Mechanism of neurotrophic action of nobiletin in PC12D cells

Biochemistry

Volumn 44, Issue 42, 2005, Pages 13683-13691

  Nagase, Hiroyuki ^a   Yamakuni, Tohru ^a   Matsuzaki, Kentaro ^a   Maruyama, Yuji ^a   Kasahara, Jiro ^a   Hinohara, Yoshimi ^b   Kondo, Shunzo ^b   Mimaki, Yoshihiro ^c   Sashida, Yutaka ^c   Tank, A William ^d   Fukunaga, Kohji ^a   Ohizumi, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; ENZYMES; GENES; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; MORPHOLOGY; NEUROLOGY;

BULBECTOMY-INDUCED MEMORY IMPAIRMENT; MEDIATED TRANSCRIPTION; NEURITE OUTGROWTH; NONPEPTIDE COMPOUNDS;

CELLS;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; K 252A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NOBELITIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE (CALCIUM,CALMODULIN); PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CITRUS FRUIT; CONCENTRATION RESPONSE; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENZYME ACTIVATION; FLAVONES; HIPPOCAMPUS; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, ELECTRON, SCANNING; NEURONS; PC12 CELLS; PHOSPHORYLATION; RATS; TRANSCRIPTION, GENETIC;

ANIMALIA; CITRUS;

EID: 27144472889     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050643x     Document Type: Article

References (41)

1. Levi-Montalcini, R. (1987) The nerve growth factor 35 years later, Science 237, 1154-1162.
2. Sofroniew, M. V., Howe, C. I., and Mobley, W. C. (2001) Nerve growth factor signaling, neuroprotection, and neural repair, Annu. Rev. Neurosci. 24, 1217-1281.
3. Kesner, R. P. (1988) Enhancement of the acoustic startle response by stimulation of an excitatory pathway from the central amygdala/basal nucleus of Meynert to the pontine reticular formation, Neurobiol. Aging 9, 609-616.
4. Bartus, R. T. (2000) On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis, Exp. Neurol. 163, 495-529.
5. Cummings, J. L. (2004) Alzheimer's disease, N. Engl. J. Med. 351, 56-67.
6. Kasa, P., Rakonczay, Z., and Guly, K. (1997) The cholinergic system in Alzheimer's disease, Prog. Neurobiol. 52, 511-535.
7. Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., and Delong, M. R. (1982) Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain, Science 215, 1237-1239.
8. Patrick, C. W., Jr., Kukreti, S., and McIntire, L. V. (1996) Quantitative effects of peripheral monocytes and nerve growth factor on CNS neuronal morphometric outgrowth parameters in vivo, Exp. Neurol. 138, 277-285.
9. Woodruff, R. H., and Franklin, R. J. (1997) Growth factors and remyelination in the CNS, Histol. Histopathol. 12, 459-466.
10. Brinton, R. D., and Yamazaki, R. S. (1998) Advances and challenges in the preventation and treatment of Alzheimer's disease, Pharmacol Res. 15, 386-398.
11. Connor, B., and Dragunow, M. (1998) The role of neuronal growth factors in neurodegenerative disorders of the human brain, Brain Res. Rev. 27, 1-39.
12. Capsoni, S., Giannotta, S., and Cattaneo, A. (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice, Proc. Natl. Acad. Sci. U.S.A. 99, 12432-12437.
13. Eriksdotter-Jonhangen, M., et al. (1998) Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease, Dementia Geriatr. Cognit. Disord. 9, 246-257.
14. Chen, X. Q., Fawcett, J. R., Rahman, Y. E., Ala, T. A., and Prey, W. H., II (1998) Delivery of nerve growth factor to the brain via the olfactory pathway, J. Alzheimer's Dis. 1, 35-44.
15. Furukawa, K.-I., Sakai, K., Watanabe, S., Maruyama, K., Murakami, M., Yamaguchi, K., and Ohizumi, Y. (1993) Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin, J. Biol. Chem. 268, 26026-26031.
16. Obara, Y., Aoki, T., Kusano, M., and Ohizumi, Y. (2002) β-Eudesmol induces neunte outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase, J. Pharmacol. Exp. Ther. 301, 803-811.
17. Ohizumi, Y. (1997) Application of physiologically active substances isolated from natural resources to pharmacological studies, Jpn. J. Pharmacol. 73, 263-289.
18. Liu, J. (1993) FK506 and cyclosporin: molecular probes for studying intracellular signal transduction, Trends Pharmacol. Sci. 14, 182-188.
19. Machida, K., and Osawa, K. (1989) On the flavonoid constituents from the peels of Citrus hassaku Hort. ex Tanaka, Chem. Pharm. Bull. 37, 1092-1094.
20. Katoh-Semba, R., Kitajima, S., Yamazaki, Y., and Sano, M. (1987) Neuritic growth from a new subline of PC12 pheochromocytoma cells: cyclic AMP mimics the action of nerve growth factor, J. Neurosci. Res. 17, 36-44.
21. Li, P., Yamakuni, T., Matsunaga, K., Kondo, S., and Ohizumi, Y. (2003) Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells, J. Pharmacol. Sci. 93, 122-125.
22. Li, P., Matsunaga, K., Yamakuni, T., and Ohizumi, Y. (2003) Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells, Dev. Brain Res. 145, 177-183.
23. Suzuki, T., Yamakuni, T., Hagiwara, M., and Ichinose, H. (2002) Identification of ATP-2 as a transcriptional regulator for the tyrosine hydroxylase gene, J. Biol. Chem. 277, 40768-40774.
24. Piech-Dumas, K. M., et al. (2001) The cAMP responsive element and CREB partially mediate the response of the tyrosine hydroxylase gene to phorbol ester, J. Neurochem. 76, 1376-1385.
25. Yamakuni, T., Yamamoto, T., Hoshino, M., Song, S.-Y., Yamamoto, H., Kunikata-Sumitomo, M., Minegishi, A., Kubota, M., Ito, M., and Konishi, S. (1998) A novel protein containing cdc10/SW16 motifs regulates expression of mRNA encoding catecholamine biosynthesizing enzymes, J. Biol. Chem. 273, 27051-27054.
26. Arakane, F., Fukunaga, K., Araki, S., Abe, S., Satake, M., Miyazaki, K., Okamura, H., and Miyamoto, E. (1994) Glycolipid isolated from Aplysia kurodai can activate cyclic adenosine 3′,5′-monophosphate-dependent protein kinase from rat brain, J. Neurochem. 62, 86-93.
27. Martin, J. B., and Doty, D. M. (1949) Determination of inorganic phosphate. Modification of isobutyl alcohol procedure, Anal. Chem. 21, 965-967.
28. Green, L. A., and Tischler, A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor, Proc. Natl. Acad. Sci. U.S.A. 73, 2424-2428.
29. Marshall, C. (1995) Specificity of receptor tyrosine kinase signalling: transient versus sustained extracellular signal regulated kinase activation, Cell 80, 179-185.
30. Shao, Y., Akmentin, W., Toledo-Aral, J. J., Rosenbaum, J., Valdez, G., Cabot, J. B., Hilbush, B. S., and Haleoua, S. (2002) Pincher, a pinocytic chaperone for nerve growth factor/TrkA siganaling endosomes, J. Cell Biol. 157, 679-691.
31. Nikaido, T., Ohmoto, T., Sankawa, U., Hamanaka, T., and Totsuka, K. (1982) Inhibition of cyclic AMP phosphodiesterase by flavonoids, Planta Med. 46, 162-166.
32. Yao, H., York, R. D., Misra-Press, A., Carr, D. W., and Strok, P. J. (1998) The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor, J. Biol. Chem. 273, 8240-8247.
33. York, R. D., Yao, H., Dillon, T., Ellig, C. L., Eckert, S. P., McCleskey, E. W., and Stork, P. J. S. (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor, Nature 392, 622-626.
34. Vossler, M. R., Yao, H., York, R. D., Pan, M. G., Rim, C. S., and Strok, P. J. (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway, Cell 89, 73-82.
35. 1 muscarinic acetylcholine receptors to the activayion of ERK1/2, J. Biol. Chem. 276, 25568-25581.
36. Xing, J., Ginty, D. D., and Greenberg, M. E. (1996) Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase, Science 273, 959-963.
37. 2+ stimulation of CREB-dependent transcription and ERK nuclear translocation, Neuron 21, 869-883.
38. Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., and Kandel, E. R. (1997) Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory, Cell 88, 615-626.
39. Frey, U., Huang, Y.-Y., and Kandel, E. R. (1993) Effects of cAMP simulate a late stage LTP in hippocampal CA1 neurons, Science 260, 1661-1664.
40. Vitolo, O. V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O., and Shelanski, M. (2002) Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling, Proc. Natl. Acad. Sci. U.S.A. 99, 13217-13221.
41. 2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polmethoxy flavonoid, nobiletin, Mol. Cancer Ther. 3, 839-847.