Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1δ production

Journal of Immunology

Volumn 189, Issue 8, 2012, Pages 3795-3799

  Haneklaus, Moritz ^a   Gerlic, Motti ^b   Kurowska Stolarska, Mariola ^c   Rainey, Ashleigh Ann ^c   Pich, Dagmar ^d   McInnes, Iain B ^c   Hammerschmidt, Wolfgang ^d   O'Neill, Luke A J ^a   Masters, Seth L ^a,b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; MICRORNA; MICRORNA 223; MICRORNA BART15; UNCLASSIFIED DRUG; VIRUS RNA;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPSTEIN BARR VIRUS; EXOSOME; GENE EXPRESSION; GENE FUNCTION; GENETIC REGULATION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; VIRUS CELL INTERACTION; VIRUS INHIBITION;

3' UNTRANSLATED REGIONS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL LINEAGE; CELLS, CULTURED; HEK293 CELLS; HERPESVIRUS 4, HUMAN; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICRORNAS; MONOCYTES; MYELOID CELLS; PROTEIN BINDING; RNA, VIRAL; VIRAL MATRIX PROTEINS;

EID: 84867320879     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200312     Document Type: Article

References (16)

1. O'Neill, L. A., F. J. Sheedy, and C. E. McCoy. 2011. MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat. Rev. Immunol. 11: 163-175.
2. Martinon, F., A. Mayor, and J. Tschopp. 2009. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27: 229-265.
3. Bauernfeind, F. G., G. Horvath, A. Stutz, E. S. Alnemri, K. MacDonald, D. Speert, T. Fernandes-Alnemri, J. Wu, B. G. Monks, K. A. Fitzgerald, et al. 2009. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183: 787-791.
4. Mathonnet, G., M. R. Fabian, Y. V. Svitkin, A. Parsyan, L. Huck, T. Murata, S. Biffo, W. C. Merrick, E. Darzynkiewicz, R. S. Pillai, et al. 2007. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science 317: 1764-1767. (Pubitemid 47461843)
5. Guarda, G., M. Zenger, A. S. Yazdi, K. Schroder, I. Ferrero, P. Menu, A. Tardivel, C. Mattmann, and J. Tschopp. 2011. Differential expression of NLRP3 among hematopoietic cells. J. Immunol. 186: 2529-2534.
6. Frankel, L. B., N. R. Christoffersen, A. Jacobsen, M. Lindow, A. Krogh, and A. H. Lund. 2008. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J. Biol. Chem. 283: 1026-1033.
7. Johnnidis, J. B., M. H. Harris, R. T. Wheeler, S. Stehling-Sun, M. H. Lam, O. Kirak, T. R. Brummelkamp, M. D. Fleming, and F. D. Camargo. 2008. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451: 1125-1129. (Pubitemid 351317447)
8. Pegtel, D. M., K. Cosmopoulos, D. A. Thorley-Lawson, M. A. van Eijndhoven, E. S. Hopmans, J. L. Lindenberg, T. D. de Gruijl, T. Würdinger, and J. M. Middeldorp. 2010. Functional delivery of viral miRNAs via exosomes. Proc. Natl. Acad. Sci. USA 107: 6328-6333.
9. Savina, A., M. Furlán, M. Vidal, and M. I. Colombo. 2003. Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J. Biol. Chem. 278: 20083-20090.
10. Ichinohe, T., I. K. Pang, and A. Iwasaki. 2010. Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat. Immunol. 11: 404-410.
11. Baek, D., J. Villén, C. Shin, F. D. Camargo, S. P. Gygi, and D. P. Bartel. 2008. The impact of microRNAs on protein output. Nature 455: 64-71.
12. Cheng, S. C., F. L. van de Veerdonk, M. Lenardon, M. Stoffels, T. Plantinga, S. Smeekens, L. Rizzetto, L. Mukaremera, K. Preechasuth, D. Cavalieri, et al. 2011. The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. J. Leukoc. Biol. 90: 357-366.
13. Netea, M. G., C. A. Nold-Petry, M. F. Nold, L. A. Joosten, B. Opitz, J. H. van der Meer, F. L. van de Veerdonk, G. Ferwerda, B. Heinhuis, I. Devesa, et al. 2009. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113: 2324-2335.
14. Yao, L., J. Setsuda, C. Sgadari, B. Cherney, and G. Tosato. 2001. Interleukin-18 expression induced by Epstein-Barr virus-infected cells. J. Leukoc. Biol. 69: 779-784. (Pubitemid 32466417)
15. Krauer, K. G., D. K. Belzer, D. Liaskou, M. Buck, S. Cross, T. Honjo, and T. Sculley. 1998. Regulation of interleukin-1beta transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP. Virology 252: 418-430. (Pubitemid 29013424)
16. Kanneganti, T. D. 2010. Central roles of NLRs and inflammasomes in viral infection. Nat. Rev. Immunol. 10: 688-698.