What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling

Trends in Pharmacological Sciences

Volumn 35, Issue 12, 2014, Pages 639-647

  Onaran, H Ongun ^a   Rajagopal, Sudarshan ^b   Costa, Tommaso ^c  

^a ANKARA UNIVERSITY   (Turkey)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

GPCR

Indexed keywords

BETA ARRESTIN; CARRIER PROTEIN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE;

ALLOSTERISM; BINDING SITE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; LIGAND BINDING; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MEASUREMENT ERROR; METHODOLOGY; MOLECULAR DOCKING; MOLECULAR MECHANICS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RECEPTOR BINDING; RECEPTOR OCCUPANCY; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; STOICHIOMETRY; THERMODYNAMICS; AGONISTS; CHEMISTRY; KINETICS; METABOLISM;

KINETICS; RECEPTORS, G-PROTEIN-COUPLED; THERMODYNAMICS;

EID: 84913535661     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.09.010     Document Type: Review

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