Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling

Journal of Biological Chemistry

Volumn 285, Issue 10, 2010, Pages 7805-7817

  Busillo, John M ^a   Armando, Sylvain ^b   Sengupta, Rajarshi ^c   Meucci, Olimpia ^c   Bouvier, Michel ^b   Benovic, Jeffrey L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARRESTINS; CALCIUM MOBILIZATION; CHEMOKINE RECEPTOR CXCR4; DIFFERENTIAL MODULATION; G PROTEIN COUPLED RECEPTORS; G PROTEIN-COUPLED RECEPTOR KINASE; HEK293 CELLS; HUMAN IMMUNODEFICIENCY VIRUS; NEGATIVE MODULATION; PROTEIN KINASE C; SITE-SPECIFIC; TANDEM MASS SPECTROMETRY; TERMINAL RESIDUES;

ACTIVATION ANALYSIS; CALCIUM; MASS SPECTROMETRY; PROTEINS; SIGNALING; VIRUSES;

PHOSPHORYLATION;

ARRESTIN 2; ARRESTIN 3; CALCIUM ION; CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 6; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE; PROTEIN KINASE C; SERINE; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; CALCIUM MOBILIZATION; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PHOSPHO-SPECIFIC; ARRESTINS; ASTROCYTES; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G-PROTEIN-COUPLED RECEPTOR KINASES; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASE C; RECEPTORS, CXCR4; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 77951230331     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.091173     Document Type: Article

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