PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

Acta Neuropathologica

Volumn 130, Issue 5, 2015, Pages 633-642

  Radford, Helois ^a   Moreno, Julie A ^a,b   Verity, Nicholas ^a   Halliday, Mark ^a   Mallucci, Giovanna R ^a,c  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dementia; Neurodegeneration; PERK; Tau; Unfolded Protein Response

Indexed keywords

GSK 2606414; INITIATION FACTOR 2ALPHA; NEUROPROTECTIVE AGENT; PANCREATIC ER KINASE; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; TAU PROTEIN; UNCLASSIFIED DRUG; 7-METHYL-5-(1-((3-(TRIFLUOROMETHYL)PHENYL)ACETYL)-2,3-DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO(2,3-D)PYRIMIDIN-4-AMINE; ADENINE; INDOLE DERIVATIVE; MAPT PROTEIN, HUMAN; PERK KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE R;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; GENE OVEREXPRESSION; MALE; MOUSE; MOUSE MODEL; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; ATROPHY; BRAIN; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOTOR ACTIVITY; MUTATION; NERVE CELL; ORGAN SIZE; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ADENINE; ANIMALS; ATROPHY; BRAIN; DISEASE MODELS, ANIMAL; EIF-2 KINASE; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMANS; INDOLES; MALE; MICE, TRANSGENIC; MOTOR ACTIVITY; MUTATION; NEURONS; NEUROPROTECTIVE AGENTS; ORGAN SIZE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 84945181747     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1487-z     Document Type: Article

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