-
1
-
-
84926637156
-
Respiratory epithelial cells orchestrate pulmonary innate immunity
-
Whitsett JA, Alenghat T. Respiratory epithelial cells orchestrate pulmonary innate immunity. Nat Immunol 2015;16:27-35.
-
(2015)
Nat Immunol
, vol.16
, pp. 27-35
-
-
Whitsett, J.A.1
Alenghat, T.2
-
2
-
-
40449140937
-
The NLR gene family: A standard nomenclature
-
Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, et al. The NLR gene family: a standard nomenclature. Immunity 2008;28:285-287.
-
(2008)
Immunity
, vol.28
, pp. 285-287
-
-
Ting, J.P.1
Lovering, R.C.2
Alnemri, E.S.3
Bertin, J.4
Boss, J.M.5
Davis, B.K.6
Flavell, R.A.7
Girardin, S.E.8
Godzik, A.9
Harton, J.A.10
-
4
-
-
84936891896
-
Inflammasomes: Mechanism of action, role in disease, and therapeutics
-
Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 2015;21:677-687.
-
(2015)
Nat Med
, vol.21
, pp. 677-687
-
-
Guo, H.1
Callaway, J.B.2
Ting, J.P.3
-
5
-
-
84899817657
-
Inflammasomes in respiratory disease: From bench to bedside
-
Brusselle GG, Provoost S, Bracke KR, Kuchmiy A, Lamkanfi M. Inflammasomes in respiratory disease: from bench to bedside. Chest 2014;145:1121-1133.
-
(2014)
Chest
, vol.145
, pp. 1121-1133
-
-
Brusselle, G.G.1
Provoost, S.2
Bracke, K.R.3
Kuchmiy, A.4
Lamkanfi, M.5
-
6
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009;458:514-518.
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
Horvath, G.5
Caffrey, D.R.6
Latz, E.7
Fitzgerald, K.A.8
-
7
-
-
77950362382
-
The inflammasomes
-
Schroder K, Tschopp J. The inflammasomes. Cell 2010;140:821-832.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
8
-
-
0033815330
-
Salmonella induces macrophage death by caspase-1-dependent necrosis
-
Brennan MA, Cookson BT. Salmonella induces macrophage death by caspase-1-dependent necrosis. Mol Microbiol 2000;38:31-40.
-
(2000)
Mol Microbiol
, vol.38
, pp. 31-40
-
-
Brennan, M.A.1
Cookson, B.T.2
-
9
-
-
84901310586
-
Mechanisms and functions of inflammasomes
-
Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes. Cell 2014;157:1013-1022.
-
(2014)
Cell
, vol.157
, pp. 1013-1022
-
-
Lamkanfi, M.1
Dixit, V.M.2
-
10
-
-
84927745897
-
Pyroptotic cell death defends against intracellular pathogens
-
Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev 2015;265:130-142.
-
(2015)
Immunol Rev
, vol.265
, pp. 130-142
-
-
Jorgensen, I.1
Miao, E.A.2
-
11
-
-
62649139025
-
Immunological and inflammatory functions of the interleukin-1 family
-
Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009;27:519-550.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 519-550
-
-
Dinarello, C.A.1
-
12
-
-
84892867717
-
Interleukin-18, more than a Th1 cytokine
-
Novick D, Kim S, Kaplanski G, Dinarello CA. Interleukin-18, more than a Th1 cytokine. Semin Immunol 2013;25:439-448.
-
(2013)
Semin Immunol
, vol.25
, pp. 439-448
-
-
Novick, D.1
Kim, S.2
Kaplanski, G.3
Dinarello, C.A.4
-
13
-
-
78649819208
-
Chemical probing reveals insights into the signaling mechanism of inflammasome activation
-
Gong YN, Wang X, Wang J, Yang Z, Li S, Yang J, Liu L, Lei X, Shao F. Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Res 2010;20:1289-1305.
-
(2010)
Cell Res
, vol.20
, pp. 1289-1305
-
-
Gong, Y.N.1
Wang, X.2
Wang, J.3
Yang, Z.4
Li, S.5
Yang, J.6
Liu, L.7
Lei, X.8
Shao, F.9
-
14
-
-
84898635026
-
Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
-
Ghonime MG, Shamaa OR, Das S, Eldomany RA, Fernandes-Alnemri T, Alnemri ES, Gavrilin MA, Wewers MD. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol 2014;192:3881-3888.
-
(2014)
J Immunol
, vol.192
, pp. 3881-3888
-
-
Ghonime, M.G.1
Shamaa, O.R.2
Das, S.3
Eldomany, R.A.4
Fernandes-Alnemri, T.5
Alnemri, E.S.6
Gavrilin, M.A.7
Wewers, M.D.8
-
15
-
-
67349271142
-
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
-
Gross O, Poeck H, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009;459:433-436.
-
(2009)
Nature
, vol.459
, pp. 433-436
-
-
Gross, O.1
Poeck, H.2
Bscheider, M.3
Dostert, C.4
Hannesschläger, N.5
Endres, S.6
Hartmann, G.7
Tardivel, A.8
Schweighoffer, E.9
Tybulewicz, V.10
-
16
-
-
70049101754
-
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
-
Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog 2009;5:e1000559.
-
(2009)
PLoS Pathog
, vol.5
, pp. e1000559
-
-
Shio, M.T.1
Eisenbarth, S.C.2
Savaria, M.3
Vinet, A.F.4
Bellemare, M.J.5
Harder, K.W.6
Sutterwala, F.S.7
Bohle, D.S.8
Descoteaux, A.9
Flavell, R.A.10
-
17
-
-
84867304098
-
NLRP3 inflammasome activity is negatively controlled by MIR-223
-
Bauernfeind F, Rieger A, Schildberg FA, Knolle PA, Schmid-Burgk JL, Hornung V. NLRP3 inflammasome activity is negatively controlled by miR-223. J Immunol 2012;189:4175-4181.
-
(2012)
J Immunol
, vol.189
, pp. 4175-4181
-
-
Bauernfeind, F.1
Rieger, A.2
Schildberg, F.A.3
Knolle, P.A.4
Schmid-Burgk, J.L.5
Hornung, V.6
-
18
-
-
84867320879
-
Cutting edge: MIR-223 and EBV MIR-BART15 regulate the NLRP3 inflammasome and IL-1β production
-
Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL. Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production. J Immunol 2012;189:3795-3799.
-
(2012)
J Immunol
, vol.189
, pp. 3795-3799
-
-
Haneklaus, M.1
Gerlic, M.2
Kurowska-Stolarska, M.3
Rainey, A.A.4
Pich, D.5
McInnes, I.B.6
Hammerschmidt, W.7
O'Neill, L.A.8
Masters, S.L.9
-
19
-
-
84872782298
-
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
-
Py BF, Kim MS, Vakifahmetoglu-Norberg H, Yuan J. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell 2013;49:331-338.
-
(2013)
Mol Cell
, vol.49
, pp. 331-338
-
-
Py, B.F.1
Kim, M.S.2
Vakifahmetoglu-Norberg, H.3
Yuan, J.4
-
20
-
-
84869785875
-
Cutting edge: Nitric oxide inhibits the NLRP3 inflammasome
-
Hernandez-Cuellar E, Tsuchiya K, Hara H, Fang R, Sakai S, Kawamura I, Akira S, Mitsuyama M. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 2012;189:5113-5117.
-
(2012)
J Immunol
, vol.189
, pp. 5113-5117
-
-
Hernandez-Cuellar, E.1
Tsuchiya, K.2
Hara, H.3
Fang, R.4
Sakai, S.5
Kawamura, I.6
Akira, S.7
Mitsuyama, M.8
-
21
-
-
79957526145
-
The role of uric acid as an endogenous danger signal in immunity and inflammation
-
Ghaemi-Oskouie F, Shi Y. The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr Rheumatol Rep 2011;13:160-166.
-
(2011)
Curr Rheumatol Rep
, vol.13
, pp. 160-166
-
-
Ghaemi-Oskouie, F.1
Shi, Y.2
-
22
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006;440:228-232.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
Roose-Girma, M.6
Lee, W.P.7
Weinrauch, Y.8
Monack, D.M.9
Dixit, V.M.10
-
24
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008;9:847-856.
-
(2008)
Nat Immunol
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
Rock, K.L.6
Fitzgerald, K.A.7
Latz, E.8
-
25
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011;12:222-230.
-
(2011)
Nat Immunol
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
Haspel, J.A.2
Rathinam, V.A.3
Lee, S.J.4
Dolinay, T.5
Lam, H.C.6
Englert, J.A.7
Rabinovitch, M.8
Cernadas, M.9
Kim, H.P.10
-
26
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011;469:221-225.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
27
-
-
84924617839
-
Vimentin regulates activation of the NLRP3 inflammasome
-
dos Santos G, Rogel MR, Baker MA, Troken JR, Urich D, Morales-Nebreda L, Sennello JA, Kutuzov MA, Sitikov A, Davis JM, et al. Vimentin regulates activation of the NLRP3 inflammasome. Nat Commun 2015;6:6574.
-
(2015)
Nat Commun
, vol.6
, pp. 6574
-
-
Dos Santos, G.1
Rogel, M.R.2
Baker, M.A.3
Troken, J.R.4
Urich, D.5
Morales-Nebreda, L.6
Sennello, J.A.7
Kutuzov, M.A.8
Sitikov, A.9
Davis, J.M.10
-
28
-
-
84862777872
-
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
-
Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012;36:401-414.
-
(2012)
Immunity
, vol.36
, pp. 401-414
-
-
Shimada, K.1
Crother, T.R.2
Karlin, J.3
Dagvadorj, J.4
Chiba, N.5
Chen, S.6
Ramanujan, V.K.7
Wolf, A.J.8
Vergnes, L.9
Ojcius, D.M.10
-
29
-
-
84882614243
-
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
-
Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, et al. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity 2013;39:311-323.
-
(2013)
Immunity
, vol.39
, pp. 311-323
-
-
Iyer, S.S.1
He, Q.2
Janczy, J.R.3
Elliott, E.I.4
Zhong, Z.5
Olivier, A.K.6
Sadler, J.J.7
Knepper-Adrian, V.8
Han, R.9
Qiao, L.10
-
30
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
-
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol 2010;11:897-904.
-
(2010)
Nat Immunol
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
Dunne, A.2
Subramanian, S.L.3
Hull, R.L.4
Tannahill, G.M.5
Sharp, F.A.6
Becker, C.7
Franchi, L.8
Yoshihara, E.9
Chen, Z.10
-
31
-
-
77649179433
-
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
-
Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 2010;10:210-215.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 210-215
-
-
Tschopp, J.1
Schroder, K.2
-
32
-
-
84937513657
-
MTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation
-
Moon JS, Hisata S, Park MA, DeNicola GM, Ryter SW, Nakahira K, Choi AM. mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Reports 2015;12:102-115.
-
(2015)
Cell Reports
, vol.12
, pp. 102-115
-
-
Moon, J.S.1
Hisata, S.2
Park, M.A.3
DeNicola, G.M.4
Ryter, S.W.5
Nakahira, K.6
Choi, A.M.7
-
33
-
-
84961290384
-
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
-
Moon JS, Lee S, Park MA, Siempos II, Haslip M, Lee PJ, Yun M, Kim CK, Howrylak J, Ryter SW, et al. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest 2015;125:665-680.
-
(2015)
J Clin Invest
, vol.125
, pp. 665-680
-
-
Moon, J.S.1
Lee, S.2
Park, M.A.3
Siempos, I.I.4
Haslip, M.5
Lee, P.J.6
Yun, M.7
Kim, C.K.8
Howrylak, J.9
Ryter, S.W.10
-
35
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
-
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 2008;456:264-268.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
-
36
-
-
84893771777
-
Cellular and molecular mechanisms of chronic obstructive pulmonary disease
-
Barnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med 2014;35:71-86.
-
(2014)
Clin Chest Med
, vol.35
, pp. 71-86
-
-
Barnes, P.J.1
-
37
-
-
40449118020
-
Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent
-
Doz E, Noulin N, Boichot E, Guénon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, et al. Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol 2008;180:1169-1178.
-
(2008)
J Immunol
, vol.180
, pp. 1169-1178
-
-
Doz, E.1
Noulin, N.2
Boichot, E.3
Guénon, I.4
Fick, L.5
Le Bert, M.6
Lagente, V.7
Ryffel, B.8
Schnyder, B.9
Quesniaux, V.F.10
-
38
-
-
84861777306
-
IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13
-
Kang MJ, Choi JM, Kim BH, Lee CM, Cho WK, Choe G, Kim DH, Lee CG, Elias JA. IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13. Am J Respir Crit Care Med 2012;185:1205-1217.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 1205-1217
-
-
Kang, M.J.1
Choi, J.M.2
Kim, B.H.3
Lee, C.M.4
Cho, W.K.5
Choe, G.6
Kim, D.H.7
Lee, C.G.8
Elias, J.A.9
-
39
-
-
84911870336
-
Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: An insight into the pathogenesis of COPD
-
Eltom S, Belvisi MG, Stevenson CS, Maher SA, Dubuis E, Fitzgerald KA, Birrell MA. Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD. PLoS One 2014;9:e112829.
-
(2014)
PLoS One
, vol.9
, pp. e112829
-
-
Eltom, S.1
Belvisi, M.G.2
Stevenson, C.S.3
Maher, S.A.4
Dubuis, E.5
Fitzgerald, K.A.6
Birrell, M.A.7
-
40
-
-
80052482830
-
P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke
-
Eltom S, Stevenson CS, Rastrick J, Dale N, Raemdonck K, Wong S, Catley MC, Belvisi MG, Birrell MA. P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke. PLoS One 2011;6:e24097.
-
(2011)
PLoS One
, vol.6
, pp. e24097
-
-
Eltom, S.1
Stevenson, C.S.2
Rastrick, J.3
Dale, N.4
Raemdonck, K.5
Wong, S.6
Catley, M.C.7
Belvisi, M.G.8
Birrell, M.A.9
-
41
-
-
79960767641
-
Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD
-
Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG. Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD. Eur Respir J 2011;38:1019-1028.
-
(2011)
Eur Respir J
, vol.38
, pp. 1019-1028
-
-
Pauwels, N.S.1
Bracke, K.R.2
Dupont, L.L.3
Van Pottelberge, G.R.4
Provoost, S.5
Vanden Berghe, T.6
Vandenabeele, P.7
Lambrecht, B.N.8
Joos, G.F.9
Brusselle, G.G.10
-
42
-
-
0029744374
-
Dose-dependent cigarette smoking-related inflammatory responses in healthy adults
-
Kuschner WG, D'Alessandro A, Wong H, Blanc PD. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J 1996;9:1989-1994.
-
(1996)
Eur Respir J
, vol.9
, pp. 1989-1994
-
-
Kuschner, W.G.1
D'Alessandro, A.2
Wong, H.3
Blanc, P.D.4
-
43
-
-
67349217427
-
Interleukin-18 in induced sputum: Association with lung function in chronic obstructive pulmonary disease
-
Rovina N, Dima E, Gerassimou C, Kollintza A, Gratziou C, Roussos C. Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. Respir Med 2009;103:1056-1062.
-
(2009)
Respir Med
, vol.103
, pp. 1056-1062
-
-
Rovina, N.1
Dima, E.2
Gerassimou, C.3
Kollintza, A.4
Gratziou, C.5
Roussos, C.6
-
44
-
-
69749111918
-
ATP in the pathogenesis of lung emphysema
-
Mortaz E, Braber S, Nazary M, Givi ME, Nijkamp FP, Folkerts G. ATP in the pathogenesis of lung emphysema. Eur J Pharmacol 2009;619:92-96.
-
(2009)
Eur J Pharmacol
, vol.619
, pp. 92-96
-
-
Mortaz, E.1
Braber, S.2
Nazary, M.3
Givi, M.E.4
Nijkamp, F.P.5
Folkerts, G.6
-
45
-
-
84891909387
-
Serum uric acid as a predictor of mortality and future exacerbations of COPD
-
Bartziokas K, Papaioannou AI, Loukides S, Papadopoulos A, Haniotou A, Papiris S, Kostikas K. Serum uric acid as a predictor of mortality and future exacerbations of COPD. Eur Respir J 2014;43:43-53.
-
(2014)
Eur Respir J
, vol.43
, pp. 43-53
-
-
Bartziokas, K.1
Papaioannou, A.I.2
Loukides, S.3
Papadopoulos, A.4
Haniotou, A.5
Papiris, S.6
Kostikas, K.7
-
46
-
-
84901240710
-
Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD
-
Di Stefano A, Caramori G, Barczyk A, Vicari C, Brun P, Zanini A, Cappello F, Garofano E, Padovani A, Contoli M, et al. Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD. Thorax 2014;69:516-524.
-
(2014)
Thorax
, vol.69
, pp. 516-524
-
-
Di Stefano, A.1
Caramori, G.2
Barczyk, A.3
Vicari, C.4
Brun, P.5
Zanini, A.6
Cappello, F.7
Garofano, E.8
Padovani, A.9
Contoli, M.10
-
47
-
-
40049104892
-
Immunology of asthma and chronic obstructive pulmonary disease
-
Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 2008;8:183-192.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 183-192
-
-
Barnes, P.J.1
-
49
-
-
34547655975
-
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
-
Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MA, Muskens F, Hoogsteden HC, Luttmann W, Ferrari D, Di Virgilio F, et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 2007;13:913-919.
-
(2007)
Nat Med
, vol.13
, pp. 913-919
-
-
Idzko, M.1
Hammad, H.2
Van Nimwegen, M.3
Kool, M.4
Willart, M.A.5
Muskens, F.6
Hoogsteden, H.C.7
Luttmann, W.8
Ferrari, D.9
Di Virgilio, F.10
-
50
-
-
84921966782
-
NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation
-
Kim SR, Kim DI, Kim SH, Lee H, Lee KS, Cho SH, Lee YC. NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation. Cell Death Dis 2014;5:e1498.
-
(2014)
Cell Death Dis
, vol.5
, pp. e1498
-
-
Kim, S.R.1
Kim, D.I.2
Kim, S.H.3
Lee, H.4
Lee, K.S.5
Cho, S.H.6
Lee, Y.C.7
-
51
-
-
79959963904
-
NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant
-
Besnard AG, Guillou N, Tschopp J, Erard F, Couillin I, Iwakura Y, Quesniaux V, Ryffel B, Togbe D. NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant. Allergy 2011;66:1047-1057.
-
(2011)
Allergy
, vol.66
, pp. 1047-1057
-
-
Besnard, A.G.1
Guillou, N.2
Tschopp, J.3
Erard, F.4
Couillin, I.5
Iwakura, Y.6
Quesniaux, V.7
Ryffel, B.8
Togbe, D.9
-
52
-
-
84863263746
-
Analysis of NLRP3 in the development of allergic airway disease in mice
-
Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP. Analysis of NLRP3 in the development of allergic airway disease in mice. J Immunol 2012;188:2884-2893.
-
(2012)
J Immunol
, vol.188
, pp. 2884-2893
-
-
Allen, I.C.1
Jania, C.M.2
Wilson, J.E.3
Tekeppe, E.M.4
Hua, X.5
Brickey, W.J.6
Kwan, M.7
Koller, B.H.8
Tilley, S.L.9
Ting, J.P.10
-
53
-
-
79954597670
-
An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma
-
Published erratum appears in Immunity 34:627.
-
Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis e Sousa C, Hammad H, et al. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 2011;34:527-540. [Published erratum appears in Immunity 34:627.]
-
(2011)
Immunity
, vol.34
, pp. 527-540
-
-
Kool, M.1
Willart, M.A.2
Van Nimwegen, M.3
Bergen, I.4
Pouliot, P.5
Virchow, J.C.6
Rogers, N.7
Osorio, F.8
Reis E Sousa, C.9
Hammad, H.10
-
54
-
-
84937779676
-
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation
-
Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol 2015;16:859-870.
-
(2015)
Nat Immunol
, vol.16
, pp. 859-870
-
-
Bruchard, M.1
Rebé, C.2
Derangère, V.3
Togbé, D.4
Ryffel, B.5
Boidot, R.6
Humblin, E.7
Hamman, A.8
Chalmin, F.9
Berger, H.10
-
55
-
-
64049096334
-
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
-
Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 2009;30:566-575.
-
(2009)
Immunity
, vol.30
, pp. 566-575
-
-
Thomas, P.G.1
Dash, P.2
Aldridge, J.R.3
Ellebedy, A.H.4
Reynolds, C.5
Funk, A.J.6
Martin, W.J.7
Lamkanfi, M.8
Webby, R.J.9
Boyd, K.L.10
-
56
-
-
60549112774
-
Inflammasome recognition of influenza virus is essential for adaptive immune responses
-
Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 2009;206:79-87.
-
(2009)
J Exp Med
, vol.206
, pp. 79-87
-
-
Ichinohe, T.1
Lee, H.K.2
Ogura, Y.3
Flavell, R.4
Iwasaki, A.5
-
57
-
-
64049111768
-
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
-
Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 2009;30:556-565.
-
(2009)
Immunity
, vol.30
, pp. 556-565
-
-
Allen, I.C.1
Scull, M.A.2
Moore, C.B.3
Holl, E.K.4
McElvania-TeKippe, E.5
Taxman, D.J.6
Guthrie, E.H.7
Pickles, R.J.8
Ting, J.P.9
-
58
-
-
79251515144
-
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4
-
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, et al. Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog 2010;6:e1001191.
-
(2010)
PLoS Pathog
, vol.6
, pp. e1001191
-
-
McNeela, E.A.1
Burke, A.2
Neill, D.R.3
Baxter, C.4
Fernandes, V.E.5
Ferreira, D.6
Smeaton, S.7
El-Rachkidy, R.8
McLoughlin, R.M.9
Mori, A.10
-
59
-
-
79959567502
-
Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection
-
Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M. Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One 2011;6:e21477.
-
(2011)
PLoS One
, vol.6
, pp. e21477
-
-
Shimada, K.1
Crother, T.R.2
Karlin, J.3
Chen, S.4
Chiba, N.5
Ramanujan, V.K.6
Vergnes, L.7
Ojcius, D.M.8
Arditi, M.9
-
60
-
-
77957133396
-
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome
-
Mishra BB, Moura-Alves P, Sonawane A, Hacohen N, Griffiths G, Moita LF, Anes E. Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cell Microbiol 2010;12:1046-1063.
-
(2010)
Cell Microbiol
, vol.12
, pp. 1046-1063
-
-
Mishra, B.B.1
Moura-Alves, P.2
Sonawane, A.3
Hacohen, N.4
Griffiths, G.5
Moita, L.F.6
Anes, E.7
-
61
-
-
84856033488
-
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis
-
Dorhoi A, Nouailles G, Jörg S, Hagens K, Heinemann E, Pradl L, Oberbeck-Müller D, Duque-Correa MA, Reece ST, Ruland J, et al. Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol 2012;42:374-384.
-
(2012)
Eur J Immunol
, vol.42
, pp. 374-384
-
-
Dorhoi, A.1
Nouailles, G.2
Jörg, S.3
Hagens, K.4
Heinemann, E.5
Pradl, L.6
Oberbeck-Müller, D.7
Duque-Correa, M.A.8
Reece, S.T.9
Ruland, J.10
-
62
-
-
77957908944
-
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
-
McElvania Tekippe E, Allen IC, Hulseberg PD, Sullivan JT, McCann JR, Sandor M, Braunstein M, Ting JP. Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PLoS One 2010;5:e12320.
-
(2010)
PLoS One
, vol.5
, pp. e12320
-
-
McElvania Tekippe, E.1
Allen, I.C.2
Hulseberg, P.D.3
Sullivan, J.T.4
McCann, J.R.5
Sandor, M.6
Braunstein, M.7
Ting, J.P.8
-
64
-
-
65649140025
-
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
-
Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 2009;179:903-913.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 903-913
-
-
Gasse, P.1
Riteau, N.2
Charron, S.3
Girre, S.4
Fick, L.5
Pétrilli, V.6
Tschopp, J.7
Lagente, V.8
Quesniaux, V.F.9
Ryffel, B.10
-
65
-
-
77957101431
-
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis
-
Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, et al. Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 2010;182:774-783.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 774-783
-
-
Riteau, N.1
Gasse, P.2
Fauconnier, L.3
Gombault, A.4
Couegnat, M.5
Fick, L.6
Kanellopoulos, J.7
Quesniaux, V.F.8
Marchand-Adam, S.9
Crestani, B.10
-
66
-
-
84863229387
-
Statins and pulmonary fibrosis: The potential role of NLRP3 inflammasome activation
-
Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, et al.; COPDGene Investigators. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med 2012;185:547-556.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 547-556
-
-
COPDGene Investigators1
Xu, J.F.2
Washko, G.R.3
Nakahira, K.4
Hatabu, H.5
Patel, A.S.6
Fernandez, I.E.7
Nishino, M.8
Okajima, Y.9
Yamashiro, T.10
Ross, J.C.11
-
68
-
-
84904001774
-
Regulation of the inflammasome by ceramide in cystic fibrosis lungs
-
Grassmé H, Carpinteiro A, Edwards MJ, Gulbins E, Becker KA. Regulation of the inflammasome by ceramide in cystic fibrosis lungs. Cell Physiol Biochem 2014;34:45-55.
-
(2014)
Cell Physiol Biochem
, vol.34
, pp. 45-55
-
-
Grassmé, H.1
Carpinteiro, A.2
Edwards, M.J.3
Gulbins, E.4
Becker, K.A.5
-
70
-
-
5344233478
-
Pulmonary arterial hypertension
-
Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med 2004;351:1655-1665.
-
(2004)
N Engl J Med
, vol.351
, pp. 1655-1665
-
-
Farber, H.W.1
Loscalzo, J.2
-
71
-
-
84875930040
-
Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome
-
Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E. Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal 2013;18:1753-1764.
-
(2013)
Antioxid Redox Signal
, vol.18
, pp. 1753-1764
-
-
Villegas, L.R.1
Kluck, D.2
Field, C.3
Oberley-Deegan, R.E.4
Woods, C.5
Yeager, M.E.6
El Kasmi, K.C.7
Savani, R.C.8
Bowler, R.P.9
Nozik-Grayck, E.10
-
72
-
-
84939446887
-
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice
-
Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, et al. Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol 2015;309:L378-L387.
-
(2015)
Am J Physiol Lung Cell Mol Physiol
, vol.309
, pp. L378-L387
-
-
Cero, F.T.1
Hillestad, V.2
Sjaastad, I.3
Yndestad, A.4
Aukrust, P.5
Ranheim, T.6
Lunde, I.G.7
Olsen, M.B.8
Lien, E.9
Zhang, L.10
-
73
-
-
84929104248
-
NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β
-
Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, et al. NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β. J Biol Chem 2015;290:5065-5077.
-
(2015)
J Biol Chem
, vol.290
, pp. 5065-5077
-
-
Mizushina, Y.1
Shirasuna, K.2
Usui, F.3
Karasawa, T.4
Kawashima, A.5
Kimura, H.6
Kobayashi, M.7
Komada, T.8
Inoue, Y.9
Mato, N.10
-
74
-
-
84861785677
-
Inflammasome-regulated cytokines are critical mediators of acute lung injury
-
Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, et al. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med 2012;185:1225-1234.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 1225-1234
-
-
Dolinay, T.1
Kim, Y.S.2
Howrylak, J.3
Hunninghake, G.M.4
An, C.H.5
Fredenburgh, L.6
Massaro, A.F.7
Rogers, A.8
Gazourian, L.9
Nakahira, K.10
-
75
-
-
84892880111
-
Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: Derivation and validation
-
discussion e1001577
-
Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, et al. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med 2013;10:e1001577, discussion e1001577.
-
(2013)
PLoS Med
, vol.10
, pp. e1001577
-
-
Nakahira, K.1
Kyung, S.Y.2
Rogers, A.J.3
Gazourian, L.4
Youn, S.5
Massaro, A.F.6
Quintana, C.7
Osorio, J.C.8
Wang, Z.9
Zhao, Y.10
-
76
-
-
77957788222
-
Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia
-
Ray NB, Durairaj L, Chen BB, McVerry BJ, Ryan AJ, Donahoe M, Waltenbaugh AK, O'Donnell CP, Henderson FC, Etscheidt CA, et al. Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia. Nat Med 2010;16:1120-1127.
-
(2010)
Nat Med
, vol.16
, pp. 1120-1127
-
-
Ray, N.B.1
Durairaj, L.2
Chen, B.B.3
McVerry, B.J.4
Ryan, A.J.5
Donahoe, M.6
Waltenbaugh, A.K.7
O'Donnell, C.P.8
Henderson, F.C.9
Etscheidt, C.A.10
|