Increased expression of glial fibrillary acidic protein in prefrontal cortex in psychotic illness

Schizophrenia Research

Volumn 150, Issue 1, 2013, Pages 252-257

  Feresten, Abigail H ^a   Barakauskas, Vilte ^a   Ypsilanti, Athena ^a   Barr, Alasdair M ^a   Beasley, Clare L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Aldehyde dehydrogenase; Antipsychotic; Astrocyte; Bipolar disorder; Schizophrenia; Vimentin

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1 L1; BIOLOGICAL MARKER; BRAIN PROTEIN; CLOZAPINE; EXCITATORY AMINO ACID TRANSPORTER 1; GLIAL FIBRILLARY ACIDIC PROTEIN; HALOPERIDOL; ILLICIT DRUG; UNCLASSIFIED DRUG; VIMENTIN;

ADULT; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; AUTOPSY; BIPOLAR DISORDER; CELL COUNT; CELLULAR DISTRIBUTION; CINGULATE GYRUS; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; NONHUMAN; PATHOPHYSIOLOGY; PH; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RAT; SCHIZOPHRENIA; SEX DIFFERENCE; SUICIDE; WESTERN BLOTTING;

ALDEHYDE DEHYDROGENASE; ANTIPSYCHOTIC; ASTROCYTE; BIPOLAR DISORDER; SCHIZOPHRENIA; VIMENTIN;

ADULT; ALDEHYDE DEHYDROGENASE; ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; CHI-SQUARE DISTRIBUTION; EXCITATORY AMINO ACID TRANSPORTER 1; FEMALE; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MALE; MIDDLE AGED; MOLECULAR WEIGHT; PREFRONTAL CORTEX; PSYCHOTIC DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; VIMENTIN;

EID: 84884144854     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2013.07.024     Document Type: Article

References (43)

1. Åberg K., Saetre P., Lindholm E., Ekholm B., Pettersson U., Adolfsson R., Jazin E. Human QKI, a new candidate gene for schizophrenia involved in myelination. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2006, 141(1):84-90.
2. Barakauskas V.E., Ypsilanti A.R., Barr A.M., Innis S.M., Honer W.G., Beasley C.L. Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 34(4):669-673.
3. Barley K., Dracheva S., Byne W. Subcortical oligodendrocyte-and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder. Schizophr. Res. 2009, 112(1):54-64.
4. Bauer D., Gupta D., Harotunian V., Meador-Woodruff J.H., McCullumsmith R.E. Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia. Schizophr. Res. 2008, 104(1):108-120.
5. Bauer D., Haroutunian V., Meador-Woodruff J.H., McCullumsmith R.E. Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia. Schizophr. Res. 2010, 117(1):92-98.
6. Beasley C.L., Pennington K., Behan A., Wait R., Dunn M.J., Cotter D. Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes. Proteomics 2006, 6(11):3414-3425.
7. Benitez-King G., Ramirez-Rodriguez G., Ortiz L., Meza I. The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia. Curr. Drug Targets CNS Neurol. Disord. 2004, 3(6):515-533.
8. Cahoy J.D., Emery B., Kaushal A., Foo L.C., Zamanian J.L., Christopherson K.S., Xing Y., Lubischer J.L., Krieg P.A., Krupenko S.A. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 2008, 28(1):264-278.
9. Calvo J.L., Carbonell A.L., Boya J. Co-expression of glial fibrillary acidic protein and vimentin in reactive astrocytes following brain injury in rats. Brain Res. 1991, 566(1):333-336.
10. Craddock N., O'Donovan M.C., Owen M.J. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J. Med. Genet. 2005, 42(3):193-204.
11. Damadzic R., Bigelow L.B., Krimer L.S., Goldenson D.A., Saunders R.C., Kleinman J.E., Herman M.M. A quantitative immunohistochemical study of astrocytes in the entorhinal cortex in schizophrenia, bipolar disorder and major depression: absence of significant astrocytosis. Brain Res. Bull. 2001, 55(5):611-618.
12. Danbolt N.C. Glutamate uptake. Prog. Neurobiol. 2001, 65(1):1-105.
13. Drexhage R.C., Van der Heul-Nieuwenhuijsen L., Padmos R.C., Van Beveren N., Cohen D., Versnel M.A., Nolen W.A., Drexhage H.A. Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients. Int. J. Neuropsychopharmacol. 2010, 13(10):1369-1381.
14. English J.A., Dicker P., Föcking M., Dunn M.J., Cotter D.R. 2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease. Proteomics 2009, 9(12):3368-3382.
15. Fatemi S.H., Folsom T.D., Reutiman T.J., Pandian T., Braun N.N., Haug K. Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats. Schizophr. Res. 2008, 104(1):127-134.
16. Guidotti A., Auta J., Davis J.M., Gerevini V.D., Dwivedi Y., Grayson D.R., Impagnatiello F., Pandey G., Pesold C., Sharma R. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry 2000, 57(11):1061-1069.
17. Hayes D.M., Deeny M.A., Shaner C.A., Nixon K. Determining the threshold for alcohol-induced brain damage: new evidence with gliosis markers. Alcohol. Clin. Exp. Res. 2013, 37(3):425-434.
18. Johnston-Wilson N.L., Sims C.D., Hofmann J.P., Anderson L., Shore A.D., Torrey E.F., Yolken R.H. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. Mol. Psychiatry 2000, 5(2):142-149.
19. Katsel P., Byne W., Roussos P., Tan W., Siever L., Haroutunian V. Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia. Neuropsychopharmacology 2011, 36(6):1171-1177.
20. Konopaske G.T., Dorph-Petersen K.-A., Sweet R.A., Pierri J.N., Zhang W., Sampson A.R., Lewis D.A. Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol. Psychiatry 2008, 63(8):759-765.
21. Li Y., Zhou Y., Danbolt N.C. The rates of postmortem proteolysis of glutamate transporters differ dramatically between cells and between transporter subtypes. J. Histochem. Cytochem. 2012, 60(11):811-821.
22. Martins-de-Souza D., Gattaz W.F., Schmitt A., Rewerts C., Maccarrone G., Dias-Neto E., Turck C.W. Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 2009, 259(3):151-163.
23. McCullumsmith R.E., Gupta D., Beneyto M., Kreger E., Haroutunian V., Davis K.L., Meador-Woodruff J.H. Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia. Schizophr. Res. 2007, 90(1):15-27.
24. Middeldorp J., Hol E.M. GFAP in health and disease. Prog. Neurobiol. 2011, 93(3):421-443.
25. Moehle M.S., Luduena R.F., Haroutunian V., Meador-Woodruff J.H., McCullumsmith R.E. Regional differences in expression of β-tubulin isoforms in schizophrenia. Schizophr. Res. 2012, 135(1-3):181-186.
26. Pennington K., Beasley C.L., Dicker P., Fagan A., English J., Pariante C.M., Wait R., Dunn M.J., Cotter D.R. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol. Psychiatry 2008, 13(12):1102-1117.
27. Pennington K., Dicker P., Dunn M.J., Cotter D.R. Proteomic analysis reveals protein changes within layer 2 of the insular cortex in schizophrenia. Proteomics 2008, 8(23-24):5097-5107.
28. Radomska K.J., Halvardson J., Reinius B., Carlström E.L., Emilsson L., Feuk L., Jazin E. RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes. Hum. Mol. Genet. 2013, 22(7):1373-1382.
29. Raivich G., Bohatschek M., Kloss C.U., Werner A., Jones L.L., Kreutzberg G.W. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res. Rev. 1999, 30(1):77-105.
30. Rajkowska G., Miguel-Hidalgo J.J., Makkos Z., Meltzer H., Overholser J., Stockmeier C. Layer-specific reductions in GFAP-reactive astroglia in the dorsolateral prefrontal cortex in schizophrenia. Schizophr. Res. 2002, 57(2):127-138.
31. Rao J.S., Kellom M., Reese E.A., Rapoport S.I., Kim H.W. Dysregulated glutamate and dopamine transporters in postmortem frontal cortex from bipolar and schizophrenic patients. J. Affect. Disord. 2012, 136(1):63-71.
32. Rao J.S., Kim H.W., Harry G.J., Rapoport S.I., Reese E.A. Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients. Schizophr. Res. 2013, 10.1016/j.schres.2013.02.017.
33. Rocha E., Achaval M., Santos P., Rodnight R. Lithium treatment causes gliosis and modifies the morphology of hippocampal astrocytes in rats. Neuroreport 1998, 9(17):3971-3974.
34. Schirch D., Villar E., Maras B., Barra D., Schirch V. Domain structure and function of 10-formyltetrahydrofolate dehydrogenase. J. Biol. Chem. 1994, 269(40):24728-24735.
35. Schulte S., Stoffel W. UDP galactose: ceramide galactosyltransferase and glutamate/aspartate transporter. Eur. J. Biochem. 1995, 233(3):947-953.
36. Shan D., Lucas E.K., Drummond J.B., Haroutunian V., Meador-Woodruff J.H., McCullumsmith R.E. Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia. Schizophr. Res. 2013, 104(1-3):108-120.
37. Sofroniew M.V., Vinters H.V. Astrocytes: biology and pathology. Acta Neuropathol. 2010, 119(1):7-35.
38. Steffek A.E., McCullumsmith R.E., Haroutunian V., Meador-Woodruff J.H. Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia. Schizophr. Res. 2008, 103(1):71-82.
39. Toro C.T., Hallak J.E., Dunham J.S., Deakin J.F. Glial fibrillary acidic protein and glutamine synthetase in subregions of prefrontal cortex in schizophrenia and mood disorder. Neurosci. Lett. 2006, 404(3):276-281.
40. Torrey E.F., Webster M., Knable M., Johnston N., Yolken R.H. The Stanley Foundation brain collection and neuropathology consortium. Schizophr. Res. 2000, 44(2):151-155.
41. Webster M.J., O'Grady J., Kleinman J.E., Weickert C.S. Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. Neuroscience 2005, 133(2):453-461.
42. Williams M.R., Hampton T., Pearce R.K., Hirsch S.R., Ansorge O., Thom M., Maier M. Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 2013, 263(1):41-52.
43. Yang Y., Vidensky S., Jin L., Jie C., Lorenzini I., Frankl M., Rothstein J.D. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia 2011, 59(2):200-207.