The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

Nature

Volumn 503, Issue 7476, 2013, Pages 410-413

  Gerhart Hines, Zachary ^a   Feng, Dan ^a   Emmett, Matthew J ^a   Everett, Logan J ^a   Loro, Emanuele ^a   Briggs, Erika R ^a   Bugge, Anne ^a   Hou, Catherine ^b   Ferrara, Christine ^c   Seale, Patrick ^a   Pryma, Daniel A ^b   Khurana, Tejvir S ^a   Lazar, Mitchell A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; NORADRENALIN; NUCLEAR RECEPTOR NR1D1; NUCLEAR RECEPTOR REV ERBALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

BODY TEMPERATURE; CIRCADIAN RHYTHM; COLD TOLERANCE; HOMEOSTASIS; PHYSIOLOGICAL RESPONSE; PROTEIN; RODENT;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGY; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CIRCADIAN RHYTHM; CIRCADIAN THERMOGENIC PLASTICITY; COLD; COLD EXPOSURE; COLD TOLERANCE; CONTROLLED STUDY; DEFENSE MECHANISM; EVOLUTIONARY ADAPTATION; GENE DELETION; GENE EXPRESSION; GENE LOSS; GENE REPRESSION; MAMMAL; MOLECULAR CLOCK; MOUSE; NONHUMAN; OSCILLATION; OXYGEN CONSUMPTION; PLASTICITY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REPRESSOR GENE; SHIVERING; THERMOGENESIS;

ACCLIMATIZATION; ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE REGULATION; CIRCADIAN RHYTHM; COLD TEMPERATURE; DOWN-REGULATION; ION CHANNELS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; THERMOGENESIS; TIME FACTORS;

MAMMALIA; MUS;

EID: 84888042813     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12642     Document Type: Article

References (30)

1. Bass, J. Circadian topology of metabolism. Nature 491, 348-356 (2012).
2. Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
3. Takahashi, J. S., Hong, H.-K., Ko, C. H. & McDearmon, E. L. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nature Rev. Genet. 9, 764-775 (2008).
4. Sahar, S. & Sassone-Corsi, P. Metabolism and cancer: the circadian clock connection. Nature Rev. Cancer 9, 886-896 (2009).
5. Asher, G.&Schibler, U. Crosstalk between components of circadian andmetabolic cycles in mammals. Cell Metab. 13, 125-137 (2011).
6. Bass, J. & Takahashi, J. S. Circadian integration of metabolism and energetics. Science 330, 1349-1354 (2010).
7. Feng, D. & Lazar, M. A. Clocks, metabolism, and the epigenome. Mol. Cell 47, 158-167 (2012).
8. Buhr, E. D., Yoo, S.-H.&Takahashi, J.S. Temperature as a universal resettingcue for mammalian circadian oscillators. Science 330, 379-385 (2010).
9. Feng, D. et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331, 1315-1319 (2011).
10. Woldt, E. et al. Rev-erb-a modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nature Med. (2013).
11. Bugge, A. et al. Rev-erba and Rev-erbb coordinately protect the circadian clock and normal metabolic function. Genes Dev. 26, 657-667 (2012).
12. Cho, H. et al. Regulation of circadian behaviour and metabolism by Rev-erb-a and Rev-erb-b. Nature 485, 123-127 (2012).
13. Delezie, J. et al. The nuclear receptor Rev-erba is required for the daily balance of carbohydrate and lipid metabolism. FASEB J. 26, 3321-3335 (2012).
14. Le Martelot, G. et al. Rev-erba participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 7, e1000181 (2009).
15. Solt, L. A. et al. Regulation of circadian behaviour and metabolism by synthetic Rev-erb agonists. Nature 485, 62-68 (2012).
16. Cannon, B. & Nedergaard, J. Nonshivering thermogenesis and its adequate measurement in metabolic studies. J. Exp. Biol. 214, 242-253 (2011).
17. Preitner, N. et al. The orphan nuclear receptor Rev-erba controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251-260 (2002).
18. Lim, S. et al. Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nature Protocols 7, 606-615 (2012).
19. Golozoubova, V. et al. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J. 15, 2048-2050 (2001).
20. Talan, M. I., Tatelman, H. M. & Engel, B. T. Cold tolerance and metabolic heat production in male C57BL/6J mice at different times of day. Physiol. Behav. 50, 613-616 (1991).
21. Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998).
22. Pearen, M. A. et al. The orphan nuclear receptor, NOR-1, is a target of b-adrenergic signaling in skeletal muscle. Endocrinology 147, 5217-5227 (2006).
23. Cypess, A. M. et al. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc. Natl Acad. Sci. USA 109, 10001-10005 (2012).
24. Vosselman, M. J. et al. Systemic b-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans. Diabetes 61, 3106-3113 (2012).
25. Nedergaard, J.&Cannon, B.UCP1mRNAdoesnot produce heat. Biochim. Biophys. Acta 1831, 943-949 (2013).
26. Cypess, A. M. et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517 (2009).
27. VanMarken Lichtenbelt, W. D. et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500-1508 (2009).
28. Virtanen, K. A. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525 (2009).
29. Van der Veen, D. R., Shao, J., Chapman, S., Leevy, W. M. & Duffield, G. E. A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging. Obesity 20, 1527-1529 (2012).
30. Saito, S., Saito, C. T. & Shingai, R. Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals. Gene 408, 37-44 (2008).