Astrocytes as new targets to improve cognitive functions

Progress in Neurobiology

Volumn 144, Issue , 2016, Pages 48-67

  Dallérac, Glenn ^a   Rouach, Nathalie ^a  

^a PSL RESEARCH UNIVERSITY   (France)

Author keywords

Alzheimer; Astroglial network; Autism spectrum disorder; Bipolar disorder; Depression; Epilepsy; Fragile X; Huntington; Memory; Neurodegenerative diseases; Neuroglial interactions; Parkinson; Psychiatric diseases; Rett syndrome; Schizophrenia

Indexed keywords

PROTEIN AGGREGATE;

ASTROCYTE; AUTISM; BIPOLAR DISORDER; BRAIN DISEASE; CELL COMMUNICATION; CELL INTERACTION; COGNITION; DEGENERATIVE DISEASE; EPILEPSY; EXCITOTOXICITY; HUMAN; MACROGLIA; MAJOR DEPRESSION; NERVE CELL NETWORK; NEUROTRANSMISSION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; ANIMAL; BRAIN DISEASES; COGNITIVE DYSFUNCTION; COMPLICATION; PHYSIOLOGY;

ANIMALS; ASTROCYTES; BRAIN DISEASES; COGNITION; COGNITIVE DYSFUNCTION; HUMANS;

EID: 84962583798     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2016.01.003     Document Type: Review

References (306)

1. Altshuler, L.L., Abulseoud, O.A., Foland-Ross, L., Bartzokis, G., Chang, S., Mintz, J., Hellemann, G., Vinters, H.V., Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder. Bipolar Disord. 12 (2010), 541–549, 10.1111/j.1399-5618.2010.00838.x.
2. Amzica, F., Massimini, M., Manfridi, A., Spatial buffering during slow and paroxysmal sleep oscillations in cortical networks of glial cells in vivo. J. Neurosci. 22 (2002), 1042–1053.
3. Amzica, F., Steriade, M., Neuronal and glial membrane potentials during sleep and paroxysmal oscillations in the neocortex. J. Neurosci. 20 (2000), 6648–6665.
4. Angulo, M.C., Kozlov, A.S., Charpak, S., Audinat, E., Glutamate released from glial cells synchronizes neuronal activity in the hippocampus. J. Neurosci. 24 (2004), 6920–6927, 10.1523/JNEUROSCI.0473-04.2004.
5. Anlauf, E., Derouiche, A., Glutamine synthetase as an astrocytic marker: its cell type and vesicle localization. Front. Endocrinol. (Lausanne), 4, 2013, 144, 10.3389/fendo.2013.00144.
6. Aqdam, M.J., Kamali, K., Rahgozar, M., Ohadi, M., Manoochehri, M., Tahami, A., Bostanshirin, L., Khorshid, H.R.K., Association of CALHM1 gene polymorphism with late onset Alzheimer's disease in Iranian population. Avicenna J. Med. Biotechnol. 2 (2010), 153–157.
7. Araneda, S., Commin, L., Atlagich, M., Kitahama, K., Parraguez, V.H., Pequignot, J.-M., Dalmaz, Y., VEGF overexpression in the astroglial cells of rat brainstem following ozone exposure. Neurotoxicology 29 (2008), 920–927, 10.1016/j.neuro.2008.09.006.
8. Araque, A., Carmignoto, G., Haydon, P.G., Oliet, S.H.R., Robitaille, R., Volterra, A., Gliotransmitters travel in time and space. Neuron 81 (2014), 728–739, 10.1016/j.neuron.2014.02.007.
9. Ariano, M.A., Cepeda, C., Calvert, C.R., Flores-Hernandez, J., Hernandez-Echeagaray, E., Klapstein, G.J., Chandler, S.H., Aronin, N., DiFiglia, M., Levine, M.S., Flores-Hernández, J., Hernández-Echeagaray, E., Striatal potassium channel dysfunction in Huntington's disease transgenic mice. J. Neurophysiol. 93 (2005), 2565–2574, 10.1152/jn.00791.2004.
10. Aronson, M., Hagberg, B., Gillberg, C., Attention deficits and autistic spectrum problems in children exposed to alcohol during gestation: a follow-up study. Dev. Med. Child Neurol. 39 (1997), 583–587.
11. Arundine, M., Tymianski, M., Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 34 (2003), 325–337.
12. Assous, M., Had-Aissouni, L., Gubellini, P., Melon, C., Nafia, I., Salin, P., Kerkerian-Le-Goff, L., Kachidian, P., Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra. Neurobiol. Dis. 65 (2014), 69–81, 10.1016/j.nbd.2014.01.011.
13. Bakos, J., Bacova, Z., Grant, S.G., Castejon, A.M., Ostatnikova, D., Are molecules involved in neuritogenesis and axon guidance related to autism pathogenesis?. Neuromol. Med. 17 (2015), 297–304, 10.1007/s12017-015-8357-7.
14. Ballas, N., Lioy, D.T., Grunseich, C., Mandel, G., Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology. Nat. Neurosci. 12 (2009), 311–317, 10.1038/nn.2275.
15. Banaclocha, M.A.M., Neuromagnetic dialogue between neuronal minicolumns and astroglial network: a new approach for memory and cerebral computation. Brain Res. Bull. 73 (2007), 21–27, 10.1016/j.brainresbull.2007.01.012.
16. Banasr, M., Duman, R.S., Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors. Biol. Psychiatry 64 (2008), 863–870, 10.1016/j.biopsych.2008.06.008.
17. Bartzokis, G., Tishler, T.A., MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntingon's disease. Cell. Mol. Biol. (Noisy-le-grand) 46 (2000), 821–833.
18. Bassell, G.J., Warren, S.T., Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron 60 (2008), 201–214, 10.1016/j.neuron.2008.10.004.
19. Beard, J.L., Connor, J.R., Jones, B.C., Iron in the brain. Nutr. Rev. 51 (1993), 157–170.
20. Bedner, P., Dupper, A., Huttmann, K., Muller, J., Herde, M.K., Dublin, P., Deshpande, T., Schramm, J., Haussler, U., Haas, C.A., Henneberger, C., Theis, M., Steinhauser, C., Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain 138 (2015), 1208–1222, 10.1093/brain/awv067.
21. Behrens, P.F., Franz, P., Woodman, B., Lindenberg, K.S., Landwehrmeyer, G.B., Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain 125 (2002), 1908–1922.
22. Bernard, R., Kerman, I.A., Thompson, R.C., Jones, E.G., Bunney, W.E., Barchas, J.D., Schatzberg, A.F., Myers, R.M., Akil, H., Watson, S.J., Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol. Psychiatry 16 (2011), 634–646, 10.1038/mp.2010.44.
23. Bernardinelli, Y., Muller, D., Nikonenko, I., Astrocyte-synapse structural plasticity. Neural Plast., 2014, 2014, 232105, 10.1155/2014/232105.
24. Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B.L., Pozzan, T., Volterra, A., Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 391 (1998), 281–285.
25. Bezzi, P., Volterra, A., A neuron-glia signalling network in the active brain. Curr. Opin. Neurobiol. 11 (2001), 387–394.
26. Binder, D.K., Oshio, K., Ma, T., Verkman, A.S., Manley, G.T., Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport 15 (2004), 259–262, 10.1097/00001756-200402090-00009.
27. Björkhem, I., Lövgren-Sandblom, A., Leoni, V., Meaney, S., Brodin, L., Salveson, L., Winge, K., Pålhagen, S., Svenningsson, P., Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. Neurosci. Lett. 555 (2013), 102–105, 10.1016/j.neulet.2013.09.003.
28. Block, M.L., Calderón-Garcidueñas, L., Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci. 32 (2009), 506–516, 10.1016/j.tins.2009.05.009.
29. Bohn, M.C., O'Banion, M.K., Young, D.A., Giuliano, R., Hussain, S., Dean, D.O., Cunningham, L.A., In vitro studies of glucocorticoid effects on neurons and astrocytes. Ann. N. Y. Acad. Sci. 746 (1994), 243–258 discussion 258–9, 289–93.
30. Bordey, A., Sontheimer, H., Properties of human glial cells associated with epileptic seizure foci. Epilepsy Res. 32 (1998), 286–303, 10.1016/S0920-1211(98)00059-X.
31. Bosson, A., Boisseau, S., Buisson, A., Savasta, M., Albrieux, M., Disruption of dopaminergic transmission remodels tripartite synapse morphology and astrocytic calcium activity within substantia nigra pars reticulata. Glia 63 (2015), 673–683, 10.1002/glia.22777.
32. Brockett, A.T., LaMarca, E.A., Gould, E., Physical exercise enhances cognitive flexibility as well as astrocytic and synaptic markers in the Medial Prefrontal Cortex. PLOS ONE, 10, 2015, e0124859, 10.1371/journal.pone.0124859.
33. Bushong, E.A., Martone, M.E., Jones, Y.Z., Ellisman, M.H., Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J. Neurosci. 22 (2002), 183–192.
34. Calabrese, V., Cornelius, C., Rizzarelli, E., Owen, J.B., Dinkova-Kostova, A.T., Butterfield, D.A., Nitric oxide in cell survival: a janus molecule. Antioxid. Redox Signal. 11 (2009), 2717–2739, 10.1089/ARS.2009.2721.
35. Cassano, T., Serviddio, G., Gaetani, S., Romano, A., Dipasquale, P., Cianci, S., Bellanti, F., Laconca, L., Romano, A.D., Padalino, I., LaFerla, F.M., Nicoletti, F., Cuomo, V., Vendemiale, G., Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiol. Aging 33 (2012), 1121.e1–1121.e12, 10.1016/j.neurobiolaging.2011.09.021.
36. Castaldo, P., Cataldi, M., Magi, S., Lariccia, V., Arcangeli, S., Amoroso, S., Role of the mitochondrial sodium/calcium exchanger in neuronal physiology and in the pathogenesis of neurological diseases. Prog. Neurobiol. 87 (2009), 58–79, 10.1016/j.pneurobio.2008.09.017.
37. Catts, V.S., Wong, J., Fillman, S.G., Fung, S.J., Shannon Weickert, C., Increased expression of astrocyte markers in schizophrenia: association with neuroinflammation. Aust. N. Z. J. Psychiatry 48 (2014), 722–734, 10.1177/0004867414531078.
38. Caudle, R.M., Memory in astrocytes: a hypothesis. Theor. Biol. Med. Model., 3, 2006, 2.
39. Cavus, I., Kasoff, W.S., Cassaday, M.P., Jacob, R., Gueorguieva, R., Sherwin, R.S., Krystal, J.H., Spencer, D.D., Abi-Saab, W.M., Extracellular metabolites in the cortex and hippocampus of epileptic patients. Ann. Neurol. 57 (2005), 226–235.
40. Chen, J., Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications. Rev. Neurosci. 25 (2014), 269–280, 10.1515/revneuro-2013-0046.
41. Chen, J., Tan, Z., Zeng, L., Zhang, X., He, Y., Gao, W., Wu, X., Li, Y., Bu, B., Wang, W., Duan, S., Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia 61 (2013), 178–191, 10.1002/glia.22425.
42. Cheung, G., Chever, O., Rouach, N., Connexons and pannexons: newcomers in neurophysiology. Front. Cell. Neurosci., 8, 2014, 348, 10.3389/fncel.2014.00348.
43. Chever, O., Lee, C.-Y., Rouach, N., Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission. J. Neurosci. 34 (2014), 11228–11232, 10.1523/JNEUROSCI.0015-14.2014.
44. Chever, O., Dossi, E., Pannasch, U., Derangeon, M., Rouach, N., Astroglial networks promote neuronal coordination. Sci. Signal., 9, 2016, ra6, 10.1126/scisignal.aad3066.
45. Christianson, A.L., Chesler, N., Kromberg, J.G., Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. Dev. Med. Child Neurol. 36 (1994), 361–369.
46. Clarke, L.E., Barres, B.A., Glia keep synapse distribution under wraps. Cell 154 (2013), 267–268, 10.1016/j.cell.2013.06.045.
47. Clasadonte, J., Dong, J., Hines, D.J., Haydon, P.G., Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 17540–17545, 10.1073/pnas.1311967110.
48. Cotter, D.R., Pariante, C.M., Everall, I.P., Glial cell abnormalities in major psychiatric disorders: the evidence and implications. Brain Res. Bull. 55 (2001), 585–595, 10.1016/S0361-9230(01)00527-5.
49. Coulter, D.A., Steinhauser, C., Role of astrocytes in epilepsy. Cold Spring Harb. Perspect. Med., 5, 2015, a022434, 10.1101/cshperspect.a022434.
50. Cowan, C.M., Mudher, A., Are tau aggregates toxic or protective in tauopathies?. Front. Neurol., 4, 2013, 114, 10.3389/fneur.2013.00114.
51. Crossin, K.L., Tai, M.H., Krushel, L.A., Mauro, V.P., Edelman, G.M., Glucocorticoid receptor pathways are involved in the inhibition of astrocyte proliferation. Proc. Natl. Acad. Sci. U. S. A. 94 (1997), 2687–2692.
52. Crunelli, V., Carmignoto, G., New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment. J. Physiol. 591 (2013), 775–785, 10.1113/jphysiol.2012.243378.
53. Czéh, B., Müller-Keuker, J.I.H., Rygula, R., Abumaria, N., Hiemke, C., Domenici, E., Fuchs, E., Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology 32 (2007), 1490–1503, 10.1038/sj.npp.1301275.
54. Czéh, B., Simon, M., Schmelting, B., Hiemke, C., Fuchs, E., Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment. Neuropsychopharmacology 31 (2006), 1616–1626, 10.1038/sj.npp.1300982.
55. Dallérac, G., Chever, O., Rouach, N., How do astrocytes shape synaptic transmission? Insights from electrophysiology. Front. Cell. Neurosci., 7, 2013, 159, 10.3389/fncel.2013.00159.
56. David, Y., Cacheaux, L.P., Ivens, S., Lapilover, E., Heinemann, U., Kaufer, D., Friedman, A., Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?. J. Neurosci. 29 (2009), 10588–10599, 10.1523/JNEUROSCI.2323-09.2009.
57. De Lanerolle, N.C., Lee, T.S., Spencer, D.D., Astrocytes and epilepsy. Neurotherapeutics 7 (2010), 424–438, 10.1016/j.nurt.2010.08.002 pii:S1933-7213(10)00113-3.
58. De Lima, M.N.M., Polydoro, M., Laranja, D.C., Bonatto, F., Bromberg, E., Moreira, J.C.F., Dal-Pizzol, F., Schröder, N., Recognition memory impairment and brain oxidative stress induced by postnatal iron administration. Eur. J. Neurosci. 21 (2005), 2521–2528, 10.1111/j.1460-9568.2005.04083.x.
59. Devinsky, O., Vezzani, A., Najjar, S., De Lanerolle, N.C., Rogawski, M.A., Glia and epilepsy: excitability and inflammation. Trends Neurosci. 36 (2013), 174–184, 10.1016/j.tins.2012.11.008 pii:S0166-2236(12)00205-6.
60. DeVivo, D.C., Leckie, M.P., Ferrendelli, J.S., McDougal, D.B., Chronic ketosis and cerebral metabolism. Ann. Neurol. 3 (1978), 331–337, 10.1002/ana.410030410.
61. + in the transition from the interictal state to seizures. Brain Res. 48 (1972), 173–183.
62. 2+ signals contribute to neuronal excitotoxicity after status epilepticus. J. Neurosci. 27 (2007), 10674–10684, 10.1523/JNEUROSCI.2001-07.2007.
63. Djukic, B., Casper, K.B., Philpot, B.D., Chin, L.-S., McCarthy, K.D., Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J. Neurosci. 27 (2007), 11354–11365, 10.1523/JNEUROSCI.0723-07.2007.
64. Dong, X., Wang, Y., Qin, Z., Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacol. Sin. 30 (2009), 379–387, 10.1038/aps.2009.24.
65. Dörrie, N., Föcker, M., Freunscht, I., Hebebrand, J., Fetal alcohol spectrum disorders. Eur. Child Adolesc. Psychiatry 23 (2014), 863–875, 10.1007/s00787-014-0571-6.
66. During, M.J., Spencer, D.D., Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 341 (1993), 1607–1610, 10.1016/0140-6736(93)90754-5.
67. Dwork, A.J., Arango, V., Underwood, M., Ilievski, B., Rosoklija, G., Sackeim, H.A., Lisanby, S.H., Absence of histological lesions in primate models of ECT and magnetic seizure therapy. Am. J. Psychiatry 161 (2004), 576–578.
68. Eid, T., Thomas, M.J., Spencer, D.D., Runden-Pran, E., Lai, J.C., Malthankar, G.V., Kim, J.H., Danbolt, N.C., Ottersen, O.P., de Lanerolle, N.C., Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy. Lancet 363 (2004), 28–37.
69. Falkai, P., Honer, W.G., David, S., Bogerts, B., Majtenyi, C., Bayer, T.A., No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study. Neuropathol. Appl. Neurobiol. 25 (1999), 48–53.
70. Falsone, A., Falsone, S.F., Legal but lethal: functional protein aggregation at the verge of toxicity. Front. Cell. Neurosci., 9, 2015, 45, 10.3389/fncel.2015.00045.
71. Fatemi, S.H., Folsom, T.D., Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study. Mol. Autism, 2, 2011, 6, 10.1186/2040-2392-2-6.
72. Fellin, T., Gomez-Gonzalo, M., Gobbo, S., Carmignoto, G., Haydon, P.G., Astrocytic glutamate is not necessary for the generation of epileptiform neuronal activity in hippocampal slices. J. Neurosci. 26 (2006), 9312–9322, 10.1523/JNEUROSCI.2836-06.2006.
73. Fellin, T., Halassa, M.M., Terunuma, M., Succol, F., Takano, H., Frank, M., Moss, S.J., Haydon, P.G., Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 15037–15042, 10.1073/pnas.0906419106.
74. Fellin, T., Pascual, O., Gobbo, S., Pozzan, T., Haydon, P.G., Carmignoto, G., Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43 (2004), 729–743, 10.1016/j.neuron.2004.08.011.
75. Feresten, A.H., Barakauskas, V., Ypsilanti, A., Barr, A.M., Beasley, C.L., Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness. Schizophr. Res. 150 (2013), 252–257, 10.1016/j.schres.2013.07.024.
76. Fields, R.D., Araque, A., Johansen-Berg, H., Lim, S.-S., Lynch, G., Nave, K.-A., Nedergaard, M., Perez, R., Sejnowski, T., Wake, H., Glial biology in learning and cognition. Neuroscientist, 2013, 10.1177/1073858413504465.
77. Fossat, P., Turpin, F.R., Sacchi, S., Dulong, J., Shi, T., Rivet, J.-M., Sweedler, J.V., Pollegioni, L., Millan, M.J., Oliet, S.H.R., Mothet, J.-P., Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex. Cereb. Cortex, 2011, 1–12, 10.1093/cercor/bhr130.
78. Freeman, J.M., Vining, E.P., Pillas, D.J., Pyzik, P.L., Casey, J.C., Kelly, L.M., The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 102 (1998), 1358–1363.
79. Fujii, S., Tanaka, K.F., Ikenaka, K., Yamazaki, Y., Increased adenosine levels in mice expressing mutant glial fibrillary acidic protein in astrocytes result in failure of induction of LTP reversal (depotentiation) in hippocampal CA1 neurons. Brain Res. 1578 (2014), 1–13, 10.1016/j.brainres.2014.07.005.
80. Fujiki, M., Steward, O., High frequency transcranial magnetic stimulation mimics the effects of ECS in upregulating astroglial gene expression in the murine CNS. Brain Res. Mol. Brain Res. 44 (1997), 301–308.
81. Fujita, T., Chen, M.J., Li, B., Smith, N.A., Peng, W., Sun, W., Toner, M.J., Kress, B.T., Wang, L., Benraiss, A., Takano, T., Wang, S., Nedergaard, M., Neuronal transgene expression in dominant-negative SNARE mice. J. Neurosci. 34 (2014), 16594–16604, 10.1523/JNEUROSCI.2585-14.2014.
82. Fukui, S., Nawashiro, H., Ookawara, T., Suzuki, K., Otani, N., Ooigawa, H., Shima, K., Extracellular superoxide dismutase following cerebral ischemia in mice. Acta Neurochir. Suppl. 86 (2003), 83–85.
83. Fumagalli, E., Funicello, M., Rauen, T., Gobbi, M., Mennini, T., Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur. J. Pharmacol. 578 (2008), 171–176.
84. Furman, J.L., Sama, D.M., Gant, J.C., Beckett, T.L., Murphy, M.P., Bachstetter, A.D., Van Eldik, L.J., Norris, C.M., Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J. Neurosci. 32 (2012), 16129–16140.
85. Gallagher, P., Young, A.H., Mifepristone (RU-486) treatment for depression and psychosis: a review of the therapeutic implications. Neuropsychiatr. Dis. Treat. 2 (2006), 33–42.
86. Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., Leonarduzzi, G., Oxidized cholesterol as the driving force behind the development of Alzheimer's disease. Front. Aging Neurosci. 7 (2015), 1–21, 10.3389/fnagi.2015.00119.
87. Gardoni, F., Di Luca, M., New targets for pharmacological intervention in the glutamatergic synapse. Eur. J. Pharmacol. 545 (2006), 2–10, 10.1016/j.ejphar.2006.06.022.
88. Garriga-Canut, M., Schoenike, B., Qazi, R., Bergendahl, K., Daley, T.J., Pfender, R.M., Morrison, J.F., Ockuly, J., Stafstrom, C., Sutula, T., Roopra, A., 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat. Neurosci. 9 (2006), 1382–1387, 10.1038/nn1791.
89. Gholizadeh, S., Arsenault, J., Xuan, I.C.Y., Pacey, L.K., Hampson, D.R., Reduced phenotypic severity following adeno-associated virus-mediated Fmr1 gene delivery in fragile X mice. Neuropsychopharmacology 39 (2014), 3100–3111, 10.1038/npp.2014.167.
90. Gholizadeh, S., Halder, S.K., Hampson, D.R., Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain. Brain Res. 1596 (2015), 22–30, 10.1016/j.brainres.2014.11.023.
91. Giaume, C., Koulakoff, A., Roux, L., Holcman, D., Rouach, N., Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat. Rev. Neurosci. 11 (2010), 87–99, 10.1038/nrn2757.
92. Giaume, C., Leybaert, L., Naus, C.C., Sáez, J.C., Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front. Pharmacol., 4, 2013, 88, 10.3389/fphar.2013.00088.
93. Gibbs, M.E., Behavioral and pharmacological unravelling of memory formation. Neurochem. Res. 16 (1991), 715–726.
94. Gibbs, M.E., Hertz, L., Inhibition of astrocytic energy metabolism by D-lactate exposure impairs memory. Neurochem. Int. 52 (2008), 1012–1018, 10.1016/j.neuint.2007.10.014.
95. Gibbs, M.E., Hutchinson, D., Hertz, L., Astrocytic involvement in learning and memory consolidation. Neurosci. Biobehav. Rev. 32 (2008), 927–944, 10.1016/j.neubiorev.2008.02.001.
96. Gibbs, M.E., Lloyd, H.G.E., Santa, T., Hertz, L., Glycogen is a preferred glutamate precursor during learning in 1-day-old chick: biochemical and behavioral evidence. J. Neurosci. Res. 85 (2007), 3326–3333, 10.1002/jnr.21307.
97. Gibbs, M.E., O'Dowd, B.S., Hertz, L., Robinson, S.R., Sedman, G.L., Ng, K.T., Inhibition of glutamine synthetase activity prevents memory consolidation. Brain Res. Cogn. Brain Res. 4 (1996), 57–64.
98. Gilgun-Sherki, Y., Melamed, E., Offen, D., Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 40 (2001), 959–975.
99. Gomes, F.V., Llorente, R., Del Bel, E.A., Viveros, M.-P., López-Gallardo, M., Guimarães, F.S., Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol. Schizophr. Res. 164 (2015), 155–163, 10.1016/j.schres.2015.01.015.
100. Gómez-Gonzalo, M., Losi, G., Chiavegato, A., Zonta, M., Cammarota, M., Brondi, M., Vetri, F., Uva, L., Pozzan, T., de Curtis, M., Ratto, G.M., Carmignoto, G., An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol., 8, 2010, e1000352, 10.1371/journal.pbio.1000352.
101. Gómez-Pinilla, F., So, V., Kesslak, J.P., Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise. Neuroscience 85 (1998), 53–61, 10.1016/S0306-4522(97)00576-9.
102. Gomez-Villafuertes, R., Mellström, B., Naranjo, J.R., Searching for a role of NCX/NCKX exchangers in neurodegeneration. Mol. Neurobiol. 35 (2007), 195–202.
103. Graham, S.F., Nasarauddin, M.B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P.G., Love, S., Passmore, A.P., Elliott, C.T., Meharg, A., Green, B.D., Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's disease and dementia with Lewy bodies. J. Alzheimers Dis. 44 (2015), 851–857, 10.3233/JAD-141869.
104. Grossman, R.G., Hampton, T., Depolarization of cortical glial cells during electrocortical activity. Brain Res. 11 (1968), 316–324.
105. Guizzetti, M., Moore, N.H., Giordano, G., VanDeMark, K.L., Costa, L.G., Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia 58 (2010), 1395–1406, 10.1002/glia.21015.
106. Gundersen, V., Protein aggregation in Parkinson's disease. Acta Neurol. Scand. Suppl., 82–87, 2010, 10.1111/j.1600-0404.2010.01382.x.
107. Haber, M., Zhou, L., Murai, K.K., Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses. J. Neurosci. 26 (2006), 8881–8891, 10.1523/JNEUROSCI.1302-06.2006.
108. Hagemann, T.L., Connor, J.X., Messing, A., Alexander disease-associated glial fibrillary acidic protein mutations in mice induce Rosenthal fiber formation and a white matter stress response. J. Neurosci. 26 (2006), 11162–11173, 10.1523/JNEUROSCI.3260-06.2006.
109. Hagemann, T.L., Paylor, R., Messing, A., Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease. J. Neurosci. 33 (2013), 18698–18706, 10.1523/JNEUROSCI.3693-13.2013.
110. Halassa, M.M., Fellin, T., Takano, H., Dong, J.-H., Haydon, P.G., Synaptic islands defined by the territory of a single astrocyte. J. Neurosci. 27 (2007), 6473–6477, 10.1523/JNEUROSCI.1419-07.2007.
111. Halassa, M.M., Florian, C., Fellin, T., Munoz, J.R., Lee, S.-Y., Abel, T., Haydon, P.G., Frank, M.G., Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 61 (2009), 213–219, 10.1016/j.neuron.2008.11.024.
112. Halassa, M.M., Haydon, P.G., Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu. Rev. Physiol. 72 (2010), 335–355, 10.1146/annurev-physiol-021909-135843.
113. Halliwell, B., Reactive oxygen species and the central nervous system. J. Neurochem. 59 (1992), 1609–1623.
114. Han, X., Chen, M., Wang, F., Windrem, M., Wang, S., Shanz, S., Xu, Q., Oberheim, N.A., Bekar, L., Betstadt, S., Silva, A.J., Takano, T., Goldman, S.A., Nedergaard, M., Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 12 (2013), 342–353, 10.1016/j.stem.2012.12.015.
115. Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002), 353–356, 10.1126/science.1072994.
116. Harrison, P.J., The neuropathology of primary mood disorder. Brain, 2002.
117. Hayashida, N., Fujimoto, M., Tan, K., Prakasam, R., Shinkawa, T., Li, L., Ichikawa, H., Takii, R., Nakai, A., Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. EMBO J. 29 (2010), 3459–3469, 10.1038/emboj.2010.225.
118. Heales, S.J.R., Lam, A.A.J., Duncan, A.J., Land, J.M., Neurodegeneration or neuroprotection: the pivotal role of astrocytes. Neurochem. Res. 29 (2004), 513–519, 10.1023/B:NERE.0000014822.69384.0f.
119. Heeman, B., Van den Haute, C., Aelvoet, S.-A., Valsecchi, F., Rodenburg, R.J., Reumers, V., Debyser, Z., Callewaert, G., Koopman, W.J.H., Willems, P.H.G.M., Baekelandt, V., Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J. Cell Sci. 124 (2011), 1115–1125, 10.1242/jcs.078303.
120. Henneberger, C., Papouin, T., Oliet, S.H.R., Dmitri, A., Rusakov, D.A., Long-term potentiation depends on release of D-serine from astrocytes. Nature 463 (2010), 232–236, 10.1038/nature08673.
121. Herbert, M.R., Large brains in autism: the challenge of pervasive abnormality. Neuroscientist 11 (2005), 417–440, 10.1177/0091270005278866.
122. Heresco-Levy, U., Javitt, D.C., Ebstein, R., Vass, A., Lichtenberg, P., Bar, G., Catinari, S., Ermilov, M., D-Serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia. Biol. Psychiatry 57 (2005), 577–585, 10.1016/j.biopsych.2004.12.037.
123. Hermann, B.P., Lin, J.J., Jones, J.E., Seidenberg, M., The emerging architecture of neuropsychological impairment in epilepsy. Neurol. Clin. 27 (2009), 881–907, 10.1016/j.ncl.2009.08.001.
124. Hertz, L., Gibbs, M.E., O'Dowd, B.S., Sedman, G.L., Robinson, S.R., Syková, E., Hajek, I., Hertz, E., Peng, L., Huang, R., Ng, K.T., Astrocyte-neuron interaction during one-trial aversive learning in the neonate chick. Neurosci. Biobehav. Rev. 20 (1996), 537–551.
125. Hetherington, H.P., Pan, J.W., Spencer, D.D., 1H and 31P spectroscopy and bioenergetics in the lateralization of seizures in temporal lobe epilepsy. J. Magn. Reson. Imaging 16 (2002), 477–483.
126. Heverin, M., Maioli, S., Pham, T., Mateos, L., Camporesi, E., Ali, Z., Winblad, B., Cedazo-Minguez, A., Björkhem, I., 27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. Behav. Brain Res. 278 (2015), 356–359, 10.1016/j.bbr.2014.10.018.
127. Heyes, C., New thinking: the evolution of human cognition. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 367 (2012), 2091–2096, 10.1098/rstb.2012.0111.
128. Howland, D.S., Liu, J., She, Y., Goad, B., Maragakis, N.J., Kim, B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G., DeGennaro, L.J., Cleveland, D.W., Rothstein, J.D., Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 1604–1609, 10.1073/pnas.032539299.
129. Huber, K.M., Gallagher, S.M., Warren, S.T., Bear, M.F., Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 7746–7750, 10.1073/pnas.122205699.
130. Huck, S., Grass, F., Hörtnagl, H., The glutamate analogue alpha-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro. J. Neurosci. 4 (1984), 2650–2657.
131. Hudry, E., Wu, H.-Y., Arbel-Ornath, M., Hashimoto, T., Matsouaka, R., Fan, Z., Spires-Jones, T.L., Betensky, R.A., Bacskai, B.J., Hyman, B.T., Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. J. Neurosci. 32 (2012), 3176–3192.
132. Huh, W.J., Khurana, S.S., Geahlen, J.H., Kohli, K., Waller, R.A., Mills, J.C., Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach. Gastroenterology, 142, 2012 21–24.e7.
133. Ingram, J.L., Peckham, S.M., Tisdale, B., Rodier, P.M., Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicol. Teratol. 22 (2000), 319–324.
134. Iwata, M., Shirayama, Y., Ishida, H., Hazama, G.I., Nakagome, K., Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats. Hippocampus 21 (2011), 877–884, 10.1002/hipo.20803.
135. Jabs, R., Seifert, G., Steinhauser, C., Astrocytic function and its alteration in the epileptic brain. Epilepsia 49:Suppl. 2 (2008), 3–12.
136. Jacobs, S., Doering, L.C., Astrocytes prevent abnormal neuronal development in the fragile × mouse. J. Neurosci. 30 (2010), 4508–4514, 10.1523/JNEUROSCI.5027-09.2010.
137. Jefferys, J.G., Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions. Physiol. Rev. 75 (1995), 689–723.
138. Kang, N., Xu, J., Xu, Q., Nedergaard, M., Kang, J., Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons. J. Neurophysiol. 94 (2005), 4121–4130, 10.1152/jn.00448.2005.
139. Kato, S., Takikawa, M., Nakashima, K., Hirano, A., Cleveland, D.W., Kusaka, H., Shibata, N., Kato, M., Nakano, I., Ohama, E., New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1 (2000), 163–184.
140. Konnerth, A., Heinemann, U., Yaari, Y., Nonsynaptic epileptogenesis in the mammalian hippocampus in vitro. I. Development of seizurelike activity in low extracellular calcium. J. Neurophysiol. 56 (1986), 409–423.
141. Kovacs, R., Heinemann, U., Steinhauser, C., Mechanisms underlying blood–brain barrier dysfunction in brain pathology and epileptogenesis: role of astroglia. Epilepsia 53:Suppl. 6 (2012), 53–59, 10.1111/j.1528-1167.2012.03703.x.
142. Kragh, J., Bolwig, T.G., Woldbye, D.P., Jørgensen, O.S., Electroconvulsive shock and lidocaine-induced seizures in the rat activate astrocytes as measured by glial fibrillary acidic protein. Biol. Psychiatry 33 (1993), 794–800.
143. Kruszewski, M., Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat. Res. 531 (2003), 81–92.
144. Kuchibhotla, K.V., Goldman, S.T., Lattarulo, C.R., Wu, H.-Y., Hyman, B.T., Bacskai, B.J., Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59 (2008), 214–225, 10.1016/j.neuron.2008.06.008.
145. Kuchibhotla, K.V., Lattarulo, C.R., Hyman, B.T., Bacskai, B.J., Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 323 (2009), 1211–1215, 10.1126/science.1169096.
146. Laming, P.R., Potassium signalling in the brain: its role in behaviour. Neurochem. Int. 36 (2000), 271–290, 10.1016/S0197-0186(99)00136-9.
147. Lamusuo, S., Jutila, L., Ylinen, A., Kalviainen, R., Mervaala, E., Haaparanta, M., Jaaskelainen, S., Partanen, K., Vapalahti, M., Rinne, J., [18F]FDG-PET reveals temporal hypometabolism in patients with temporal lobe epilepsy even when quantitative MRI and histopathological analysis show only mild hippocampal damage. Arch. Neurol. 58 (2001), 933–939.
148. Lane, H.-Y., Lin, C.-H., Green, M.F., Hellemann, G., Huang, C.-C., Chen, P.-W., Tun, R., Chang, Y.-C., Tsai, G.E., Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor. JAMA Psychiatry 70 (2013), 1267–1275, 10.1001/jamapsychiatry.2013.2159.
149. Laping, N.J., Teter, B., Nichols, N.R., Rozovsky, I., Finch, C.E., Glial fibrillary acidic protein: regulation by hormones, cytokines, and growth factors. Brain Pathol. 4 (1994), 259–275.
150. Laurence, J.A., Fatemi, S.H., Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects. Cerebellum 4 (2005), 206–210, 10.1080/14734220500208846.
151. Lecavalier, L., Handbook of Autism and Anxiety. 2014, 10.1007/978-3-319-06796-4.
152. Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., Lee, S.-J., Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J. Biol. Chem. 285 (2010), 9262–9272, 10.1074/jbc.M109.081125.
153. Lee, H.S., Ghetti, A., Pinto-Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitron-Resendiz, S., Pina-Crespo, J.C., Roberts, A.J., Verma, I.M., Sejnowski, T.J., Heinemann, S.F., Astrocytes contribute to gamma oscillations and recognition memory. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), E3343–E3352, 10.1073/pnas.1410893111.
154. Lee, H.U., Yamazaki, Y., Tanaka, K.F., Furuya, K., Sokabe, M., Hida, H., Takao, K., Miyakawa, T., Fujii, S., Ikenaka, K., Increased astrocytic ATP release results in enhanced excitability of the hippocampus. Glia 61 (2013), 210–224, 10.1002/glia.22427.
155. Lee, S.H., Magge, S., Spencer, D.D., Sontheimer, H., Cornell-Bell, A.H., Human epileptic astrocytes exhibit increased gap junction coupling. Glia 15 (1995), 195–202.
156. Lee, W., Reyes, R.C., Gottipati, M.K., Lewis, K., Lesort, M., Parpura, V., Gray, M., Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model. Neurobiol. Dis. 58 (2013), 192–199, 10.1016/j.nbd.2013.06.002.
157. Leoni, V., Mariotti, C., Nanetti, L., Salvatore, E., Squitieri, F., Bentivoglio, A.R., Bandettini di Poggio, M., Bandettini Del Poggio, M., Piacentini, S., Monza, D., Valenza, M., Cattaneo, E., Di Donato, S., Whole body cholesterol metabolism is impaired in Huntington's disease. Neurosci. Lett. 494 (2011), 245–249, 10.1016/j.neulet.2011.03.025.
158. Levin, E.D., Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging. Curr. Alzheimer Res. 2 (2005), 191–196.
159. Liévens, J.C., Woodman, B., Mahal, A., Spasic-Boscovic, O., Samuel, D., Kerkerian-Le Goff, L., Bates, G.P., Impaired glutamate uptake in the R6 Huntington's disease transgenic mice. Neurobiol. Dis. 8 (2001), 807–821, 10.1006/nbdi.2001.0430.
160. Lim, D., Fedrizzi, L., Tartari, M., Zuccato, C., Cattaneo, E., Brini, M., Carafoli, E., Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease. J. Biol. Chem. 283 (2008), 5780–5789, 10.1074/jbc.M704704200.
161. Lima, A., Sardinha, V.M., Oliveira, A.F., Reis, M., Mota, C., Silva, M.A., Marques, F., Cerqueira, J.J., Pinto, L., Sousa, N., Oliveira, J.F., Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats. Mol. Psychiatry 19 (2014), 834–841, 10.1038/mp.2013.182.
162. Lioy, D.T., Garg, S.K., Monaghan, C.E., Raber, J., Foust, K.D., Kaspar, B.K., Hirrlinger, P.G., Kirchhoff, F., Bissonnette, J.M., Ballas, N., Mandel, G., A role for glia in the progression of Rett's syndrome. Nature 475 (2011), 497–500, 10.1038/nature10214.
163. Lipton, S.A., Choi, Y.B., Pan, Z.H., Lei, S.Z., Chen, H.S., Sucher, N.J., Loscalzo, J., Singel, D.J., Stamler, J.S., A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364 (1993), 626–632, 10.1038/364626a0.
164. Liu, Q., Li, B., Zhu, H.-Y., Wang, Y.-Q., Yu, J., Wu, G.-C., Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression. Eur. Neuropsychopharmacol. 19 (2009), 796–805, 10.1016/j.euroneuro.2009.06.010.
165. Losi, G., Cammarota, M., Carmignoto, G., The role of astroglia in the epileptic brain. Front. Pharmacol., 3, 2012, 132, 10.3389/fphar.2012.00132.
166. Luo, J., Sun, L., Lin, X., Liu, G., Yu, J., Parisiadou, L., Xie, C., Ding, J., Cai, H., A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons. Hum. Mol. Genet. 23 (2014), 6567–6574, 10.1093/hmg/ddu377.
167. Lytton, W.W., Computer modelling of epilepsy. Nat. Rev. Neurosci. 9 (2008), 626–637, 10.1038/nrn2416.
168. Ma, T.M., Abazyan, S., Abazyan, B., Nomura, J., Yang, C., Seshadri, S., Sawa, A., Snyder, S.H., Pletnikov, M.V., Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Mol. Psychiatry 18 (2013), 557–567, 10.1038/mp.2012.97.
169. Maezawa, I., Swanberg, S., Harvey, D., LaSalle, J.M., Jin, L.-W., Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J. Neurosci. 29 (2009), 5051–5061, 10.1523/JNEUROSCI.0324-09.2009.
170. Magistretti, P.J., Neuron-glia metabolic coupling and plasticity. J. Exp. Biol. 209 (2006), 2304–2311, 10.1242/jeb.02208.
171. Maier, C.M., Chan, P.H., Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist 8 (2002), 323–334.
172. Manning, T.J. Jr., Sontheimer, H., Spontaneous intracellular calcium oscillations in cortical astrocytes from a patient with intractable childhood epilepsy (Rasmussen's encephalitis). Glia 21 (1997), 332–337.
173. Martorana, F., Brambilla, L., Valori, C.F., Bergamaschi, C., Roncoroni, C., Aronica, E., Volterra, A., Bezzi, P., Rossi, D., The BH4 domain of Bcl-X(L) rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals. Hum. Mol. Genet. 21 (2012), 826–840.
174. Matute, C., Melone, M., Vallejo-Illarramendi, A., Conti, F., Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics. Glia 49 (2005), 451–455, 10.1002/glia.20119.
175. Mazzetti, A.P., Fiorile, M.C., Primavera, A., Lo Bello, M., Glutathione transferases and neurodegenerative diseases. Neurochem. Int. 82 (2015), 10–18, 10.1016/j.neuint.2015.01.008.
176. McDougle, C.J., Landino, S.M., Vahabzadeh, A., O'Rourke, J., Zurcher, N.R., Finger, B.C., Palumbo, M.L., Helt, J., Mullett, J.E., Hooker, J.M., Carlezon, W.A., Toward an immune-mediated subtype of autism spectrum disorder. Brain Res. 1617 (2014), 72–92, 10.1016/j.brainres.2014.09.048.
177. McNamara, J.O., Cellular and molecular basis of epilepsy. J. Neurosci. 14 (1994), 3413–3425.
178. Melone, M., Vitellaro-Zuccarello, L., Vallejo-Illarramendi, A., Pérez-Samartin, A., Matute, C., Cozzi, A., Pellegrini-Giampietro, D.E., Rothstein, J.D., Conti, F., The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine. Mol. Psychiatry 6 (2001), 380–386, 10.1038/sj.mp.4000880.
179. Miller, B.R., Dorner, J.L., Shou, M., Sari, Y., Barton, S.J., Sengelaub, D.R., Kennedy, R.T., Rebec, G.V., Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse. Neuroscience 153 (2008), 329–337.
180. Molinaro, P., Cataldi, M., Cuomo, O., Viggiano, D., Pignataro, G., Sirabella, R., Secondo, A., Boscia, F., Pannaccione, A., Scorziello, A., Sokolow, S., Herchuelz, A., Di Renzo, G., Annunziato, L., Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits. Adv. Exp. Med. Biol. 961 (2013), 213–222, 10.1007/978-1-4614-4756-6_18.
181. Mothet, J.-P., Pollegioni, L., Ouanounou, G., Martineau, M., Fossier, P., Baux, G., Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc. Natl. Acad. Sci. U. S. A. 102 (2005), 5606–5611.
182. Mothet, J.-P., Le Bail, M., Billard, J.-M., Time and space profiling of NMDA receptor co-agonist functions. J. Neurochem., 2015, 10.1111/jnc.13204.
183. Murphy, S., Simmons, M.L., Agullo, L., Garcia, A., Feinstein, D.L., Galea, E., Reis, D.J., Minc-Golomb, D., Schwartz, J.P., Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 16 (1993), 323–328.
184. Nadkarni, S., Jung, P., Spontaneous oscillations of dressed neurons: a new mechanism for epilepsy?. Phys. Rev. Lett., 91, 2003, 268101.
185. Nadkarni, S., Jung, P., Synaptic inhibition and pathologic hyperexcitability through enhanced neuron-astrocyte interaction: a modeling study. J. Integr. Neurosci. 4 (2005), 207–226.
186. Nagy, C., Suderman, M., Yang, J., Szyf, M., Mechawar, N., Ernst, C., Turecki, G., Astrocytic abnormalities and global DNA methylation patterns in depression and suicide. Mol. Psychiatry 20 (2015), 320–328.
187. Nakazawa, M., Kodama, S., Matsuo, T., Effects of ketogenic diet on electroconvulsive threshold and brain contents of adenosine nucleotides. Brain Dev. 5 (1983), 375–380.
188. Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N., Fitzsimmons, G., Whitney, A., Cross, J.H., The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 7 (2008), 500–506, 10.1016/S1474-4422(08)70092-9.
189. Newman, L.A., Korol, D.L., Gold, P.E., Lactate produced by glycogenolysis in astrocytes regulates memory processing. PLoS ONE, 6, 2011, e28427, 10.1371/journal.pone.0028427.
190. Nguyen, M.V.C., Du, F., Felice, C.A., Shan, X., Nigam, A., Mandel, G., Robinson, J.K., Ballas, N., MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain. J. Neurosci. 32 (2012), 10021–10034, 10.1523/JNEUROSCI.1316-12.2012.
191. Norris, C.M., Kadish, I., Blalock, E.M., Chen, K.-C., Thibault, V., Porter, N.M., Landfield, P.W., Kraner, S.D., Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. J. Neurosci. 25 (2005), 4649–4658.
192. O'Connor, E.R., Sontheimer, H., Spencer, D.D., de Lanerolle, N.C., Astrocytes from human hippocampal epileptogenic foci exhibit action potential-like responses. Epilepsia 39 (1998), 347–354.
193. O'Dowd, B.S., Zhao, W.Q., Ng, K.T., Robinson, S.R., Chicks injected with antisera to either S-100 alpha or S-100 beta protein develop amnesia for a passive avoidance task. Neurobiol. Learn. Mem. 67 (1997), 197–206, 10.1006/nlme.1997.3766.
194. Oberheim, N.A., Tian, G.F., Han, X., Peng, W., Takano, T., Ransom, B., Nedergaard, M., Loss of astrocytic domain organization in the epileptic brain. J. Neurosci. 28 (2008), 3264–3276.
195. Oberheim, N.A., Wang, X., Goldman, S., Nedergaard, M., Astrocytic complexity distinguishes the human brain. Trends Neurosci. 29 (2006), 547–553, 10.1016/j.tins.2006.08.004.
196. Oliet, S.H., Piet, R., Poulain, D.A., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science 292 (2001), 923–926, 10.1126/science.1059162.
197. Oliveira, J.M.A., Mitochondrial bioenergetics and dynamics in Huntington's disease: tripartite synapses and selective striatal degeneration. J. Bioenergy Biomembr. 42 (2010), 227–234, 10.1007/s10863-010-9287-6.
198. Ostroff, L.E., Manzur, M.K., Cain, C.K., Ledoux, J.E., Synapses lacking astrocyte appear in the amygdala during consolidation of Pavlovian threat conditioning. J. Comp. Neurol. 522 (2014), 2152–2163, 10.1002/cne.23523.
199. Pacey, L.K.K., Doering, L.C., Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome. Glia 55 (2007), 1601–1609, 10.1002/glia.20573.
200. Panatier, A., Robitaille, R., Astrocytic mGluR5s and the tripartite synapse. Neuroscience, 2015, 10.1016/j.neuroscience.2015.03.063.
201. Panatier, A., Theodosis, D.T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D.A., Oliet, S.H.R., Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell 125 (2006), 775–784, 10.1016/j.cell.2006.02.051.
202. Pangrsic, T., Potokar, M., Stenovec, M., Kreft, M., Fabbretti, E., Nistri, A., Pryazhnikov, E., Khiroug, L., Giniatullin, R., Zorec, R., Exocytotic release of ATP from cultured astrocytes. J. Biol. Chem. 282 (2007), 28749–28758.
203. Pannasch, U., Freche, D., Dallérac, G., Ghézali, G., Escartin, C., Ezan, P., Cohen-Salmon, M., Benchenane, K., Abudara, V., Dufour, A., Lübke, J.H.R., Déglon, N., Knott, G., Holcman, D., Rouach, N., Connexin 30 sets synaptic strength by controlling astroglial synapse invasion. Nat. Neurosci., 2014, 10.1038/nn.3662.
204. Pannasch, U., Rouach, N., Emerging role for astroglial networks in information processing: from synapse to behavior. Trends Neurosci. 36 (2013), 405–417, 10.1016/j.tins.2013.04.004.
205. Pannasch, U., Vargová, L., Reingruber, J., Ezan, P., Holcman, D., Giaume, C., Syková, E., Rouach, N., Astroglial networks scale synaptic activity and plasticity. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 8467–8472, 10.1073/pnas.1016650108.
206. Papouin, T., Ladépêche, L., Ruel, J., Sacchi, S., Labasque, M., Hanini, M., Groc, L., Pollegioni, L., Mothet, J.-P., Oliet, S.H.R., Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell 150 (2012), 633–646, 10.1016/j.cell.2012.06.029.
207. Pardo, A.C., Wong, V., Benson, L.M., Dykes, M., Tanaka, K., Rothstein, J.D., Maragakis, N.J., Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Exp. Neurol. 201 (2006), 120–130.
208. Pariante, C.M., Pearce, B.D., Pisell, T.L., Owens, M.J., Miller, A.H., Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol. Pharmacol. 52 (1997), 571–581.
209. Park, H., Han, K.-S., Seo, J., Lee, J., Dravid, S.M., Woo, J., Chun, H., Cho, S., Bae, J.Y., An, H., Koh, W., Yoon, B.-E., Berlinguer-Palmini, R., Mannaioni, G., Traynelis, S.F., Bae, Y.C., Choi, S.-Y., Lee, C.J., Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol. Brain, 8, 2015, 7, 10.1186/s13041-015-0097-y.
210. Parpura, V., Basarsky, T.A., Liu, F., Jeftinija, K., Jeftinija, S., Haydon, P.G., Glutamate-mediated astrocyte-neuron signalling. Nature 369 (1994), 744–747.
211. Pascual, J.M., Wang, D., Hinton, V., Engelstad, K., Saxena, C.M., Van Heertum, R.L., De Vivo, D.C., Brain glucose supply and the syndrome of infantile neuroglycopenia. Arch. Neurol. 64 (2007), 507–513.
212. Pascual, O., Casper, K.B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S.J., McCarthy, K., Haydon, P.G., Astrocytic purinergic signaling coordinates synaptic networks. Science 310 (2005), 113–116, 10.1126/science.1116916.
213. Paulsen, J.S., Ready, R.E., Hamilton, J.M., Mega, M.S., Cummings, J.L., Neuropsychiatric aspects of Huntington's disease. J. Neurol. Neurosurg. Psychiatry 71 (2001), 310–314, 10.1136/jnnp.71.3.310.
214. Pellerin, L., Bouzier-Sore, A.-K., Aubert, A., Serres, S., Merle, M., Costalat, R., Magistretti, P.J., Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia 55 (2007), 1251–1262, 10.1002/glia.20528.
215. Pereira, A., Furlan, F.A., Astrocytes and human cognition: modeling information integration and modulation of neuronal activity. Prog. Neurobiol. 92 (2010), 405–420, 10.1016/j.pneurobio.2010.07.001.
216. Petroff, O.A., Errante, L.D., Rothman, D.L., Kim, J.H., Spencer, D.D., Glutamate–glutamine cycling in the epileptic human hippocampus. Epilepsia 43 (2002), 703–710.
217. Piet, R., Vargová, L., Syková, E., Poulain, D.A., Oliet, S.H.R., Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 2151–2155, 10.1073/pnas.0308408100.
218. Poskanzer, K.E., Yuste, R., Astrocytic regulation of cortical UP states. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 18453–18458, 10.1073/pnas.1112378108.
219. Rajkowska, G., Miguel-Hidalgo, J.J., Gliogenesis and glial pathology in depression. CNS Neurol. Disord. Drug Targets 6 (2007), 219–233.
220. Rajkowska, G., Miguel-Hidalgo, J.J., Makkos, Z., Meltzer, H., Overholser, J., Stockmeier, C., Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophrenia. Schizophr. Res. 57 (2002), 127–138.
221. Rangroo Thrane, V., Thrane, A.S., Wang, F., Cotrina, M.L., Smith, N.A., Chen, M., Xu, Q., Kang, N., Fujita, T., Nagelhus, E.A., Nedergaard, M., Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering. Nat. Med. 19 (2013), 1643–1648, 10.1038/nm.3400.
222. Rasooli-Nejad, S., Palygin, O., Lalo, U., Pankratov, Y., Cannabinoid receptors contribute to astroglial Ca2+-signalling and control of synaptic plasticity in the neocortex. Philos. Trans. R. Soc. Lond. B: Biol. Sci., 369, 2014, 20140077, 10.1098/rstb.2014.0077.
223. Ribeiro, M., Rosenstock, T.R., Cunha-Oliveira, T., Ferreira, I.L., Oliveira, C.R., Rego, A.C., Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells. Free Radic. Biol. Med. 53 (2012), 1857–1867, 10.1016/j.freeradbiomed.2012.09.004.
224. Robertson, J.M., The astrocentric hypothesis: proposed role of astrocytes in consciousness and memory formation. J. Physiol. Paris 96 (2002), 251–255, 10.1016/S0928-4257(02)00013-X.
225. Robertson, J.M., Astrocyte domains and the three-dimensional and seamless expression of consciousness and explicit memories. Med. Hypotheses 81 (2013), 1017–1024, 10.1016/j.mehy.2013.09.021.
226. Rodriguez, J.J., Olabarria, M., Chvatal, A., Verkhratsky, A., Astroglia in dementia and Alzheimer's disease. Cell Death Differ. 16 (2009), 378–385.
227. Ronesi, J.A., Huber, K.M., Metabotropic glutamate receptors and fragile X mental retardation protein: partners in translational regulation at the synapse. Sci. Signal., 2008, 1–4.
228. Rossi, D., Brambilla, L., Valori, C.F., Roncoroni, C., Crugnola, A., Yokota, T., Bredesen, D.E., Volterra, A., Focal degeneration of astrocytes in amyotrophic lateral sclerosis. Cell Death Differ. 15 (2008), 1691–1700.
229. Rossi, D., Astrocyte physiopathology: at the crossroads of intercellular networking, inflammation and cell death. Prog. Neurobiol. 130 (2015), 86–120, 10.1016/j.pneurobio.2015.04.003.
230. Rossignol, D.A., Frye, R.E., Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front. Physiol., 5, 2014, 150, 10.3389/fphys.2014.00150.
231. Rothstein, J.D., Martin, L.J., Kuncl, R.W., Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N. Engl. J. Med. 326 (1992), 1464–1468.
232. Rothstein, J.D., Patel, S., Regan, M.R., Haenggeli, C., Huang, Y.H., Bergles, D.E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D.S., Toan, S.V., Bruijn, L.I., Su, Z.-Z., Gupta, P., Fisher, P.B., Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433 (2005), 73–77.
233. Rothstein, J.D., Tsai, G., Kuncl, R.W., Clawson, L., Cornblath, D.R., Drachman, D.B., Pestronk, A., Stauch, B.L., Coyle, J.T., Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann. Neurol. 28 (1990), 18–25.
234. Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., Giaume, C., Astroglial metabolic networks sustain hippocampal synaptic transmission. Science 322 (2008), 1551–1555, 10.1126/science.1164022.
235. Sada, N., Lee, S., Katsu, T., Otsuki, T., Inoue, T., Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science 347 (2015), 1362–1367, 10.1126/science.aaa1299.
236. Sadzot, B., Debets, R.M., Maquet, P., van Veelen, C.W., Salmon, E., van Emde Boas, W., Velis, D.N., van Huffelen, A.C., Franck, G., Regional brain glucose metabolism in patients with complex partial seizures investigated by intracranial EEG. Epilepsy Res. 12 (1992), 121–129.
237. Samoilova, M., Wentlandt, K., Adamchik, Y., Velumian, A.A., Carlen, P.L., Connexin 43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures. Exp. Neurol. 210 (2008), 762–775.
238. Sampedro-Piquero, P., De Bartolo, P., Petrosini, L., Zancada-Menendez, C., Arias, J.L., Begega, A., Astrocytic plasticity as a possible mediator of the cognitive improvements after environmental enrichment in aged rats. Neurobiol. Learn. Mem. 114 (2014), 16–25, 10.1016/j.nlm.2014.04.002.
239. Sasaki, T., Ishikawa, T., Abe, R., Nakayama, R., Asada, A., Matsuki, N., Ikegaya, Y., Astrocyte calcium signalling orchestrates neuronal synchronization in organotypic hippocampal slices. J. Physiol. 592 (2014), 2771–2783, 10.1113/jphysiol.2014.272864.
240. Scemes, E., Giaume, C., Astrocyte calcium waves: what they are and what they do. Glia 54 (2006), 716–725, 10.1002/glia.20374.
241. Schipper, H.M., Bennett, D.A., Liberman, A., Bienias, J.L., Schneider, J.A., Kelly, J., Arvanitakis, Z., Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment. Neurobiol. Aging 27 (2006), 252–261, 10.1016/j.neurobiolaging.2005.01.016.
242. Schipper, H.M., Gupta, A., Szarek, W.A., Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD. Curr. Alzheimer Res. 6 (2009), 424–430.
243. Schipper, H.M., Song, W., A heme oxygenase-1 transducer model of degenerative and developmental brain disorders. Int. J. Mol. Sci. 16 (2015), 5400–5419, 10.3390/ijms16035400.
244. Scuderi, C., Stecca, C., Iacomino, A., Steardo, L., Role of astrocytes in major neurological disorders: the evidence and implications. IUBMB Life 65 (2013), 957–961, 10.1002/iub.1223.
245. Shafaati, M., Marutle, A., Pettersson, H., Lövgren-Sandblom, A., Olin, M., Pikuleva, I., Winblad, B., Nordberg, A., Björkhem, I., Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. J. Lipid Res. 52 (2011), 1004–1010, 10.1194/jlr.M014548.
246. Shin, J.-Y., Fang, Z.-H., Yu, Z.-X., Wang, C.-E., Li, S.-H., Li, X.-J., Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J. Cell Biol. 171 (2005), 1001–1012, 10.1083/jcb.200508072.
247. Si, X., Miguel-Hidalgo, J.J., O'Dwyer, G., Stockmeier, C.A., Rajkowska, G., Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression. Neuropsychopharmacology 29 (2004), 2088–2096.
248. Sibille, J., Dao Duc, K., Holcman, D., Rouach, N., The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. PLoS Comput. Biol., 11, 2015, e1004137, 10.1371/journal.pcbi.1004137.
249. Sibille, J., Pannasch, U., Rouach, N., Astroglial potassium clearance contributes to short-term plasticity of synaptically evoked currents at the tripartite synapse. J. Physiol. 592 (2014), 87–102, 10.1113/jphysiol.2013.261735.
250. Sibille, J., Zapata, J., Teillon, J., Rouach, N., Astroglial calcium signaling displays short-term plasticity and adjusts synaptic efficacy. Front. Cell. Neurosci., 9, 2015, 189, 10.3389/fncel.2015.00189.
251. Sim, F.J., Windrem, M.S., Goldman, S.A., Fate determination of adult human glial progenitor cells. Neuron Glia Biol. 5 (2009), 45–55, 10.1017/S1740925X09990317.
252. Sirven, J., Whedon, B., Caplan, D., Liporace, J., Glosser, D., O'Dwyer, J., Sperling, M.R., The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia 40 (1999), 1721–1726.
253. Sisodia, S.S., Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?. Cell 95 (1998), 1–4.
254. Smith, R.E., Haroutunian, V., Davis, K.L., Meador-Woodruff, J.H., Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia. Am. J. Psychiatry 158 (2001), 1393–1399.
255. Spencer, J.P., Jenner, P., Daniel, S.E., Lees, A.J., Marsden, D.C., Halliwell, B., Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species. J. Neurochem. 71 (1998), 2112–2122.
256. Steffek, A.E., McCullumsmith, R.E., Haroutunian, V., Meador-Woodruff, J.H., Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia. Schizophr. Res. 103 (2008), 71–82, 10.1016/j.schres.2008.04.032.
257. Stehberg, J., Moraga-Amaro, R., Salazar, C., Becerra, A., Echeverría, C., Orellana, J.A., Bultynck, G., Ponsaerts, R., Leybaert, L., Simon, F., Sáez, J.C., Retamal, M.A., Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J. 26 (2012), 3649–3657, 10.1096/fj.11-198416.
258. Steiner, J., Bernstein, H.-G., Bielau, H., Berndt, A., Brisch, R., Mawrin, C., Keilhoff, G., Bogerts, B., Evidence for a wide extra-astrocytic distribution of S100B in human brain. BMC Neurosci., 8, 2007, 2, 10.1186/1471-2202-8-2.
259. Steward, O., Electroconvulsive seizures upregulate astroglial gene expression selectively in the dentate gyrus. Brain Res. Mol. Brain Res. 25 (1994), 217–224.
260. Stewart, V.C., Stone, R., Gegg, M.E., Sharpe, M.A., Hurst, R.D., Clark, J.B., Heales, S.J.R., Preservation of extracellular glutathione by an astrocyte derived factor with properties comparable to extracellular superoxide dismutase. J. Neurochem. 83 (2002), 984–991.
261. Strauss, U., Zhou, F.-W., Henning, J., Battefeld, A., Wree, A., Köhling, R., Haas, S.J.-P., Benecke, R., Rolfs, A., Gimsa, U., Increasing extracellular potassium results in subthalamic neuron activity resembling that seen in a 6-hydroxydopamine lesion. J. Neurophysiol. 99 (2008), 2902–2915, 10.1152/jn.00402.2007.
262. Sun, X., Ji, C., Hu, T., Wang, Z., Chen, G., Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling. J. Neuroinflamm., 10, 2013, 157.
263. Sun, J.-D., Liu, Y., Yuan, Y.-H., Li, J., Chen, N.-H., Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats. Neuropsychopharmacology 37 (2012), 1305–1320, 10.1038/npp.2011.319.
264. Sun, W., McConnell, E., Pare, J.-F., Xu, Q., Chen, M., Peng, W., Lovatt, D., Han, X., Smith, Y., Nedergaard, M., Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science 339 (2013), 197–200, 10.1126/science.1226740.
265. Suzuki, A., Stern, S.A., Bozdagi, O., Huntley, G.W., Walker, R.H., Magistretti, P.J., Alberini, C.M., Astrocyte–neuron lactate transport is required for long-term memory formation. Cell 144 (2011), 810–823, 10.1016/j.cell.2011.02.018.
266. Takano, K., Tanaka, N., Kawabe, K., Moriyama, M., Nakamura, Y., Extracellular superoxide dismutase induced by dopamine in cultured astrocytes. Neurochem. Res. 38 (2013), 32–41, 10.1007/s11064-012-0882-2.
267. Thompson, P.M., Vinters, H.V., Pathologic lesions in neurodegenerative diseases. Prog. Mol. Biol. Transl. Sci. 107 (2012), 1–40, 10.1016/B978-0-12-385883-2.00009-6.
268. Tian, G.-F., Azmi, H., Takano, T., Xu, Q., Peng, W., Lin, J., Oberheim, N., Lou, N., Wang, X., Zielke, H.R., Kang, J., Nedergaard, M., An astrocytic basis of epilepsy. Nat. Med. 11 (2005), 973–981, 10.1038/nm1277.
269. Tong, X., Ao, Y., Faas, G.C., Nwaobi, S.E., Xu, J., Haustein, M.D., Anderson, M.A., Mody, I., Olsen, M.L., Sofroniew, M.V., Khakh, B.S., Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat. Neurosci. 17 (2014), 694–703.
270. Tsai, G., Coyle, J.T., Glutamatergic mechanisms in schizophrenia. Annu. Rev. Pharmacol. Toxicol. 42 (2002), 165–179, 10.1146/annurev.pharmtox.42.082701.160735.
271. Tydlacka, S., Wang, C.-E., Wang, X., Li, S., Li, X.-J., Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J. Neurosci. 28 (2008), 13285–13295, 10.1523/JNEUROSCI.4393-08.2008.
272. Valenza, M., Cattaneo, E., Emerging roles for cholesterol in Huntington's disease. Trends Neurosci. 34 (2011), 474–486, 10.1016/j.tins.2011.06.005.
273. Vallejo-Illarramendi, A., Torres-Ramos, M., Melone, M., Conti, F., Matute, C., Clozapine reduces GLT-1 expression and glutamate uptake in astrocyte cultures. Glia 50 (2005), 276–279, 10.1002/glia.20172.
274. Vargas, D.L., Nascimbene, C., Krishnan, C., Zimmerman, A.W., Pardo, C.A., Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57 (2005), 67–81, 10.1002/ana.20315.
275. Verkhratsky, A., Rodríguez, J.J., Parpura, V., Calcium signalling in astroglia. Mol. Cell. Endocrinol. 353 (2012), 45–56, 10.1016/j.mce.2011.08.039.
276. Verkhratsky, A., Sofroniew, M.V., Messing, A., deLanerolle, N.C., Rempe, D., Rodriguez, J.J., Nedergaard, M., Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro, 4, 2012, 10.1042/AN20120010.
277. Virgin, C.E., Ha, T.P., Packan, D.R., Tombaugh, G.C., Yang, S.H., Horner, H.C., Sapolsky, R.M., Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity. J. Neurochem. 57 (1991), 1422–1428.
278. Volterra, A., Trotti, D., Tromba, C., Floridi, S., Racagni, G., Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J. Neurosci. 14 (1994), 2924–2932.
279. Vonsattel, J.P., Myers, R.H., Stevens, T.J., Ferrante, R.J., Bird, E.D., Richardson, E.P. Jr., Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44 (1985), 559–577.
280. Wallraff, A., Köhling, R., Heinemann, U., Theis, M., Willecke, K., Steinhäuser, C., The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J. Neurosci. 26 (2006), 5438–5447, 10.1523/JNEUROSCI.0037-06.2006.
281. Wang, C., Luan, Z., Yang, Y., Wang, Z., Cui, Y., Gu, G., Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes. Neurosci. Lett. 497 (2011), 122–127, 10.1016/j.neulet.2011.04.044.
282. Wang, E.-S., Yao, H.-B., Chen, Y.-H., Wang, G., Gao, W.-W., Sun, Y.-R., Guo, J.-G., Hu, J.-W., Jiang, C.-C., Hu, J., Proteomic analysis of the cerebrospinal fluid of Parkinson's disease patients pre- and post-deep brain stimulation. Cell. Physiol. Biochem. 31 (2013), 625–637, 10.1159/000350082.
283. Wang, F., Smith, N., Xu, Q., Fujita, T., Baba, A., Matsuda, T., Takano, T., Bekar, L., Nedergaard, M., Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Sci. Signal., 5, 2012, ra26, 10.1126/scisignal.2002334.
284. Wang, F., Xu, Q., Wang, W., Takano, T., Nedergaard, M.B., Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 7911–7916, 10.1073/pnas.1120380109.
285. Wang, Y., Yang, P., Tang, J., Lin, J., Cai, X., Wang, X., Zheng, G., Potassium channels: possible new therapeutic targets in Parkinson's disease. Med. Hypotheses 71 (2008), 546–550, 10.1016/j.mehy.2008.05.021.
286. Ward, R.J., Zucca, F.A., Duyn, J.H., Crichton, R.R., Zecca, L., The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol. 13 (2014), 1045–1060, 10.1016/S1474-4422(14)70117-6.
287. Webster, M.J., O'Grady, J., Kleinman, J.E., Weickert, C.S., Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. Neuroscience 133 (2005), 453–461, 10.1016/j.neuroscience.2005.02.037.
288. Wenker, I., An active role for astrocytes in synaptic plasticity?. J. Neurophysiol. 104 (2010), 1216–1218, 10.1152/jn.00429.2010.
289. Wetherington, J., Serrano, G., Dingledine, R., Astrocytes in the epileptic brain. Neuron 58 (2008), 168–178, 10.1016/j.neuron.2008.04.002.
290. Wieser, H.-G., ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 45 (2004), 695–714, 10.1111/j.0013-9580.2004.09004.x.
291. Wilder, R.M., The effects of ketonemia on the course of epilepsy. Mayo Clin. Proc. 2 (1921), 307–308.
292. Williams, M.R., Hampton, T., Pearce, R.K.B., Hirsch, S.R., Ansorge, O., Thom, M., Maier, M., Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 263 (2013), 41–52, 10.1007/s00406-012-0328-5.
293. Wu, A., Derrico, C.A., Hatem, L., Colvin, R.A., Alzheimer's amyloid-beta peptide inhibits sodium/calcium exchange measured in rat and human brain plasma membrane vesicles. Neuroscience 80 (1997), 675–684.
294. Wu, H.-Y., Hudry, E., Hashimoto, T., Uemura, K., Fan, Z.-Y., Berezovska, O., Grosskreutz, C.L., Bacskai, B.J., Hyman, B.T., Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. J. Neurosci. 32 (2012), 5298–5309.
295. Wyss-Coray, T., Loike, J.D., Brionne, T.C., Lu, E., Anankov, R., Yan, F., Silverstein, S.C., Husemann, J., Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat. Med. 9 (2003), 453–457, 10.1038/nm838.
296. Xu, L., Emery, J.F., Ouyang, Y.-B., Voloboueva, L.A., Giffard, R.G., Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia 58 (2010), 1042–1049, 10.1002/glia.20985.
297. Xu, X.-H., Pan, Y.-P., Wang, X.-L., mRNA expression alterations of inward rectifier potassium channels in rat brain with cholinergic impairment. Neurosci. Lett. 322 (2002), 25–28.
298. Yang, H., Yang, M., Guan, H., Liu, Z., Zhao, S., Takeuchi, S., Yanagisawa, D., Tooyama, I., Mitochondrial ferritin in neurodegenerative diseases. Neurosci. Res. 77 (2013), 1–7, 10.1016/j.neures.2013.07.005.
299. Yang, Q., Feng, B., Zhang, K., Guo, Y., Liu, S., Wu, Y., Li, X., Zhao, M., Excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome. PLoS Genet., 8, 2012, e1003172, 10.1371/journal.pgen.1003172.
300. Yang, Y., Ge, W., Chen, Y., Zhang, Z., Shen, W., Wu, C., Poo, M., Duan, S., Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 15194–15199, 10.1073/pnas.2431073100.
301. Yasui, D.H., Xu, H., Dunaway, K.W., Lasalle, J.M., Jin, L.-W., Maezawa, I., MeCP2 modulates gene expression pathways in astrocytes. Mol. Autism, 4, 2013, 3, 10.1186/2040-2392-4-3.
302. Yuskaitis, C.J., Beurel, E., Jope, R.S., Evidence of reactive astrocytes but not peripheral immune system activation in a mouse model of Fragile X syndrome. Biochim. Biophys. Acta 1802 (2010), 1006–1012, 10.1016/j.bbadis.2010.06.015.
303. Zhang, D.-D., Yu, H.-L., Ma, W.-W., Liu, Q.-R., Han, J., Wang, H., Xiao, R., 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. Neuroscience 300 (2015), 163–173, 10.1016/j.neuroscience.2015.05.022.
304. Zhang, H., Li, Q., Graham, R.K., Slow, E., Hayden, M.R., Bezprozvanny, I., Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiol. Dis. 31 (2008), 80–88, 10.1016/j.nbd.2008.03.010.
305. Zhang, J., Li, Y., Chen, Z.G., Dang, H., Ding, J.H., Fan, Y., Hu, G., Glia protein aquaporin-4 regulates aversive motivation of spatial memory in morris water maze. CNS Neurosci. Ther. 19 (2013), 937–944, 10.1111/cns.12191.
306. Zhou, J., Kong, H., Hua, X., Xiao, M., Ding, J., Hu, G., Altered blood–brain barrier integrity in adult aquaporin-4 knockout mice. Neuroreport 19 (2008), 1–5, 10.1097/WNR.0b013e3282f2b4eb.