Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects

Cerebellum

Volumn 4, Issue 3, 2005, Pages 206-210

  Laurence, J A ^a   Fatemi, S H ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Autism; Cerebellum; GFAP; Schizophrenia; Western blotting

Indexed keywords

BETA ACTIN; GLIAL FIBRILLARY ACIDIC PROTEIN;

ADULT; ARTICLE; AUTISM; BRAIN INJURY; CELL MIGRATION; CEREBELLUM; CEREBELLUM CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; FRONTAL CORTEX; GLIOSIS; HUMAN; IMMUNE SYSTEM; MACROGLIA; MALE; NERVE CONDUCTION; PARIETAL LOBE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; WESTERN BLOTTING;

ADULT; AUTISTIC DISORDER; CEREBELLAR CORTEX; FEMALE; FRONTAL LOBE; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MALE; PARIETAL LOBE; POSTMORTEM CHANGES; REFERENCE VALUES;

EID: 25144495490     PISSN: 14734222     EISSN: None     Source Type: Journal    
DOI: 10.1080/14734220500208846     Document Type: Article

References (20)

1. Lauritsen M, Ewald H. The genetics of autism. Acta Psychiatr Scand. 2001;103:411-27.
2. Rodier PM. The early origins of autism. Sci Am. 2000;282:56-63.
3. Fatemi SH, Halt AR, Stary JM, Realmuto GM, Jalali-Mousavi M. Reduction in anti-apoptotic protein Bcl-2 in autistic cerebellum. Neuroreport. 2001;12:929-33.
4. Fatemi SH, Stary JM, Halt AR, Realmuto GR. Dysregulation of Reelin and Bcl-2 proteins in autistic cerebellum. J Autism Dev Disord. 2001;31:529-35.
5. Fatemi SH, Emamiam ES, Sidwell RW, Kist DA, Earle J, Bailey K. Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice. Mol Psych. 2002;7:633-40.
6. Blatt GJ, Fitzgerald CM, Guptill JT, Booker AB, Kemper TL, Bauman ML. Density and distribution of hippocampal neurotransmitter receptors in autism: An autoradiographic study. J Aut Dev Dis. 2001;31:537-44.
7. Perry EK, Lee ML, Martin-Ruiz CM, et al. Cholinergic activity in autism: Abnormalities in the cerebral cortex and basal forebrain. Am J Psychiatry. 2001;7:1058-66.
8. Palmen SJMC, van Engelend H, Hof PR, Schmitz C. Neuropathological findings in autism. Brain. 2004;127: 2572-583.
9. Singh VK, Warren R, Averett R, Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Ped Neurol. 1997;17:88-90.
10. Ahlsen G, Rosengren L, Belfrage M, et al. Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders. Biol Psychiatry. 1993;33:734-43.
11. Rosengren LE, Ahlsen G, Belfrage M, Gillberg C, Haglid KG, Hamberger A. A sensitive ELISA for glial fibrillary acidic protein: Application in CSF of children. J Neurosci Methods. 1992;44:113-19.
12. Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005;57:67-81.
13. Newcombe J, Woodroofe MN, Cuzner ML. Distribution of glial fibrillary acidic protein in gliosed human white matter. J Neurochem. 1986;47:1713-19.
14. Delacourte A. General and dramatic glial reaction in Alzheimer brains. Neurology. 1990;40:33-7.
15. Porchet P, Probst A, Bouras C, Drabernova E, Draber P, Riederer BM. Analysis of glial fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease. Proteomics. 2003;3:1476-85.
16. Araghi-Niknam M, Fatemi SH. Levels of Bcl-2 and P53 are altered in superior fontal and cerebellar cortices of autistic subjects. Cell Mol Neurobiol. 2003;23: 945-52.
17. Colantuoni C, Jeon OH, Hyder K, et al. Gene expression profiling in postmortem Rett Syndrome brain: Differential gene expression and patient classification. Neurobiol Dis. 2001;8:847-65.
18. Radewicz K, Garey LJ, Gentleman SM, Reynolds R. Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. J Neuropathol Exp Neurol. 2000;9:137-50.
19. Fatemi SH, Araghi-Niknam M, Laurence JA, et al. Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophrenia. Schiz Res. 2004;69:317-23.
20. Fatemi SH, Araghi-Niknam M, Laurence JA, Stary JM, Lee S, Sidwell R. Glial fibrillary acidic protein and glutamic acid decarboxylase 65 & 67 kDa proteins are increased in brains of neonatal Balb/c mice following viral infection in utero. Schiz Res. 2004;69:121-3.