Obesity and metabolic syndrome in circadian Clock mutant nice

Science

Volumn 308, Issue 5724, 2005, Pages 1043-1045

  Turek, Fred W ^a,b   Joshu, Corinne ^b,c   Kohsaka, Akira ^b,c   Lin, Emily ^b,c   Ivanova, Ganka ^a,c   McDearmon, Erin ^b,d   Laposky, Aaron ^b   Losee Olson, Sue ^b   Easton, Amy ^b   Jensen, Dalan R ^e   Eckel, Robert H ^e   Takahashi, Joseph S ^a,b,d   Bass, Joseph ^a,b,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c EVANSTON NORTHWESTERN HEALTHCARE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; METABOLISM; POLYPEPTIDES;

CIRCADIAN CLOCK; HYPERGLYCEMIA; METABOLIC SYNDROMES; OBESITY;

MUTAGENESIS;

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR CLOCK;

BIOLOGY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL METABOLISM; CIRCADIAN RHYTHM; ENERGY BALANCE; ENERGY EXPENDITURE; FATTY LIVER; FEEDING; FOOD INTAKE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; HOMEOSTASIS; HYPERGLYCEMIA; HYPERLEPTINEMIA; HYPERLIPIDEMIA; HYPOINSULINEMIA; HYPOTHALAMUS; LOCOMOTION; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; OXIDATION REDUCTION REACTION; PACEMAKER NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION INITIATION;

ADIPOCYTES; ANIMALS; BODY WEIGHT; BRAIN; CIRCADIAN RHYTHM; DIETARY FATS; ENERGY INTAKE; ENERGY METABOLISM; FEEDING BEHAVIOR; HEPATOCYTES; HYPERGLYCEMIA; HYPERLIPIDEMIAS; INSULIN; LEPTIN; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; MUTATION; NEUROPEPTIDES; OBESITY; TRANS-ACTIVATORS; WEIGHT GAIN;

MAMMALIA;

EID: 20844461135     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1108750     Document Type: Article

References (29)

1. E. Van Cauter, F. W. Turek, in Handbook of Physiology, Section 7: The Endocrine System, B. S. McEwen, Ed. (Oxford Univ. Press, New York, 2000), pp. 313-330.
2. S. M. Reppert, D. R. Weaver, Nature 418, 935 (2002).
3. J. S. Takahashi, F. W. Turek, R. Y. Moore, Eds., Handbook of Behavioral Neurobiology (Kluwer Academic/Plenum, New York, 2001), vol. 12, pp. 770.
4. A. Balsalobre, F. Damiola, U. Schibler, Cell 93, 929 (1998).
5. K. A. Stokkan, S. Yamazaki, H. Tei, Y. Sakaki, M. Menaker, Science 291, 490 (2001).
6. K. Yagita, F. Tamanini, G. T. van Der Horst, H. Okamura, Science 292, 278 (2001).
7. M. Abe et al., J. Neurosci. 22, 350 (2002).
8. S. H. Yoo et al., Proc. Natl. Acad. Sci. U.S.A. 101, 5339 (2004).
9. R. D. Rudic et al., PLoS Biol. 2, e377 (2004).
10. J. Rutter, M. Reick, L. C. Wu, S. L. McKnight, Science 293, 510 (2001).
11. M. H. Vitaterna et al., Science 264, 719 (1994).
12. D. P. King et al., Cell 89, 641 (1997).
13. M. P. Antoch et al., Cell 89, 655 (1997).
14. Male mice were used in all studies.
15. J. T. Willie, R. M. Chemelli, C. M. Sinton, M. Yanagisawa, Annu. Rev. Neurosci. 24, 429 (2001).
16. S. Taheri, J. M. Zeitzer, E. Mignot, Annu. Rev. Neurosci. 25, 283 (2002).
17. K. Yamada et al., Int. J. Obes. Relat. Metab. Disord. 26, 132 (2002).
18. N. Kanamoto et al., Endocrinology 145, 4144 (2004).
19. D. J. Burks et al., Nature 407, 377 (2000).
20. J. C. Bruning et al., Science 289, 2122 (2000).
21. S. E. la Fleur, A. Kalsbeek, J. Wortel, M. L. Fekkes, R. M. Buijs, Diabetes 50, 1237 (2001).
22. Y. Kitamura, D. Accili, Rev. Endocr. Metab. Disord. 5, 143 (2004).
23. S. Panda et al., Cell 109, 307 (2002).
24. R. A. Akhtar et al., Curr. Biol. 12, 540 (2002).
25. K. F. Storch et al., Nature 417, 78 (2002).
26. C. B. Saper, T. C. Chou, J. K. Elmquist, Neuron 36, 199 (2002).
27. M. A. Cowley et al., Neuron 37, 649 (2003).
28. B. Bodosi et al., Am. J. Physiol. Regul. Integr. Comp. Physiol. 287, R1071 (2004).
29. Supported by NIH grants AG18200, DK0267S, AG11412, HL75029, HL59598, and DK26356. We thank the Northwestern University Robert H. Lurie Comprehensive Cancer Center Pathology Core Faculty for their assistance. All animal procedures were performed at Northwestern University following institutional guidelines. J.S.T. is a cofounder of, has equity in, and is a member of the scientific advisory board of Hypnion Inc., which develops sleep-related pharmaceuticals. He is also on the scientific advisory boards of NutraGenomics Inc. and the Allen Institute for Brain Science. F.W.T. is a cofounder of and has equity in Slowave Inc., which develops sleep-related pharmaceuticals, and is on the board of directors of the National Sleep Foundation. Additional paid consulting relationships are disclosed in the SOM.