Activins as regulators of branching morphogenesis

Developmental Biology

Volumn 238, Issue 1, 2001, Pages 1-12

  Ball, Emma M A ^a   Risbridger, Gail P ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Activin; Branching morphogenesis; Embryogenesis; Epithelium; Follistatin; Inhibin; Mesenchyme; Organogenesis; Stroma; TGF

Indexed keywords

ACTIVIN; FOLLISTATIN; INHIBIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; EMBRYO DEVELOPMENT; EPITHELIUM; MESENCHYME; MORPHOGENESIS; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STROMA;

EID: 0035476481     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0399     Document Type: Review

References (122)

1. Effect of retinoic acid on prostatic development
2. A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A
3. Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carcinoma cells
4. Basal lamina of embryonic salivary epithelia: Production by the epithelium and role in maintaining lobular morphology
5. Ureteric bud cells secrete multiple factors, including bFGF, which rescue renal progenitors from apoptosis
6. Measurement of activin B in human saliva and localization of activin subunits in rat salivary glands
7. Regulation of prostate branching morphogenesis by activin A and follistatin
8. Activin is a local regulator of human cytotrophoblast cell differentiation
9. Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro
10. Influence of epidermal growth factor and transforming growth factor beta-1 on patterns of fetal mouse lung branching morphogenesis in organ culture
11. Epithelio-mesenchymal interactions in primordial gland structures which become responsive to androgenic stimulation
12. The endocrinology and developmental biology of the prostate
13. Growth factors as mediators of androgen action during the development of the male urogenital tract
14. Inability of Tfm (testicular feminization) epithelial cells to express androgen-dependent seminal vesicle secretory proteins in chimeric tissue recombinants
15. The Smads: Transcriptional regulation and mouse models
16. Collecting duct morphogenesis
17. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3
18. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
19. Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors
20. The effect of androgen deprivation on branching morphogenesis in the mouse prostate
21. The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4
22. Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro
23. Molecular cloning of the mouse activin beta E subunit gene
24. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development
25. Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition
26. Effects of hepatocyte growth factor (HGF) and activin A on the morphogenesis of rat submandibular gland-derived epithelial cells in serum-free collagen gel culture
27. Expression of immunoreactive activin A in fetal rat pancreas
28. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
29. The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
30. Morphological and functional heterogeneity in the rat prostatic gland
31. Notochord repression of endodermal Sonic hedgehog permits pancreas development
32. Regulation of pancreas development by hedgehog signaling
33. TGF-beta signaling from cell membrane to nucleus through SMAD proteins
34. Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor
35. Pancreatic morphogenesis and extracellular matrix organization during rat development
36. Epithelial/mesenchymal interactions and branching morphogenesis of the lung
37. Cloning of a new member of the TGF-beta superfamily: A putative new activin betaC chain
38. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo
39. Signaling of transforming growth factor-beta family members through Smad proteins
40. Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
41. Importance of nidogen binding to laminin gammal for branching epithelial morphogenesis of the submandibular gland
42. Activin receptor patterning of foregut organogenesis
43. Role of the activin-follistatin system in the morphogenesis and regeneration of the renal tubules
44. Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation
45. Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
46. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin
47. Transforming growth factor beta2, but not beta1 and beta3, is critical for early rat lung branching
48. Inhibitory effects of activin on the growth and morphogenesis of primary and transformed mammary epithelial cells
49. Number of glomeruli is increased in the kidney of transgenic mice expressing the truncated type II activin receptor
50. Hepatocyte growth factor induces branching tubulogenesis in MDCK cells by modulating the activinfollistatin system
51. Ontogeny of activin B and follistatin in developing embryonic mouse pancreas: Implications for lineage selection
52. Cloning of a second type of activin receptor and functional characterization in Xenopus embryos
53. Different phenotypes for mice deficient in either activins or activin receptor type II
54. Functional analysis of activins during mammalian development
55. Multiple defects and perinatal death in mice deficient in follistatin
56. Localization of activin betaA, betaA and betaC subunits in human prostate and evidence for formation of new activin heterodimers of betaC subunit
57. Control of digit formation by activin signalling
58. Genetic control of branching morphogenesis
59. Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development
60. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
61. Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick
62. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
63. TGF-beta signaling by Smad proteins
64. Stage-dependent responses of the developing lung to retinoic acid signaling
65. Activin-binding protein from rat ovary is follistatin
66. Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary gland
67. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
68. Molecular cloning and functional analysis of a new activin beta subunit: A dorsal mesoderm-inducing activity in Xenopus
69. Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages
70. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
71. Effects of activin A on proliferation and differentiation of human lung fibroblasts
72. Activin receptors are expressed on human lung fibroblast and activin A facilitates fibroblast-mediated collagen gel contraction
73. Antagonistic effects of dexamethasone and retinoic acid on rat lung morphogenesis
74. Sonic hedgehog regulates branching morphogenesis in the mammalian lung
75. Follistatin: A multifunctional regulatory protein. Front
76. BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis
77. Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium
78. Matrix metalloproteinases and their inhibitors regulate in vitro ureteric bud branching morphogenesis
79. Branching morphogenesis during kidney development
80. Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation
81. Inhibin-related proteins in rat prostate
82. Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse
83. Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid- and late-gestation rat embryogenesis
84. Inhibins and activins regulate mammary epithelial cell differentiation through mesenchymal-epithelial interactions
85. Transforming growth factor-beta selectively inhibits branching morphogenesis but not tubulogenesis
86. Involvement of hepatocyte growth factor in kidney development
87. Hepatocyte growth factor promotes growth and lumen formation of fetal lung epithelial cells in primary culture
88. Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis
89. Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor
90. Postnatal mammary gland morphogenesis
91. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
92. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
93. The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice
94. Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules
95. Expression of green fluorescent protein in the ureteric bud of transgenic mice: A new tool for the analysis of ureteric bud morphogenesis
96. Morphogenesis of ductal networks in the mouse prostate
97. Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell
98. Immunohistochemical and in-situ hybridization analysis of androgen receptor expression during the development of the mouse prostate gland
99. Characterization of type I receptors for transforming growth factor-beta and activin
100. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
101. Ductal budding and branching patterns in the developing prostate
102. Multiple hormone interactions in the developmental biology of the mammary gland
103. The tissue distribution of activin beta A- and beta B-subunit and follistatin messenger ribonucleic acids suggests multiple sites of action for the activin-follistatin system during human development
104. Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction
105. Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis
106. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
107. Retinoic acid induces activin receptor IIB mRNA in F9 embryonal carcinoma cells
108. Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
109. Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
110. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
111. Integrin alpha subunit mRNAs are differentially expressed in early Xenopus embryos
112. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
113. The Smad pathway
114. Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism
115. Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants
116. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
117. Expression and localization of inhibin/activin subunits and activin receptors in MCF-7 cells, a human breast cancer cell line
118. Inhibin/activin subunits and activin receptors in human breast cell lines and lactating rat mammary glands
119. Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture
120. Identification and developmental expression of two activin receptors in baboon lung
121. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene
122. Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways