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Volumn 35, Issue 32, 2015, Pages 11346-11357

Defective age-dependent metaplasticity in a mouse model of alzheimer’s disease

Author keywords

AD; APPswe; LTD; LTP; PS1 E9; Pull push metaplasticity; Sliding threshold

Indexed keywords

CALCIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; AMPA RECEPTOR; CALCIUM;

EID: 84939165157     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5289-14.2015     Document Type: Article
Times cited : (58)

References (50)
  • 1
    • 84864916107 scopus 로고    scopus 로고
    • Intracellular Ca2+ stores and Ca2+ influx are both required for BDNF to rapidly increase quantal vesicular transmitter release
    • Medline
    • Amaral MD, Pozzo-Miller L (2012) Intracellular Ca2+ stores and Ca2+ influx are both required for BDNF to rapidly increase quantal vesicular transmitter release. Neural Plast 2012:203536. Medline
    • (2012) Neural Plast , vol.2012
    • Amaral, M.D.1    Pozzo-Miller, L.2
  • 2
    • 0023224483 scopus 로고
    • A physiological basis for a theory of synapse modification
    • CrossRef Medline
    • Bear MF, Cooper LN, Ebner FF (1987) A physiological basis for a theory of synapse modification. Science 237:42–48. CrossRef Medline
    • (1987) Science , vol.237 , pp. 42-48
    • Bear, M.F.1    Cooper, L.N.2    Ebner, F.F.3
  • 3
    • 84902085333 scopus 로고    scopus 로고
    • Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer’s disease
    • CrossRef Medline
    • Berchtold NC, Sabbagh MN, Beach TG, Kim RC, Cribbs DH, Cotman CW (2014) Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer’s disease. Neurobiol Aging 35:1961–1972. CrossRef Medline
    • (2014) Neurobiol Aging , vol.35 , pp. 1961-1972
    • Berchtold, N.C.1    Sabbagh, M.N.2    Beach, T.G.3    Kim, R.C.4    Cribbs, D.H.5    Cotman, C.W.6
  • 4
    • 50249135503 scopus 로고    scopus 로고
    • Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease
    • CrossRef Medline
    • Bezprozvanny I, Mattson MP (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease. Trends Neurosci 31:454–463. CrossRef Medline
    • (2008) Trends Neurosci , vol.31 , pp. 454-463
    • Bezprozvanny, I.1    Mattson, M.P.2
  • 5
    • 0020074887 scopus 로고
    • Theory for the development of neuron selectivity: Orientation specificity and binocular interaction in visual cortex
    • Medline
    • Bienenstock EL, Cooper LN, Munro PW (1982) Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J Neurosci 2:32–48. Medline
    • (1982) J Neurosci , vol.2 , pp. 32-48
    • Bienenstock, E.L.1    Cooper, L.N.2    Munro, P.W.3
  • 6
    • 0029082204 scopus 로고
    • Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block
    • CrossRef Medline
    • Bowie D, Mayer ML (1995) Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block. Neuron 15:453–462. CrossRef Medline
    • (1995) Neuron , vol.15 , pp. 453-462
    • Bowie, D.1    Mayer, M.L.2
  • 7
    • 0031788324 scopus 로고    scopus 로고
    • Effects of PKA and PKC on miniature excitatory postsynaptic currents in CA1 pyramidal cells
    • Medline
    • Carroll RC, Nicoll RA, Malenka RC (1998) Effects of PKA and PKC on miniature excitatory postsynaptic currents in CA1 pyramidal cells. J Neurophysiol 80:2797–2800. Medline
    • (1998) J Neurophysiol , vol.80 , pp. 2797-2800
    • Carroll, R.C.1    Nicoll, R.A.2    Malenka, R.C.3
  • 10
    • 84867704094 scopus 로고    scopus 로고
    • TheBCMtheory of synapse modification at 30: Interaction of theory with experiment
    • CrossRef
    • Cooper LN, Bear MF (2012) TheBCMtheory of synapse modification at 30: interaction of theory with experiment. Nature Rev Neurosci 13:798–810. CrossRef
    • (2012) Nature Rev Neurosci , vol.13 , pp. 798-810
    • Cooper, L.N.1    Bear, M.F.2
  • 12
    • 0035399822 scopus 로고    scopus 로고
    • Agerelated impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
    • Medline
    • Fitzjohn SM, Morton RA, Kuenzi F, Rosahl TW, Shearman M, Lewis H, Smith D, Reynolds DS, Davies CH, Collingridge GL, Seabrook GR (2001) Agerelated impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein. J Neurosci 21:4691–4698. Medline
    • (2001) J Neurosci , vol.21 , pp. 4691-4698
    • Fitzjohn, S.M.1    Morton, R.A.2    Kuenzi, F.3    Rosahl, T.W.4    Shearman, M.5    Lewis, H.6    Smith, D.7    Reynolds, D.S.8    Davies, C.H.9    Collingridge, G.L.10    Seabrook, G.R.11
  • 13
    • 0030917601 scopus 로고    scopus 로고
    • Alzheimer’s presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid betapeptide: Involvement of calcium and oxyradicals
    • Medline
    • Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP (1997) Alzheimer’s presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid betapeptide: involvement of calcium and oxyradicals. J Neurosci 17:4212–4222. Medline
    • (1997) J Neurosci , vol.17 , pp. 4212-4222
    • Guo, Q.1    Sopher, B.L.2    Furukawa, K.3    Pham, D.G.4    Robinson, N.5    Martin, G.M.6    Mattson, M.P.7
  • 14
    • 84864957971 scopus 로고    scopus 로고
    • Presenilins: Role in calcium homeostasis
    • CrossRef Medline
    • Honarnejad K, Herms J (2012) Presenilins: role in calcium homeostasis. Int J Biochem Cell Biol 44:1983–1986. CrossRef Medline
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 1983-1986
    • Honarnejad, K.1    Herms, J.2
  • 15
    • 34848875687 scopus 로고    scopus 로고
    • Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    • CrossRef Medline
    • Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL, Malinow R (2007) Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell 131:160–173. CrossRef Medline
    • (2007) Cell , vol.131 , pp. 160-173
    • Hu, H.1    Real, E.2    Takamiya, K.3    Kang, M.G.4    Ledoux, J.5    Huganir, R.L.6    Malinow, R.7
  • 16
    • 84863011342 scopus 로고    scopus 로고
    • Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex
    • CrossRef Medline
    • Huang S, Treviño M, He K, Ardiles A, Pasquale R, Guo Y, Palacios A, Huganir R, Kirkwood A (2012) Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron 73:497–510. CrossRef Medline
    • (2012) Neuron , vol.73 , pp. 497-510
    • Huang, S.1    Treviño, M.2    He, K.3    Ardiles, A.4    Pasquale, R.5    Guo, Y.6    Palacios, A.7    Huganir, R.8    Kirkwood, A.9
  • 18
    • 81255199255 scopus 로고    scopus 로고
    • Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo
    • CrossRef Medline
    • Jung CK, Fuhrmann M, Honarnejad K, Van Leuven F, Herms J (2011) Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo. J Neurochem 119:1064–1073. CrossRef Medline
    • (2011) J Neurochem , vol.119 , pp. 1064-1073
    • Jung, C.K.1    Fuhrmann, M.2    Honarnejad, K.3    Van Leuven, F.4    Herms, J.5
  • 19
    • 59649114125 scopus 로고    scopus 로고
    • Synaptic AMPA receptor plasticity and behavior
    • CrossRef Medline
    • Kessels HW, Malinow R (2009) Synaptic AMPA receptor plasticity and behavior. Neuron 61:340–350. CrossRef Medline
    • (2009) Neuron , vol.61 , pp. 340-350
    • Kessels, H.W.1    Malinow, R.2
  • 20
    • 84863115506 scopus 로고    scopus 로고
    • Ca-permeable AMPA receptors in homeostatic synaptic plasticity
    • Medline
    • Lee HK (2012) Ca-permeable AMPA receptors in homeostatic synaptic plasticity. Front Mol Neurosci 5:17. Medline
    • (2012) Front Mol Neurosci , vol.5
    • Lee, H.K.1
  • 21
    • 0034702259 scopus 로고    scopus 로고
    • Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
    • CrossRef Medline
    • Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000) Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405:955–959. CrossRef Medline
    • (2000) Nature , vol.405 , pp. 955-959
    • Lee, H.K.1    Barbarosie, M.2    Kameyama, K.3    Bear, M.F.4    Huganir, R.L.5
  • 23
    • 74049162430 scopus 로고    scopus 로고
    • Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus
    • CrossRef Medline
    • Lee HK, Takamiya K, He K, Song L, Huganir RL (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. J Neurophysiol 103:479–489. CrossRef Medline
    • (2010) J Neurophysiol , vol.103 , pp. 479-489
    • Lee, H.K.1    Takamiya, K.2    He, K.3    Song, L.4    Huganir, R.L.5
  • 24
    • 79957715137 scopus 로고    scopus 로고
    • Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor
    • CrossRef Medline
    • Makino Y, Johnson RC, Yu Y, Takamiya K, Huganir RL (2011) Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor. Proc Natl Acad Sci U S A 108:8450–8455. CrossRef Medline
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 8450-8455
    • Makino, Y.1    Johnson, R.C.2    Yu, Y.3    Takamiya, K.4    Huganir, R.L.5
  • 25
    • 0031435496 scopus 로고    scopus 로고
    • Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II
    • CrossRef Medline
    • Mammen AL, Kameyama K, Roche KW, Huganir RL (1997) Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. J Biol Chem 272:32528–32533. CrossRef Medline
    • (1997) J Biol Chem , vol.272 , pp. 32528-32533
    • Mammen, A.L.1    Kameyama, K.2    Roche, K.W.3    Huganir, R.L.4
  • 26
    • 80051750907 scopus 로고    scopus 로고
    • Hippocampal synaptic plasticity in Alzheimer’s disease: What have we learned so far from transgenic models?
    • Medline
    • Marchetti C, Marie H (2011) Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models? Rev Neurosci 22:373–402. Medline
    • (2011) Rev Neurosci , vol.22 , pp. 373-402
    • Marchetti, C.1    Marie, H.2
  • 28
    • 79961009447 scopus 로고    scopus 로고
    • Soluble oligomers of amyloid-beta peptide disrupt membrane trafficking of alpha-amino-3- hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
    • CrossRef Medline
    • Miñano-Molina AJ, España J, Martín E, Barneda-Zahonero B, Fadó R, Solé M, Trullás R, Saura CA, Rodríguez-Alvarez J (2011) Soluble oligomers of amyloid-beta peptide disrupt membrane trafficking of alpha-amino-3- hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction. J Biol Chem 286:27311–27321. CrossRef Medline
    • (2011) J Biol Chem , vol.286 , pp. 27311-27321
    • Miñano-Molina, A.J.1    España, J.2    Martín, E.3    Barneda-Zahonero, B.4    Fadó, R.5    Solé, M.6    Trullás, R.7    Saura, C.A.8    Rodríguez-Alvarez, J.9
  • 29
    • 80051988063 scopus 로고    scopus 로고
    • Constitutive cAMP response element binding protein (CREB) activation by Alzheimer’s disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling
    • CrossRef Medline
    • Müller M, Cárdenas C, Mei L, Cheung KH, Foskett JK (2011) Constitutive cAMP response element binding protein (CREB) activation by Alzheimer’s disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling. Proc Natl Acad Sci U S A 108:13293–13298. CrossRef Medline
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13293-13298
    • Müller, M.1    Cárdenas, C.2    Mei, L.3    Cheung, K.H.4    Foskett, J.K.5
  • 30
    • 24944528380 scopus 로고    scopus 로고
    • Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII
    • CrossRef Medline
    • Oh MC, Derkach VA (2005) Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII. Nat Neurosci 8:853–854. CrossRef Medline
    • (2005) Nat Neurosci , vol.8 , pp. 853-854
    • Oh, M.C.1    Derkach, V.A.2
  • 31
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-beta-induced neuronal dysfunction in Alzheimer’s disease: From synapses toward neural networks
    • CrossRef Medline
    • Palop JJ, Mucke L (2010) Amyloid-beta-induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat Neurosci 13:812–818. CrossRef Medline
    • (2010) Nat Neurosci , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 33
    • 0035132867 scopus 로고    scopus 로고
    • Visual experience and deprivation bidirectionally modify the composition and function of NMDAreceptors in visual cortex
    • CrossRef Medline
    • Philpot BD, Sekhar AK, Shouval HZ, Bear MF (2001) Visual experience and deprivation bidirectionally modify the composition and function of NMDAreceptors in visual cortex. Neuron 29:157–169. CrossRef Medline
    • (2001) Neuron , vol.29 , pp. 157-169
    • Philpot, B.D.1    Sekhar, A.K.2    Shouval, H.Z.3    Bear, M.F.4
  • 34
    • 0038045581 scopus 로고    scopus 로고
    • Evidence for altered NMDA receptor function as a basis for metaplasticity in visual cortex
    • Medline
    • Philpot BD, Espinosa JS, Bear MF (2003) Evidence for altered NMDA receptor function as a basis for metaplasticity in visual cortex. J Neurosci 23:5583–5588. Medline
    • (2003) J Neurosci , vol.23 , pp. 5583-5588
    • Philpot, B.D.1    Espinosa, J.S.2    Bear, M.F.3
  • 35
    • 0033607178 scopus 로고    scopus 로고
    • Bidirectional, experiencedependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development
    • CrossRef Medline
    • Quinlan EM, Olstein DH, Bear MF (1999) Bidirectional, experiencedependent regulation of N-methyl-D-aspartate receptor subunit composition in the rat visual cortex during postnatal development. Proc Natl Acad Sci U S A 96:12876–12880. CrossRef Medline
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12876-12880
    • Quinlan, E.M.1    Olstein, D.H.2    Bear, M.F.3
  • 36
    • 1642452716 scopus 로고    scopus 로고
    • A molecular mechanism for stabilization of learning-induced synaptic modifications
    • CrossRef Medline
    • Quinlan EM, Lebel D, Brosh I, Barkai E (2004) A molecular mechanism for stabilization of learning-induced synaptic modifications. Neuron 41:185–192. CrossRef Medline
    • (2004) Neuron , vol.41 , pp. 185-192
    • Quinlan, E.M.1    Lebel, D.2    Brosh, I.3    Barkai, E.4
  • 37
    • 0030175899 scopus 로고    scopus 로고
    • Characterization of multiple phosphorylation sites on theAMPAreceptor GluR1 subunit
    • CrossRef Medline
    • Roche KW, O’Brien RJ, Mammen AL, Bernhardt J, Huganir RL (1996) Characterization of multiple phosphorylation sites on theAMPAreceptor GluR1 subunit. Neuron 16:1179–1188. CrossRef Medline
    • (1996) Neuron , vol.16 , pp. 1179-1188
    • Roche, K.W.1    O’Brien, R.J.2    Mammen, A.L.3    Bernhardt, J.4    Huganir, R.L.5
  • 38
    • 0033573390 scopus 로고    scopus 로고
    • Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons
    • Medline
    • Rumbaugh G, Vicini S (1999) Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons. J Neurosci 19:10603–10610. Medline
    • (1999) J Neurosci , vol.19 , pp. 10603-10610
    • Rumbaugh, G.1    Vicini, S.2
  • 39
    • 84867758439 scopus 로고    scopus 로고
    • AKAP15-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorportation of Ca2+-permeable AMPA receptors
    • CrossRef Medline
    • Sanderson JL, Gorski JA, Gibson ES, Lam P, Freund RK, Chick WS, Dell’Acqua ML (2012) AKAP15-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorportation of Ca2+-permeable AMPA receptors. J Neurosci 32:15036–15052. CrossRef Medline
    • (2012) J Neurosci , vol.32 , pp. 15036-15052
    • Sanderson, J.L.1    Gorski, J.A.2    Gibson, E.S.3    Lam, P.4    Freund, R.K.5    Chick, W.S.6    Dell’Acqua, M.L.7
  • 40
    • 20044383377 scopus 로고    scopus 로고
    • Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer’s disease: Relationships to beta-amyloid deposition and neurotransmitter abnormalities
    • CrossRef Medline
    • Savonenko A, Xu GM, Melnikova T, Morton JL, Gonzales V, Wong MP, Price DL, Tang F, Markowska AL, Borchelt DR (2005) Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer’s disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. Neurobiol Dis 18:602–617. CrossRef Medline
    • (2005) Neurobiol Dis , vol.18 , pp. 602-617
    • Savonenko, A.1    Xu, G.M.2    Melnikova, T.3    Morton, J.L.4    Gonzales, V.5    Wong, M.P.6    Price, D.L.7    Tang, F.8    Markowska, A.L.9    Borchelt, D.R.10
  • 42
    • 72849142054 scopus 로고    scopus 로고
    • Alzheimer’s disease: Synaptic dysfunction and Abeta
    • CrossRef Medline
    • Shankar GM, Walsh DM (2009) Alzheimer’s disease: synaptic dysfunction and Abeta. Mol Neurodegener 4:48. CrossRef Medline
    • (2009) Mol Neurodegener , vol.4
    • Shankar, G.M.1    Walsh, D.M.2
  • 44
    • 23444448170 scopus 로고    scopus 로고
    • Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    • CrossRef Medline
    • Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT (2005) Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 25:7278–7287. CrossRef Medline
    • (2005) J Neurosci , vol.25 , pp. 7278-7287
    • Spires, T.L.1    Meyer-Luehmann, M.2    Stern, E.A.3    McLean, P.J.4    Skoch, J.5    Nguyen, P.T.6    Bacskai, B.J.7    Hyman, B.T.8
  • 45
    • 0033021663 scopus 로고    scopus 로고
    • Inhibitory control of LTP and LTD: Stability of synapse strength
    • Medline
    • Steele PM, Mauk MD (1999) Inhibitory control of LTP and LTD: stability of synapse strength. J Neurophysiol 81:1559–1566. Medline
    • (1999) J Neurophysiol , vol.81 , pp. 1559-1566
    • Steele, P.M.1    Mauk, M.D.2
  • 46
    • 1342288871 scopus 로고    scopus 로고
    • Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer’slinked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability
    • CrossRef Medline
    • Stutzmann GE, Caccamo A, LaFerla FM, Parker I (2004) Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer’slinked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci 24:508–513. CrossRef Medline
    • (2004) J Neurosci , vol.24 , pp. 508-513
    • Stutzmann, G.E.1    Caccamo, A.2    Laferla, F.M.3    Parker, I.4
  • 47
    • 33646945317 scopus 로고    scopus 로고
    • Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer’s disease mice
    • CrossRef Medline
    • Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I (2006) Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer’s disease mice. J Neurosci 26: 5180–5189. CrossRef Medline
    • (2006) J Neurosci , vol.26 , pp. 5180-5189
    • Stutzmann, G.E.1    Smith, I.2    Caccamo, A.3    Oddo, S.4    Laferla, F.M.5    Parker, I.6
  • 48
    • 2542584749 scopus 로고    scopus 로고
    • Progressive age-related development of Alzheimer-like pathology in APP/ PS1 mice
    • CrossRef Medline
    • Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O (2004) Progressive age-related development of Alzheimer-like pathology in APP/ PS1 mice. Ann Neurol 55:801–814. CrossRef Medline
    • (2004) Ann Neurol , vol.55 , pp. 801-814
    • Trinchese, F.1    Liu, S.2    Battaglia, F.3    Walter, S.4    Mathews, P.M.5    Arancio, O.6
  • 49
  • 50
    • 0034095106 scopus 로고    scopus 로고
    • Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer’s disease mutation is normalized with a benzodiazepine
    • CrossRef Medline
    • Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R (2000) Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer’s disease mutation is normalized with a benzodiazepine. Neurobiol Dis 7:54–63. CrossRef Medline
    • (2000) Neurobiol Dis , vol.7 , pp. 54-63
    • Zaman, S.H.1    Parent, A.2    Laskey, A.3    Lee, M.K.4    Borchelt, D.R.5    Sisodia, S.S.6    Malinow, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.