메뉴 건너뛰기




Volumn 38, Issue 13, 2010, Pages 4296-4312

Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ADENYLATE KINASE; AMINE OXIDASE (FLAVIN CONTAINING); APOLIPOPROTEIN C1; CCAAT BINDING FACTOR; CYTOCHROME C OXIDASE; DESMIN; EPENDYMIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID SYNTHASE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HAPTOGLOBIN; HISTONE DEACETYLASE 4; IMMUNOGLOBULIN HEAVY CHAIN; LIVER X RECEPTOR; MANNOSE 6 PHOSPHATE; MELANOMA ANTIGEN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; PROTEIN KINASE C THETA; PROTEIN SWI; RAB11 PROTEIN; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR ALPHA 1; SPERMINE SYNTHASE; STEAROYL COENZYME A; TRANSKETOLASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; ZINC FINGER PROTEIN;

EID: 77955258637     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq180     Document Type: Article
Times cited : (50)

References (57)
  • 3
    • 4344668155 scopus 로고    scopus 로고
    • RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR
    • Lau,P., Nixon,S.J., Parton,R.G. and Muscat,G.E. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J. Biol. Chem., 279, 36828-36840.
    • (2004) J. Biol. Chem. , vol.279 , pp. 36828-36840
    • Lau, P.1    Nixon, S.J.2    Parton, R.G.3    Muscat, G.E.4
  • 4
    • 34548306952 scopus 로고    scopus 로고
    • Retinoid-related orphan receptor gamma regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production
    • Raichur,S., Lau,P., Staels,B. and Muscat,G.E. (2007) Retinoid-related orphan receptor gamma regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production. J. Mol. Endocrinol., 39, 29-44.
    • (2007) J. Mol. Endocrinol. , vol.39 , pp. 29-44
    • Raichur, S.1    Lau, P.2    Staels, B.3    Muscat, G.E.4
  • 6
    • 66849099394 scopus 로고    scopus 로고
    • Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
    • Jetten,A.M. (2009) Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl. Recept. Signal, 7, e003.
    • (2009) Nucl. Recept. Signal , vol.7
    • Jetten, A.M.1
  • 8
    • 49649099595 scopus 로고    scopus 로고
    • The orphan nuclear receptor, ROR{alpha}, regulates gene expression that controls lipid metabolism: STAGGERER (SG/SG) mice are resistant to diet-induced obesity
    • Lau,P., Fitzsimmons,R.L., Raichur,S., Wang,S.C., Lechtken,A. and Muscat,G.E. (2008) The orphan nuclear receptor, ROR{alpha}, regulates gene expression that controls lipid metabolism: STAGGERER (SG/SG) mice are resistant to diet-induced obesity. J. Biol. Chem., 283, 18411-18421.
    • (2008) J. Biol. Chem. , vol.283 , pp. 18411-18421
    • Lau, P.1    Fitzsimmons, R.L.2    Raichur, S.3    Wang, S.C.4    Lechtken, A.5    Muscat, G.E.6
  • 9
    • 0033749620 scopus 로고    scopus 로고
    • Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply
    • Schmitz-Peiffer,C. (2000) Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. Cell Signal, 12, 583-594.
    • (2000) Cell Signal , vol.12 , pp. 583-594
    • Schmitz-Peiffer, C.1
  • 10
    • 0027476102 scopus 로고
    • Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice
    • Brennan,K.J. and Hardeman,E.C. (1993) Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice. J. Biol. Chem., 268, 719-725.
    • (1993) J. Biol. Chem. , vol.268 , pp. 719-725
    • Brennan, K.J.1    Hardeman, E.C.2
  • 11
    • 0023445765 scopus 로고
    • Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression
    • Muscat,G.E. and Kedes,L. (1987) Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression. Mol. Cell Biol., 7, 4089-4099.
    • (1987) Mol. Cell Biol. , vol.7 , pp. 4089-4099
    • Muscat, G.E.1    Kedes, L.2
  • 13
    • 0024283304 scopus 로고
    • Transgenic animals
    • Jaenisch, R. (1988) Transgenic animals. Science, 240, 1468-1474.
    • (1988) Science , vol.240 , pp. 1468-1474
    • Jaenisch, R.1
  • 14
    • 23844470961 scopus 로고    scopus 로고
    • An improved method for determination of gene copy numbers in transgenic mice by serial dilution curves obtained by real-time quantitative PCR assay
    • Mitrecic,D., Huzak,M., Curlin,M. and Gajovic,S. (2005) An improved method for determination of gene copy numbers in transgenic mice by serial dilution curves obtained by real-time quantitative PCR assay. J. Biochem. Biophys. Methods, 64, 83-98.
    • (2005) J. Biochem. Biophys. Methods , vol.64 , pp. 83-98
    • Mitrecic, D.1    Huzak, M.2    Curlin, M.3    Gajovic, S.4
  • 15
    • 33747154772 scopus 로고    scopus 로고
    • Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
    • Bookout,A.L., Jeong,Y., Downes,M., Yu,R.T., Evans,R.M. and Mangelsdorf,D.J. (2006) Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell, 126, 789-799.
    • (2006) Cell , vol.126 , pp. 789-799
    • Bookout, A.L.1    Jeong, Y.2    Downes, M.3    Yu, R.T.4    Evans, R.M.5    Mangelsdorf, D.J.6
  • 17
    • 67651166611 scopus 로고    scopus 로고
    • Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues
    • Myers,S.A., Eriksson,N., Burow,R., Wang,S.C. and Muscat,G.E. (2009) Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues. Mol. Cell Endocrinol., 309, 101-108.
    • (2009) Mol. Cell Endocrinol. , vol.309 , pp. 101-108
    • Myers, S.A.1    Eriksson, N.2    Burow, R.3    Wang, S.C.4    Muscat, G.E.5
  • 18
    • 0032510947 scopus 로고    scopus 로고
    • Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle
    • Brozinick,J.T. Jr and Birnbaum,M.J. (1998) Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle. J. Biol. Chem., 273, 14679-14682.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14679-14682
    • Brozinick J.T., Jr.1    Birnbaum, M.J.2
  • 20
    • 44249088564 scopus 로고    scopus 로고
    • The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle
    • Pearen,M.A., Myers,S.A., Raichur,S., Ryall,J.G., Lynch,G.S. and Muscat,G.E. (2008) The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology, 149, 2853-2865.
    • (2008) Endocrinology , vol.149 , pp. 2853-2865
    • Pearen, M.A.1    Myers, S.A.2    Raichur, S.3    Ryall, J.G.4    Lynch, G.S.5    Muscat, G.E.6
  • 21
    • 0028837173 scopus 로고
    • The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions
    • McBroom,L.D., Flock,G. and Giguere,V. (1995) The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions. Mol. Cell Biol., 15, 796-808.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 796-808
    • McBroom, L.D.1    Flock, G.2    Giguere, V.3
  • 26
    • 0028197552 scopus 로고
    • Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors
    • Giguere,V., Tini,M., Flock,G., Ong,E., Evans,R.M. and Otulakowski,G. (1994) Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. Genes Dev., 8, 538-553.
    • (1994) Genes Dev. , vol.8 , pp. 538-553
    • Giguere, V.1    Tini, M.2    Flock, G.3    Ong, E.4    Evans, R.M.5    Otulakowski, G.6
  • 27
    • 0141925771 scopus 로고    scopus 로고
    • Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
    • Kovacic,S., Soltys,C.L., Barr,A.J., Shiojima,I., Walsh,K. and Dyck,J.R. (2003) Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J. Biol. Chem., 278, 39422-39427.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39422-39427
    • Kovacic, S.1    Soltys, C.L.2    Barr, A.J.3    Shiojima, I.4    Walsh, K.5    Dyck, J.R.6
  • 28
    • 25444524850 scopus 로고    scopus 로고
    • Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
    • Hahn-Windgassen,A., Nogueira,V., Chen,C.C., Skeen,J.E., Sonenberg,N. and Hay,N. (2005) Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J. Biol. Chem., 280, 32081-32089.
    • (2005) J. Biol. Chem. , vol.280 , pp. 32081-32089
    • Hahn-Windgassen, A.1    Nogueira, V.2    Chen, C.C.3    Skeen, J.E.4    Sonenberg, N.5    Hay, N.6
  • 30
    • 40849092782 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle
    • Osler,M.E. and Zierath,J.R. (2008) Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle. Endocrinology, 149, 935-941.
    • (2008) Endocrinology , vol.149 , pp. 935-941
    • Osler, M.E.1    Zierath, J.R.2
  • 31
    • 54549090146 scopus 로고    scopus 로고
    • The emerging role of nuclear receptor ROR{alpha} and its crosstalk with LXR in Xeno- and endobiotic gene regulation
    • Wada,T., Kang,H.S., Jetten,A.M. and Xie,W. (2008) The emerging role of nuclear receptor ROR{alpha} and its crosstalk with LXR in Xeno- and endobiotic gene regulation. Exp. Biol. Med. (Maywood), 233, 1191-1201.
    • (2008) Exp. Biol. Med. (Maywood) , vol.233 , pp. 1191-1201
    • Wada, T.1    Kang, H.S.2    Jetten, A.M.3    Xie, W.4
  • 32
    • 40849086444 scopus 로고    scopus 로고
    • Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
    • Wada,T., Kang,H.S., Angers,M., Gong,H., Bhatia,S., Khadem,S., Ren,S., Ellis,E., Strom,S.C., Jetten,A.M. et al. (2008) Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol. Pharmacol., 73, 891-899.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 891-899
    • Wada, T.1    Kang, H.S.2    Angers, M.3    Gong, H.4    Bhatia, S.5    Khadem, S.6    Ren, S.7    Ellis, E.8    Strom, S.C.9    Jetten, A.M.10
  • 33
    • 34047101856 scopus 로고    scopus 로고
    • Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages
    • Askari,B., Kanter,J.E., Sherrid,A.M., Golej,D.L., Bender,A.T., Liu,J., Hsueh,W.A., Beavo,J.A., Coleman,R.A. and Bornfeldt,K.E. (2007) Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes, 56, 1143-1152.
    • (2007) Diabetes , vol.56 , pp. 1143-1152
    • Askari, B.1    Kanter, J.E.2    Sherrid, A.M.3    Golej, D.L.4    Bender, A.T.5    Liu, J.6    Hsueh, W.A.7    Beavo, J.A.8    Coleman, R.A.9    Bornfeldt, K.E.10
  • 34
    • 34447579941 scopus 로고    scopus 로고
    • Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet
    • Kudo,T., Tamagawa,T., Kawashima,M., Mito,N. and Shibata,S. (2007) Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet. J. Biol. Rhythms, 22, 312-323.
    • (2007) J. Biol. Rhythms , vol.22 , pp. 312-323
    • Kudo, T.1    Tamagawa, T.2    Kawashima, M.3    Mito, N.4    Shibata, S.5
  • 35
    • 40849145708 scopus 로고    scopus 로고
    • Lipid droplets in lipogenesis and lipolysis
    • Ducharme,N.A. and Bickel,P.E. (2008) Lipid droplets in lipogenesis and lipolysis. Endocrinology, 149, 942-949.
    • (2008) Endocrinology , vol.149 , pp. 942-949
    • Ducharme, N.A.1    Bickel, P.E.2
  • 36
    • 34547946930 scopus 로고    scopus 로고
    • Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
    • Choi,C.S., Savage,D.B., Kulkarni,A., Yu,X.X., Liu,Z.X., Morino,K., Kim,S., Distefano,A., Samuel,V.T., Neschen,S. et al. (2007) Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem., 282, 22678-22688.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22678-22688
    • Choi, C.S.1    Savage, D.B.2    Kulkarni, A.3    Yu, X.X.4    Liu, Z.X.5    Morino, K.6    Kim, S.7    Distefano, A.8    Samuel, V.T.9    Neschen, S.10
  • 40
    • 37549000623 scopus 로고    scopus 로고
    • Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity
    • Kumar,A., Harris,T.E., Keller,S.R., Choi,K.M., Magnuson,M.A. and Lawrence,J.C. Jr (2008) Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol. Cell Biol., 28, 61-70.
    • (2008) Mol. Cell Biol. , vol.28 , pp. 61-70
    • Kumar, A.1    Harris, T.E.2    Keller, S.R.3    Choi, K.M.4    Magnuson, M.A.5    Lawrence J.C. Jr6
  • 41
    • 33749489511 scopus 로고    scopus 로고
    • Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane
    • Gonzalez,E. and McGraw,T.E. (2006) Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane. Mol. Biol. Cell, 17, 4484-4493.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 4484-4493
    • Gonzalez, E.1    McGraw, T.E.2
  • 43
    • 63849125267 scopus 로고    scopus 로고
    • Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase
    • Hegarty,B.D., Turner,N., Cooney,G.J. and Kraegen,E.W. (2009) Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase. Acta. Physiol. (Oxf), 196, 129-145.
    • (2009) Acta. Physiol. (Oxf) , vol.196 , pp. 129-145
    • Hegarty, B.D.1    Turner, N.2    Cooney, G.J.3    Kraegen, E.W.4
  • 45
    • 15744365009 scopus 로고    scopus 로고
    • Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice
    • Planavila,A., Alegret,M., Sanchez,R.M., Rodriguez-Calvo,R., Laguna,J.C. and Vazquez-Carrera,M. (2005) Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice. Biochem. Pharmacol., 69, 1195-1204.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1195-1204
    • Planavila, A.1    Alegret, M.2    Sanchez, R.M.3    Rodriguez-Calvo, R.4    Laguna, J.C.5    Vazquez-Carrera, M.6
  • 46
    • 0141905919 scopus 로고    scopus 로고
    • Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
    • Rutter,G.A., Da Silva Xavier,G. and Leclerc,I. (2003) Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem. J., 375, 1-16.
    • (2003) Biochem. J. , vol.375 , pp. 1-16
    • Rutter, G.A.1    Da Silva Xavier, G.2    Leclerc, I.3
  • 47
    • 0345832116 scopus 로고    scopus 로고
    • Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    • Jorgensen,S.B., Viollet,B., Andreelli,F., Frosig,C., Birk,J.B., Schjerling,P., Vaulont,S., Richter,E.A. and Wojtaszewski,J.F. (2004) Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. J. Biol. Chem., 279, 1070-1079.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1070-1079
    • Jorgensen, S.B.1    Viollet, B.2    Andreelli, F.3    Frosig, C.4    Birk, J.B.5    Schjerling, P.6    Vaulont, S.7    Richter, E.A.8    Wojtaszewski, J.F.9
  • 50
    • 0035039274 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise
    • Musi,N., Fujii,N., Hirshman,M.F., Ekberg,I., Froberg,S., Ljungqvist,O., Thorell,A. and Goodyear,L.J. (2001) AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes, 50, 921-927.
    • (2001) Diabetes , vol.50 , pp. 921-927
    • Musi, N.1    Fujii, N.2    Hirshman, M.F.3    Ekberg, I.4    Froberg, S.5    Ljungqvist, O.6    Thorell, A.7    Goodyear, L.J.8
  • 54
    • 33745196745 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
    • Viollet,B., Foretz,M., Guigas,B., Horman,S., Dentin,R., Bertrand,L., Hue,L. and Andreelli,F. (2006) Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J. Physiol., 574, 41-53.
    • (2006) J. Physiol. , vol.574 , pp. 41-53
    • Viollet, B.1    Foretz, M.2    Guigas, B.3    Horman, S.4    Dentin, R.5    Bertrand, L.6    Hue, L.7    Andreelli, F.8
  • 55
    • 62649093597 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells
    • Yang,J., Craddock,L., Hong,S. and Liu,Z.M. (2009) AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells. J. Cell Biochem., 106, 414-426.
    • (2009) J. Cell Biochem. , vol.106 , pp. 414-426
    • Yang, J.1    Craddock, L.2    Hong, S.3    Liu, Z.M.4
  • 56
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
    • Hardie,D.G., Carling,D. and Carlson,M. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem., 67, 821-855.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.