-
(2015)
Cancer Discov
, vol.6
, pp. 202-216
-
-
Peng, W.1
Chen, J.Q.2
Liu, C.3
Malu, S.4
Creasy, C.5
Tetzlaff, M.T.6
-
103
-
-
84936953099
-
Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
-
Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 2015;523:231-5
-
(2015)
Nature
, vol.523
, pp. 231-235
-
-
Spranger, S.1
Bao, R.2
Gajewski, T.F.3
-
104
-
-
84967321420
-
The where, the when, and the how of immune monitoring for cancerimmunotherapies in the era of checkpoint inhibition
-
Hegde PS, Karanikas V, Evers S. The where, the when, and the how of immune monitoring for cancerimmunotherapies in the era of checkpoint inhibition. Clin Cancer Res 2016;22:1865-74.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1865-1874
-
-
Hegde, P.S.1
Karanikas, V.2
Evers, S.3
|