The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

Cell Metabolism

Volumn 23, Issue 4, 2016, Pages 610-621

  He, Baokun ^a   Nohara, Kazunari ^a   Park, Noheon ^b   Park, Yong Sung ^a   Guillory, Bobby ^c   Zhao, Zhaoyang ^a   Garcia, Jose M ^c   Koike, Nobuya ^d   Lee, Cheng Chi ^a   Takahashi, Joseph S ^b,e   Yoo, Seung Hee ^a   Chen, Zheng ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

circadian clock; clock amplitude enhancing small molecule; metabolic syndrome; natural flavonoid; Nobiletin; retinoid acid receptor related orphan receptors (RORs)

Indexed keywords

NOBILETIN; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK; TRIACYLGLYCEROL; FLAVONE DERIVATIVE; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RORA PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CIRCADIAN RHYTHM; COMPARATIVE STUDY; CONTROLLED STUDY; DIET INDUCED OBESITY; ENERGY EXPENDITURE; FOOD INTAKE; GENE EXPRESSION; INSULIN SENSITIVITY; LIPID HOMEOSTASIS; LOCOMOTION; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OSCILLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RESPIRATORY QUOTIENT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LIVER; MALE; METABOLISM; MOUSE MUTANT; PATHOLOGY;

ANIMALS; CIRCADIAN RHYTHM; FLAVONES; GENE EXPRESSION REGULATION; LIVER; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MICE, OBESE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1;

EID: 84963668005     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.03.007     Document Type: Article

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