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Volumn 352, Issue 3, 2015, Pages 480-493

Bias analyses of preclinical and clinical D2 dopamine ligands: Studies with immediate and complex signaling pathways

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA ARRESTIN; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE; DOPAMINE D2L RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; LIGAND;

EID: 84921525907     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.220293     Document Type: Article
Times cited : (32)

References (46)
  • 2
    • 79952032110 scopus 로고    scopus 로고
    • The physiology, signaling, and pharmacology of dopamine receptors
    • Beaulieu JM and Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63:182-217.
    • (2011) Pharmacol Rev , vol.63 , pp. 182-217
    • Beaulieu, J.M.1    Gainetdinov, R.R.2
  • 3
    • 0021058380 scopus 로고
    • Operational models of pharmacological agonism
    • Black JW and Leff P (1983) Operational models of pharmacological agonism. Proc R Soc Lond B Biol Sci 220:141-162.
    • (1983) Proc R Soc Lond B Biol Sci , vol.220 , pp. 141-162
    • Black, J.W.1    Leff, P.2
  • 4
    • 3042665659 scopus 로고    scopus 로고
    • Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery
    • Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, and Barak LS (2004) Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol Pharmacol 66:106-112.
    • (2004) Mol Pharmacol , vol.66 , pp. 106-112
    • Bohn, L.M.1    Dykstra, L.A.2    Lefkowitz, R.J.3    Caron, M.G.4    Barak, L.S.5
  • 5
    • 0034619796 scopus 로고    scopus 로고
    • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
    • Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, and Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408:720-723.
    • (2000) Nature , vol.408 , pp. 720-723
    • Bohn, L.M.1    Gainetdinov, R.R.2    Lin, F.T.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 7
    • 84919722766 scopus 로고    scopus 로고
    • New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling
    • Brust TF, Hayes MP, Roman DL, and Watts VJ (2015) New functional activity of aripiprazole revealed: robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochem Pharmacol 93:85-91.
    • (2015) Biochem Pharmacol , vol.93 , pp. 85-91
    • Brust, T.F.1    Hayes, M.P.2    Roman, D.L.3    Watts, V.J.4
  • 9
    • 84907653319 scopus 로고    scopus 로고
    • Drug-induced sensitization of adenylyl cyclase: Assay streamlining and miniaturization for small molecule and siRNA screening applications
    • Conley JM, Brust TF, Xu R, Burris KD, and Watts VJ (2014) Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications. J Vis Exp 83:e51218.
    • (2014) J Vis Exp , vol.83 , pp. e51218
    • Conley, J.M.1    Brust, T.F.2    Xu, R.3    Burris, K.D.4    Watts, V.J.5
  • 10
    • 33746046362 scopus 로고    scopus 로고
    • Higher-order organization and regulation of adenylyl cyclases
    • Cooper DM and Crossthwaite AJ (2006) Higher-order organization and regulation of adenylyl cyclases. Trends Pharmacol Sci 27:426-431.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 426-431
    • Cooper, D.M.1    Crossthwaite, A.J.2
  • 11
    • 46749158660 scopus 로고    scopus 로고
    • Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle
    • Deshpande DA, Theriot BS, Penn RB, and Walker JK (2008) Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. FASEB J 22:2134-2141.
    • (2008) FASEB J , vol.22 , pp. 2134-2141
    • Deshpande, D.A.1    Theriot, B.S.2    Penn, R.B.3    Walker, J.K.4
  • 12
    • 79960382104 scopus 로고    scopus 로고
    • Biased ligands for better cardiovascular drugs: Dissecting G-protein-coupled receptor pharmacology
    • DeWire SM and Violin JD (2011) Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circ Res 109:205-216.
    • (2011) Circ Res , vol.109 , pp. 205-216
    • DeWire, S.M.1    Violin, J.D.2
  • 13
    • 45849112499 scopus 로고    scopus 로고
    • On the analysis of ligand-directed signaling at G protein-coupled receptors
    • Ehlert FJ (2008) On the analysis of ligand-directed signaling at G protein-coupled receptors. Naunyn Schmiedebergs Arch Pharmacol 377:549-577.
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.377 , pp. 549-577
    • Ehlert, F.J.1
  • 14
    • 84921528454 scopus 로고    scopus 로고
    • Dopamine D(2) receptor-mediated heterologous sensitization of AC5 requires signalosome assembly
    • Ejendal KF, Dessauer CW, Hébert TE, and Watts VJ (2012) Dopamine D(2) receptor-mediated heterologous sensitization of AC5 requires signalosome assembly. J Signal Transduct 2012:210324.
    • (2012) J Signal Transduct , vol.2012 , pp. 210324
    • Ejendal, K.F.1    Dessauer, C.W.2    Hébert, T.E.3    Watts, V.J.4
  • 16
    • 0026562725 scopus 로고
    • Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits
    • Federman AD, Conklin BR, Schrader KA, Reed RR, and Bourne HR (1992) Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature 356:159-161.
    • (1992) Nature , vol.356 , pp. 159-161
    • Federman, A.D.1    Conklin, B.R.2    Schrader, K.A.3    Reed, R.R.4    Bourne, H.R.5
  • 18
    • 3042630989 scopus 로고    scopus 로고
    • Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: Evidence for induction of ligand-specific receptor states
    • Gay EA, Urban JD, Nichols DE, Oxford GS, and Mailman RB (2004) Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states. Mol Pharmacol 66:97-105.
    • (2004) Mol Pharmacol , vol.66 , pp. 97-105
    • Gay, E.A.1    Urban, J.D.2    Nichols, D.E.3    Oxford, G.S.4    Mailman, R.B.5
  • 19
    • 34248560933 scopus 로고    scopus 로고
    • Estimation of agonist activity at G protein-coupled receptors: Analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15
    • Griffin MT, Figueroa KW, Liller S, and Ehlert FJ (2007) Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15. J Pharmacol Exp Ther 321:1193-1207.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1193-1207
    • Griffin, M.T.1    Figueroa, K.W.2    Liller, S.3    Ehlert, F.J.4
  • 20
    • 84935925892 scopus 로고    scopus 로고
    • What is pharmacological 'affinity'? Relevance to biased agonism and antagonism
    • Kenakin T (2014) What is pharmacological 'affinity'? Relevance to biased agonism and antagonism. Trends Pharmacol Sci 35 :434-441.
    • (2014) Trends Pharmacol Sci , vol.35 , pp. 434-441
    • Kenakin, T.1
  • 21
    • 84880675341 scopus 로고    scopus 로고
    • Measurements of ligand bias and functional affinity
    • Kenakin T and Christopoulos A (2013a) Measurements of ligand bias and functional affinity. Nat Rev Drug Discov 12:483.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 483
    • Kenakin, T.1    Christopoulos, A.2
  • 22
    • 84875227396 scopus 로고    scopus 로고
    • Signalling bias in new drug discovery: Detection, quantification and therapeutic impact
    • Kenakin T and Christopoulos A (2013b) Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nat Rev Drug Discov 12: 205-216.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 205-216
    • Kenakin, T.1    Christopoulos, A.2
  • 24
    • 0018862848 scopus 로고
    • A quantitative analysis of beta-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modeling of ligand binding data
    • Kent RS, De Lean A, and Lefkowitz RJ (1980) A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. Mol Pharmacol 17:14-23.
    • (1980) Mol Pharmacol , vol.17 , pp. 14-23
    • Kent, R.S.1    De Lean, A.2    Lefkowitz, R.J.3
  • 27
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by betaarrestins
    • Lefkowitz RJ and Shenoy SK (2005) Transduction of receptor signals by betaarrestins. Science 308:512-517.
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 28
    • 80053208017 scopus 로고    scopus 로고
    • Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting
    • Lin Y and Smrcka AV (2011) Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting. Mol Pharmacol 80:551-557.
    • (2011) Mol Pharmacol , vol.80 , pp. 551-557
    • Lin, Y.1    Smrcka, A.V.2
  • 29
    • 51649084026 scopus 로고    scopus 로고
    • Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics
    • Masri B, Salahpour A, Didriksen M, Ghisi V, Beaulieu JM, Gainetdinov RR, and Caron MG (2008) Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics. Proc Natl Acad Sci USA 105:13656-13661.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13656-13661
    • Masri, B.1    Salahpour, A.2    Didriksen, M.3    Ghisi, V.4    Beaulieu, J.M.5    Gainetdinov, R.R.6    Caron, M.G.7
  • 31
    • 0034954445 scopus 로고    scopus 로고
    • Dopamine D-4 and D-2L receptor stimulation of the mitogen-activated protein kinase pathway is dependent on transactivation of the platelet-derived growth factor receptor
    • Oak JN, Lavine N, and Van Tol HHM (2001) Dopamine D-4 and D-2L receptor stimulation of the mitogen-activated protein kinase pathway is dependent on transactivation of the platelet-derived growth factor receptor. Mol Pharmacol 60:92-103.
    • (2001) Mol Pharmacol , vol.60 , pp. 92-103
    • Oak, J.N.1    Lavine, N.2    Van Tol, H.H.M.3
  • 32
    • 55549086457 scopus 로고    scopus 로고
    • Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation
    • Quan W, Kim JH, Albert PR, Choi H, and Kim KM (2008) Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation. Biochem Biophys Res Commun 377:705-709.
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 705-709
    • Quan, W.1    Kim, J.H.2    Albert, P.R.3    Choi, H.4    Kim, K.M.5
  • 33
    • 84880663464 scopus 로고    scopus 로고
    • Quantifying biased agonism: Understanding the links between affinity and efficacy
    • Rajagopal S (2013) Quantifying biased agonism: understanding the links between affinity and efficacy. Nat Rev Drug Discov 12:483.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 483
    • Rajagopal, S.1
  • 38
    • 50449091328 scopus 로고    scopus 로고
    • Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells
    • Vidi PA, Chemel BR, Hu CD, and Watts VJ (2008) Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells. Mol Pharmacol 74:544-551.
    • (2008) Mol Pharmacol , vol.74 , pp. 544-551
    • Vidi, P.A.1    Chemel, B.R.2    Hu, C.D.3    Watts, V.J.4
  • 39
    • 70349283075 scopus 로고    scopus 로고
    • Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling
    • Wang WC, Mihlbachler KA, Brunnett AC, and Liggett SB (2009) Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling. Proc Natl Acad Sci USA 106: 15007-15012.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15007-15012
    • Wang, W.C.1    Mihlbachler, K.A.2    Brunnett, A.C.3    Liggett, S.B.4
  • 40
    • 0036089264 scopus 로고    scopus 로고
    • Molecular mechanisms for heterologous sensitization of adenylate cyclase
    • Watts VJ (2002) Molecular mechanisms for heterologous sensitization of adenylate cyclase. J Pharmacol Exp Ther 302:1-7.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 1-7
    • Watts, V.J.1
  • 41
    • 19444378697 scopus 로고    scopus 로고
    • Sensitization of adenylate cyclase by Gα i/o-coupled receptors
    • Watts VJ and Neve KA (2005) Sensitization of adenylate cyclase by Gα i/o-coupled receptors. Pharmacol Ther 106:405-421.
    • (2005) Pharmacol Ther , vol.106 , pp. 405-421
    • Watts, V.J.1    Neve, K.A.2
  • 42
    • 0029860160 scopus 로고    scopus 로고
    • Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors
    • Watts VJ and Neve KA (1996) Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors. Mol Pharmacol 50:966-976.
    • (1996) Mol Pharmacol , vol.50 , pp. 966-976
    • Watts, V.J.1    Neve, K.A.2
  • 43
    • 0030752966 scopus 로고    scopus 로고
    • Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors
    • Watts VJ and Neve KA (1997) Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors. Mol Pharmacol 52:181-186.
    • (1997) Mol Pharmacol , vol.52 , pp. 181-186
    • Watts, V.J.1    Neve, K.A.2
  • 44
    • 79952488185 scopus 로고    scopus 로고
    • Therapeutic potential of β-arrestin- and G protein-biased agonists
    • Whalen EJ, Rajagopal S, and Lefkowitz RJ (2011) Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends Mol Med 17:126-139.
    • (2011) Trends Mol Med , vol.17 , pp. 126-139
    • Whalen, E.J.1    Rajagopal, S.2    Lefkowitz, R.J.3
  • 45
    • 51249095825 scopus 로고    scopus 로고
    • A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-proteincoupled receptors
    • Zhao X, Jones A, Olson KR, Peng K, Wehrman T, Park A, Mallari R, Nebalasca D, Young SW, and Xiao SH (2008) A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-proteincoupled receptors. J Biomol Screen 13:737-747.
    • (2008) J Biomol Screen , vol.13 , pp. 737-747
    • Zhao, X.1    Jones, A.2    Olson, K.R.3    Peng, K.4    Wehrman, T.5    Park, A.6    Mallari, R.7    Nebalasca, D.8    Young, S.W.9    Xiao, S.H.10
  • 46
    • 84880589600 scopus 로고    scopus 로고
    • Arginine vasopressin enhances cell survival via a G protein-coupled receptor kinase 2/β-arrestin1/extracellular-regulated kinase 1/2-dependent pathway in H9c2 cells
    • Zhu W, Tilley DG, Myers VD, Coleman RC, and Feldman AM (2013) Arginine vasopressin enhances cell survival via a G protein-coupled receptor kinase 2/β-arrestin1/extracellular-regulated kinase 1/2-dependent pathway in H9c2 cells. Mol Pharmacol 84:227-235.
    • (2013) Mol Pharmacol , vol.84 , pp. 227-235
    • Zhu, W.1    Tilley, D.G.2    Myers, V.D.3    Coleman, R.C.4    Feldman, A.M.5


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