Activin βC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate

Endocrinology

Volumn 144, Issue 10, 2003, Pages 4410-4419

  Mellor, Sally L ^a   Ball, Emma M A ^a   O'Connor, Anne E ^a   Ethier, Jean François ^b,e   Cranfield, Mark ^c   Schmitt, Jacqueline F ^a   Phillips, David J ^a   Groome, Nigel P ^c   Risbridger, Gail P ^a,d  

^a MONASH UNIVERSITY   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c OXFORD BROOKES UNIVERSITY   (United Kingdom)

^d MONASH MEDICAL CENTRE   (Australia)

^e OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ACTIVIN A; ACTIVIN BETA C; ACTIVIN C; MYELOPID; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; INHBB PROTEIN, HUMAN; INHBC PROTEIN, HUMAN; INHIBIN; INHIBIN BETA A SUBUNIT;

ANIMAL CELL; ARTICLE; CELL GROWTH; COMPARATIVE STUDY; CONTROLLED STUDY; DIMERIZATION; DRUG ACTIVITY; DRUG EFFECT; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; INHIBITION KINETICS; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE; PROSTATE TUMOR; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM; TUMOR CELL LINE; ANIMAL; CELL CULTURE; CELL DIVISION; CELL LINE; CHO CELL; GENETICS; HAMSTER; MALE; METABOLISM; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY;

ACTIVINS; ANIMALS; CELL DIVISION; CELL LINE; CHO CELLS; CRICETINAE; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INHIBIN-BETA SUBUNITS; MALE; PROMOTER REGIONS (GENETICS); PROSTATE; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0141785441     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0225     Document Type: Article

References (39)

1. McPherson SJ, Mellor SL, Wang H, Evans LW, Groome NP, Risbridger GP 1999 Expression of activin A and follistatin core proteins by human prostate tumor cell lines. Endocrinology 140:5303-5309
2. Luisi S, Florio P, Reis FM, Petraglia F 2001 Expression and secretion of activin A: possible physiological and clinical implications. Eur J Endocrinol 145:225-36
3. McDowell N, Gurdon JB 1999 Activin as a morphogen in Xenopus mesoderm induction. Semin Cell Dev Biol 10:311-317
4. de Kretser DM, Hedger MP, Phillips DJ 1999 Activin A and follistatin: their role in the acute phase reaction and inflammation. J Endocrinol 161:195-198
5. Hubner G, Alzheimer C, Werner S 1999 Activin: a novel player in tissue repair processes. Histol Histopathol 14:295-304
6. Lebrun JJ, Takabe K, Chen Y, Vale W 1999 Roles of pathway-specific and inhibitory Smads in activin receptor signaling. Mol Endocrinol 13:15-23
7. Wrana JL, Attisano L 2000 The Smad pathway. Cytokine Growth Factor Rev 11:5-13
8. Pangas SA, Woodruff TK 2000 Activin signal transduction pathways. Trends Endocrinol Metab 11:309-314
9. Chen X, Rubock MJ, Whitman M 1996 A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383:691-696
10. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M 1997 Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389:85-89
11. Dural DL, Ellsworth BS, Clay CM 1999 Is gonadotrope expression of the gonadotropin releasing hormone receptor gene mediated by autocrine/paracrine stimulation of an activin response element? Endocrinology 140:1949-1952
12. Jonk LJ, Itoh S, Heldin CH, ten Dijke P, Kruijer W 1998 Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer. J Biol Chem 273:21145-21152
13. Nagarajan RP, Zhang J, Li W, Chen Y 1999 Regulation of Smad7 promoter by direct association with Smad3 and Smad4. J Biol Chem 274:33412-33418
14. Zhang Z, Zhao Y, Batres Y, Lin MF, Ying SY 1997 Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP. Biochem Biophys Res Commun 234:362-365
15. Thomas TZ, Wang H, Niclasen P, O'Bryan MK, Evans LW, Groome NP, Pedersen J, Risbridger GP 1997 Expression and localization of activin subunits and follistatins in tissues from men with high grade prostate cancer. J Clin Endocrinol Metab 82:3851-3858
16. Thomas TZ, Chapman SM, Hong W, Gurusingfhe C, Mellor SL, Fletcher R, Pedersen J, Risbridger GP 1998 Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia. Prostate 34:34-43
17. C chain. Biochem Biophys Res Commun 206:608-613
18. E are closely linked and exhibit a liver-specific expression pattern in adult tissues. Biochem Biophys Res Commun 231:655-661
19. C subunit. J Clin Endocrinol Metab 85:4851-4858
20. E subunit. Mol Cell Endocrinol 194:117
21. C subunit mRNA in reproductive tissues. J Mol Endocrinol 17:61-65
22. McPherson SJ, Thomas TZ, Wang H, Gurusinghe CJ, Risbridger GP 1997 Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145. J Endocrinol 154:535-545
23. E genes are not essential for mouse liver growth, differentiation, and regeneration. Mol Cell Biol 20:6127-6137
24. Risbridger GP, Mellor SL, McPherson SJ, Schmitt JF 2001 The contribution of inhibins and activins to malignant prostate disease. Mol Cell Endocrinol 180:149-153
25. Alarid ET, Windle JJ, Whyte DB, Mellon PL 1996 Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development 122:3319-3329
26. Huang HJ, Sebastian J, Strahl BD, Wu JC, Miller WL 2001 The promoter for the ovine follicle-stimulating hormone-β gene (FSHβ) confers FSHβ-like expression on luciferase in transgenic mice: regulatory studies in vivo and in vitro. Endocrinology 142:2260-2266
27. Carcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L, Massague J 1994 Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol Cell Biol 14:3810-3821
28. Evans LW, Muttukrishna S, Groome NP 1998 Development, validation and application of an ultra-sensitive two-site enzyme immunoassay for human follistatin. J Endocrinol 156:275-282
29. Knight PG, Muttukrishna S, Groome NP 1996 Development and application of a two-site enzyme immunoassay for the determination of 'total' activin-A concentrations in serum and follicular fluid. J Endocrinol 148:267-279
30. Robertson DM, Foulds LM, Prisk M, Hedger MP 1992 Inhibin/activin β-subunit monomer: isolation and characterization. Endocrinology 130:1680-1687
31. Gonzalez-Manchon C, Vale W 1989 Activin-A, inhibin and transforming growth factor-β modulate growth of two gonadal cell lines. Endocrinology 125:1666-1672
32. Ethier J-F, Farnworth PG, Findlay JK, Ooi G 2002 Transforming growth factor-β modulates inhibin A bioactivity in the Lβ gonadotrope cell line by competing for binding to β-glycan. Mol Endocrinol 16:2754-2763
33. Pernasetti F, Vasilyev W, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon PL 2001 Cell-specific transcriptional regulation of follicle-stimulating hormone-β by activin and gonadotropin-releasing hormone in the LβT2 pituitary gonadotrope cell model. Endocrinology 142:2284-2295
34. Dalkin AC, Gilrain JT, Bradshaw D, Myers CE 1996 Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells. Endocrinology 137:5230-5235
35. Delbaere A, Sidis Y, Schneyer AL 1999 Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin. Endocrinology 140:2463-2470
36. Yeo C, Whitman M 2001 Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell 7:949-957
37. E: evidence for the formation of novel activin dimers. J Mol Endocrinol 28:137-148
38. Evans LW, Muttukrishna S, Knight PG, Groome NP 1997 Development, validation and application of a two-site enzyme-linked immunosorbent assay for activin-AB. J Endocrinol 153:221-230
39. Brown CW, Houston-Hawkins DE, Woodruff TK, Matzuk MM 2000 Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet 25:453-457