-
1
-
-
84885463900
-
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
-
24107777
-
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. JA Moreno, M Halliday, C Molloy, H Radford, N Verity, JM Axten, CA Ortori, AE Willis, PM Fischer, DA Barrett, GR Mallucci, Sci Transl Med 2013 5 206ra138 24107777
-
(2013)
Sci Transl Med
, vol.5
-
-
Moreno, J.A.1
Halliday, M.2
Molloy, C.3
Radford, H.4
Verity, N.5
Axten, J.M.6
Ortori, C.A.7
Willis, A.E.8
Fischer, P.M.9
Barrett, D.A.10
Mallucci, G.R.11
-
2
-
-
84866905708
-
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3- dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
-
10.1021/jm300713s 22827572
-
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3- dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). JM Axten, JR Medina, Y Feng, A Shu, SP Romeril, SW Grant, WH Li, DA Heerding, E Minthorn, T Mencken, C Atkins, Q Liu, S Rabindran, R Kumar, X Hong, A Goetz, T Stanley, JD Taylor, SD Sigethy, GH Tomberlin, AM Hassell, KM Kahler, LM Shewchuk, RT Gampe, J Med Chem 2012 55 7193 7207 10.1021/jm300713s 22827572
-
(2012)
J Med Chem
, vol.55
, pp. 7193-7207
-
-
Axten, J.M.1
Medina, J.R.2
Feng, Y.3
Shu, A.4
Romeril, S.P.5
Grant, S.W.6
Li, W.H.7
Heerding, D.A.8
Minthorn, E.9
Mencken, T.10
Atkins, C.11
Liu, Q.12
Rabindran, S.13
Kumar, R.14
Hong, X.15
Goetz, A.16
Stanley, T.17
Taylor, J.D.18
Sigethy, S.D.19
Tomberlin, G.H.20
Hassell, A.M.21
Kahler, K.M.22
Shewchuk, L.M.23
Gampe, R.T.24
more..
-
3
-
-
35848935017
-
Translational control and the unfolded protein response
-
DOI 10.1089/ars.2007.1764
-
Translational control and the unfolded protein response. RC Wek, DR Cavener, Antioxid Redox Signal 2007 9 2357 2371 10.1089/ars.2007.1764 17760508 (Pubitemid 350064140)
-
(2007)
Antioxidants and Redox Signaling
, vol.9
, Issue.12
, pp. 2357-2371
-
-
Wek, R.C.1
Cavener, D.R.2
-
4
-
-
84884164633
-
Translational control by eIF2 kinases in long-lasting synaptic plasticity and long-term memory
-
23707798
-
Translational control by eIF2 kinases in long-lasting synaptic plasticity and long-term memory. MA Trinh, E Klann, Neurobiol Learn Mem 2013 105 93 99 23707798
-
(2013)
Neurobiol Learn Mem
, vol.105
, pp. 93-99
-
-
Trinh, M.A.1
Klann, E.2
-
5
-
-
32544446451
-
Coping with stress: EIF2 kinases and translational control
-
Coping with stress: eIF2 kinases and translational control. RC Wek, H-Y Jiang, TG Anthony, Biochem Soc Trans 2006 34 7 11 10.1042/BST0340007 16246168 (Pubitemid 43235522)
-
(2006)
Biochemical Society Transactions
, vol.34
, Issue.1
, pp. 7-11
-
-
Wek, R.C.1
Jiang, H.-Y.2
Anthony, T.G.3
-
6
-
-
34347342030
-
Shut-down of translation, a global neuronal stress response: Mechanisms and pathological relevance
-
DOI 10.2174/138161207780858401
-
Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance. W Paschen, CG Proud, G Mies, Curr Pharm Des 2007 13 1887 1902 10.2174/138161207780858401 17584115 (Pubitemid 47017993)
-
(2007)
Current Pharmaceutical Design
, vol.13
, Issue.18
, pp. 1887-1902
-
-
Paschen, W.1
Proud, C.G.2
Mies, G.3
-
7
-
-
34247153647
-
Translational control of synaptic plasticity and learning and memory
-
Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press Mathews MB, Sonenberg N, Hershey JW
-
Translational control of synaptic plasticity and learning and memory. E Klann, JD Richter, Translational Control in Biology and Medicine Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, Mathews MB, Sonenberg N, Hershey JW, 2007 485 506
-
(2007)
Translational Control in Biology and Medicine
, pp. 485-506
-
-
Klann, E.1
Richter, J.D.2
-
8
-
-
39849094746
-
The role of protein synthesis during the labile phases of memory: Revisiting the skepticism
-
DOI 10.1016/j.nlm.2007.08.007, PII S1074742707001244
-
The role of protein synthesis during the labile phases of memory: revisiting the skepticism. C Alberini, Neurobiol Learn Mem 2008 89 234 246 10.1016/j.nlm.2007.08.007 17928243 (Pubitemid 351318267)
-
(2008)
Neurobiology of Learning and Memory
, vol.89
, Issue.3
, pp. 234-246
-
-
Alberini, C.M.1
-
9
-
-
84870838478
-
Endoplasmic reticulum dysfunction in neurological disease
-
10.1016/S1474-4422(12)70238-7 23237905
-
Endoplasmic reticulum dysfunction in neurological disease. BD Roussel, AJ Kruppa, E Miranda, DC Crowther, DA Lomas, SJ Marciniak, Lancet Neurol 2013 12 105 118 10.1016/S1474-4422(12)70238-7 23237905
-
(2013)
Lancet Neurol
, vol.12
, pp. 105-118
-
-
Roussel, B.D.1
Kruppa, A.J.2
Miranda, E.3
Crowther, D.C.4
Lomas, D.A.5
Marciniak, S.J.6
-
10
-
-
84883453343
-
Suppression of eIF2 kinases alleviates Alzheimer's disease-related plasticity and memory deficits
-
10.1038/nn.3486 23933749
-
Suppression of eIF2 kinases alleviates Alzheimer's disease-related plasticity and memory deficits. T Ma, MA Trinh, AJ Wexler, C Bourbon, E Gatti, P Pierre, DR Cavener, E Klann, Nat Neurosci 2013 16 1299 1305 10.1038/nn.3486 23933749
-
(2013)
Nat Neurosci
, vol.16
, pp. 1299-1305
-
-
Ma, T.1
Trinh, M.A.2
Wexler, A.J.3
Bourbon, C.4
Gatti, E.5
Pierre, P.6
Cavener, D.R.7
Klann, E.8
-
11
-
-
84863086454
-
Brain-specific disruption of the eIF2 kinase PERK decreases ATF4 expression and impairs behavioral flexibility
-
10.1016/j.celrep.2012.04.010 22813743
-
Brain-specific disruption of the eIF2 kinase PERK decreases ATF4 expression and impairs behavioral flexibility. MA Trinh, H Kaphzan, RC Wek, P Pierre, DR Cavener, E Klann, Cell Rep 2012 1 676 688 10.1016/j.celrep.2012.04. 010 22813743
-
(2012)
Cell Rep
, vol.1
, pp. 676-688
-
-
Trinh, M.A.1
Kaphzan, H.2
Wek, R.C.3
Pierre, P.4
Cavener, D.R.5
Klann, E.6
-
12
-
-
0036091476
-
The PERK eukaryotic initiation factor 2α kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
-
DOI 10.1128/MCB.22.11.3864-3874.2002
-
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. P Zhang, B McGrath, S Li, A Frank, F Zambito, J Reinert, M Gannon, K Ma, K McNaughton, DR Cavener, Mol Cell Biol 2002 22 3864 3874 10.1128/MCB.22.11.3864-3874.2002 11997520 (Pubitemid 34525227)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.11
, pp. 3864-3874
-
-
Zhang, P.1
McGrath, B.2
Li, S.3
Frank, A.4
Zambito, F.5
Reinert, J.6
Gannon, M.7
Ma, K.8
McNaughton, K.9
Cavener, D.R.10
-
13
-
-
3042696843
-
Wolcott-Rallison syndrome: Clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity
-
DOI 10.2337/diabetes.53.7.1876
-
Wolcott-Rallison syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. V Senée, KM Vattem, M Delépine, LA Rainbow, C Haton, A Lecoq, NJ Shaw, JJ Robert, R Rooman, C Diatloff-Zito, JL Michaud, B Bin-Abbas, D Taha, B Zabel, P Franceschini, AK Topaloglu, GM Lathrop, TG Barrett, M Nicolino, RC Wek, C Julier, Diabetes 2004 53 1876 1883 10.2337/diabetes.53.7.1876 15220213 (Pubitemid 38857047)
-
(2004)
Diabetes
, vol.53
, Issue.7
, pp. 1876-1883
-
-
Senee, V.1
Vattem, K.M.2
Delepine, M.3
Rainbow, L.A.4
Haton, C.5
Lecoq, A.6
Shaw, N.J.7
Robert, J.-J.8
Rooman, R.9
Diatloff-Zito, C.10
Michaud, J.L.11
Bin-Abbas, B.12
Taha, D.13
Zabel, B.14
Franceschini, P.15
Topaloglu, A.K.16
Lathrop, G.M.17
Barrett, T.G.18
Nicolino, M.19
Wek, R.C.20
Julier, C.21
more..
-
14
-
-
84873975872
-
Biomarkers for Alzheimer's disease in plasma, serum and blood - Conceptual and practical problems
-
10.1186/alzrt164 23470193
-
Biomarkers for Alzheimer's disease in plasma, serum and blood-conceptual and practical problems. D Galasko, TE Golde, Alzheimers Res Ther 2013 5 10 10.1186/alzrt164 23470193
-
(2013)
Alzheimers Res Ther
, vol.5
, pp. 10
-
-
Galasko, D.1
Golde, T.E.2
-
15
-
-
84891864287
-
Open questions for Alzheimer's disease immunotherapy
-
10.1186/alzrt233 24393284
-
Open questions for Alzheimer's disease immunotherapy. TE Golde, Alzheimers Res Ther 2014 6 3 10.1186/alzrt233 24393284
-
(2014)
Alzheimers Res Ther
, vol.6
, pp. 3
-
-
Golde, T.E.1
|