-
1
-
-
79960888524
-
Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
-
Brown, S.; Teo, A.; Pauklin, S.; Hannan, N.; Cho, C.H.-H.; Lim, B.; Vardy, L.; Dunn, N.R.; Trotter, M.; Pedersen, R.; et al. Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 2011, 29, 1176–1185h.
-
(2011)
Stem Cells
, vol.29
, pp. 1176h-1185h
-
-
Brown, S.1
Teo, A.2
Pauklin, S.3
Hannan, N.4
Cho, C.H.5
Lim, B.6
Vardy, L.7
Dunn, N.R.8
Trotter, M.9
Pedersen, R.10
-
2
-
-
0033625428
-
Endogenous patterns of TGFβ superfamily signaling during early Xenopus development
-
Faure, S.; Lee, M.A.; Keller, T.; ten Dijke, P.; Whitman, M. Endogenous patterns of TGFβ superfamily signaling during early Xenopus development. Development 2000, 127, 2917–2931.
-
(2000)
Development
, vol.127
, pp. 2917-2931
-
-
Faure, S.1
Lee, M.A.2
Keller, T.3
Ten Dijke, P.4
Whitman, M.5
-
3
-
-
0026621796
-
α-Inhibin is a tumor-suppressor gene with gonadal specificity in mice
-
Matzuk, M.M.; Finegold, M.J.; Su, J.-G.J.; Hsueh, A.J.; Bradley, A. α-Inhibin is a tumor-suppressor gene with gonadal specificity in mice. Nature 1992, 360, 313–319.
-
(1992)
Nature
, vol.360
, pp. 313-319
-
-
Matzuk, M.M.1
Finegold, M.J.2
Su, J.-G.J.3
Hsueh, A.J.4
Bradley, A.5
-
4
-
-
0033200373
-
BMP signalling in early Xenopus development
-
Dale, L.; Jones, C.M. BMP signalling in early Xenopus development. Bioessays 1999, 21, 751–760.
-
(1999)
Bioessays
, vol.21
, pp. 751-760
-
-
Dale, L.1
Jones, C.M.2
-
5
-
-
4644311906
-
Activin A and follistatin in systemic inflammation
-
Jones, K.L.; de Kretser, D.M.; Patella, S.; Phillips, D.J. Activin A and follistatin in systemic inflammation. Mol. Cell. Endocrinol. 2004, 225, 119–125.
-
(2004)
Mol. Cell. Endocrinol
, vol.225
, pp. 119-125
-
-
Jones, K.L.1
De Kretser, D.M.2
Patella, S.3
Phillips, D.J.4
-
6
-
-
84891113093
-
Mechanism of pro-tumorigenic effect of BMP-6: Neovascularization involving tumor-associated macrophages and IL-1α
-
Kwon, S.J.; Lee, G.T.; Lee, J.-H.; Iwakura, Y.; Kim, W.-J.; Kim, I.Y. Mechanism of pro-tumorigenic effect of BMP-6: Neovascularization involving tumor-associated macrophages and IL-1α. Prostate 2014, 74, 121–133.
-
(2014)
Prostate
, vol.74
, pp. 121-133
-
-
Kwon, S.J.1
Lee, G.T.2
Lee, J.-H.3
Iwakura, Y.4
Kim, W.-J.5
Kim, I.Y.6
-
7
-
-
24744446473
-
Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells
-
Burdette, J.E.; Jeruss, J.S.; Kurley, S.J.; Lee, E.J.; Woodruff, T.K. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Cancer Res. 2005, 65, 7968–7975.
-
(2005)
Cancer Res
, vol.65
, pp. 7968-7975
-
-
Burdette, J.E.1
Jeruss, J.S.2
Kurley, S.J.3
Lee, E.J.4
Woodruff, T.K.5
-
8
-
-
33750833717
-
Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages
-
Ogawa, K.; Funaba, M.; Chen, Y.; Tsujimoto, M. Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol. 2006, 177, 6787–6794.
-
(2006)
J. Immunol
, vol.177
, pp. 6787-6794
-
-
Ogawa, K.1
Funaba, M.2
Chen, Y.3
Tsujimoto, M.4
-
9
-
-
0026442926
-
Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
-
Green, J.B.; New, H.V.; Smith, J.C. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 1992, 71, 731–739.
-
(1992)
Cell
, vol.71
, pp. 731-739
-
-
Green, J.B.1
New, H.V.2
Smith, J.C.3
-
10
-
-
84879037098
-
Targeting TGF-β signaling in cancer
-
Katz, L.H.; Li, Y.; Chen, J.-S.; Muñoz, N.M.; Majumdar, A.; Chen, J.; Mishra, L. Targeting TGF-β signaling in cancer. Expert Opin. Ther. Targets 2013, 17, 743–760.
-
(2013)
Expert Opin. Ther. Targets
, vol.17
, pp. 743-760
-
-
Katz, L.H.1
Li, Y.2
Chen, J.-S.3
Muñoz, N.M.4
Majumdar, A.5
Chen, J.6
Mishra, L.7
-
11
-
-
4644339713
-
Activin and follistatin in female reproduction
-
Muttukrishna, S.; Tannetta, D.; Groome, N.; Sargent, I. Activin and follistatin in female reproduction. Mol. Cell. Endocrinol. 2004, 225, 45–56.
-
(2004)
Mol. Cell. Endocrinol
, vol.225
, pp. 45-56
-
-
Muttukrishna, S.1
Tannetta, D.2
Groome, N.3
Sargent, I.4
-
12
-
-
78649982907
-
The dynamic roles of TGF-β in cancer
-
Meulmeester, E.; ten Dijke, P. The dynamic roles of TGF-β in cancer. J. Pathol. 2010, 223, 206–219.
-
(2010)
J. Pathol
, vol.223
, pp. 206-219
-
-
Meulmeester, E.1
Ten Dijke, P.2
-
13
-
-
0008478647
-
Chemical and biological characterization of the inhibin family of protein hormones
-
Vale, W.; Rivier, C.; Hsueh, A.; Campen, C.; Meunier, H.; Bicsak, T.; Vaughan, J.; Corrigan, A.; Bardin, W.; Sawchenko, P. Chemical and biological characterization of the inhibin family of protein hormones. Recent Prog. Horm. Res. 1988, 44, 1–34.
-
(1988)
Recent Prog. Horm. Res
, vol.44
, pp. 1-34
-
-
Vale, W.1
Rivier, C.2
Hsueh, A.3
Campen, C.4
Meunier, H.5
Bicsak, T.6
Vaughan, J.7
Corrigan, A.8
Bardin, W.9
Sawchenko, P.10
-
14
-
-
84885063519
-
Targeting the transforming growth factor-β signaling in cancer therapy
-
Sheen, Y.Y.; Kim, M.-J.; Park, S.-A.; Park, S.-Y.; Nam, J.-S. Targeting the transforming growth factor-β signaling in cancer therapy. Biomol. Ther. 2013, 21, 323–331.
-
(2013)
Biomol. Ther
, vol.21
, pp. 323-331
-
-
Sheen, Y.Y.1
Kim, M.-J.2
Park, S.-A.3
Park, S.-Y.4
Nam, J.-S.5
-
15
-
-
0024693776
-
Mapping of genes for inhibin subunits α, β-A, and β-B on human and mouse chromosomes and studies of jsd mice
-
Barton, D.E.; Yang-Feng, T.L.; Mason, A.J.; Seeburg, P.H.; Francke, U. Mapping of genes for inhibin subunits α, β-A, and β-B on human and mouse chromosomes and studies of jsd mice. Genomics 1989, 5, 91–99.
-
(1989)
Genomics
, vol.5
, pp. 91-99
-
-
Barton, D.E.1
Yang-Feng, T.L.2
Mason, A.J.3
Seeburg, P.H.4
Francke, U.5
-
16
-
-
0030908028
-
Latent transforming growth factor-β: Structural features and mechanisms of activation
-
Munger, J.S.; Harpel, J.G.; Gleizes, P.-E.; Mazzieri, R.; Nunes, I.; Rifkin, D.B. Latent transforming growth factor-β: Structural features and mechanisms of activation. Kidney Int. 2007, 51, 1376–1382.
-
(2007)
Kidney Int
, vol.51
, pp. 1376-1382
-
-
Munger, J.S.1
Harpel, J.G.2
Gleizes, P.-E.3
Mazzieri, R.4
Nunes, I.5
Rifkin, D.B.6
-
17
-
-
3042838388
-
Binding proteins: Extracellular matrix association and roles in TGF-β activation
-
Hyytiäinen, M.; Penttinen, C.; Keski-Oja, J. Latent TGF-β binding proteins: Extracellular matrix association and roles in TGF-β activation. Crit. Rev. Clin. Lab. Sci. 2004, 41, 233–264.
-
(2004)
Crit. Rev. Clin. Lab. Sci
, vol.41
, pp. 233-264
-
-
Hyytiäinen, M.1
Penttinen, C.2
Keski-Oja, J.3
-
18
-
-
0036904895
-
Genetic analysis of the mammalian transforming growth factor-β superfamily
-
Chang, H.; Brown, C.W.; Matzuk, M.M. Genetic analysis of the mammalian transforming growth factor-β superfamily. Endocr. Rev. 2002, 23, 787–823.
-
(2002)
Endocr. Rev
, vol.23
, pp. 787-823
-
-
Chang, H.1
Brown, C.W.2
Matzuk, M.M.3
-
19
-
-
0027525105
-
Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors
-
Attisano, L.; Carcamo, J.; Ventura, F.; Weis, F.M.B.; Massagué, J.; Wrana, J.L. Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors. Cell 1993, 75, 1–10.
-
(1993)
Cell
, vol.75
, pp. 1-10
-
-
Attisano, L.1
Carcamo, J.2
Ventura, F.3
Weis, F.4
Massagué, J.5
Wrana, J.L.6
-
20
-
-
0026537831
-
Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
-
Lin, H.Y.; Wang, X.-F.; Ng-Eaton, E.; Weinberg, R.A.; Lodish, H.F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 1992, 68, 775–785.
-
(1992)
Cell
, vol.68
, pp. 775-785
-
-
Lin, H.Y.1
Wang, X.-F.2
Ng-Eaton, E.3
Weinberg, R.A.4
Lodish, H.F.5
-
21
-
-
1642473157
-
The transforming growth factor-β superfamily of receptors
-
De Caestecker, M. The transforming growth factor-β superfamily of receptors. Cytokine Growth Factor Rev. 2004, 15, 1–11.
-
(2004)
Cytokine Growth Factor Rev
, vol.15
, pp. 1-11
-
-
De Caestecker, M.1
-
22
-
-
0028985296
-
The GS domain of the transforming growth factor-β type I receptor is important in signal transduction
-
Franzen, P.; Heldin, C.-H.; Miyazono, K. The GS domain of the transforming growth factor-β type I receptor is important in signal transduction. Biochem. Biophys. Res. Commun. 1995, 207, 682–689.
-
(1995)
Biochem. Biophys. Res. Commun
, vol.207
, pp. 682-689
-
-
Franzen, P.1
Heldin, C.-H.2
Miyazono, K.3
-
23
-
-
0029022221
-
GS domain mutations that constitutively activate TβR-1, the downstream signaling component in the TGF-β receptor complex
-
Wieser, R.; Wrana, J.L.; Massagué, J. GS domain mutations that constitutively activate TβR-1, the downstream signaling component in the TGF-β receptor complex. EMBO J. 1995, 14, 2199–2208.
-
(1995)
EMBO J
, vol.14
, pp. 2199-2208
-
-
Wieser, R.1
Wrana, J.L.2
Massagué, J.3
-
24
-
-
0028295762
-
Characterization of type I receptors for transforming growth factor-β and activin
-
Ten Dijke, P.; Yamashita, H.; Ichijo, H.; Franzen, P.; Laiho, M.; Miyazono, K.; Heldin, C.-H. Characterization of type I receptors for transforming growth factor-β and activin. Science 1994, 264, 101–104.
-
(1994)
Science
, vol.264
, pp. 101-104
-
-
Ten Dijke, P.1
Yamashita, H.2
Ichijo, H.3
Franzen, P.4
Laiho, M.5
Miyazono, K.6
Heldin, C.-H.7
-
25
-
-
0028359376
-
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin
-
Carcamo, J.; Weis, F.M.; Ventura, F.; Wieser, R.; Wrana, J.L.; Attisano, L.; Massagué, J. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol. Cell. Biol. 1994, 14, 3810–3821.
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 3810-3821
-
-
Carcamo, J.1
Weis, F.M.2
Ventura, F.3
Wieser, R.4
Wrana, J.L.5
Attisano, L.6
Massagué, J.7
-
26
-
-
0028122987
-
Activin signalling and response to a morphogen gradient
-
Gurdon, J.B.; Harger, P.; Mitchell, A.; Lemaire, P. Activin signalling and response to a morphogen gradient. Nature 1994, 371, 487–492.
-
(1994)
Nature
, vol.371
, pp. 487-492
-
-
Gurdon, J.B.1
Harger, P.2
Mitchell, A.3
Lemaire, P.4
-
27
-
-
0032213107
-
The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells
-
Hashimoto, O.; Yamato, K.; Koseki, T.; Ohguchi, M.; Ishisaki, A.; Shoji, H.; Nakamura, T.; Hayashi, Y.; Sugino, H.; Nishihara, T. The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells. Cell. Signal. 1998, 10, 743–749.
-
(1998)
Cell. Signal
, vol.10
, pp. 743-749
-
-
Hashimoto, O.1
Yamato, K.2
Koseki, T.3
Ohguchi, M.4
Ishisaki, A.5
Shoji, H.6
Nakamura, T.7
Hayashi, Y.8
Sugino, H.9
Nishihara, T.10
-
28
-
-
0028093079
-
Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin
-
Symes, K.; Yordán, C.; Mercola, M. Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin. Development 1994, 120, 2339–2346.
-
(1994)
Development
, vol.120
, pp. 2339-2346
-
-
Symes, K.1
Yordán, C.2
Mercola, M.3
-
29
-
-
0031239988
-
Activin has direct long-range signalling activity and can form a concentration gradient by diffusion
-
McDowell, N.; Zorn, A.M.; Crease, D.J.; Gurdon, J.B. Activin has direct long-range signalling activity and can form a concentration gradient by diffusion. Curr. Biol. 1997, 7, 671–681.
-
(1997)
Curr. Biol
, vol.7
, pp. 671-681
-
-
McDowell, N.1
Zorn, A.M.2
Crease, D.J.3
Gurdon, J.B.4
-
30
-
-
63749105896
-
Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition
-
Heldin, C.-H.; Landström, M.; Moustakas, A. Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr. Opin. Cell Biol. 2009, 21, 166–176.
-
(2009)
Curr. Opin. Cell Biol
, vol.21
, pp. 166-176
-
-
Heldin, C.-H.1
Landström, M.2
Moustakas, A.3
-
31
-
-
0035069536
-
Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo
-
McDowell, N.; Gurdon, J.B.; Grainger, D.J. Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo. Int. J. Dev. Biol. 2001, 45, 199–207.
-
(2001)
Int. J. Dev. Biol
, vol.45
, pp. 199-207
-
-
McDowell, N.1
Gurdon, J.B.2
Grainger, D.J.3
-
32
-
-
84890192124
-
TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition
-
Stankic, M.; Pavlovic, S.; Chin, Y.; Brogi, E.; Padua, D.; Norton, L.; Massagué, J.; Benezra, R. TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Rep. 2013, 5, 1228–1242.
-
(2013)
Cell Rep
, vol.5
, pp. 1228-1242
-
-
Stankic, M.1
Pavlovic, S.2
Chin, Y.3
Brogi, E.4
Padua, D.5
Norton, L.6
Massagué, J.7
Benezra, R.8
-
33
-
-
84860499592
-
High concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells
-
Di, X.; Andrews, D.M.K.; Tucker, C.J.; Yu, L.; Moore, A.B.; Zheng, X.; Castro, L.; Hermon, T.; Xiao, H.; Dixon, D. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. Exp. Mol. Med. 2012, 44, 281.
-
(2012)
Exp. Mol. Med
, vol.44
, pp. 281
-
-
Di, X.1
Andrews, D.2
Tucker, C.J.3
Yu, L.4
Moore, A.B.5
Zheng, X.6
Castro, L.7
Hermon, T.8
Xiao, H.9
Dixon, D.A.10
-
34
-
-
0026585245
-
Regulation of globin gene expression in human K562 cells by recombinant Activin A
-
Frigon, N.L., Jr.; Shao, L.-E.; Young, A.L.; Maderazo, L.; Yu, J. Regulation of globin gene expression in human K562 cells by recombinant Activin A. Blood 1992, 3, 765–772.
-
(1992)
Blood
, vol.3
, pp. 765-772
-
-
Frigon, N.L.1
Shao, L.-E.2
Young, A.L.3
Maderazo, L.4
Yu, J.5
-
35
-
-
79951882526
-
Intracrine signaling mechanisms of activin A and TGF-β
-
Gressner, O.A. Intracrine signaling mechanisms of activin A and TGF-β. Vitam Horm. 2011, 85, 59–77.
-
(2011)
Vitam Horm
, vol.85
, pp. 59-77
-
-
Gressner, O.A.1
-
36
-
-
16244400050
-
TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
-
James, D.; Levine, A.J.; Besser, D.; Hemmati-Brivanlou, A. TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005, 132, 1273–1282.
-
(2005)
Development
, vol.132
, pp. 1273-1282
-
-
James, D.1
Levine, A.J.2
Besser, D.3
Hemmati-Brivanlou, A.4
-
37
-
-
48149098004
-
NANOG
-
Xu, R.-H.; Sampsell-Barron, T.L.; Gu, F.; Root, S.; Peck, R.M.; Pan, G.; Yu, J.; Antosiewicz-Bourget, J.; Tian, S.; Stewart, R.; et al. NANOG is a direct target of TGFβ/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell 2008, 3, 196–206.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 196-206
-
-
Xu, R.-H.1
Sampsell-Barron, T.L.2
Gu, F.3
Root, S.4
Peck, R.M.5
Pan, G.6
Yu, J.7
Antosiewicz-Bourget, J.8
Tian, S.9
Stewart, R.10
-
38
-
-
84885064365
-
Signaling by the TGFβ Superfamily
-
Wrana, J.L. Signaling by the TGFβ Superfamily. Cold Spring Harb. Perspect. Biol. 2013, 5, a011197–a011197.
-
(2013)
Cold Spring Harb. Perspect. Biol
, vol.5
, pp. a011197-a011197
-
-
Wrana, J.L.1
-
39
-
-
84891012505
-
Switch enhancers interpret TGF-β and hippo signaling to control cell fate in human embryonic stem cells
-
Beyer, T.A.; Weiss, A.; Khomchuk, Y.; Huang, K.; Ogunjimi, A.A.; Varelas, X.; Wrana, J.L. Switch enhancers interpret TGF-β and hippo signaling to control cell fate in human embryonic stem cells. Cell Rep. 2013, 5, 1611–1624.
-
(2013)
Cell Rep
, vol.5
, pp. 1611-1624
-
-
Beyer, T.A.1
Weiss, A.2
Khomchuk, Y.3
Huang, K.4
Ogunjimi, A.A.5
Varelas, X.6
Wrana, J.L.7
-
40
-
-
84904460051
-
Seminars in cell & developmental biology
-
Itoh, F.; Watabe, T.; Miyazono, K. Seminars in cell & developmental biology. Semin. Cell Dev. Biol. 2014, 32, 98–106.
-
(2014)
Semin. Cell Dev. Biol
, vol.32
, pp. 98-106
-
-
Itoh, F.1
Watabe, T.2
Miyazono, K.3
-
41
-
-
30944468997
-
Activin A and inhibin A differentially regulate human uterine matrix metalloproteinases: Potential interactions during decidualization and trophoblast invasion
-
Jones, R.L.; Findlay, J.K.; Farnworth, P.G.; Robertson, D.M.; Wallace, E.; Salamonsen, L.A. Activin A and inhibin A differentially regulate human uterine matrix metalloproteinases: Potential interactions during decidualization and trophoblast invasion. Endocrinology 2006, 147, 724–732.
-
(2006)
Endocrinology
, vol.147
, pp. 724-732
-
-
Jones, R.L.1
Findlay, J.K.2
Farnworth, P.G.3
Robertson, D.M.4
Wallace, E.5
Salamonsen, L.A.6
-
42
-
-
84861652694
-
Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation
-
Hedger, M.P.; Winnall, W.R. Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation. Mol. Cell. Endocrinol. 2012, 359, 30–42.
-
(2012)
Mol. Cell. Endocrinol
, vol.359
, pp. 30-42
-
-
Hedger, M.P.1
Winnall, W.R.2
-
43
-
-
0346025350
-
The role of follistatin domains in follistatin biological action
-
Keutmann, H.T.; Schneyer, A.L.; Sidis, Y. The role of follistatin domains in follistatin biological action. Mol. Endocrinol.2004, 18, 228–240.
-
(2004)
Mol. Endocrinol
, vol.18
, pp. 228-240
-
-
Keutmann, H.T.1
Schneyer, A.L.2
Sidis, Y.3
-
44
-
-
0442275213
-
Progesterone action in the human endometrium: Induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expression
-
Osteen, K.G.; Igarashi, T.M.; Bruner-Tran, K.L. Progesterone action in the human endometrium: Induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expression. Front. Biosci. 2003, 8, d78–d86.
-
(2003)
Front. Biosci
, vol.8
, pp. d78-d86
-
-
Osteen, K.G.1
Igarashi, T.M.2
Bruner-Tran, K.L.3
-
45
-
-
0030069211
-
Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors
-
De Winter, J.P.; ten Dijke, P.; de Vries, C.J.; van Achterberg, T.A.; Sugino, H.; de Waele, P.; Huylebroeck, D.; Verschueren, K.; van den Eijnden-van Raaij, A.J.M. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors. Mol. Cell. Endocrinol. 1996, 116, 105–114.
-
(1996)
Mol. Cell. Endocrinol
, vol.116
, pp. 105-114
-
-
De Winter, J.P.1
Ten Dijke, P.2
De Vries, C.J.3
Van Achterberg, T.A.4
Sugino, H.5
De Waele, P.6
Huylebroeck, D.7
Verschueren, K.8
Van Den Eijnden-Van Raaij, A.9
-
46
-
-
0030854868
-
Activin is a local regulator of human cytotrophoblast cell differentiation
-
Canigga, I.; Lye, S.J.; Cross, J.C. Activin is a local regulator of human cytotrophoblast cell differentiation. Endocrinology1997, 138, 3976–3986.
-
(1997)
Endocrinology
, vol.138
, pp. 3976-3986
-
-
Canigga, I.1
Lye, S.J.2
Cross, J.C.3
-
47
-
-
0034665293
-
Activin A stimulates type IV collagenase (Matrix metalloproteinase-2) production in mouse peritoneal macrophages
-
Ogawa, K.; Funaba, M.; Mathews, L.S.; Mizutani, T. Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages. J. Immunol. 2000, 165, 2997–3003.
-
(2000)
J. Immunol
, vol.165
, pp. 2997-3003
-
-
Ogawa, K.1
Funaba, M.2
Mathews, L.S.3
Mizutani, T.4
-
48
-
-
0034889348
-
Effect of activin A on
-
Zhao, J.; Taverne, M.A.M.; van der Weijden, G.C.; Bevers, M.M.; van den Hurk, R. Effect of activin A on in vitro development of rat preantral follicles and localization of activin A and activin receptor II. Biol. Reprod. 2001, 65, 967–977.
-
(2001)
Biol. Reprod
, vol.65
, pp. 967-977
-
-
Zhao, J.1
Taverne, M.2
Van Der Weijden, G.C.3
Bevers, M.M.4
Van Den Hurk, R.5
-
49
-
-
6344282425
-
Differential distribution of follistatin isoforms: Application of a new FS315-specific immunoassay
-
Schneyer, A.L.; Wang, Q.; Sidis, Y.; Sluss, P.M. Differential distribution of follistatin isoforms: Application of a new FS315-specific immunoassay. J. Clin. Endocrinol. Metab. 2004, 89, 5067–5075.
-
(2004)
J. Clin. Endocrinol. Metab
, vol.89
, pp. 5067-5075
-
-
Schneyer, A.L.1
Wang, Q.2
Sidis, Y.3
Sluss, P.M.4
-
50
-
-
84888609209
-
Influence of activin a supplementation during human embryonic stem cell derivation on germ cell differentiation potential
-
Duggal, G.; Heindryckx, B.; Warrier, S.; O’Leary, T.; van der Jeught, M.; Lierman, S.; Vossaert, L.; Deroo, T.; Deforce, D.; Chuva de Sousa Lopes, S.M.; et al. Influence of activin a supplementation during human embryonic stem cell derivation on germ cell differentiation potential. Stem Cells Dev. 2013, 22, 3141–3155.
-
(2013)
Stem Cells Dev
, vol.22
, pp. 3141-3155
-
-
Duggal, G.1
Heindryckx, B.2
Warrier, S.3
O’Leary, T.4
Van Der Jeught, M.5
Lierman, S.6
Vossaert, L.7
Deroo, T.8
Deforce, D.9
De Chuva Sousa Lopes, S.M.10
-
51
-
-
26444515002
-
The structure of the follistatin:Activin complex reveals antagonism of both type I and type II receptor binding
-
Thompson, T.B.; Lerch, T.F.; Cook, R.W.; Woodruff, T.K.; Jardetzky, T.S. The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. Dev. Cell2005, 9, 535–543.
-
(2005)
Dev. Cell
, vol.9
, pp. 535-543
-
-
Thompson, T.B.1
Lerch, T.F.2
Cook, R.W.3
Woodruff, T.K.4
Jardetzky, T.S.5
-
52
-
-
84885387439
-
Activin A and Wnt-dependent specification of human definitive endoderm cells
-
Toivonen, S.; Lundin, K.; Balboa, D.; Ustinov, J.; Tamminen, K.; Palgi, J.; Trokovic, R.; Tuuri, T.; Otonkoski, T. Activin A and Wnt-dependent specification of human definitive endoderm cells. Exp. Cell Res. 2013, 319, 2535–2544.
-
(2013)
Exp. Cell Res
, vol.319
, pp. 2535-2544
-
-
Toivonen, S.1
Lundin, K.2
Balboa, D.3
Ustinov, J.4
Tamminen, K.5
Palgi, J.6
Trokovic, R.7
Tuuri, T.8
Otonkoski, T.9
-
53
-
-
0030957937
-
Novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate
-
Hashimoto, O.; Nakamura, T.; Shoji, H.; Shimasaki, S.; Hayashi, Y.; Sugino, H. A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. J. Biol. Chem. 1997, 272, 13835–13842.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 13835-13842
-
-
Hashimoto, O.1
Nakamura, T.2
Shoji, H.3
Shimasaki, S.4
Hayashi, Y.5
Sugino, H.A.6
-
54
-
-
0025117393
-
Activin-binding protein from rat ovary is follistatin
-
Nakamura, T.; Takio, K.; Eto, Y.; Shibai, H.; Titani, K.; Sugino, H. Activin-binding protein from rat ovary is follistatin. Science1990, 247, 836–838.
-
(1990)
Science
, vol.247
, pp. 836-838
-
-
Nakamura, T.1
Takio, K.2
Eto, Y.3
Shibai, H.4
Titani, K.5
Sugino, H.6
-
55
-
-
77956387042
-
Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells
-
Evseenko, D.; Zhu, Y.; Schenke-Layland, K.; Kuo, J.; Latour, B.; Ge, S.; Scholes, J.; Dravid, G.; Li, X.; MacLellan, W.R.; et al. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc. Natl. Acad. Sci. USA2010, 107, 13742–13747.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 13742-13747
-
-
Evseenko, D.1
Zhu, Y.2
Schenke-Layland, K.3
Kuo, J.4
Latour, B.5
Ge, S.6
Scholes, J.7
Dravid, G.8
Li, X.9
Maclellan, W.R.10
-
56
-
-
0035974432
-
The roles of activins in repair processes of the skin and the brain
-
Munz, B.; Tretter, Y.P.; Hertel, M.; Engelhardt, F.; Alzheimer, C.; Werner, S. The roles of activins in repair processes of the skin and the brain. Mol. Cell. Endocrinol. 2001, 180, 169–177.
-
(2001)
Mol. Cell. Endocrinol
, vol.180
, pp. 169-177
-
-
Munz, B.1
Tretter, Y.P.2
Hertel, M.3
Engelhardt, F.4
Alzheimer, C.5
Werner, S.6
-
57
-
-
0022625533
-
Isolation of a 31 kDa form of inhibin from bovine follicular fluid
-
Robertson, D.M.; de Vos, F.L.; Foulds, L.M.; McLachlan, R.I.; Burger, H.G.; Morgan, F.J.; Hearn, M.T.W.; de Kretser, D.M. Isolation of a 31 kDa form of inhibin from bovine follicular fluid. Mol. Cell. Endocrinol. 1986, 44, 271–277.
-
(1986)
Mol. Cell. Endocrinol
, vol.44
, pp. 271-277
-
-
Robertson, D.M.1
De Vos, F.L.2
Foulds, L.M.3
McLachlan, R.I.4
Burger, H.G.5
Morgan, F.J.6
Hearn, M.7
De Kretser, D.M.8
-
58
-
-
34547909927
-
Activin-βA signaling is required for zebrafish fin regeneration
-
Jaźwińska, A.; Badakov, R.; Keating, M.T. Activin-βA signaling is required for zebrafish fin regeneration. Curr. Biol. 2007, 17, 1390–1395.
-
(2007)
Curr. Biol
, vol.17
, pp. 1390-1395
-
-
Jaźwińska, A.1
Badakov, R.2
Keating, M.T.3
-
59
-
-
0034704753
-
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
-
Lewis, K.A.; Gray, P.C.; Blount, A.L.; MacConell, L.A.; Wiater, E.; Bilezikjian, L.M.; Vale, W. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature2000, 404, 411–414.
-
(2000)
Nature
, vol.404
, pp. 411-414
-
-
Lewis, K.A.1
Gray, P.C.2
Blount, A.L.3
Macconell, L.A.4
Wiater, E.5
Bilezikjian, L.M.6
Vale, W.7
-
60
-
-
0034016101
-
Positive and regative regulation of TGF-β signaling
-
Miyazono, K. Positive and regative regulation of TGF-β signaling. J. Cell Sci. 2000, 113, 1101–1109.
-
(2000)
J. Cell Sci
, vol.113
, pp. 1101-1109
-
-
Miyazono, K.1
-
61
-
-
0342902626
-
Strong induction of activin expression after injury suggests an important role of activin in wound repair
-
Hübner, G.; Hu, Q.; Smola, H.; Werner, S. Strong induction of activin expression after injury suggests an important role of activin in wound repair. Dev. Biol. 1996, 173, 490–498.
-
(1996)
Dev. Biol
, vol.173
, pp. 490-498
-
-
Hübner, G.1
Hu, Q.2
Smola, H.3
Werner, S.4
-
62
-
-
67650996280
-
Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
-
Acloque, H.; Adams, M.S.; Fishwick, K.; Bronner-Fraser, M.; Nieto, M.A. Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease. J. Clin. Invest. 2009, 119, 1438–1449.
-
(2009)
J. Clin. Invest
, vol.119
, pp. 1438-1449
-
-
Acloque, H.1
Adams, M.S.2
Fishwick, K.3
Bronner-Fraser, M.4
Nieto, M.A.5
-
63
-
-
0025044478
-
The biological effects of XTC-MIF: Quantitative comparison with Xenopus bFGF
-
Green, J.B.; Howes, G.; Symes, K.; Cooke, J.; Smith, J.C. The biological effects of XTC-MIF: Quantitative comparison with Xenopus bFGF. Development 1990, 108, 173–183.
-
(1990)
Development
, vol.108
, pp. 173-183
-
-
Green, J.B.1
Howes, G.2
Symes, K.3
Cooke, J.4
Smith, J.C.5
-
64
-
-
12144285683
-
Elevated levels of activin A in heart failure: Potential role in myocardial remodeling
-
Yndestad, A.; Ueland, T.; Øie, E.; Florholmen, G.; Halvorsen, B.; Attramadal, H.; Simonsen, S.; Frøland, S.S.; Gullestad, L.; Christensen, G.; et al. Elevated levels of activin A in heart failure: Potential role in myocardial remodeling. Circulation 2004, 109, 1379–1385.
-
(2004)
Circulation
, vol.109
, pp. 1379-1385
-
-
Yndestad, A.1
Ueland, T.2
Øie, E.3
Florholmen, G.4
Halvorsen, B.5
Attramadal, H.6
Simonsen, S.7
Frøland, S.S.8
Gullestad, L.9
Christensen, G.10
-
65
-
-
0036718369
-
Reactive stroma in human prostate cancer: Induction of myofibroblast phenotype and extracellular matrix remodeling
-
Tuxhorn, J.A.; Ayala, G.E.; Smith, M.J.; Smith, V.C.; Dang, T.D.; Rowley, D.R. Reactive stroma in human prostate cancer: Induction of myofibroblast phenotype and extracellular matrix remodeling. Clin. Cancer Res. 2002, 8, 2912–2923.
-
(2002)
Clin. Cancer Res
, vol.8
, pp. 2912-2923
-
-
Tuxhorn, J.A.1
Ayala, G.E.2
Smith, M.J.3
Smith, V.C.4
Dang, T.D.5
Rowley, D.R.6
-
66
-
-
4644356541
-
Activin: An important regulator of wound repair, fibrosis, and neuroprotection
-
Sulyok, S.; Wankell, M.; Alzheimer, C.; Werner, S. Activin: An important regulator of wound repair, fibrosis, and neuroprotection. Mol. Cell. Endocrinol. 2004, 225, 127–132.
-
(2004)
Mol. Cell. Endocrinol
, vol.225
, pp. 127-132
-
-
Sulyok, S.1
Wankell, M.2
Alzheimer, C.3
Werner, S.4
-
67
-
-
0026772232
-
Differential expression of the TGF-β isoforms in embryogenesis suggests specific roles in developing and adult tissues
-
Roberts, A.B.; Sporn, M.B. Differential expression of the TGF-β isoforms in embryogenesis suggests specific roles in developing and adult tissues. Mol. Reprod. Dev.1992, 32, 91–98.
-
(1992)
Mol. Reprod. Dev
, vol.32
, pp. 91-98
-
-
Roberts, A.B.1
Sporn, M.B.2
-
68
-
-
0036095708
-
Serum and tissue expression of activin a in postmenopausal women with breast cancer
-
Reis, F.M.; Cobellis, L.; Tameirão, L.C.; Anania, G.; Luisi, S.; Silva, I.S.B.; Gioffrè, W.; di Blasio, A.M.; Petraglia, F. Serum and tissue expression of activin a in postmenopausal women with breast cancer. J. Clin. Endocrinol. Metab. 2002, 87, 2277–2282.
-
(2002)
J. Clin. Endocrinol. Metab
, vol.87
, pp. 2277-2282
-
-
Reis, F.M.1
Cobellis, L.2
Tameirão, L.C.3
Anania, G.4
Luisi, S.5
Silva, I.6
Gioffrè, W.7
Di Blasio, A.M.8
Petraglia, F.9
-
69
-
-
84870231896
-
Activin A stimulates AKR1C3 expression and growth in human prostate cancer
-
Hofland, J.; van Weerden, W.M.; Steenbergen, J.; Dits, N.F.J.; Jenster, G.; de Jong, F.H. Activin A stimulates AKR1C3 expression and growth in human prostate cancer. Endocrinology 2012, 153, 5726–5734.
-
(2012)
Endocrinology
, vol.153
, pp. 5726-5734
-
-
Hofland, J.1
Van Weerden, W.M.2
Steenbergen, J.3
Dits, N.4
Jenster, G.5
De Jong, F.H.6
-
70
-
-
84905899881
-
TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1
-
Thakur, N.; Gudey, S.K.; Marcusson, A.; Fu, J.Y.; Bergh, A.; Heldin, C.-H.; Landström, M. TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1. Cell Cycle 2014, 13, 2400–2414.
-
(2014)
Cell Cycle
, vol.13
, pp. 2400-2414
-
-
Thakur, N.1
Gudey, S.K.2
Marcusson, A.3
Fu, J.Y.4
Bergh, A.5
Heldin, C.-H.6
Landström, M.7
-
71
-
-
0012114501
-
Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells
-
Liu, Q.Y.; Niranjan, B.; Gomes, P.; Gomm, J.J.; Davies, D.; Coombes, R.C.; Buluwela, L. Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells. Cancer Res. 1996, 56, 1155–1163.
-
(1996)
Cancer Res
, vol.56
, pp. 1155-1163
-
-
Liu, Q.Y.1
Niranjan, B.2
Gomes, P.3
Gomm, J.J.4
Davies, D.5
Coombes, R.C.6
Buluwela, L.7
-
72
-
-
33747614295
-
, and bone morphogenic protein pathways in human embryonic stem cells
-
Xiao, L.; Yuan, X.; Sharkis, S.J. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 2006, 24, 1476–1486.
-
(2006)
Stem Cells
, vol.24
, pp. 1476-1486
-
-
Xiao, L.1
Yuan, X.2
Sharkis, S.J.3
-
73
-
-
2942536704
-
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein
-
Kowanetz, M.; Valcourt, U.; Bergström, R.; Heldin, C.-H.; Moustakas, A. Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein. Mol. Cell. Biol. 2004, 24, 4241–4254.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 4241-4254
-
-
Kowanetz, M.1
Valcourt, U.2
Bergström, R.3
Heldin, C.-H.4
Moustakas, A.5
-
74
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
-
Polyak, K.; Weinberg, R.A. Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat. Rev. Cancer 2009, 9, 265–273.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
75
-
-
16344378397
-
TGFβ and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
-
Valcourt, U.; Kowanetz, M.; Niimi, H.; Heldin, C.-H.; Moustakas, A. TGFβ and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol. Biol. Cell 2005, 16, 1987–2002.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 1987-2002
-
-
Valcourt, U.1
Kowanetz, M.2
Niimi, H.3
Heldin, C.-H.4
Moustakas, A.5
-
76
-
-
84867251505
-
The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression
-
Le Bras, G.F.; Taubenslag, K.J.; Andl, C.D. The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. Cell Adh. Migr. 2012, 6, 365–373.
-
(2012)
Cell Adh. Migr
, vol.6
, pp. 365-373
-
-
Le Bras, G.F.1
Taubenslag, K.J.2
Andl, C.D.3
-
77
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery, J.P.; Acloque, H.; Huang, R.Y.J.; Nieto, M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139, 871–890.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.3
Nieto, M.A.4
-
78
-
-
67649528138
-
Collective cell migration in morphogenesis, regeneration and cancer
-
Friedl, P.; Gilmour, D. Collective cell migration in morphogenesis, regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2009, 10, 1–13
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 1-13
-
-
Friedl, P.1
Gilmour, D.2
-
79
-
-
84901218516
-
Leader cell positioning drives wound-directed collective migration in TGFβ-stimulated epithelial sheets
-
Chapnick, D.A.; Liu, X. Leader cell positioning drives wound-directed collective migration in TGFβ-stimulated epithelial sheets. Mol. Biol. Cell2014, 25, 1586–1593
-
(2014)
Mol. Biol. Cell
, vol.25
, pp. 1586-1593
-
-
Chapnick, D.A.1
Liu, X.2
-
80
-
-
84917737797
-
TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion
-
Le Bras, G.F.; Taylor, C.; Koumangoye, R.B.; Revetta, F.; Loomans, H.A.; Andl, C.D. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion. Exp. Cell Res. 2014, 330, 29–42
-
(2014)
Exp. Cell Res
, vol.330
, pp. 29-42
-
-
Le Bras, G.F.1
Taylor, C.2
Koumangoye, R.B.3
Revetta, F.4
Loomans, H.A.5
Andl, C.D.6
-
81
-
-
84863104141
-
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk
-
Matise, L.A.; Palmer, T.D.; Ashby, W.J.; Nashabi, A.; Chytil, A.; Aakre, M.; Pickup, M.W.; Gorska, A.E.; Zijlstra, A.; Moses, H.L. Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk. Breast Cancer Res. 2012, 14, R98
-
(2012)
Breast Cancer Res
, vol.14
-
-
Matise, L.A.1
Palmer, T.D.2
Ashby, W.J.3
Nashabi, A.4
Chytil, A.5
Aakre, M.6
Pickup, M.W.7
Gorska, A.E.8
Zijlstra, A.9
Moses, H.L.10
-
82
-
-
0037422181
-
TGF-β-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines
-
Fink, S.P.; Mikkola, D.; Willson, J.K.V.; Markowitz, S. TGF-β-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. Oncogene2003, 22, 1317–1323
-
(2003)
Oncogene
, vol.22
, pp. 1317-1323
-
-
Fink, S.P.1
Mikkola, D.2
Willson, J.3
Markowitz, S.4
-
83
-
-
0038756352
-
Down-regulation of activin, activin receptors, and Smads in high-grade breast cancer
-
Jeruss, J.S.; Sturgis, C.D.; Rademaker, A.W.; Woodruff, T.K. Down-regulation of activin, activin receptors, and Smads in high-grade breast cancer. Cancer Res. 2003, 63, 3783–3790
-
(2003)
Cancer Res
, vol.63
, pp. 3783-3790
-
-
Jeruss, J.S.1
Sturgis, C.D.2
Rademaker, A.W.3
Woodruff, T.K.4
-
84
-
-
84902119638
-
Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer
-
Togashi, Y.; Sakamoto, H.; Hayashi, H.; Terashima, M.; de Velasco, M.A.; Fujita, Y.; Kodera, Y.; Sakai, K.; Tomida, S.; Kitano, M.; et al. Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer. Mol. Cancer2014, 13, 1–15
-
(2014)
Mol. Cancer
, vol.13
, pp. 1-15
-
-
Togashi, Y.1
Sakamoto, H.2
Hayashi, H.3
Terashima, M.4
De Velasco, M.A.5
Fujita, Y.6
Kodera, Y.7
Sakai, K.8
Tomida, S.9
Kitano, M.10
-
85
-
-
84925615181
-
Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma
-
Kelner, N.; Rodrigues, P.C.; Bufalino, A.; Fonseca, F.; dos Santos-Silva, A.R.; Miguel, M.C.C.; Pinto, C.A.L.; Leme, A.F.P.; Graner, E.; Salo, T.; et al. Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma. Head Neck2014, doi:10.1002/hed.23627
-
(2014)
Head Neck
-
-
Kelner, N.1
Rodrigues, P.C.2
Bufalino, A.3
Fonseca, F.4
Dos Santos-Silva, A.R.5
Miguel, M.6
Pinto, C.7
Leme, A.8
Graner, E.9
Salo, T.10
-
86
-
-
65549129119
-
Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma
-
Seder, C.W.; Hartojo, W.; Lin, L.; Silvers, A.L.; Wang, Z.; Thomas, D.G.; Giordano, T.J.; Chen, G.; Chang, A.C.; Orringer, M.B.; et al. Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. Neoplasia2009, 11, 388–396
-
(2009)
Neoplasia
, vol.11
, pp. 388-396
-
-
Seder, C.W.1
Hartojo, W.2
Lin, L.3
Silvers, A.L.4
Wang, Z.5
Thomas, D.G.6
Giordano, T.J.7
Chen, G.8
Chang, A.C.9
Orringer, M.B.10
-
87
-
-
0028929863
-
Functional analysis of activins during mammalian development
-
Matzuk, M.M.; Kumar, T.R.; Vassalli, A.; Bickenbach, J.R.; Roop, D.R.; Jaenisch, R.; Bradley, A. Functional analysis of activins during mammalian development. Nature1995, 374, 354–356
-
(1995)
Nature
, vol.374
, pp. 354-356
-
-
Matzuk, M.M.1
Kumar, T.R.2
Vassalli, A.3
Bickenbach, J.R.4
Roop, D.R.5
Jaenisch, R.6
Bradley, A.7
-
88
-
-
0030014349
-
Activation of human progelatinase A by collagenase and matrilysin: Activation of procollagenase by matrilysin
-
Sang, Q.A.; Bodden, M.K.; Windsor, L.J. Activation of human progelatinase A by collagenase and matrilysin: Activation of procollagenase by matrilysin. J. Protein Chem. 1996, 15, 243–253
-
(1996)
J. Protein Chem
, vol.15
, pp. 243-253
-
-
Sang, Q.A.1
Bodden, M.K.2
Windsor, L.J.3
-
89
-
-
54849187300
-
Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line
-
Yoshinaga, K.; Mimori, K.; Inoue, H.; Kamohara, Y.; Yamashita, K.; Tanaka, F.; Mori, M. Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line. Int. J. Oncol. 2008, 33, 453–459
-
(2008)
Int. J. Oncol
, vol.33
, pp. 453-459
-
-
Yoshinaga, K.1
Mimori, K.2
Inoue, H.3
Kamohara, Y.4
Yamashita, K.5
Tanaka, F.6
Mori, M.7
-
90
-
-
0034425726
-
Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions
-
Brown, C.W.; Houston-Hawkins, D.E.; Woodruff, T.K.; Matzuk, M.M. Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat. Genet. 2000, 25, 453–457
-
(2000)
Nat. Genet
, vol.25
, pp. 453-457
-
-
Brown, C.W.1
Houston-Hawkins, D.E.2
Woodruff, T.K.3
Matzuk, M.M.4
-
91
-
-
0036781973
-
A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
-
Suyama, K.; Shapiro, I.; Guttman, M.; Hazan, R.B. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell2002, 2, 301–314
-
(2002)
Cancer Cell
, vol.2
, pp. 301-314
-
-
Suyama, K.1
Shapiro, I.2
Guttman, M.3
Hazan, R.B.4
-
92
-
-
4444298259
-
N-Cadherin is regulated by Activin A and associated with tumor aggressiveness in esophageal carcinoma
-
Yoshinaga, K.; Inoue, H.; Utsunomiya, T.; Sonoda, H.; Masuda, T.; Mimori, K.; anaka, Y.; Mori, M. N-Cadherin is regulated by Activin A and associated with tumor aggressiveness in esophageal carcinoma. Clin. Cancer Res. 2004, 10, 5702–5707.
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 5702-5707
-
-
Yoshinaga, K.1
Inoue, H.2
Utsunomiya, T.3
Sonoda, H.4
Masuda, T.5
Mimori, K.6
Anaka, Y.7
Mori, M.8
-
93
-
-
78649872745
-
Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis
-
Cufí, S.; Vazquez-Martin, A.; Oliveras-Ferraros, C.; Martin-Castillo, B.; Joven, J.; Menendez, J.A. Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): From cancer stem cells to aging-associated fibrosis. Cell Cycle2010, 9, 4461–4468
-
(2010)
Cell Cycle
, vol.9
, pp. 4461-4468
-
-
Cufí, S.1
Vazquez-Martin, A.2
Oliveras-Ferraros, C.3
Martin-Castillo, B.4
Joven, J.5
Menendez, J.A.6
-
94
-
-
74949093198
-
Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer
-
Miyazono, K. Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer. Proc. Jpn. Acad. Ser. B2009, 85, 314–323
-
(2009)
Proc. Jpn. Acad. Ser. B
, vol.85
, pp. 314-323
-
-
Miyazono, K.1
-
95
-
-
0032862565
-
Identification of an activin-follistatin growth modulatory system in the human prostate: Secretion and biological activity in primary cultures of prostatic epithelial cells
-
Wang, Q.; Tabatabaei, S.; Planz, B.; Lin, C.W.; Sluss, P.M. Identification of an activin-follistatin growth modulatory system in the human prostate: Secretion and biological activity in primary cultures of prostatic epithelial cells. J. Urol. 1999, 161, 1378–1384
-
(1999)
J. Urol
, vol.161
, pp. 1378-1384
-
-
Wang, Q.1
Tabatabaei, S.2
Planz, B.3
Lin, C.W.4
Sluss, P.M.5
-
96
-
-
84877004454
-
Cytokine patterns in patients with cancer: A systematic review
-
Lippitz, B.E. Cytokine patterns in patients with cancer: A systematic review. Lancet Oncol. 2013, 14, e218–e228
-
(2013)
Lancet Oncol
, vol.14
, pp. e218-e228
-
-
Lippitz, B.E.1
-
97
-
-
0031990782
-
Overexpression of transforming growth factor (TGF) β1 type II receptor restores TGF-β1 sensitivity and signaling in human prostate cancer cells
-
Guo, Y.; Kyprianou, N. Overexpression of transforming growth factor (TGF) β1 type II receptor restores TGF-β1 sensitivity and signaling in human prostate cancer cells. Cell Growth Differ. 1998, 9, 185–193
-
(1998)
Cell Growth Differ
, vol.9
, pp. 185-193
-
-
Guo, Y.1
Kyprianou, N.2
-
98
-
-
84893858450
-
Transforming growth factor-β and matrix metalloproteinases: Functional interactions in tumor stroma-infiltrating myeloid cells
-
Article ID 521754
-
Krstic, J.; Santibanez, J.F. Transforming growth factor-β and matrix metalloproteinases: Functional interactions in tumor stroma-infiltrating myeloid cells. Sci. World J.2014, Article ID 521754
-
(2014)
Sci. World J.
-
-
Krstic, J.1
Santibanez, J.F.2
-
99
-
-
0033534572
-
Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-β superfamily
-
Barbara, N.P.; Wrana, J.L.; Letarte, M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-β superfamily. J. Biol. Chem. 1999, 274, 584–594.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 584-594
-
-
Barbara, N.P.1
Wrana, J.L.2
Letarte, M.3
-
100
-
-
84881506626
-
Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors
-
Breen, M.J.; Moran, D.M.; Liu, W.; Huang, X.; Vary, C.P.H.; Bergan, R.C. Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors. PLOS ONE2013, 8, e72407.
-
(2013)
PLOS ONE
, vol.8
-
-
Breen, M.J.1
Moran, D.M.2
Liu, W.3
Huang, X.4
Vary, C.5
Bergan, R.C.6
-
101
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell2000, 100, 57–70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
102
-
-
84861695148
-
Insensitivity to the growth inhibitory effects of activin A: An acquired capability in prostate cancer progression
-
Ottley, E.; Gold, E. Insensitivity to the growth inhibitory effects of activin A: An acquired capability in prostate cancer progression. Cytokine Growth Factor Rev. 2012, 23, 119–125.
-
(2012)
Cytokine Growth Factor Rev
, vol.23
, pp. 119-125
-
-
Ottley, E.1
Gold, E.2
-
103
-
-
65249138364
-
Activin A promotes the TGF-β-induced conversion of CD4+CD25- cells into Foxp3+ induced regulatory T cells
-
Huber, S.; Stahl, F.R.; Schrader, J.; Luth, S.; Presser, K.; Carambia, A.; Flavell, R.A.; Werner, S.; Blessing, M.; Herkel, J.; et al. Activin A promotes the TGF-β-induced conversion of CD4+CD25- cells into Foxp3+ induced regulatory T cells. J. Immunol. 2009, 182, 4633–4640.
-
(2009)
J. Immunol
, vol.182
, pp. 4633-4640
-
-
Huber, S.1
Stahl, F.R.2
Schrader, J.3
Luth, S.4
Presser, K.5
Carambia, A.6
Flavell, R.A.7
Werner, S.8
Blessing, M.9
Herkel, J.10
-
104
-
-
77954959913
-
Overexpression of activin A in oral squamous cell carcinoma: Association with poor prognosis and tumor progression
-
Chang, K.-P.; Kao, H.-K.; Liang, Y.; Cheng, M.-H.; Chang, Y.-L.; Liu, S.-C.; Lin, Y.-C.; Ko, T.-Y.; Lee, Y.-S.; Tsai, C.-L.; et al. Overexpression of activin A in oral squamous cell carcinoma: Association with poor prognosis and tumor progression. Ann. Surg. Oncol. 2010, 17, 1945–1956.
-
(2010)
Ann. Surg. Oncol
, vol.17
, pp. 1945-1956
-
-
Chang, K.-P.1
Kao, H.-K.2
Liang, Y.3
Cheng, M.-H.4
Chang, Y.-L.5
Liu, S.-C.6
Lin, Y.-C.7
Ko, T.-Y.8
Lee, Y.-S.9
Tsai, C.-L.10
-
105
-
-
4744356110
-
TGF-β induces Foxp3 + T-regulatory cells from CD4 + CD25—Precursors
-
Fu, S.; Zhang, N.; Yopp, A.C.; Chen, D.; Mao, M.; Chen, D.; Zhang, H.; Ding, Y.; Bromberg, J.S. TGF-β induces Foxp3 + T-regulatory cells from CD4 + CD25—Precursors. Am. J. Transpl. 2004, 4, 1614–1627.
-
(2004)
Am. J. Transpl
, vol.4
, pp. 1614-1627
-
-
Fu, S.1
Zhang, N.2
Yopp, A.C.3
Chen, D.4
Mao, M.5
Chen, D.6
Zhang, H.7
Ding, Y.8
Bromberg, J.S.9
-
106
-
-
79951883349
-
Activin in humoral immune responses
-
Ogawa, K.; Funaba, M. Activin in humoral immune responses. Vitam Horm. 2011, 85, 235–253.
-
(2011)
Vitam Horm
, vol.85
, pp. 235-253
-
-
Ogawa, K.1
Funaba, M.2
-
107
-
-
0027378407
-
Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells
-
Yamashita, N.; Nakajima, T.; Takahashi, H.; Kaneoka, H.; Mizushima, Y.; Sakane, T. Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells. Clin. Exp. Immunol. 2006, 94, 214–219.
-
(2006)
Clin. Exp. Immunol
, vol.94
, pp. 214-219
-
-
Yamashita, N.1
Nakajima, T.2
Takahashi, H.3
Kaneoka, H.4
Mizushima, Y.5
Sakane, T.6
-
108
-
-
0034973221
-
Role of activin A in negative regulation of normal and tumor B lymphocytes
-
Zipori, D.; Barda-Saad, M. Role of activin A in negative regulation of normal and tumor B lymphocytes. J. Leukoc. Biol. 2001, 69, 867–873.
-
(2001)
J. Leukoc. Biol
, vol.69
, pp. 867-873
-
-
Zipori, D.1
Barda-Saad, M.2
-
109
-
-
45949099550
-
A dual role of activin A in regulating immunoglobulin production of B cells
-
Ogawa, K.; Funaba, M.; Tsujimoto, M. A dual role of activin A in regulating immunoglobulin production of B cells. J. Leukoc. Biol. 2008, 83, 1451–1458
-
(2008)
J. Leukoc. Biol
, vol.83
, pp. 1451-1458
-
-
Ogawa, K.1
Funaba, M.2
Tsujimoto, M.3
-
110
-
-
13244255427
-
Inhibin resistance is associated with aggressive tumorigenicity of ovarian cancer cells
-
Steller, M.D.; Shaw, T.J.; Vanderhyden, B.C.; Ethier, J.-F. Inhibin resistance is associated with aggressive tumorigenicity of ovarian cancer cells. Mol. Cancer Res. 2005, 3, 50–61.
-
(2005)
Mol. Cancer Res
, vol.3
, pp. 50-61
-
-
Steller, M.D.1
Shaw, T.J.2
Vanderhyden, B.C.3
Ethier, J.-F.4
-
111
-
-
0033378589
-
The role of TGF-β in growth, differentiation, and maturation of B lymphocytes
-
Lebman, D.A.; Edmiston, J.S. The role of TGF-β in growth, differentiation, and maturation of B lymphocytes. Microbes Infect. 1999, 1297–1304.
-
(1999)
Microbes Infect
, pp. 1297-1304
-
-
Lebman, D.A.1
Edmiston, J.S.2
-
112
-
-
0029808482
-
Intracellular demonstration of active TGFβ1 in B cells and plasma cells of autoimmune mice: IgG-bound TGFβ1 suppresses neutrophil function and host defense against Staphylococcus aureus infection
-
Caver, T.E.; O’Sullivan, F.X.; Gold, L.I.; Gresham, H.D. Intracellular demonstration of active TGFβ1 in B cells and plasma cells of autoimmune mice: IgG-bound TGFβ1 suppresses neutrophil function and host defense against Staphylococcus aureus infection. J. Clin. Invest. 1996, 98, 2496–2506.
-
(1996)
J. Clin. Invest
, vol.98
, pp. 2496-2506
-
-
Caver, T.E.1
O’Sullivan, F.X.2
Gold, L.I.3
Gresham, H.D.4
-
113
-
-
0038341915
-
Role of activin A in murine mast cells: Modulation of cell growth, differentiation, and migration
-
Funaba, M.; Ikeda, T.; Ogawa, K.; Murakami, M.; Abe, M. Role of activin A in murine mast cells: Modulation of cell growth, differentiation, and migration. J. Leukoc. Biol.2003, 73, 793–801.
-
(2003)
J. Leukoc. Biol
, vol.73
, pp. 793-801
-
-
Funaba, M.1
Ikeda, T.2
Ogawa, K.3
Murakami, M.4
Abe, M.5
-
114
-
-
65349103038
-
Activin A attenuates several human natural killer cell functions
-
Robson, N.C.; Wei, H.; McAlpine, T.; Kirkpatrick, N.; Cebon, J.; Maraskovsky, E. Activin A attenuates several human natural killer cell functions. Blood 2009, 113, 3218–3225.
-
(2009)
Blood
, vol.113
, pp. 3218-3225
-
-
Robson, N.C.1
Wei, H.2
McAlpine, T.3
Kirkpatrick, N.4
Cebon, J.5
Maraskovsky, E.6
-
115
-
-
84893360652
-
Activin A as a mediator of NK-dendritic cell functional interactions
-
Seeger, P.; Bosisio, D.; Parolini, S.; Badolato, R.; Gismondi, A.; Santoni, A.; Sozzani, S. Activin A as a mediator of NK-dendritic cell functional interactions. J. Immunol. 2014, 192, 1241–1248.
-
(2014)
J. Immunol
, vol.192
, pp. 1241-1248
-
-
Seeger, P.1
Bosisio, D.2
Parolini, S.3
Badolato, R.4
Gismondi, A.5
Santoni, A.6
Sozzani, S.7
-
116
-
-
79958698402
-
Ericsson, J.; et al. TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer
-
Mu, Y.; Sundar, R.; Thakur, N.; Ekman, M.; Gudey, S.K.; Yakymovych, M.; Hermansson, A.; Dimitriou, H.; Bengoechea-Alonso, M.T.; Ericsson, J.; et al. TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat. Comms. 2011, 2, 330.
-
(2011)
Nat. Comms
, vol.2
, pp. 330
-
-
Mu, Y.1
Sundar, R.2
Thakur, N.3
Ekman, M.4
Gudey, S.K.5
Yakymovych, M.6
Hermansson, A.7
Dimitriou, H.8
Bengoechea-Alonso, M.T.9
-
117
-
-
79955958973
-
Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers
-
Sierra-Filardi, E.; Puig-Kröger, A.; Blanco, F.J.; Nieto, C.; Bragado, R.; Palomero, M.I.; Bernabéu, C.; Vega, M.A.; Corbí, A.L. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood 2011, 117, 5092–5101.
-
(2011)
Blood
, vol.117
, pp. 5092-5101
-
-
Sierra-Filardi, E.1
Puig-Kröger, A.2
Blanco, F.J.3
Nieto, C.4
Bragado, R.5
Palomero, M.I.6
Bernabéu, C.7
Vega, M.A.8
Corbí, A.L.9
-
118
-
-
84863691003
-
Macrophages in tumor microenvironments and the progression of tumors
-
Hao, N.-B.; Lü, M.-H.; Fan, Y.-H.; Cao, Y.-L.; Zhang, Z.-R.; Yang, S.-M. Macrophages in tumor microenvironments and the progression of tumors. Clin. Dev. Immunol. 2012, 2012, 1–11.
-
(2012)
Clin. Dev. Immunol
, vol.2012
, pp. 1-11
-
-
Hao, N.-B.1
Lü, M.-H.2
Fan, Y.-H.3
Cao, Y.-L.4
Zhang, Z.-R.5
Yang, S.-M.6
-
119
-
-
31044433663
-
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
-
Condeelis, J.; Pollard, J.W. Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006, 124, 263–266.
-
(2006)
Cell
, vol.124
, pp. 263-266
-
-
Condeelis, J.1
Pollard, J.W.2
-
120
-
-
0027300943
-
Interferon-α and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth
-
Cozzolino, F.; Torica, M.; Lucibello, M.; Morbidelli, L.; Ziche, M.; Platt, J.; Fabiani, S.; Brett, J.; Stern, D. Interferon-α and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth. J. Clin. Invest. 1993, 91, 2504–2512.
-
(1993)
J. Clin. Invest
, vol.91
, pp. 2504-2512
-
-
Cozzolino, F.1
Torica, M.2
Lucibello, M.3
Morbidelli, L.4
Ziche, M.5
Platt, J.6
Fabiani, S.7
Brett, J.8
Stern, D.9
-
121
-
-
84869223265
-
The reactive stroma microenvironment and prostate cancer progression
-
Barron, D.A.; Rowley, D.R. The reactive stroma microenvironment and prostate cancer progression. Endocr. Relat. Cancer 2012, 19, R187–R204.
-
(2012)
Endocr. Relat. Cancer
, vol.19
, pp. R187-R204
-
-
Barron, D.A.1
Rowley, D.R.2
-
122
-
-
0034781894
-
Interleukin-1β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts
-
Abe, M.; Shintani, Y.; Eto, Y.; Harada, K.; Fujinaka, Y.; Kosaka, M.; Matsumoto, T. Interleukin-1β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts. Clin. Exp. Immunol. 2001, 126, 64–68.
-
(2001)
Clin. Exp. Immunol
, vol.126
, pp. 64-68
-
-
Abe, M.1
Shintani, Y.2
Eto, Y.3
Harada, K.4
Fujinaka, Y.5
Kosaka, M.6
Matsumoto, T.7
-
123
-
-
0037446532
-
Regulation of activin A expression in mast cells and asthma: Its effect on the proliferation of human airway smooth muscle cells
-
Cho, S.H.; Yao, Z.; Wang, S.-W.; Alban, R.F.; Barbers, R.G.; French, S.W.; Oh, C.K. Regulation of activin A expression in mast cells and asthma: Its effect on the proliferation of human airway smooth muscle cells. J. Immunol. 2003, 170, 4045–4052.
-
(2003)
J. Immunol
, vol.170
, pp. 4045-4052
-
-
Cho, S.H.1
Yao, Z.2
Wang, S.-W.3
Alban, R.F.4
Barbers, R.G.5
French, S.W.6
Oh, C.K.7
-
124
-
-
29544448270
-
Activin A is an acute allergen-responsive cytokine and provides a link to TGF-β-mediated airway remodeling in asthma
-
Karagiannidis, C.; Hense, G.; Martin, C.; Epstein, M.; Rückert, B.; Mantel, P.-Y.; Menz, G.; Uhlig, S.; Blaser, K.; Schmidt-Weber, C.B. Activin A is an acute allergen-responsive cytokine and provides a link to TGF-β-mediated airway remodeling in asthma. J. Allergy Clin. Immunol. 2006, 117, 111–118.
-
(2006)
J. Allergy Clin. Immunol
, vol.117
, pp. 111-118
-
-
Karagiannidis, C.1
Hense, G.2
Martin, C.3
Epstein, M.4
Rückert, B.5
Mantel, P.-Y.6
Menz, G.7
Uhlig, S.8
Blaser, K.9
Schmidt-Weber, C.B.10
-
125
-
-
84866742560
-
TGFβ signalling in context
-
Massagué, J. TGFβ signalling in context. Nat. Rev. Mol. Cell Biol. 2012, 13, 616–630.
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 616-630
-
-
Massagué, J.1
-
127
-
-
80052265882
-
Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A
-
Sobral, L.M.; Bufalino, A.; Lopes, M.A.; Graner, E.; Salo, T.; Coletta, R.D. Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A. Oral Oncol. 2011, 47, 840–846.
-
(2011)
Oral Oncol
, vol.47
, pp. 840-846
-
-
Sobral, L.M.1
Bufalino, A.2
Lopes, M.A.3
Graner, E.4
Salo, T.5
Coletta, R.D.6
-
128
-
-
0842288323
-
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick, N.A.; Chytil, A.; Plieth, D.; Gorska, A.E.; Dumont, N.; Shappell, S.; Washington, M.K.; Neilson, E.G.; Moses, H.L. TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science2004, 303, 848–851.
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
Chytil, A.2
Plieth, D.3
Gorska, A.E.4
Dumont, N.5
Shappell, S.6
Washington, M.K.7
Neilson, E.G.8
Moses, H.L.9
-
129
-
-
23744452875
-
Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks
-
Cheng, N.; Bhowmick, N.A.; Chytil, A.; Gorksa, A.E.; Brown, K.A.; Muraoka, R.; Arteaga, C.L.; Neilson, E.G.; Hayward, S.W.; Moses, H.L. Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks. Oncogene2005, 24, 5053–5068.
-
(2005)
Oncogene
, vol.24
, pp. 5053-5068
-
-
Cheng, N.1
Bhowmick, N.A.2
Chytil, A.3
Gorksa, A.E.4
Brown, K.A.5
Muraoka, R.6
Arteaga, C.L.7
Neilson, E.G.8
Hayward, S.W.9
Moses, H.L.10
-
130
-
-
0033303686
-
Expression of activin A and follistatin core proteins by human prostate tumor cell lines
-
McPherson, S.J.; Mellor, S.L.; Wang, H.; Evans, L.W.; Groome, N.P.; Risbridger, G.P. Expression of activin A and follistatin core proteins by human prostate tumor cell lines. Endocrinology1999, 140, 5303–5309.
-
(1999)
Endocrinology
, vol.140
, pp. 5303-5309
-
-
McPherson, S.J.1
Mellor, S.L.2
Wang, H.3
Evans, L.W.4
Groome, N.P.5
Risbridger, G.P.6
-
131
-
-
0033515838
-
Differentially expressed genes in activin-induced apoptotic LNCaP cells
-
Lin, S.; Ying, S.Y. Differentially expressed genes in activin-induced apoptotic LNCaP cells. Biochem. Biophys. Res. Commun. 1999, 257, 187–192.
-
(1999)
Biochem. Biophys. Res. Commun
, vol.257
, pp. 187-192
-
-
Lin, S.1
Ying, S.Y.2
-
132
-
-
0034682848
-
Transforming growth factor-β1 inhibits cytokine-mediated induction of human metalloelastase in macrophages
-
Feinberg, M.W.; Jain, M.K.; Werner, F.; Sibinga, N.E.S.; Wiesel, P.; Wang, H.; Topper, J.N.; Perrella, M.A.; Lee, M.E. Transforming growth factor-β1 inhibits cytokine-mediated induction of human metalloelastase in macrophages. J. Biol. Chem. 2000, 275, 25766–25773.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 25766-25773
-
-
Feinberg, M.W.1
Jain, M.K.2
Werner, F.3
Sibinga, N.4
Wiesel, P.5
Wang, H.6
Topper, J.N.7
Perrella, M.A.8
Lee, M.E.9
-
133
-
-
84920885754
-
-
Nashville, TN, USA, Unpublished data
-
Loomans, H.A.; Le Bras, G.F.; Zijlstra, A.; Andl, C.D. Vanderbilt University Medical Center, Nashville, TN, USA, Unpublished data, 2014.
-
(2014)
Vanderbilt University Medical Center
-
-
Loomans, H.A.1
Le Bras, G.F.2
Zijlstra, A.3
Andl, C.D.4
-
134
-
-
0036828120
-
Inhibition of transforming growth factor-β decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model
-
Tuxhorn, J.A.; McAlhany, S.J.; Yang, F.; Dang, T.D.; Rowley, D.R. Inhibition of transforming growth factor-β decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. Cancer Res. 2002, 62, 6021–6025.
-
(2002)
Cancer Res
, vol.62
, pp. 6021-6025
-
-
Tuxhorn, J.A.1
McAlhany, S.J.2
Yang, F.3
Dang, T.D.4
Rowley, D.R.5
-
135
-
-
63049104211
-
Pollard, J.W. Microenvironmental regulation of metastasis
-
Joyce, J.A.; Pollard, J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer2009, 9, 239–252.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
-
136
-
-
84907959111
-
A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma
-
Zhou, B.; Chen, W.-L.; Wang, Y.-Y.; Lin, Z.-Y.; Zhang, D.-M.; Fan, S.; Li, J.-S. A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma. J. Oral Pathol. Med. 2014, 43, 585–592.
-
(2014)
J. Oral Pathol. Med
, vol.43
, pp. 585-592
-
-
Zhou, B.1
Chen, W.-L.2
Wang, Y.-Y.3
Lin, Z.-Y.4
Zhang, D.-M.5
Fan, S.6
Li, J.-S.7
-
137
-
-
36549084032
-
Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis
-
Kellermann, M.G.; Sobral, L.M.; da Silva, S.D.; Zecchin, K.G.; Graner, E.; Lopes, M.A.; Nishimoto, I.; Kowalski, L.P.; Coletta, R.D. Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis. Histopathology2007, 51, 849–853.
-
(2007)
Histopathology
, vol.51
, pp. 849-853
-
-
Kellermann, M.G.1
Sobral, L.M.2
Da Silva, S.D.3
Zecchin, K.G.4
Graner, E.5
Lopes, M.A.6
Nishimoto, I.7
Kowalski, L.P.8
Coletta, R.D.9
-
138
-
-
77956883321
-
Activation of fibroblasts in cancer stroma
-
Räsänen, K.; Vaheri, A. Activation of fibroblasts in cancer stroma. Exp. Cell Res. 2010, 316, 2713–2722.
-
(2010)
Exp. Cell Res
, vol.316
, pp. 2713-2722
-
-
Räsänen, K.1
Vaheri, A.2
-
139
-
-
80053977129
-
Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer
-
Kaneda, H.; Arao, T.; Matsumoto, K.; de Velasco, M.A.; Tamura, D.; Aomatsu, K.; Kudo, K.; Sakai, K.; Nagai, T.; Fujita, Y.; et al. Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer. Br. J. Cancer2011, 105, 1210–1217.
-
(2011)
Br. J. Cancer
, vol.105
, pp. 1210-1217
-
-
Kaneda, H.1
Arao, T.2
Matsumoto, K.3
De Velasco, M.A.4
Tamura, D.5
Aomatsu, K.6
Kudo, K.7
Sakai, K.8
Nagai, T.9
Fujita, Y.10
-
140
-
-
0027368913
-
Inhibition of vascular endothelial cell growth by activin-A
-
McCarthy, S.A.; Bicknell, R. Inhibition of vascular endothelial cell growth by activin-A. J. Biol. Chem. 1993, 268, 23066–23071.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 23066-23071
-
-
McCarthy, S.A.1
Bicknell, R.2
-
141
-
-
0034662610
-
Oncogene in human neuroblastoma cells: Down-regulation of an angiogenesis inhibitor identified as Activin A
-
Breit, S.; Ashman, K.; Wilting, J.; Rossler, J.; Hatzi, E.; Fotsis, T.; Schweigerer, L. Oncogene in human neuroblastoma cells: Down-regulation of an angiogenesis inhibitor identified as Activin A. Cancer Res. 2000, 60, 4595–4601.
-
(2000)
Cancer Res
, vol.60
, pp. 4595-4601
-
-
Breit, S.1
Ashman, K.2
Wilting, J.3
Rossler, J.4
Hatzi, E.5
Fotsis, T.6
Schweigerer, L.7
-
142
-
-
33745256733
-
Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors
-
Krneta, J.; Kroll, J.; Aleves, F.; Prahst, C.; Sananbenesi, F.; Dullin, C.; Kimmina, S.; Phillips, D.J.; Augustin, H.G. Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors. Cancer Res. 2006, 66, 5686–5695.
-
(2006)
Cancer Res
, vol.66
, pp. 5686-5695
-
-
Krneta, J.1
Kroll, J.2
Aleves, F.3
Prahst, C.4
Sananbenesi, F.5
Dullin, C.6
Kimmina, S.7
Phillips, D.J.8
Augustin, H.G.9
-
143
-
-
16444366683
-
Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms
-
Panopoulou, E.; Murphy, C.; Rasmussen, H.; Bagli, E.; Rofstad, E.K.; Fotsis, T. Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res. 2005, 65, 1877–1886.
-
(2005)
Cancer Res
, vol.65
, pp. 1877-1886
-
-
Panopoulou, E.1
Murphy, C.2
Rasmussen, H.3
Bagli, E.4
Rofstad, E.K.5
Fotsis, T.6
-
144
-
-
84892700407
-
IL-32 promotes angiogenesis
-
Nold-Petry, C.A.; Rudloff, I.; Baumer, Y.; Ruvo, M.; Marasco, D.; Botti, P.; Farkas, L.; Cho, S.X.; Zepp, J.A.; Azam, T.; et al. IL-32 promotes angiogenesis. J. Immunol. 2014, 192, 589–602.
-
(2014)
J. Immunol
, vol.192
, pp. 589-602
-
-
Nold-Petry, C.A.1
Rudloff, I.2
Baumer, Y.3
Ruvo, M.4
Marasco, D.5
Botti, P.6
Farkas, L.7
Cho, S.X.8
Zepp, J.A.9
Azam, T.10
-
145
-
-
77949265948
-
Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis
-
Petersen, M.; Pardali, E.; van der Horst, G.; Cheung, H.; van den Hoogen, C.; van der Pluijm, G.; ten Dijke, P. Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis. Oncogene 2009, 29, 1351–1361.
-
(2009)
Oncogene
, vol.29
, pp. 1351-1361
-
-
Petersen, M.1
Pardali, E.2
Van Der Horst, G.3
Cheung, H.4
Van Den Hoogen, C.5
Van Der Pluijm, G.6
Ten Dijke, P.7
-
146
-
-
3242757526
-
TGF-β induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
-
Nakagawa, T.; Li, J.H.; Garcia, G.; Mu, W.; Piek, E.; Bottinger, E.P.; Chen, Y.; Zhu, H.J.; Kang, D.-H.; Schreiner, G.F.; et al. TGF-β induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int. 2004, 66, 605–613.
-
(2004)
Kidney Int
, vol.66
, pp. 605-613
-
-
Nakagawa, T.1
Li, J.H.2
Garcia, G.3
Mu, W.4
Piek, E.5
Bottinger, E.P.6
Chen, Y.7
Zhu, H.J.8
Kang, D.-H.9
Schreiner, G.F.10
-
147
-
-
84874573616
-
Accelerated reendothelialization, increased neovascularization and erythrocyte extravasation after arterial injury in BAMBI−/− mice
-
Guillot, N.; Kollins, D.; Badimon, J.J.; Schlondorff, D.; Hutter, R. Accelerated reendothelialization, increased neovascularization and erythrocyte extravasation after arterial injury in BAMBI−/− mice. PLOS ONE 2013, 8, e58550.
-
(2013)
PLOS ONE
, vol.8
-
-
Guillot, N.1
Kollins, D.2
Badimon, J.J.3
Schlondorff, D.4
Hutter, R.5
-
148
-
-
84887456534
-
Role of endothelial cell metabolism in vessel sprouting
-
De Bock, K.; Georgiadou, M.; Carmeliet, P. Role of endothelial cell metabolism in vessel sprouting. Cell Metab. 2013, 18, 634–647.
-
(2013)
Cell Metab
, vol.18
, pp. 634-647
-
-
De Bock, K.1
Georgiadou, M.2
Carmeliet, P.3
-
149
-
-
0037007226
-
Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
-
Goumans, M.-J.; Valdimarsdottir, G.; Itoh, S.; Rosendahl, A.; Sideras, P.; ten Dijke, P. Balancing the activation state of the endothelium via two distinct TGF-β type I receptors. EMBO J. 2002, 21, 1743–1753.
-
(2002)
EMBO J
, vol.21
, pp. 1743-1753
-
-
Goumans, M.-J.1
Valdimarsdottir, G.2
Itoh, S.3
Rosendahl, A.4
Sideras, P.5
Ten Dijke, P.6
-
150
-
-
84877890780
-
Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-β signaling pathways
-
Park, S.; DiMaio, T.A.; Liu, W.; Wang, S.; Sorenson, C.M.; Sheibani, N. Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-β signaling pathways. J. Cell Sci. 2013, 126, 1392–1405.
-
(2013)
J. Cell Sci
, vol.126
, pp. 1392-1405
-
-
Park, S.1
Dimaio, T.A.2
Liu, W.3
Wang, S.4
Sorenson, C.M.5
Sheibani, N.6
-
151
-
-
15844405843
-
Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways
-
Bao, Y.L.; Tsuchida, K.; Liu, B.; Kurisaki, A.; Matsuzaki, T.; Sugino, H. Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways. J. Endocrinol.2005, 184, 493–504.
-
(2005)
J. Endocrinol
, vol.184
, pp. 493-504
-
-
Bao, Y.L.1
Tsuchida, K.2
Liu, B.3
Kurisaki, A.4
Matsuzaki, T.5
Sugino, H.6
|