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Volumn 22, Issue 3, 2016, Pages 342-357

Activins in reproductive biology and beyond

Author keywords

Activin; Cancer; Follistatin; Inflammation; Inhibin; Ovary; Placenta; Pre eclampsia; Pregnancy; Testis

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIVIN; ACTIVIN A; ACTIVIN C; ACTIVIN RECEPTOR; FOLLISTATIN; FOLLITROPIN; INHIBIN; MYELOPID; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; GLYCOPROTEIN; INHIBIN BETA A SUBUNIT;

EID: 84965057983     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dmv058     Document Type: Article
Times cited : (144)

References (194)
  • 2
    • 0032402288 scopus 로고    scopus 로고
    • ActivinAstimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
    • Alak BM, Coskun S, Friedman CI, Kennard EA, Kim MH, Seifer DB. ActivinAstimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro. Fertil Steril 1998;70:1126-1130.
    • (1998) Fertil Steril , vol.70 , pp. 1126-1130
    • Alak, B.M.1    Coskun, S.2    Friedman, C.I.3    Kennard, E.A.4    Kim, M.H.5    Seifer, D.B.6
  • 4
    • 77953740874 scopus 로고    scopus 로고
    • Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion
    • Archambeault DR, Yao HH. Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion. Proc Natl Acad Sci USA 2010;107:10526-10531.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10526-10531
    • Archambeault, D.R.1    Yao, H.H.2
  • 5
    • 0035476481 scopus 로고    scopus 로고
    • Activins as regulators of branching morphogenesis
    • Ball EMA, Risbridger GP. Activins as regulators of branching morphogenesis. Dev Biol 2001;238:1-12.
    • (2001) Dev Biol , vol.238 , pp. 1-12
    • Ball, E.M.A.1    Risbridger, G.P.2
  • 6
    • 53749083995 scopus 로고    scopus 로고
    • Inhibin, activin, follistatin and FSH serum levels and testicular production are highly modulated during the first spermatogenic wave in mice
    • Barakat B, O'Connor AE, Gold E, de Kretser DM, Loveland KL. Inhibin, activin, follistatin and FSH serum levels and testicular production are highly modulated during the first spermatogenic wave in mice. Reproduction 2008;136:345-359.
    • (2008) Reproduction , vol.136 , pp. 345-359
    • Barakat, B.1    O'Connor, A.E.2    Gold, E.3    de Kretser, D.M.4    Loveland, K.L.5
  • 7
    • 0028790956 scopus 로고
    • Activin stimulates Sertoli cell proliferation in a defined period of rat testis development
    • Boitani C, Stefanini M, Fragale A, Morena AR. Activin stimulates Sertoli cell proliferation in a defined period of rat testis development. Endocrinology 1995;136:5438-5444.
    • (1995) Endocrinology , vol.136 , pp. 5438-5444
    • Boitani, C.1    Stefanini, M.2    Fragale, A.3    Morena, A.R.4
  • 9
    • 0034425726 scopus 로고    scopus 로고
    • Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions
    • Brown CW, Houston-Hawkins DE,Woodruff TK, Matzuk MM. Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet 2000;25:453-457.
    • (2000) Nat Genet , vol.25 , pp. 453-457
    • Brown, C.W.1    Houston-Hawkins, D.E.2    Woodruff, T.K.3    Matzuk, M.M.4
  • 18
    • 84892442792 scopus 로고    scopus 로고
    • FOXL2-induced follistatin attenuates activin A-stimulated cell proliferation in human granulosa cell tumors
    • Cheng J-C, Chang H-M, Qiu X, Fang L, Leung PCK. FOXL2-induced follistatin attenuates activin A-stimulated cell proliferation in human granulosa cell tumors. Biochem Biophys Res Commun 2014;443:537-542.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 537-542
    • Cheng, J.-C.1    Chang, H.-M.2    Qiu, X.3    Fang, L.4    Leung, P.C.K.5
  • 20
    • 0034457003 scopus 로고    scopus 로고
    • Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice
    • Cipriano SC, Chen L, Kumar TR, Matzuk MM. Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice. Endocrinology 2000;141:2319-2327.
    • (2000) Endocrinology , vol.141 , pp. 2319-2327
    • Cipriano, S.C.1    Chen, L.2    Kumar, T.R.3    Matzuk, M.M.4
  • 23
    • 0024536405 scopus 로고
    • The isolation and physiology of inhibin and related proteins
    • de Kretser DM, Robertson DM. The isolation and physiology of inhibin and related proteins. Biol Reprod 1989;40:33-47.
    • (1989) Biol Reprod , vol.40 , pp. 33-47
    • de Kretser, D.M.1    Robertson, D.M.2
  • 26
    • 0027410586 scopus 로고
    • Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function
    • de Winter J, Vanderstichele H, Timmerman M, Blok L, Themmen A, de Jong F. Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. Endocrinology 1993;132:975-982.
    • (1993) Endocrinology , vol.132 , pp. 975-982
    • de Winter, J.1    Vanderstichele, H.2    Timmerman, M.3    Blok, L.4    Themmen, A.5    de Jong, F.6
  • 28
    • 70449475325 scopus 로고    scopus 로고
    • Analysis of activin/ TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas
    • Dias VL, Rajpert-De Meyts E, McLachlan R, Loveland KL. Analysis of activin/ TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas. Reproduction 2009;138:801-811.
    • (2009) Reproduction , vol.138 , pp. 801-811
    • Dias, V.L.1    Rajpert-De Meyts, E.2    McLachlan, R.3    Loveland, K.L.4
  • 29
    • 33845956065 scopus 로고    scopus 로고
    • Comparison of activin A and cell-free fetal DNA levels in maternal plasma from patients at high risk for preeclampsia
    • Diesch CH, HolzgreveW, Hahn S, Zhong XY. Comparison of activin A and cell-free fetal DNA levels in maternal plasma from patients at high risk for preeclampsia. Prenat Diagn 2006;26:1267-1270.
    • (2006) Prenat Diagn , vol.26 , pp. 1267-1270
    • Diesch, C.H.1    Holzgreve, W.2    Hahn, S.3    Zhong, X.Y.4
  • 30
    • 0036212281 scopus 로고    scopus 로고
    • Expression and localization of activin receptors, Smads, and betaglycan to the postnatal rat ovary
    • Drummond AE, Le MT, Ethier J-F, Dyson M, Findlay JK. Expression and localization of activin receptors, Smads, and betaglycan to the postnatal rat ovary. Endocrinology 2002;143:1423-1433.
    • (2002) Endocrinology , vol.143 , pp. 1423-1433
    • Drummond, A.E.1    Le, M.T.2    Ethier, J.-F.3    Dyson, M.4    Findlay, J.K.5
  • 32
    • 0035652394 scopus 로고    scopus 로고
    • Follistatin and activinA serum concentrations in obese and non-obese patients with polycystic ovary syndrome
    • Eldar-Geva T, Spitz IM, GroomeNP, Margalioth EJ, Homburg R. Follistatin and activinA serum concentrations in obese and non-obese patients with polycystic ovary syndrome. Hum Reprod 2001;16:2552-2556.
    • (2001) Hum Reprod , vol.16 , pp. 2552-2556
    • Eldar-Geva, T.1    Spitz, I.M.2    Groome, N.P.3    Margalioth, E.J.4    Homburg, R.5
  • 34
    • 0028792415 scopus 로고
    • Activin causes premature superovulation
    • Erickson GF, Kokka S, Rivier C. Activin causes premature superovulation. Endocrinology 1995;136:4804-4813.
    • (1995) Endocrinology , vol.136 , pp. 4804-4813
    • Erickson, G.F.1    Kokka, S.2    Rivier, C.3
  • 35
    • 0023574612 scopus 로고
    • Structural characterization of follistatin: a novel follicle-stimulating hormone release-inhibiting polypeptide from the gonad
    • Esch FS, Shimasaki S, Mercado M, Cooksey K, Ling N, Ying S, Ueno N, Guillemin R. Structural characterization of follistatin: a novel follicle-stimulating hormone release-inhibiting polypeptide from the gonad. Mol Endocrinol 1987;1:849-855.
    • (1987) Mol Endocrinol , vol.1 , pp. 849-855
    • Esch, F.S.1    Shimasaki, S.2    Mercado, M.3    Cooksey, K.4    Ling, N.5    Ying, S.6    Ueno, N.7    Guillemin, R.8
  • 37
    • 0028113568 scopus 로고
    • Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins
    • Feijen A, Goumans MJ, van den AJ, Raaij E-V. Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. Development 1994;120:3621-3637.
    • (1994) Development , vol.120 , pp. 3621-3637
    • Feijen, A.1    Goumans, M.J.2    van den, A.J.3    Raaij, E.-V.4
  • 38
    • 0027212294 scopus 로고
    • Expression of type II activin receptor genes in the male and female reproductive tissues of the rat
    • FengZM, Madigan MB, Chen CL. Expression of type II activin receptor genes in the male and female reproductive tissues of the rat. Endocrinology 1993;132:2593-2600.
    • (1993) Endocrinology , vol.132 , pp. 2593-2600
    • Feng, Z.M.1    Madigan, M.B.2    Chen, C.L.3
  • 39
    • 0032529168 scopus 로고    scopus 로고
    • Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition
    • Ferguson CA, Tucker AS, Christensen L, Lau AL, Matzuk MM, Sharpe PT. Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev 1998;12:2636-2649.
    • (1998) Genes Dev , vol.12 , pp. 2636-2649
    • Ferguson, C.A.1    Tucker, A.S.2    Christensen, L.3    Lau, A.L.4    Matzuk, M.M.5    Sharpe, P.T.6
  • 43
    • 84861656630 scopus 로고    scopus 로고
    • Activins and activin antagonists in the prostate and prostate cancer
    • Gold E, Risbridger G. Activins and activin antagonists in the prostate and prostate cancer. Mol Cell Endocrinol 2012;359:107-112.
    • (2012) Mol Cell Endocrinol , vol.359 , pp. 107-112
    • Gold, E.1    Risbridger, G.2
  • 45
    • 84874107500 scopus 로고    scopus 로고
    • Activin-bc reduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice
    • Gold E, Marino FE, Harrison C, Makanji Y, Risbridger G. Activin-bc reduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice. J Pathol 2013;229:599-607.
    • (2013) J Pathol , vol.229 , pp. 599-607
    • Gold, E.1    Marino, F.E.2    Harrison, C.3    Makanji, Y.4    Risbridger, G.5
  • 48
    • 84903270261 scopus 로고    scopus 로고
    • Activin Asupplement in the hESCs culture enhances the endoderm differentiation efficiency
    • Guo S, Mao X, He F, Liu H, Ming L. Activin Asupplement in the hESCs culture enhances the endoderm differentiation efficiency. Cell Biol Int 2014;38:849-856.
    • (2014) Cell Biol Int , vol.38 , pp. 849-856
    • Guo, S.1    Mao, X.2    He, F.3    Liu, H.4    Ming, L.5
  • 51
    • 13944271697 scopus 로고    scopus 로고
    • Antagonists of activin signaling: mechanisms and potential biological applications
    • Harrison CA, Gray PC, Vale WW, Robertson DM. Antagonists of activin signaling: mechanisms and potential biological applications. Trends Endocrinol Metab 2005; 16:73-78.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 73-78
    • Harrison, C.A.1    Gray, P.C.2    Vale, W.W.3    Robertson, D.M.4
  • 52
    • 0030957937 scopus 로고    scopus 로고
    • A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells: endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate
    • Hashimoto O, Nakamura T, Shoji H, Shimasaki S, Hayashi Y, Sugino H. A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells: endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. J Biol Chem 1997;272:13835-13842.
    • (1997) J Biol Chem , vol.272 , pp. 13835-13842
    • Hashimoto, O.1    Nakamura, T.2    Shoji, H.3    Shimasaki, S.4    Hayashi, Y.5    Sugino, H.6
  • 53
    • 84881257262 scopus 로고    scopus 로고
    • The activins and their binding protein, follistatin-diagnostic and therapeutic targets in inflammatory disease and fibrosis
    • Hedger MP, de Kretser DM. The activins and their binding protein, follistatin-diagnostic and therapeutic targets in inflammatory disease and fibrosis. Cytokine Growth Factor Rev 2013;24:285-295.
    • (2013) Cytokine Growth Factor Rev , vol.24 , pp. 285-295
    • Hedger, M.P.1    de Kretser, D.M.2
  • 55
    • 0031438047 scopus 로고    scopus 로고
    • TGF-b signalling from cell membrane to nucleus through SMAD proteins
    • Heldin C-H, Miyazono K, ten Dijke P. TGF-b signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    ten Dijke, P.3
  • 58
    • 0028561817 scopus 로고
    • Growth factors in development: the role of TGF-b related polypeptide signalling molecules in embryogenesis
    • Hogan BL, Blessing M, Winnier GE, Suzuki N, Jones CM. Growth factors in development: the role of TGF-b related polypeptide signalling molecules in embryogenesis. Dev Suppl 1994;53-60.
    • (1994) Dev Suppl , pp. 53-60
    • Hogan, B.L.1    Blessing, M.2    Winnier, G.E.3    Suzuki, N.4    Jones, C.M.5
  • 61
    • 0028942101 scopus 로고
    • Cloning of a new member of the TGF-b family: a putative new activin bC chain
    • Hotten G, Neidhardt H, Schneider C, Pohl J. Cloning of a new member of the TGF-b family: a putative new activin bC chain. Biochem Biophys Res Commun 1995; 206:608-613.
    • (1995) Biochem Biophys Res Commun , vol.206 , pp. 608-613
    • Hotten, G.1    Neidhardt, H.2    Schneider, C.3    Pohl, J.4
  • 62
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-b superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. SB-431542 is a potent and specific inhibitor of transforming growth factor-b superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002;62:65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolás, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6    Laping, N.J.7    Hill, C.S.8
  • 63
    • 0026014287 scopus 로고
    • Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin
    • Inouye S, Guo Y, Depaolo L, Shimonaka M, Ling N, Shimasaki S. Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin. Endocrinology 1991; 129:815-822.
    • (1991) Endocrinology , vol.129 , pp. 815-822
    • Inouye, S.1    Guo, Y.2    Depaolo, L.3    Shimonaka, M.4    Ling, N.5    Shimasaki, S.6
  • 64
    • 0034457246 scopus 로고    scopus 로고
    • Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin
    • Jones KL, Brauman JN, Groome NP, de Kretser DM, Phillips DJ. Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin. Endocrinology 2000a;141:1905-1908.
    • (2000) Endocrinology , vol.141 , pp. 1905-1908
    • Jones, K.L.1    Brauman, J.N.2    Groome, N.P.3    de Kretser, D.M.4    Phillips, D.J.5
  • 65
    • 0033664018 scopus 로고    scopus 로고
    • Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregnancy and in women using progestin-only contraception
    • Jones RL, Salamonsen LA, Critchley HOD, Rogers PAW, Affandi B, Findlay JK. Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregnancy and in women using progestin-only contraception. Mol Hum Reprod 2000b;6:1107-1117.
    • (2000) Mol Hum Reprod , vol.6 , pp. 1107-1117
    • Jones, R.L.1    Salamonsen, L.A.2    Critchley, H.O.D.3    Rogers, P.A.W.4    Affandi, B.5    Findlay, J.K.6
  • 66
    • 0036342740 scopus 로고    scopus 로고
    • Activin A promotes human endometrial stromal cell decidualization in vitro
    • Jones RL, Salamonsen LA, Findlay JK. Activin A promotes human endometrial stromal cell decidualization in vitro. J Clin Endocrinol Metab 2002a;87:4001-4004.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4001-4004
    • Jones, R.L.1    Salamonsen, L.A.2    Findlay, J.K.3
  • 67
    • 0036217266 scopus 로고    scopus 로고
    • Expression of activin receptors, follistatin and betaglycan by human endometrial stromal cells; consistent with a role for activins during decidualization
    • Jones RL, Salamonsen LA, Zhao YC, Ethier J-F,Drummond AE, Findlay JK. Expression of activin receptors, follistatin and betaglycan by human endometrial stromal cells; consistent with a role for activins during decidualization. Mol Hum Reprod 2002b; 8:363-374.
    • (2002) Mol Hum Reprod , vol.8 , pp. 363-374
    • Jones, R.L.1    Salamonsen, L.A.2    Zhao, Y.C.3    Ethier, J.-F.4    Drummond, A.E.5    Findlay, J.K.6
  • 68
    • 36049023174 scopus 로고    scopus 로고
    • Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia
    • Jones KL, Mansell A, Patella S, Scott BJ, Hedger MP, de Kretser DM,Phillips DJ. Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc Natl Acad Sci USA 2007; 104:16239-16244.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 16239-16244
    • Jones, K.L.1    Mansell, A.2    Patella, S.3    Scott, B.J.4    Hedger, M.P.5    de Kretser, D.M.6    Phillips, D.J.7
  • 70
    • 29144511607 scopus 로고    scopus 로고
    • MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits
    • Kaminska B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochin Biophys Acta 2005;1754:253-262.
    • (2005) Biochin Biophys Acta , vol.1754 , pp. 253-262
    • Kaminska, B.1
  • 73
    • 0034486999 scopus 로고    scopus 로고
    • Ovarian follicular concentrations of activin, follistatin, inhibin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-2 (IGFBP-2), IGFBP-3, and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age
    • Klein NA, Battaglia DE, Woodruff TK, Padmanabhan V, Giudice LC, Bremner WJ, Soules MR. Ovarian follicular concentrations of activin, follistatin, inhibin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-2 (IGFBP-2), IGFBP-3, and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age. J Clin Endocrinol Metab 2000; 85:4520-4525.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4520-4525
    • Klein, N.A.1    Battaglia, D.E.2    Woodruff, T.K.3    Padmanabhan, V.4    Giudice, L.C.5    Bremner, W.J.6    Soules, M.R.7
  • 74
    • 0024575098 scopus 로고
    • Secretion of activin by interstitial cells in the testis
    • Lee W, Mason AJ, Schwall R, Szonyi E, Mather JP. Secretion of activin by interstitial cells in the testis. Science 1989;243:396-398.
    • (1989) Science , vol.243 , pp. 396-398
    • Lee, W.1    Mason, A.J.2    Schwall, R.3    Szonyi, E.4    Mather, J.P.5
  • 75
    • 34447532431 scopus 로고    scopus 로고
    • Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions
    • Lerch TF, Shimasaki S,Woodruff TK, Jardetzky TS. Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. J Biol Chem 2007; 282:15930-15939.
    • (2007) J Biol Chem , vol.282 , pp. 15930-15939
    • Lerch, T.F.1    Shimasaki, S.2    Woodruff, T.K.3    Jardetzky, T.S.4
  • 77
    • 0032425314 scopus 로고    scopus 로고
    • Immunolocalization of inhibin and activin subunits in human endometrium across the menstrual cycle
    • Leung PH, Salamonsen LA, Findlay JK. Immunolocalization of inhibin and activin subunits in human endometrium across the menstrual cycle. Hum Reprod 1998; 13:3469-3477.
    • (1998) Hum Reprod , vol.13 , pp. 3469-3477
    • Leung, P.H.1    Salamonsen, L.A.2    Findlay, J.K.3
  • 78
    • 0028872681 scopus 로고
    • Activin promotes ovarian follicle development in vitro
    • Li R, Phillips DM, Mather JP. Activin promotes ovarian follicle development in vitro. Endocrinology 1995;136:849-856.
    • (1995) Endocrinology , vol.136 , pp. 849-856
    • Li, R.1    Phillips, D.M.2    Mather, J.P.3
  • 80
    • 33747743119 scopus 로고    scopus 로고
    • The structural basis of TGF-b, bone morphogenetic protein, and activin ligand binding
    • Lin SJ, Lerch TF, Cook RW, Jardetzky TS,Woodruff TK. The structural basis of TGF-b, bone morphogenetic protein, and activin ligand binding. Reproduction 2006; 132:179-190.
    • (2006) Reproduction , vol.132 , pp. 179-190
    • Lin, S.J.1    Lerch, T.F.2    Cook, R.W.3    Jardetzky, T.S.4    Woodruff, T.K.5
  • 82
    • 0006000627 scopus 로고
    • Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid
    • Ling N, Ying SY, Ueno N, Esch F, Denoroy L, Guillemin R. Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid. Proc Natl Acad Sci USA 1985;82:7217-7221.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7217-7221
    • Ling, N.1    Ying, S.Y.2    Ueno, N.3    Esch, F.4    Denoroy, L.5    Guillemin, R.6
  • 84
    • 0031570780 scopus 로고    scopus 로고
    • Opposing effects of activin A and follistatin on developing skeletal muscle cells
    • Link BA, Nishi R. Opposing effects of activin A and follistatin on developing skeletal muscle cells. Exp Cell Res 1997;233:350-362.
    • (1997) Exp Cell Res , vol.233 , pp. 350-362
    • Link, B.A.1    Nishi, R.2
  • 85
    • 84920921854 scopus 로고    scopus 로고
    • Intertwining of activin A and TGF-b signaling: dual roles in cancer progression and cancer cell invasion
    • Loomans H, Andl C. Intertwining of activin A and TGF-b signaling: dual roles in cancer progression and cancer cell invasion. Cancers 2014;7:70-91.
    • (2014) Cancers , vol.7 , pp. 70-91
    • Loomans, H.1    Andl, C.2
  • 90
    • 0037498471 scopus 로고    scopus 로고
    • Activin a produced by ureteric bud is a differentiation factor for metanephric mesenchyme
    • Maeshima A, Yamashita S, Maeshima K, Kojima I, Nojima Y. Activin a produced by ureteric bud is a differentiation factor for metanephric mesenchyme. J Am Soc Nephrol 2003;14:1523-1534.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1523-1534
    • Maeshima, A.1    Yamashita, S.2    Maeshima, K.3    Kojima, I.4    Nojima, Y.5
  • 93
    • 84928110139 scopus 로고    scopus 로고
    • The inhibin/activin signalling pathway in human gonadal and adrenal cancers
    • Marino FE, Risbridger G, Gold E. The inhibin/activin signalling pathway in human gonadal and adrenal cancers. Mol Hum Reprod 2014;20:1223-1237.
    • (2014) Mol Hum Reprod , vol.20 , pp. 1223-1237
    • Marino, F.E.1    Risbridger, G.2    Gold, E.3
  • 94
    • 84928121807 scopus 로고    scopus 로고
    • Activin bC modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice
    • Marino FE, Risbridger G, Gold E. Activin bC modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice. Mol Cell Endocrinol 2015;409:41-50.
    • (2015) Mol Cell Endocrinol , vol.409 , pp. 41-50
    • Marino, F.E.1    Risbridger, G.2    Gold, E.3
  • 95
    • 0347761365 scopus 로고    scopus 로고
    • Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation
    • Martins da Silva SJ, Bayne RAL, Cambray N, Hartley PS, McNeilly AS, Anderson RA. Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation. Dev Biol 2004;266:334-345.
    • (2004) Dev Biol , vol.266 , pp. 334-345
    • Martins da Silva, S.J.1    Bayne, R.A.L.2    Cambray, N.3    Hartley, P.S.4    McNeilly, A.S.5    Anderson, R.A.6
  • 96
    • 0025685417 scopus 로고
    • Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis
    • Mather JP, Attie KM, Woodruff TK, Rice GC, Philips DM. Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis. Endocrinology 1990;127:3206-3214.
    • (1990) Endocrinology , vol.127 , pp. 3206-3214
    • Mather, J.P.1    Attie, K.M.2    Woodruff, T.K.3    Rice, G.C.4    Philips, D.M.5
  • 97
    • 0025905181 scopus 로고
    • Expression cloning of an activin receptor, a predicted transmembrane serine kinase
    • Mathews LS, Vale WW. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 1991;65:973-982.
    • (1991) Cell , vol.65 , pp. 973-982
    • Mathews, L.S.1    Vale, W.W.2
  • 99
    • 0026621796 scopus 로고
    • Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
    • Matzuk MM,Finegold MJ, Su JG, Hsueh AJ, Bradley A.Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 1992;360:313-319.
    • (1992) Nature , vol.360 , pp. 313-319
    • Matzuk, M.M.1    Finegold, M.J.2    Su, J.G.3    Hsueh, A.J.4    Bradley, A.5
  • 101
    • 0028929864 scopus 로고
    • Different phenotypes for mice deficient in either activins or activin receptor type II
    • Matzuk MM, Kumar TR, Bradley A. Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 1995b;374:356-360.
    • (1995) Nature , vol.374 , pp. 356-360
    • Matzuk, M.M.1    Kumar, T.R.2    Bradley, A.3
  • 102
    • 0028918915 scopus 로고
    • Multiple defects and perinatal death in mice deficient in follistatin
    • Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, Bradley A. Multiple defects and perinatal death in mice deficient in follistatin. Nature 1995c;374:360-363.
    • (1995) Nature , vol.374 , pp. 360-363
    • Matzuk, M.M.1    Lu, N.2    Vogel, H.3    Sellheyer, K.4    Roop, D.R.5    Bradley, A.6
  • 106
    • 0030833192 scopus 로고    scopus 로고
    • Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145
    • McPherson S, Thomas T, Wang H, Gurusinghe C, Risbridger G. Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145. J Endocrinol 1997;154:535-545.
    • (1997) J Endocrinol , vol.154 , pp. 535-545
    • McPherson, S.1    Thomas, T.2    Wang, H.3    Gurusinghe, C.4    Risbridger, G.5
  • 108
    • 0034655352 scopus 로고    scopus 로고
    • Regulation of germ cell and Sertoli cell development by activin, follistatin, and FSH
    • Meehan T, Schlatt S, O'Bryan MK, de Kretser DM, Loveland KL. Regulation of germ cell and Sertoli cell development by activin, follistatin, and FSH. Dev Biol 2000; 220:225-237.
    • (2000) Dev Biol , vol.220 , pp. 225-237
    • Meehan, T.1    Schlatt, S.2    O'Bryan, M.K.3    de Kretser, D.M.4    Loveland, K.L.5
  • 111
    • 78751681537 scopus 로고    scopus 로고
    • Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis
    • Mendis SHS, Meachem SJ, Sarraj MA, Loveland KL. Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis. Biol Reprod 2011;84:379-391.
    • (2011) Biol Reprod , vol.84 , pp. 379-391
    • Mendis, S.H.S.1    Meachem, S.J.2    Sarraj, M.A.3    Loveland, K.L.4
  • 113
    • 0038647411 scopus 로고    scopus 로고
    • Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia
    • Michel U, Gerber JE, O'Connor A, Bunkowski S, BrückW, Nau R, Phillips DJ. Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia. J Neurochem 2003;86:238-245.
    • (2003) J Neurochem , vol.86 , pp. 238-245
    • Michel, U.1    Gerber, J.E.2    O'Connor, A.3    Bunkowski, S.4    Brück, W.5    Nau, R.6    Phillips, D.J.7
  • 121
    • 11044221232 scopus 로고    scopus 로고
    • Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the villous tissue of miscarriage patients
    • Muttukrishna S, Bearfield C, Johns J, Jauniaux E. Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the villous tissue of miscarriage patients. Mol Hum Reprod 2004b;10:793-798.
    • (2004) Mol Hum Reprod , vol.10 , pp. 793-798
    • Muttukrishna, S.1    Bearfield, C.2    Johns, J.3    Jauniaux, E.4
  • 122
    • 33644916664 scopus 로고    scopus 로고
    • Uterine vein and maternal urinary levels of activin A and inhibin A in pre-eclampsia patients
    • Muttukrishna S, Hyett J, Paine M, Moodley J, Groome N, Rodeck C. Uterine vein and maternal urinary levels of activin A and inhibin A in pre-eclampsia patients. Clin Endocrinol 2006;64:469-473.
    • (2006) Clin Endocrinol , vol.64 , pp. 469-473
    • Muttukrishna, S.1    Hyett, J.2    Paine, M.3    Moodley, J.4    Groome, N.5    Rodeck, C.6
  • 123
    • 80053199530 scopus 로고    scopus 로고
    • Inhibin beta B: a useful tumor marker in uterine endometrioid adenocarcinomas?
    • Mylonas I. Inhibin beta B: a useful tumor marker in uterine endometrioid adenocarcinomas? Histol Histopathol 2011;26:1415-1422.
    • (2011) Histol Histopathol , vol.26 , pp. 1415-1422
    • Mylonas, I.1
  • 124
    • 33748861115 scopus 로고    scopus 로고
    • Expression of inhibin/activin subunits alpha (a), beta A (bA) and beta B bB) in placental tissue of normal and intrauterine growth restricted (IUGR) pregnancies
    • Mylonas I, Schiessl B, Jeschke U, Vogl J, Makrigiannakis A, Kuhn C, Kunze S, Schulze S, Kainer F, Friese K. Expression of inhibin/activin subunits alpha (a), beta A (bA) and beta B bB) in placental tissue of normal and intrauterine growth restricted (IUGR) pregnancies. J Mol Histol 2006;37:43-52.
    • (2006) J Mol Histol , vol.37 , pp. 43-52
    • Mylonas, I.1    Schiessl, B.2    Jeschke, U.3    Vogl, J.4    Makrigiannakis, A.5    Kuhn, C.6    Kunze, S.7    Schulze, S.8    Kainer, F.9    Friese, K.10
  • 126
    • 84899744426 scopus 로고    scopus 로고
    • Serum activin A and follistatin levels in gestational diabetes and the association of the activin A-follistatin system with anthropometric parameters in offspring
    • Näf S, Escote X, Ballesteros M, Yañez RE, Simón-Muela I, Gil P, Albaiges G, Vendrell J, Megia A. Serum activin A and follistatin levels in gestational diabetes and the association of the activin A-follistatin system with anthropometric parameters in offspring. PLoS One 2014;9:e92175.
    • (2014) PLoS One , vol.9 , pp. e92175
    • Näf, S.1    Escote, X.2    Ballesteros, M.3    Yañez, R.E.4    Simón-Muela, I.5    Gil, P.6    Albaiges, G.7    Vendrell, J.8    Megia, A.9
  • 128
    • 0025935385 scopus 로고
    • Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells
    • Nakamura T, Sugino K, Titani K, Sugino H. Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells. J Biol Chem 1991;266:19432-19437.
    • (1991) J Biol Chem , vol.266 , pp. 19432-19437
    • Nakamura, T.1    Sugino, K.2    Titani, K.3    Sugino, H.4
  • 130
    • 0036840172 scopus 로고    scopus 로고
    • Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice
    • Narula A, Kilen S, Ma E, Kroeger J, Goldberg E,Woodruff TK. Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice. Am J Pathol 2002;161:1723-1734.
    • (2002) Am J Pathol , vol.161 , pp. 1723-1734
    • Narula, A.1    Kilen, S.2    Ma, E.3    Kroeger, J.4    Goldberg, E.5    Woodruff, T.K.6
  • 131
    • 84920806324 scopus 로고    scopus 로고
    • The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling
    • Naujok O, Diekmann U, Lenzen S. The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling. Stem Cell Rev 2014;10:480-493.
    • (2014) Stem Cell Rev , vol.10 , pp. 480-493
    • Naujok, O.1    Diekmann, U.2    Lenzen, S.3
  • 133
    • 0035070193 scopus 로고    scopus 로고
    • Circulating follistatin concentrations are higher and activin concentrations are lower in polycystic ovarian syndrome
    • Norman RJ, Milner CR, Groome NP, Robertson DM. Circulating follistatin concentrations are higher and activin concentrations are lower in polycystic ovarian syndrome. Hum Reprod 2001;16:668-672.
    • (2001) Hum Reprod , vol.16 , pp. 668-672
    • Norman, R.J.1    Milner, C.R.2    Groome, N.P.3    Robertson, D.M.4
  • 134
    • 0032999372 scopus 로고    scopus 로고
    • Serum activin A and follistatin concentrations during human pregnancy: a cross-sectional and longitudinal study
    • O'Connor AE, McFarlane JR, Hayward S, Yohkaichiya T, Groome NP, de Kretser DM. Serum activin A and follistatin concentrations during human pregnancy: a cross-sectional and longitudinal study. Hum Reprod 1999;14:827-832.
    • (1999) Hum Reprod , vol.14 , pp. 827-832
    • O'Connor, A.E.1    McFarlane, J.R.2    Hayward, S.3    Yohkaichiya, T.4    Groome, N.P.5    de Kretser, D.M.6
  • 135
    • 0029003329 scopus 로고
    • Molecular cloning and functional analysis of a new activin b subunit: a dorsal mesoderm-inducing activity in Xenopus
    • Oda S, Nishimatsu S, Murakami K, Ueno N. Molecular cloning and functional analysis of a new activin b subunit: a dorsal mesoderm-inducing activity in Xenopus. Biochem Biophys Res Commun 1995;210:581-588.
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 581-588
    • Oda, S.1    Nishimatsu, S.2    Murakami, K.3    Ueno, N.4
  • 136
    • 33747887227 scopus 로고    scopus 로고
    • Regulated production of activin A and inhibin B throughout the cycle of the seminiferous epithelium in the rat
    • Okuma Y, O'Connor AE, Hayashi T, Loveland KL, de Kretser DM, Hedger MP. Regulated production of activin A and inhibin B throughout the cycle of the seminiferous epithelium in the rat. J Endocrinol 2006;190:331-340.
    • (2006) J Endocrinol , vol.190 , pp. 331-340
    • Okuma, Y.1    O'Connor, A.E.2    Hayashi, T.3    Loveland, K.L.4    de Kretser, D.M.5    Hedger, M.P.6
  • 138
    • 0031959554 scopus 로고    scopus 로고
    • Immunohistochemical localization of activin A in human endometrial tissues during the menstrual cycle and in early pregnancy
    • Otani T, Minami S, Kokawa K, Shikone T, Yamoto M, Nakano R. Immunohistochemical localization of activin A in human endometrial tissues during the menstrual cycle and in early pregnancy. Obstet Gynecol 1998;91:685-692.
    • (1998) Obstet Gynecol , vol.91 , pp. 685-692
    • Otani, T.1    Minami, S.2    Kokawa, K.3    Shikone, T.4    Yamoto, M.5    Nakano, R.6
  • 139
    • 0001153311 scopus 로고
    • Inhibin and activin modulate the release of gonadotropin-releasing hormone, human chorionic gonadotropin, and progesterone from cultured human placental cells
    • Petraglia F, Vaughan J, Vale W. Inhibin and activin modulate the release of gonadotropin-releasing hormone, human chorionic gonadotropin, and progesterone from cultured human placental cells. Proc Natl Acad Sci USA 1989; 86:5114-5117.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5114-5117
    • Petraglia, F.1    Vaughan, J.2    Vale, W.3
  • 142
    • 0031762897 scopus 로고    scopus 로고
    • Expression and secretion of inhibin and activin in normal and neoplastic uterine tissues. high levels of serum activin A in women with endometrial and cervical carcinoma
    • Petraglia F, Florio P, Luisi S, Gallo R, Gadducci A, Vigano` P, Blasio AMD, Genazzani AR, Vale W. Expression and secretion of inhibin and activin in normal and neoplastic uterine tissues. high levels of serum activin A in women with endometrial and cervical carcinoma. J Clin Endocrinol Metab 1998;83:1194-1200.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1194-1200
    • Petraglia, F.1    Florio, P.2    Luisi, S.3    Gallo, R.4    Gadducci, A.5    P.6    Vigano7    Blasio, A.M.D.9    Genazzani, A.R.10    Vale, W.11
  • 143
    • 0032191877 scopus 로고    scopus 로고
    • Follistatin: a multifunctional regulatory protein
    • Phillips DJ, de Kretser DM. Follistatin: a multifunctional regulatory protein. Front Neuroendocrinol 1998;19:287-322.
    • (1998) Front Neuroendocrinol , vol.19 , pp. 287-322
    • Phillips, D.J.1    de Kretser, D.M.2
  • 145
    • 33751197285 scopus 로고    scopus 로고
    • A study of luteal phase expression of inhibin, activin, and follistatin subunits in the endometrium of women with recurrent miscarriage
    • Prakash A, Li TC, Tuckerman E, Laird S,Wells M, Ledger WL. A study of luteal phase expression of inhibin, activin, and follistatin subunits in the endometrium of women with recurrent miscarriage. Fertil Steril 2006;86:1723-1730.
    • (2006) Fertil Steril , vol.86 , pp. 1723-1730
    • Prakash, A.1    Li, T.C.2    Tuckerman, E.3    Laird, S.4    Wells, M.5    Ledger, W.L.6
  • 146
    • 34848826258 scopus 로고    scopus 로고
    • Differential effects of aging on activin A and its binding protein, follistatin, across the menopause transition
    • Reame NE, Lukacs JL, Olton P, Ansbacher R, Padmanabhan V. Differential effects of aging on activin A and its binding protein, follistatin, across the menopause transition. Fertil Steril 2007;88:1003-1005.
    • (2007) Fertil Steril , vol.88 , pp. 1003-1005
    • Reame, N.E.1    Lukacs, J.L.2    Olton, P.3    Ansbacher, R.4    Padmanabhan, V.5
  • 147
    • 84887212518 scopus 로고    scopus 로고
    • Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia
    • Reddy A, Suri S, Sargent IL, Redman CW, Muttukrishna S. Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia. PLoS One 2009;4:e4453.
    • (2009) PLoS One , vol.4 , pp. e4453
    • Reddy, A.1    Suri, S.2    Sargent, I.L.3    Redman, C.W.4    Muttukrishna, S.5
  • 148
    • 0028963661 scopus 로고
    • Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse
    • Ritvos O, Tuuri T, Erämaa M, Sainio K, Hildén K, Saxén L, Gilbert SF. Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse. Mech Dev 1995;50:229-245.
    • (1995) Mech Dev , vol.50 , pp. 229-245
    • Ritvos, O.1    Tuuri, T.2    Erämaa, M.3    Sainio, K.4    Hildén, K.5    Saxén, L.6    Gilbert, S.F.7
  • 149
    • 0027482490 scopus 로고
    • Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle
    • Roberts VJ, Barth S, el-Roeiy A, Yen SS. Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle. J Clin Endocrinol Metab 1993; 77:1402-1410.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1402-1410
    • Roberts, V.J.1    Barth, S.2    el-Roeiy, A.3    Yen, S.S.4
  • 152
    • 58349118696 scopus 로고    scopus 로고
    • Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study)
    • Roten LT, Johnson MP, Forsmo S, Fitzpatrick E, Dyer TD, Brennecke SP, Blangero J, Moses EK, Austgulen R. Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). Eur J Hum Genet 2008;17:250-257.
    • (2008) Eur J Hum Genet , vol.17 , pp. 250-257
    • Roten, L.T.1    Johnson, M.P.2    Forsmo, S.3    Fitzpatrick, E.4    Dyer, T.D.5    Brennecke, S.P.6    Blangero, J.7    Moses, E.K.8    Austgulen, R.9
  • 153
    • 0033055349 scopus 로고    scopus 로고
    • Decreased inhibin tone and increased activin A secretion characterize reproductive aging in women
    • Santoro N, Adel T, Skurnick JH. Decreased inhibin tone and increased activin A secretion characterize reproductive aging in women. Fertil Steril 1999;71:658-662.
    • (1999) Fertil Steril , vol.71 , pp. 658-662
    • Santoro, N.1    Adel, T.2    Skurnick, J.H.3
  • 154
  • 155
    • 0028015934 scopus 로고
    • Mice homozygous for a null mutation of activin beta B are viable and fertile
    • Schrewe H, Gendron-Maguire M, Harbison ML, Gridley T. Mice homozygous for a null mutation of activin beta B are viable and fertile. Mech Dev 1994;47:43-51.
    • (1994) Mech Dev , vol.47 , pp. 43-51
    • Schrewe, H.1    Gendron-Maguire, M.2    Harbison, M.L.3    Gridley, T.4
  • 156
    • 14044280077 scopus 로고    scopus 로고
    • Inhibin B, activin A, and follistatin and the pathogenesis of polycystic ovary syndrome
    • Shen ZJ, Chen XP, Chen YG. Inhibin B, activin A, and follistatin and the pathogenesis of polycystic ovary syndrome. Int J Gynaecol Obstet 2005;88:336-337.
    • (2005) Int J Gynaecol Obstet , vol.88 , pp. 336-337
    • Shen, Z.J.1    Chen, X.P.2    Chen, Y.G.3
  • 158
    • 0033002981 scopus 로고    scopus 로고
    • Comparison ofmaternal serum total activin A and inhibin A in normal, preeclamptic, and nonproteinuric gestationally hypertensive pregnancies
    • Silver HM, Lambert-Messerlian GM, Star JA,Hogan J,Canick JA. Comparison ofmaternal serum total activin A and inhibin A in normal, preeclamptic, and nonproteinuric gestationally hypertensive pregnancies. Am J Obstet Gynecol 1999;180:1131-1137.
    • (1999) Am J Obstet Gynecol , vol.180 , pp. 1131-1137
    • Silver, H.M.1    Lambert-Messerlian, G.M.2    Star, J.A.3    Hogan, J.4    Canick, J.A.5
  • 159
    • 0026039487 scopus 로고
    • Injected Wnt RNA induces a complete body axis in Xenopus embryos
    • Sokol S, Christian JL, Moon RT, Melton DA. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 1991;67:741-752.
    • (1991) Cell , vol.67 , pp. 741-752
    • Sokol, S.1    Christian, J.L.2    Moon, R.T.3    Melton, D.A.4
  • 161
    • 0027268691 scopus 로고
    • Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell
    • Sugino K, Kurosawa N, Nakamura T, Takio K, Shimasaki S, Ling N, Titani K, Sugino H. Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell. J Biol Chem 1993;268:15579-15587.
    • (1993) J Biol Chem , vol.268 , pp. 15579-15587
    • Sugino, K.1    Kurosawa, N.2    Nakamura, T.3    Takio, K.4    Shimasaki, S.5    Ling, N.6    Titani, K.7    Sugino, H.8
  • 162
    • 47549097589 scopus 로고    scopus 로고
    • Effect of TGF-b/Smad signaling on sertoli cell and possible mechanism related to complete sertoli cell-only syndrome
    • Sun T, Xin Z, Jin Z, Wu Y, Gong Y. Effect of TGF-b/Smad signaling on sertoli cell and possible mechanism related to complete sertoli cell-only syndrome. Mol Cell Biochem 2008;319:1-7.
    • (2008) Mol Cell Biochem , vol.319 , pp. 1-7
    • Sun, T.1    Xin, Z.2    Jin, Z.3    Wu, Y.4    Gong, Y.5
  • 164
    • 84924612803 scopus 로고    scopus 로고
    • Overexpression of activin-A and -B in malignant mesothelioma-attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth
    • Tamminen JA, Yin M,Rönty M, Sutinen E, Pasternack A, Ritvos O, Myllärniemi M, Koli K. Overexpression of activin-A and -B in malignant mesothelioma-attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res 2015;332:102-115.
    • (2015) Exp Cell Res , vol.332 , pp. 102-115
    • Tamminen, J.A.1    Yin, M.2    Rönty, M.3    Sutinen, E.4    Pasternack, A.5    Ritvos, O.6    Myllärniemi, M.7    Koli, K.8
  • 166
    • 84884533678 scopus 로고    scopus 로고
    • Follistatin and activins in polycystic ovary syndrome: relationship to metabolic and hormonal markers
    • Teede H, Ng S, Hedger M, Moran L. Follistatin and activins in polycystic ovary syndrome: relationship to metabolic and hormonal markers. Metab Clin Exp 2013; 62:1394-1400.
    • (2013) Metab Clin Exp , vol.62 , pp. 1394-1400
    • Teede, H.1    Ng, S.2    Hedger, M.3    Moran, L.4
  • 167
    • 26444515002 scopus 로고    scopus 로고
    • The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding
    • Thompson TB, Lerch TF, Cook RW,Woodruff TK, Jardetzky TS. The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. Dev Cell 2005;9:535-543.
    • (2005) Dev Cell , vol.9 , pp. 535-543
    • Thompson, T.B.1    Lerch, T.F.2    Cook, R.W.3    Woodruff, T.K.4    Jardetzky, T.S.5
  • 171
    • 0023515180 scopus 로고
    • Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone
    • Ueno N, Ling N, Ying SY, Esch F, Shimasaki S, Guillemin R. Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone. Proc Natl Acad Sci USA 1987; 84:8282-8286.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8282-8286
    • Ueno, N.1    Ling, N.2    Ying, S.Y.3    Esch, F.4    Shimasaki, S.5    Guillemin, R.6
  • 172
    • 0022907945 scopus 로고
    • Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid
    • Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 1986;321:776-779.
    • (1986) Nature , vol.321 , pp. 776-779
    • Vale, W.1    Rivier, J.2    Vaughan, J.3    McClintock, R.4    Corrigan, A.5    Woo, W.6    Karr, D.7    Spiess, J.8
  • 173
    • 0030880537 scopus 로고    scopus 로고
    • Human testicular germ cell tumours express inhibin subunits, activin receptors and follistatin mRNAs
    • van Schaik RH, Wierikx CD, Looijenga LH, Oosterhuis JW, de Jong FH. Human testicular germ cell tumours express inhibin subunits, activin receptors and follistatin mRNAs. Br J Cancer 1997;76:1191-1198.
    • (1997) Br J Cancer , vol.76 , pp. 1191-1198
    • van Schaik, R.H.1    Wierikx, C.D.2    Looijenga, L.H.3    Oosterhuis, J.W.4    de Jong, F.H.5
  • 174
    • 0028176755 scopus 로고
    • Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction
    • Vassalli A, Matzuk MM, Gardner HA, Lee KF, Jaenisch R. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev 1994;8:414-427.
    • (1994) Genes Dev , vol.8 , pp. 414-427
    • Vassalli, A.1    Matzuk, M.M.2    Gardner, H.A.3    Lee, K.F.4    Jaenisch, R.5
  • 175
    • 0038541935 scopus 로고    scopus 로고
    • Activin B in patients with granulosa cell tumors: serum levels in comparison to inhibin
    • Vihko KK, Blauer M, Puistola U, Tuohimaa P. Activin B in patients with granulosa cell tumors: serum levels in comparison to inhibin. Acta Obstet Gynecol Scand 2003; 82:570-574.
    • (2003) Acta Obstet Gynecol Scand , vol.82 , pp. 570-574
    • Vihko, K.K.1    Blauer, M.2    Puistola, U.3    Tuohimaa, P.4
  • 177
    • 0037334311 scopus 로고    scopus 로고
    • Maternal serum activin A levels in association with intrauterine fetal growth restriction
    • Wallace EM, Schneider-Kolsky ME, Edwards A, Baker L, Jenkin G. Maternal serum activin A levels in association with intrauterine fetal growth restriction. BJOG 2003; 110:306-310.
    • (2003) BJOG , vol.110 , pp. 306-310
    • Wallace, E.M.1    Schneider-Kolsky, M.E.2    Edwards, A.3    Baker, L.4    Jenkin, G.5
  • 178
    • 1842784908 scopus 로고    scopus 로고
    • First trimester levels of inhibins and activin A in normal and failing pregnancies
    • Wallace EM, Marjono B, Tyzack K, Tong S. First trimester levels of inhibins and activin A in normal and failing pregnancies. Clin Endocrinol 2004;60:484-490.
    • (2004) Clin Endocrinol , vol.60 , pp. 484-490
    • Wallace, E.M.1    Marjono, B.2    Tyzack, K.3    Tong, S.4
  • 179
    • 66149084397 scopus 로고    scopus 로고
    • A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGF-b) ligands
    • Walton KL, Makanji Y, Wilce MC, Chan KL, Robertson DM, Harrison CA. A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGF-b) ligands. J Biol Chem 2009;284:9311-9320.
    • (2009) J Biol Chem , vol.284 , pp. 9311-9320
    • Walton, K.L.1    Makanji, Y.2    Wilce, M.C.3    Chan, K.L.4    Robertson, D.M.5    Harrison, C.A.6
  • 180
    • 77952784624 scopus 로고    scopus 로고
    • Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex
    • Walton KL, Makanji Y, Chen J, Wilce MC, Chan KL, Robertson DM, Harrison CA. Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex. J Biol Chem 2010;285:17029-17037.
    • (2010) J Biol Chem , vol.285 , pp. 17029-17037
    • Walton, K.L.1    Makanji, Y.2    Chen, J.3    Wilce, M.C.4    Chan, K.L.5    Robertson, D.M.6    Harrison, C.A.7
  • 181
    • 84861681431 scopus 로고    scopus 로고
    • Newinsights into themechanisms of activin action and inhibition
    • Walton KL, Makanji Y, Harrison CA.Newinsights into themechanisms of activin action and inhibition. Mol Cell Endocrinol 2012;359:2-12.
    • (2012) Mol Cell Endocrinol , vol.359 , pp. 2-12
    • Walton, K.L.1    Makanji, Y.2    Harrison, C.A.3
  • 182
    • 4143080187 scopus 로고    scopus 로고
    • Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth
    • Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Wankell M, Werner S, Thesleff I. Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth. Dev Dyn 2004;231:98-108.
    • (2004) Dev Dyn , vol.231 , pp. 98-108
    • Wang, X.P.1    Suomalainen, M.2    Jorgez, C.J.3    Matzuk, M.M.4    Wankell, M.5    Werner, S.6    Thesleff, I.7
  • 183
    • 84857640697 scopus 로고    scopus 로고
    • Serum activinA does not predict ectopic pregnancy as a single measurement test, alone or as part of a multi-marker panel including progesterone and hCG
    • Warrick J, Gronowski A, Moffett C, Zhao Q, Bishop E,Woodworth A. Serum activinA does not predict ectopic pregnancy as a single measurement test, alone or as part of a multi-marker panel including progesterone and hCG. Clin Chim Acta 2012; 413:707-711.
    • (2012) Clin Chim Acta , vol.413 , pp. 707-711
    • Warrick, J.1    Gronowski, A.2    Moffett, C.3    Zhao, Q.4    Bishop, E.5    Woodworth, A.6
  • 184
    • 84921287110 scopus 로고    scopus 로고
    • Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker
    • Williamson RD, O'Keeffe GW, Kenny LC. Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker. Cytokine 2015;71:360-365.
    • (2015) Cytokine , vol.71 , pp. 360-365
    • Williamson, R.D.1    O'Keeffe, G.W.2    Kenny, L.C.3
  • 185
    • 84874886604 scopus 로고    scopus 로고
    • Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens
    • Winnall WR, Wu H, Sarraj MA, Rogers PAW, de Kretser DM, Girling JE, Hedger MP. Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens. Reprod Fertil Dev 2013;25:570-580.
    • (2013) Reprod Fertil Dev , vol.25 , pp. 570-580
    • Winnall, W.R.1    Wu, H.2    Sarraj, M.A.3    Rogers, P.A.W.4    de Kretser, D.M.5    Girling, J.E.6    Hedger, M.P.7
  • 188
    • 84869872645 scopus 로고    scopus 로고
    • Regulation of activin A release from murine bone marrow-derived neutrophil precursors by tumour necrosis factor-a and insulin
    • Wu H, Chen Y, Winnall WR, Phillips DJ, Hedger MP. Regulation of activin A release from murine bone marrow-derived neutrophil precursors by tumour necrosis factor-a and insulin. Cytokine 2013;61:199-204.
    • (2013) Cytokine , vol.61 , pp. 199-204
    • Wu, H.1    Chen, Y.2    Winnall, W.R.3    Phillips, D.J.4    Hedger, M.P.5
  • 189
    • 80755187146 scopus 로고    scopus 로고
    • Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells
    • Xu X, Browning V, Odorico J. Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev 2011;128:412-427.
    • (2011) Mech Dev , vol.128 , pp. 412-427
    • Xu, X.1    Browning, V.2    Odorico, J.3
  • 190
    • 0031040843 scopus 로고    scopus 로고
    • Expression and localization of inhibin/activin subunits and activin receptors in the normal rat prostate
    • Ying S-Y, Zhang Z, Huang G. Expression and localization of inhibin/activin subunits and activin receptors in the normal rat prostate. Life Sci 1997;60:397-401.
    • (1997) Life Sci , vol.60 , pp. 397-401
    • Ying, S.-Y.1    Zhang, Z.2    Huang, G.3
  • 191
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38MAPkinase pathway
    • Zarubin T, Han J. Activation and signaling of the p38MAPkinase pathway. Cell Res 2005; 15:11-18.
    • (2005) Cell Res , vol.15 , pp. 11-18
    • Zarubin, T.1    Han, J.2
  • 192
    • 0031578249 scopus 로고    scopus 로고
    • Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP
    • Zhang Z, Zhao Y, Batres Y, Lin M-F, Ying S-Y. Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP. Biochem Biophys Res Commun 1997;234:362-365.
    • (1997) Biochem Biophys Res Commun , vol.234 , pp. 362-365
    • Zhang, Z.1    Zhao, Y.2    Batres, Y.3    Lin, M.-F.4    Ying, S.-Y.5
  • 194
    • 0032519946 scopus 로고    scopus 로고
    • Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture
    • Zhao J, Lee M, Smith S, Warburton D. Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture. Dev Biol 1998;194:182-195.
    • (1998) Dev Biol , vol.194 , pp. 182-195
    • Zhao, J.1    Lee, M.2    Smith, S.3    Warburton, D.4


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