Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 34, 2010, Pages 15240-15245

  Meng, Qing Jun ^a   Maywood, Elizabeth S ^b   Bechtold, David A ^a   Lu, Wei Qun ^a,d   Li, Jian ^a   Gibbs, Julie E ^a   Dupré, Sandrine M ^a   Chesham, Johanna E ^b   Rajamohan, Francis ^c   Knafels, John ^c   Sneed, Blossom ^c   Zawadzke, Laura E ^c   Ohren, Jeffrey F ^c   Walton, Kevin M ^c   Wager, Travis T ^c   Hastings, Michael H ^b   Loudon, Andrew S I ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d SHANGHAI OCEAN UNIVERSITY   (China)

Author keywords

Circadian clock; Pacemaking; Period protein; Suprachiasmatic nucleus; Tau mutation

Indexed keywords

CASEIN KINASE I; PER2 PROTEIN; PF 4800567; PF 670462; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CIRCADIAN RHYTHM SIGNALING PROTEIN; PER2 PROTEIN, MOUSE; PF-670462; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2; VIPR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLOCK; MOUSE; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SUPRACHIASMATIC NUCLEUS; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GENE SILENCING; GENETICS; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; TRANSGENIC MOUSE;

MAMMALIA; MUS;

ANIMALS; BASE SEQUENCE; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CIRCADIAN RHYTHM; GENE KNOCKDOWN TECHNIQUES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PERIOD CIRCADIAN PROTEINS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE, TYPE II; RNA, SMALL INTERFERING; SUPRACHIASMATIC NUCLEUS;

EID: 77957000375     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1005101107     Document Type: Article

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