Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: An insight into the pathogenesis of COPD

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Eltom, Suffwan ^a   Belvisi, Maria G ^a   Stevenson, Christopher S ^b,d   Maher, Sarah A ^a   Dubuis, Eric ^a   Fitzgerald, Kate A ^c   Birrell, Mark A ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b HOFFMANN LA ROCHE INC   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d Respivert   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AIM2 PROTEIN; ASC PROTEIN; CASPASE 11; CIGARETTE SMOKE; CRYOPYRIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; IPAF PROTEIN; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; CASP11 PROTEIN, MOUSE; CASPASE; PASSIVE SMOKING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; LEUKOCYTE MIGRATION; MALE; MOUSE; NEUTROPHILIA; NONHUMAN; PATHOGENESIS; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; ADVERSE EFFECTS; ANALYSIS OF VARIANCE; ANIMAL; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICALLY INDUCED; CHEMISTRY; COMPLICATION; METABOLISM; PASSIVE SMOKING; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TRANSGENIC MOUSE;

ANALYSIS OF VARIANCE; ANIMALS; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CASPASE 1; CASPASES; INFLAMMASOMES; INTERLEUKIN-1; INTERLEUKIN-18; MICE; MICE, TRANSGENIC; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIGNAL TRANSDUCTION; TOBACCO SMOKE POLLUTION;

EID: 84911870336     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112829     Document Type: Article

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