Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages

Human Reproduction

Volumn 17, Issue 12, 2002, Pages 3072-3078

  Muttukrishna, S ^a   Jauniaux, E ^a   Greenwold, N ^a   McGarrigle, H ^a   Jivraj, S ^b   Carter, S ^b   Elgaddal, S ^b   Groome, N ^c   Regan, L ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c OXFORD BROOKES UNIVERSITY   (United Kingdom)

Author keywords

Activin A; Early pregnancy; Follistatin; Inhibin A; Miscarriage

Indexed keywords

ACTIVIN A; CHORIONIC GONADOTROPIN; ESTRADIOL; FOLLISTATIN; INHIBIN A; INHIBIN B; PROGESTERONE; ACTIVIN; BIOLOGICAL MARKER; INHIBIN;

ADULT; ANAMNESIS; ARTICLE; ASSAY; BIRTH; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL PRACTICE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MARKER; ENDOCRINE SYSTEM; ESTRADIOL BLOOD LEVEL; FEMALE; GESTATIONAL AGE; GONADOTROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; OUTCOMES RESEARCH; PREGNANCY; PROGESTERONE BLOOD LEVEL; PROTEIN BLOOD LEVEL; RECURRENT DISEASE; SPONTANEOUS ABORTION; STATISTICAL SIGNIFICANCE; SYMPTOM; BLOOD; LONGITUDINAL STUDY; MISSED ABORTION; RECURRENT ABORTION;

ABORTION, HABITUAL; ABORTION, MISSED; ACTIVINS; ADULT; BIOLOGICAL MARKERS; CHORIONIC GONADOTROPIN; ESTRADIOL; FEMALE; FOLLISTATIN; GESTATIONAL AGE; HUMANS; INHIBIN-BETA SUBUNITS; INHIBINS; LONGITUDINAL STUDIES; PREGNANCY; PROGESTERONE;

EID: 0036906219     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/17.12.3072     Document Type: Article

References (42)

1. Alberman, E. (1992) Spontaneous abortion: Epidemiology. In Stabile, S., Grudzinskas, G. and Chard, T. (eds) Spontaneous Abortion: Diagnosis and Treatment. Springer-Verlag, London, UK. pp. 9-30.
2. Asashima, M., Nakano, H., Shimada, K., Kinoshita, K., Shibai, H. and Ueno, N. (1990) Mesodermal induction in early amphibian embryos by activin A erythroid differentiation factor. Wilhelm Roux's Arch. Dev. Biol., 198, 330-335.
3. Ariizumi, T., Moriya, N., Uchiyama, H. and Asashima, M. (1991) Concentration dependent inducing activity of activin A. Wilhelm Roux's Arch. Dev. Biol., 200, 230-233.
4. Birdsall, M., Ledger, W., Groome, N., Abdalla, H. and Muttukrishna, S. (1997) Inhibin A and activin A in the first trimester of human pregnancy. J. Clin. Endocrinol. Metab., 82, 1557-1560.
5. Caniggia, I., Lye, S.J. and Cross, J.C. (1997) Activin is a local regulator of human cytotrophoblasts cell differentiation. Endocrinology, 138, 3976-3986.
6. Check, J.H., Lurie, D., Davies, E. and Vetter, B. (1992) Comparison of first trimester serum estradiol levels in aborters versus nonaborters during maintenance of normal progesterone levels. Gynecol. Obstet. Invest., 34, 206-210.
7. Confino, E., Demir, R.H., Friberg, J. and Gleicher, N. (1986) The predictive value of hCG-β subunit levels in pregnancies achieved by in vitro fertilization and embryo transfer: An international collaborative study. Fertil. Steril., 45, 526-531.
8. Csapo, A.I. and Pulkkinen, M. (1978) Indispensability of the human corpus luteum in the maintenance of early pregnancy. Lutectomy evidence. Obs. Gyn. Surv., 33, 69-81.
9. Darne, F.J., McGarrigle, H.H. and Lachelin G.C.L. (1989) Diurnal variation of plasma and saliva oestrogen, progesterone, cortisol and plasma dehydroepiandrosterone sulphate in late pregnancy. Eur. J. Obs. Gyn. Reprod. Biol., 32, 57-66.
10. Evans, L.W., Muttukrishna, S. and Groome, N. (1998) Development, validation and application of an ultra sensitive two-site enzyme immunoassay for human follistatin. J. Endocrin., 156, 275-282.
11. Fowler, P.A., Evans, L.W., Groome, N.P., Templeton, A. and Knight, P.G. (1998) A longitudinal study of maternal serum inhibin-A, inhibin-B, activin-A, activin-AB, pro-alpha C and follistatin during pregnancy. Hum. Reprod., 13, 3530-3536.
12. France, J.T., Keelan, J., Song, L., Liddell, H., Zanderigo, A. and Knox, B. (1996) Serum concentrations of human chorionic gonadotrophin and immunoreactive inhibin in early pregnancy and recurrent miscarriage: A longitudinal study. Aust. New Zea. J. Obs. Gyn., 36, 325-330.
13. Grandone, E., Margaglione, M., Colaizzo, D., D'Addedda, M., Cappucci, G., Vecchione, G., Scianname, N., Pavone, G. and Di Minno, G. (1997) Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb. Haemost., 77, 822-824.
14. Green, J.B. and Smith, J.C., (1990) Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature, 347, 391-394.
15. Groome, N.P., Illingworth, P.J., O'Brien, M., Pai, R., Rodger, F.E., Mather, J. and McNeilly, A.S. (1996) Measurement of dimeric inhibin-B throughout the human menstrual cycle. J. Clin. Endocrinol. Metab., 81, 1401-1405.
16. Hassold, T. (1986) Chromosome abnormalities in human reproductive wastage. Trends Genet., 2, 105-110.
17. Hustin, J., Jauniaux, E. and Schaaps, J.P. (1990) Histological study of the materno-embryonic interface in spontaneous abortion. Placenta, 11, 477-486.
18. Jauniaux, E., Zaidi, J., Jurkovic, D., Campbell, S. and Hustin, J. (1994) Comparison of color Doppler features and pathologic findings in complicated early pregnancy. Hum. Reprod., 9, 2432-2437.
19. Jenkin, G., McFarlane, J.R., and De Kretser, D. (1995) Implication of inhibin and related proteins in fetal development. Reprod. Fert. Dev., 7, 323-331.
20. Johnson, M.R., Riddle, A.F., Grudzinskas, J.G., Sharma, V., Collins, W.P. and Nicolaides, K.H. (1993) The role of trophoblast dysfunction in the aetiology of miscarriage. Brit. J. Obs. Gyn., 100, 353-359.
21. Keelan, J.L., Groome, N. and Mitchell, M. (1998) Regulation of activin A production by human amnion, decidua and placenta in vitro by pro-inflammatory cytokines. Placenta, 19, 429-434.
22. Lockwood, G.M., Ledger, W.L., Barlow, D.H., Groome, N.P. and Muttukrishna, S. (1997) Measurement of inhibin and activin in early human pregnancy: Demonstration of feto-placental origin and role in prediction of early pregnancy outcome. Biol. Reprod., 57, 1490-1494.
23. Mather, J.P., Moore, A. and Li, R.H. (1997) Activins, inhibins, and follistatins, further thoughts on a growing family of regulators. Proc. Soc. Biol. Med., 215, 209-222.
24. Mohan, A., Asselin, J., Sargent, I.L., Groome, N. P. and Muttukrishna, S. (2001) Effect of cytokines and growth factors on the secretion of inhibin A, activin A and follistatin by term placental villous trophoblasts in culture. Eur. J. Endocrinology, 145, 505-511.
25. Muttukrishna, S. (2001) Inhibin, activin and follistatin in human pregnancy. In Muttukrishna, S. and Ledger, W.L. (eds) Inhibin, Activin and Follistatin in Human Reproductive Physiology. Imperial College Press, London, UK, pp. 119-140.
26. Muttukrishna, S., Fowler, P.A., Groome, N., Mitchell, G.G., Robertson, W.R. and Knight, P.G. (1994) Serum concentrations of dimeric inhibin during the spontaneous human menstrual cycle and after treatment with exogenous gonadotrophin. Hum. Reprod., 9, 1634-1642.
27. A dimer) during human pregnancy. Clin. Endocrinology, 42, 391-397.
28. Muttukrishna, S., Fowler, P.A., George, L., Groome, N.P. and Knight, P.G. (1996) Changes in peripheral serum levels of 'total' activin A during the human menstrual cycle and pregnancy. J. Clin. Endocrinol. Metab., 81, 3328-3334.
29. Muttukrishna, S., Child, T.J., Groome, N.P. and Ledger, W.L. (1997) The source of circulating levels of inhibin A, pro-alpha C containing inhibins and activin A in early pregnancy. Hum. Reprod., 12, 1089-1093.
30. Muttukrishna, S., North, R.A., Morris, J., Schellenberg, J.C., Taylor, R.S., Asselin, J., Ledger, W.L., and Redman, C.W.G. (2000) Serum inhibin A and activin A are elevated prior to the onset of pre-eclampsia. Hum. Reprod., 15, 1640-1645.
31. Muttukrishna, S., Tannetta, D., Groome, N., Redman, C. and Sargent, I. (2001) Secretion of activin A by peripheral blood mononuclear cells (PBMCs) in culture and flowcytometric detection of intra cytoplasmic inhibin/activin subunits and activin receptors. Mol. Cell Endocrinology, 180, 194.
32. Muttukrishna, S., Jauniaux, E., Pahal, G., Groome, N.P. and Rodeck, C.H. (2002) In vivo distribution of inhibin A, activin A and follistatin in early pregnancy. Abstract, 811, Ceska Gyn. (Suppl.), 2, 76.
33. Nygren, K.G., Johansson, E.D.B. and Wide, L. (1973) Evaluation of the prognosis of threatened abortion from the peripheral plasma levels of progesterone, estradiol and human chorionic gonadotrophin. Am. J. Obs. Gyn., 116, 916-922.
34. Ogasawara, M., Kajiura, S., Katano, K., Aoyama, T. and Aoki, K. (1997) Are serum progesterone levels predictive of recurrent miscarriage in future pregnancies? Fertil. Steril., 68, 806-809.
35. Ong, C.Y., Liao, A.W., Spencer, K., Munim, S. and Nicolaides, K. (2000) First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. Brit. J. Obs. Gyn., 107, 1265-1270.
36. Phillips, D.J., Jones, K.L., Jean-Pierre, Y., Scheerlinck, Hedger, M.P. and De Kretser, D.M. (2001) Evidence for activin A and follistatin involvement in the systemic inflammatory response. Mol. Cell Endocrinology, 180, 155-162.
37. Phipps, M.G., Hogan, J.W., Peipert, J.F., Lambert-Messerlian, G.M., Canick, J.A. and Seifer, D.B. (2000) Progesterone, inhibin and hCG multiple marker strategy to differentiate viable from non viable pregnancies. Obs. Gyn., 95, 227-231.
38. Regan, L. (1997). Sporadic and recurrent miscarriage. In Grudzinskas, J.G. and O'Brien, P.M.S. (eds) Problems in Early Pregnancy. Advances in Diagnosis and Management. RCOG press, pp. 31-52.
39. Riley, S.C., Leask, R., Balfour, C., Brennand, J.E. and Groome, N.P. (2000) Production of inhibin forms by the fetal membranes, decidua, placenta and fetus at parturition. Hum. Reprod., 15, 578-583.
40. Treetampinich, C., O'Connor, A.E., MacLachlan, V., Groome, N.P., and De Kretser, D. (2000). Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome. Hum. Reprod., 15, 2028-2032.
41. Whittaker, P.G., Stewart, M.O., Taylor, A. and Lind, T. (1989) Some endocrinological events associated with early pregnancy failure. Brit. J. Obs. Gyn., 10, 1207-1214.
42. Zayed, F., Ghazawi, I., Francis, L. and Alchalabi, H. (2001) Predictive value of human chorionic gonadotrophin beta hCG in early pregnancy after assisted conception. Arc. Gyn. Obs., 265, 7-10.