Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

Immunity

Volumn 40, Issue 4, 2014, Pages 477-489

  Xiao, Sheng ^a   Yosef, Nir ^a,b   Yang, Jianfei ^c   Wang, Yonghui ^d   Zhou, Ling ^d   Zhu, Chen ^a   Wu, Chuan ^a   Baloglu, Erkan ^c   Schmidt, Darby ^c   Ramesh, Radha ^c   Lobera, Mercedes ^c   Sundrud, Mark S ^c   Tsai, Pei Yun ^e   Xiang, Zhijun ^d   Wang, Jinsong ^d   Xu, Yan ^d   Lin, Xichen ^d   Kretschmer, Karsten ^e   Rahl, Peter B ^f   Young, Richard A ^f,g   Zhong, Zhong ^d   Hafler, David A ^h   Regev, Aviv ^b,i   Ghosh, Shomir ^c   Marson, Alexander ^j,k   Kuchroo, Vijay K ^a   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c GLAXOSMITHKLINE   (United States)

^d GLAXOSMITHKLINE   (China)

^e CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^f WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENOLS; ANIMALS; BENZENEACETAMIDES; BENZHYDRYL COMPOUNDS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL LINEAGE; CYTOKINES; DIGOXIN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE REGULATORY NETWORKS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPLE SCLEROSIS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PEPTIDE FRAGMENTS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SYSTEMS BIOLOGY; T-LYMPHOCYTE SUBSETS; TH17 CELLS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84898688169     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.04.004     Document Type: Article

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