Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of chlamydia pneumoniae lung infection

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Shimada, Kenichi ^a   Crother, Timothy R ^a   Karlin, Justin ^a   Chen, Shuang ^a   Chiba, Norika ^a   Ramanujan, V Krishnan ^b   Vergnes, Laurent ^a   Ojcius, David M ^c   Arditi, Moshe ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN; CELL PROTEIN; CRYOPYRIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; REACTIVE OXYGEN METABOLITE; RECOMBINANT INTERLEUKIN 1BETA; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; TLR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COUNT; CHLAMYDIAL PNEUMONIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; HOST RESISTANCE; IN VITRO STUDY; INFECTION RESISTANCE; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PHENOTYPE; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; BACTERIAL PNEUMONIA; CHLAMYDIASIS; CHLAMYDOPHILA PNEUMONIAE; DISEASE MODEL; ENZYMOLOGY; HUMAN; IMMUNOLOGY; LUNG; METABOLISM; MICROBIOLOGY; MITOCHONDRION; PATHOLOGY; PHAGOCYTOSIS; PROTEIN SYNTHESIS; SECRETION; SURVIVAL;

BACTERIA (MICROORGANISMS); CHLAMYDOPHILA PNEUMONIAE; MUS;

ANIMALS; CARRIER PROTEINS; CASPASE 1; CHLAMYDIA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; DISEASE MODELS, ANIMAL; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1BETA; LUNG; MACROPHAGES, ALVEOLAR; MICE; MITOCHONDRIA; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE SYNTHASE TYPE II; PHAGOCYTOSIS; PNEUMONIA, BACTERIAL; PROTEIN BIOSYNTHESIS; REACTIVE OXYGEN SPECIES; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTOR 2;

EID: 79959567502     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021477     Document Type: Article

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