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Volumn 25, Issue 18, 2005, Pages 4649-4658

Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models

Author keywords

Ca2+ regulation; Glia; Hypertrophy; Microarray; Phosphatase; Reactive

Indexed keywords

CALCINEURIN; CYCLOSPORIN A;

EID: 18244391440     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0365-05.2005     Document Type: Article
Times cited : (197)

References (62)
  • 2
    • 18244391281 scopus 로고    scopus 로고
    • Experimental design and data analysis
    • Blalock EM, ed, Norwell, MA: Kluwer Academic
    • Blalock EM (2003) Experimental design and data analysis. In: A beginner's guide to microarrays. (Blalock EM, ed), pp 179-241. Norwell, MA: Kluwer Academic.
    • (2003) A Beginner's Guide to Microarrays , pp. 179-241
    • Blalock, E.M.1
  • 3
    • 0038206578 scopus 로고    scopus 로고
    • Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment
    • Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW (2003) Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci 23:3807-3819.
    • (2003) J Neurosci , vol.23 , pp. 3807-3819
    • Blalock, E.M.1    Chen, K.C.2    Sharrow, K.3    Herman, J.P.4    Porter, N.M.5    Foster, T.C.6    Landfield, P.W.7
  • 4
    • 1242341923 scopus 로고    scopus 로고
    • Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    • Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW (2004) Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci USA 101:2173-2178.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2173-2178
    • Blalock, E.M.1    Geddes, J.W.2    Chen, K.C.3    Porter, N.M.4    Markesbery, W.R.5    Landfield, P.W.6
  • 6
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signaling: Choreographing the social lives of cells
    • Crabtree GR, Olson EN (2002) NFAT signaling: choreographing the social lives of cells. Cell [Suppl] 109:S67-S79.
    • (2002) Cell [Suppl] , vol.109
    • Crabtree, G.R.1    Olson, E.N.2
  • 7
    • 0028169349 scopus 로고
    • The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: Relationship to calcineurin
    • Dawson TM, Steiner JP, Lyons WE, Fotuhi M, Blue M, Snyder SH (1994) The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. Neuroscience 62:569-580.
    • (1994) Neuroscience , vol.62 , pp. 569-580
    • Dawson, T.M.1    Steiner, J.P.2    Lyons, W.E.3    Fotuhi, M.4    Blue, M.5    Snyder, S.H.6
  • 8
    • 0028649481 scopus 로고
    • The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging
    • Disterhoft JF, Moyer Jr JR, Thompson LT (1994) The calcium rationale in aging and Alzheimer's disease. Evidence from an animal model of normal aging. Ann NY Acad Sci 747:382-406.
    • (1994) Ann NY Acad Sci , vol.747 , pp. 382-406
    • Disterhoft, J.F.1    Moyer Jr., J.R.2    Thompson, L.T.3
  • 9
    • 12744278445 scopus 로고    scopus 로고
    • Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstem
    • Duale H, Kasparov S, Paton JF, Teschemacher AG (2005) Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstem. Exp Physiol 90:71-78.
    • (2005) Exp Physiol , vol.90 , pp. 71-78
    • Duale, H.1    Kasparov, S.2    Paton, J.F.3    Teschemacher, A.G.4
  • 10
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes - Implications for their role in neurologic disease
    • Eddleston M, Mucke L (1993) Molecular profile of reactive astrocytes - implications for their role in neurologic disease. Neuroscience 54:15-36.
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston, M.1    Mucke, L.2
  • 11
    • 0038198881 scopus 로고    scopus 로고
    • Neurons, glia, and plasticity in normal brain aging
    • Finch CE (2003) Neurons, glia, and plasticity in normal brain aging. Neurobiol Aging 24 [Suppl 1]:S123-S127, S131.
    • (2003) Neurobiol Aging , vol.24 , Issue.1 SUPPL.
    • Finch, C.E.1
  • 13
    • 0031451847 scopus 로고    scopus 로고
    • 2+-dependent processes: Relation to hippocampal synaptic plasticity
    • 2+-dependent processes: relation to hippocampal synaptic plasticity. Hippocampus 7:602-612.
    • (1997) Hippocampus , vol.7 , pp. 602-612
    • Foster, T.C.1    Norris, C.M.2
  • 15
    • 0037101641 scopus 로고    scopus 로고
    • Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines
    • Gemma C, Mesches MH, Sepesi B, Choo K, Holmes DB, Bickford PC (2002) Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. J Neurosci 22:6114-6120.
    • (2002) J Neurosci , vol.22 , pp. 6114-6120
    • Gemma, C.1    Mesches, M.H.2    Sepesi, B.3    Choo, K.4    Holmes, D.B.5    Bickford, P.C.6
  • 16
    • 0033231419 scopus 로고    scopus 로고
    • Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions
    • Gonzalez M, Ruggiero FP, Chang Q, Shi YJ, Rich MM, Kraner S, Balice-Gordon RJ (1999) Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions. Neuron 24:567-583.
    • (1999) Neuron , vol.24 , pp. 567-583
    • Gonzalez, M.1    Ruggiero, F.P.2    Chang, Q.3    Shi, Y.J.4    Rich, M.M.5    Kraner, S.6    Balice-Gordon, R.J.7
  • 18
    • 0023032057 scopus 로고
    • The distribution of calcineurin in rat brain by light and electron microscopic immunohistochemistry and enzyme-immunoassay
    • Goto S, Matsukado Y, Mihara Y, Inoue N, Miyamoto E (1986) The distribution of calcineurin in rat brain by light and electron microscopic immunohistochemistry and enzyme-immunoassay. Brain Res 397:161-172.
    • (1986) Brain Res , vol.397 , pp. 161-172
    • Goto, S.1    Matsukado, Y.2    Mihara, Y.3    Inoue, N.4    Miyamoto, E.5
  • 20
    • 0024991506 scopus 로고
    • Identification of an autoinhibitory domain in calcineurin
    • Hashimoto Y, Perrino BA, Soderling TR (1990) Identification of an autoinhibitory domain in calcineurin. J Biol Chem 265:1924-1927.
    • (1990) J Biol Chem , vol.265 , pp. 1924-1927
    • Hashimoto, Y.1    Perrino, B.A.2    Soderling, T.R.3
  • 21
    • 0037086435 scopus 로고    scopus 로고
    • Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesions
    • Kadish I, Pradier L, van Groen T (2002) Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesions. Brain Res Bull 57:587-594.
    • (2002) Brain Res Bull , vol.57 , pp. 587-594
    • Kadish, I.1    Pradier, L.2    Van Groen, T.3
  • 22
    • 1642397093 scopus 로고    scopus 로고
    • Gliosis growth factors in the adult and aging brain
    • de Vellis JS, ed, Totowa, NJ: Humana
    • Labourdette G, Eclancher F (2002) Gliosis growth factors in the adult and aging brain. In: Neuroglia in the aging brain (de Vellis JS, ed), pp 157-178. Totowa, NJ: Humana.
    • (2002) Neuroglia in the Aging Brain , pp. 157-178
    • Labourdette, G.1    Eclancher, F.2
  • 24
    • 0019295966 scopus 로고
    • Mammalian brain aging: Theoretical implications of changes in brain and endocrine systems during mid- and late-life
    • Landfield PW, Sundberg DK, Smith MS, Eldridge JC, Morris M (1980) Mammalian brain aging: theoretical implications of changes in brain and endocrine systems during mid- and late-life. Peptides [Suppl 1]:185-196.
    • (1980) Peptides , Issue.1 SUPPL. , pp. 185-196
    • Landfield, P.W.1    Sundberg, D.K.2    Smith, M.S.3    Eldridge, J.C.4    Morris, M.5
  • 25
    • 0024954411 scopus 로고
    • Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease
    • Landfield PW, Campbell LW, Hao SY, Kerr DS (1989) Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease. Ann NY Acad Sci 568:95-105.
    • (1989) Ann NY Acad Sci , vol.568 , pp. 95-105
    • Landfield, P.W.1    Campbell, L.W.2    Hao, S.Y.3    Kerr, D.S.4
  • 26
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee CK, Weindruch R, Prolla TA (2000) Gene-expression profile of the ageing brain in mice. Nat Genet 25:294-297.
    • (2000) Nat Genet , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 27
    • 0034657414 scopus 로고    scopus 로고
    • Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice
    • Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM (2000) Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol 149:793-798.
    • (2000) J Cell Biol , vol.149 , pp. 793-798
    • Leissring, M.A.1    Akbari, Y.2    Fanger, C.M.3    Cahalan, M.D.4    Mattson, M.P.5    LaFerla, F.M.6
  • 28
    • 0038128348 scopus 로고    scopus 로고
    • Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: Peculiarities, mechanisms, and consequences
    • Lowenstein PR, Castro MG (2003) Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences. Gene Ther 10:946-954.
    • (2003) Gene Ther , vol.10 , pp. 946-954
    • Lowenstein, P.R.1    Castro, M.G.2
  • 29
    • 0020609098 scopus 로고
    • Activation of calcineurin by limited proteolysis
    • Manalan AS, Klee CB (1983) Activation of calcineurin by limited proteolysis. Proc Natl Acad Sci USA 80:4291-4295.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4291-4295
    • Manalan, A.S.1    Klee, C.B.2
  • 30
    • 0242690133 scopus 로고    scopus 로고
    • Calcineurin in memory and bidirectional plasticity
    • Mansuy IM (2003) Calcineurin in memory and bidirectional plasticity. Biochem Biophys Res Commun 311:1195-1208.
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 1195-1208
    • Mansuy, I.M.1
  • 34
    • 0033230601 scopus 로고    scopus 로고
    • Genetic approaches to memory storage
    • Mayford M, Kandel ER (1999) Genetic approaches to memory storage. Trends Genet 15:463-470.
    • (1999) Trends Genet , vol.15 , pp. 463-470
    • Mayford, M.1    Kandel, E.R.2
  • 36
    • 0035380762 scopus 로고    scopus 로고
    • Microarrays in brain research: The good, the bad and the ugly
    • Mirnics K (2001) Microarrays in brain research: the good, the bad and the ugly. Nat Rev Neurosci 2:444-447.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 444-447
    • Mirnics, K.1
  • 37
    • 0035426751 scopus 로고    scopus 로고
    • Analysis of complex brain disorders with gene expression microarrays: Schizophrenia as a disease of the synapse
    • Mirnics K, Middleton FA, Lewis DA, Levitt P (2001) Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 24:479-486.
    • (2001) Trends Neurosci , vol.24 , pp. 479-486
    • Mirnics, K.1    Middleton, F.A.2    Lewis, D.A.3    Levitt, P.4
  • 39
    • 0035690976 scopus 로고    scopus 로고
    • Interleukin-1, neuroinflammation, and Alzheimer's disease
    • Mrak RE, Griffin WS (2001) Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol Aging 22:903-908.
    • (2001) Neurobiol Aging , vol.22 , pp. 903-908
    • Mrak, R.E.1    Griffin, W.S.2
  • 41
    • 0033526991 scopus 로고    scopus 로고
    • IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-AIc1
    • Musaro A, McCullagh KJ, Naya FJ, Olson EN, Rosenthal N (1999) IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-AIc1. Nature 400:581-585.
    • (1999) Nature , vol.400 , pp. 581-585
    • Musaro, A.1    McCullagh, K.J.2    Naya, F.J.3    Olson, E.N.4    Rosenthal, N.5
  • 43
    • 0030797316 scopus 로고    scopus 로고
    • Calcium channel density and hippocampal cell death with age in long-term culture
    • Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW (1997) Calcium channel density and hippocampal cell death with age in long-term culture. J Neurosci 17:5629-5639.
    • (1997) J Neurosci , vol.17 , pp. 5629-5639
    • Porter, N.M.1    Thibault, O.2    Thibault, V.3    Chen, K.C.4    Landfield, P.W.5
  • 44
    • 0035105022 scopus 로고    scopus 로고
    • Cyclosporin A-sensitive signaling pathway involving calcineurin regulates survival of reactive astrocytes
    • Pyrzynska B, Lis A, Mosieniak G, Kaminska B (2001) Cyclosporin A-sensitive signaling pathway involving calcineurin regulates survival of reactive astrocytes. Neurochem Int 38:409-415.
    • (2001) Neurochem Int , vol.38 , pp. 409-415
    • Pyrzynska, B.1    Lis, A.2    Mosieniak, G.3    Kaminska, B.4
  • 45
    • 0035171622 scopus 로고    scopus 로고
    • A novel calcineurin splice variant that modifies calcineurin activity
    • Reuter A, Mi J, Sehrsam I, Ludolph AC, Volkel H (2001) A novel calcineurin splice variant that modifies calcineurin activity. Eur J Biochem 268:5955-5960.
    • (2001) Eur J Biochem , vol.268 , pp. 5955-5960
    • Reuter, A.1    Mi, J.2    Sehrsam, I.3    Ludolph, A.C.4    Volkel, H.5
  • 46
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet JL, Malhotra SK, Privat A, Gage FH (1997) Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 20:570-577.
    • (1997) Trends Neurosci , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 48
    • 0007692414 scopus 로고    scopus 로고
    • In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
    • Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WS (1996) In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging 17:761-766.
    • (1996) Neurobiol Aging , vol.17 , pp. 761-766
    • Sheng, J.G.1    Ito, K.2    Skinner, R.D.3    Mrak, R.E.4    Rovnaghi, C.R.5    Van Eldik, L.J.6    Griffin, W.S.7
  • 49
    • 0029782113 scopus 로고    scopus 로고
    • Increase in single L-type calcium channels in hippocampal neurons during aging
    • Thibault O, Landfield PW (1996) Increase in single L-type calcium channels in hippocampal neurons during aging. Science 272:1017-1020.
    • (1996) Science , vol.272 , pp. 1017-1020
    • Thibault, O.1    Landfield, P.W.2
  • 51
    • 0035892243 scopus 로고    scopus 로고
    • 2+]i and L-type calcium channel activity in aged hippocampal neurons: Relationship to impaired synaptic plasticity
    • 2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. J Neurosci 21:9744-9756.
    • (2001) J Neurosci , vol.21 , pp. 9744-9756
    • Thibault, O.1    Hadley, R.2    Landfield, P.W.3
  • 53
    • 0028102425 scopus 로고
    • S100 beta expression in Alzheimer's disease: Relation to neuropathology in brain regions
    • Van Eldik LJ, Griffin WS (1994) S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions. Biochim Biophys Acta 1223:398-403.
    • (1994) Biochim Biophys Acta , vol.1223 , pp. 398-403
    • Van Eldik, L.J.1    Griffin, W.S.2
  • 54
    • 0016261856 scopus 로고
    • Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study
    • Vaughan DW, Peters A (1974) Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J Neurocytol 3:405-429.
    • (1974) J Neurocytol , vol.3 , pp. 405-429
    • Vaughan, D.W.1    Peters, A.2
  • 56
    • 0042508791 scopus 로고    scopus 로고
    • Neuropathologic changes in Alzheimer's disease
    • Wenk GL (2003) Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry 64 [Suppl 9]:7-10.
    • (2003) J Clin Psychiatry , vol.64 , Issue.9 SUPPL. , pp. 7-10
    • Wenk, G.L.1
  • 58
    • 0015870176 scopus 로고
    • Morphology of the aging brain, human and animal
    • Wisniewski HM, Terry RD (1973) Morphology of the aging brain, human and animal. Prog Brain Res 40:167-186.
    • (1973) Prog Brain Res , vol.40 , pp. 167-186
    • Wisniewski, H.M.1    Terry, R.D.2
  • 59
    • 0026070319 scopus 로고
    • Spatial relationships between astrocytes and classical plaque components
    • Wisniewski HM, Wegiel J (1991) Spatial relationships between astrocytes and classical plaque components. Neurobiol Aging 12:593-600.
    • (1991) Neurobiol Aging , vol.12 , pp. 593-600
    • Wisniewski, H.M.1    Wegiel, J.2
  • 60
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease - A double-edged sword
    • Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease - a double-edged sword. Neuron 35:419-432.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 61
    • 0029077755 scopus 로고
    • Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1
    • Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, Mucke L (1995) Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. Am J Pathol 147:53-67.
    • (1995) Am J Pathol , vol.147 , pp. 53-67
    • Wyss-Coray, T.1    Feng, L.2    Masliah, E.3    Ruppe, M.D.4    Lee, H.S.5    Toggas, S.M.6    Rockenstein, E.M.7    Mucke, L.8
  • 62
    • 0034103644 scopus 로고    scopus 로고
    • Survival of hippocampal and cortical neurons in a mixture of MEM+ and B27-supplemented neurobasal medium
    • Xie C, Markesbery WR, Lovell MA (2000) Survival of hippocampal and cortical neurons in a mixture of MEM+ and B27-supplemented neurobasal medium. Free Radic Biol Med 28:665-672.
    • (2000) Free Radic Biol Med , vol.28 , pp. 665-672
    • Xie, C.1    Markesbery, W.R.2    Lovell, M.A.3


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