Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission

Journal of Neuroscience

Volumn 34, Issue 34, 2014, Pages 11228-11232

  Chever, Oana ^a,b   Lee, Chun Yao ^a   Rouach, Nathalie ^a  

^a INSERM   (France)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Astrocytes; Basal synaptic transmission; Connexin43; Hemichannel; Hippocampus; Physiology

Indexed keywords

ADENOSINE TRIPHOSPHATE; CONNEXIN 43; CARBENOXOLONE; ETHIDIUM; GAP 26 PEPTIDE; GREEN FLUORESCENT PROTEIN; PEPTIDE; PURINERGIC P2 RECEPTOR ANTAGONIST; PYRIDOXAL 5 PHOSPHATE; PYRIDOXAL PHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID;

ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; GAP JUNCTION; HIPPOCAMPAL CA1 REGION; IMMUNOREACTIVITY; MACROGLIA; MEMBRANE STEADY POTENTIAL; MOUSE; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SYNAPTIC TRANSMISSION; ANALOGS AND DERIVATIVES; ANIMAL; ASTROCYTE; CYTOLOGY; DRUG EFFECTS; ELECTROSTIMULATION; GENETICS; HIPPOCAMPUS; IN VITRO STUDY; METABOLISM; NERVE CELL; NEWBORN; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CARBENOXOLONE; CONNEXIN 43; ELECTRIC STIMULATION; ETHIDIUM; EXCITATORY POSTSYNAPTIC POTENTIALS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; IN VITRO TECHNIQUES; MICE; MICE, TRANSGENIC; NEURONS; PATCH-CLAMP TECHNIQUES; PEPTIDES; PURINERGIC P2 RECEPTOR ANTAGONISTS; PYRIDOXAL PHOSPHATE; SYNAPTIC TRANSMISSION;

EID: 84906257686     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0015-14.2014     Document Type: Article

References (23)

1. Agulhon C., Sun MY, Murphy T, Myers T, Lauderdale K, Fiacco TA (2012) Calcium signaling and gliotransmission in normal vs. reactive astrocytes. Front Pharmacol 3:139. CrossRef Medline
2. Anselmi F., Hernandez VH, Crispino G, Seydel A, Ortolano S, Roper SD, Kessaris N., Richardson W, Rickheit G, Filippov MA, Monyer H, Mammano F (2008) ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2signals across the inner ear. Proc Natl Acad Sci U S A 105:18770-18775. CrossRef Medline
3. Araque A., Carmignoto G, Haydon PG, Oliet SH, Robitaille R, Volterra A (2014) Gliotransmitters travel in time and space. Neuron 81:728-739. CrossRef Medline
4. Contreras J. E, Sáez JC, Bukauskas FF, Bennett MV (2003) Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci U S A 100:11388-11393. CrossRef Medline
5. Fiala J. C, Kirov SA, Feinberg MD, Petrak LJ, George P, Goddard CA, Harris KM (2003) Timing of neuronal and glial ultrastructure disruption during brain slice preparation and recovery in vitro. J Comp Neurol 465:90-103. CrossRef Medline
6. Frisch C., Theis M, De Souza Silva MA, Dere E, Söhl G, Teubner B, Namestkova K, Willecke K, Huston JP (2003) Mice with astrocyte-directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels. Eur J Neurosci 18:2313-2318. CrossRef Medline
7. Giaume C., Leybaert L, Naus CC, Sáez JC (2013) Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol 4:88. CrossRef Medline
8. Gordon G. R, Baimoukhametova DV, Hewitt SA, Rajapaksha WR, Fisher TE, Bains J. S (2005) Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy. Nat Neurosci 8:1078-1086. CrossRef Medline
9. Hamilton N. B, Attwell D (2010) Do astrocytes really exocytose neurotransmitters? Nat Rev Neurosci 11:227-238. CrossRef Medline
10. Han Y., Yu HX, Sun ML, Wang Y, Xi W, Yu YQ (2014) Astrocyte-restricted disruption of connexin-43 impairs neuronal plasticity in mouse barrel cortex. Eur J Neurosci 39:35-45. CrossRef Medline
11. Iglesias R., Dahl G, Qiu F, Spray DC, Scemes E (2009) Pannexin 1: the molecular substrate of astrocyte "hemichannels. " J Neurosci 29:7092-7097. CrossRef Medline
12. Kang J., Kang N, Lovatt D, Torres A, Zhao Z, Lin J, Nedergaard M (2008) Connexin 43 hemichannels are permeable to ATP. J Neurosci 28:4702-4711. CrossRef Medline
13. Nedergaard M., Verkhratsky A (2012) Artifact versus reality-how astrocytes contribute to synaptic events. Glia 60:1013-1023. CrossRef Medline
14. Orellana J. A, Martinez AD, Retamal MA (2013) Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules. Neuropharmacology 75:567-582. CrossRef Medline
15. Panatier A., Vallée J, Haber M, Murai KK, Lacaille JC, Robitaille R (2011) Astrocytes are endogenous regulators of basal transmission at central synapses. Cell 146:785-798. CrossRef Medline
16. Pankratov Y., Castro E, Miras-Portugal MT, Krishtal O (1998) A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus. Eur J Neurosci 10: 3898-3902. CrossRef Medline
17. Pannasch U., Rouach N (2013) Emerging role for astroglial networks in information processing: from synapse to behavior. Trends Neurosci 36: 405-417. CrossRef Medline
18. Pannasch U., Vargová L, Reingruber J, Ezan P, Holcman D, Giaume C, Syková E, Rouach N (2011) Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A 108:8467-8472. CrossRef Medline
19. Pearson R. A, Dale N, Llaudet E, Mobbs P (2005) ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. Neuron 46:731-744. CrossRef Medline
20. Stehberg J., Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G., Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA (2012) Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J 26:3649-3657. CrossRef Medline
21. Takano T., He W, Han X, Wang F, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M (2014) Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia 62:78-95. CrossRef Medline
22. Theis M., Jauch R, Zhuo L, Speidel D, Wallraff A, Döring B, Frisch C, Söhl G, Teubner B., Euwens C, Huston J, Steinhäuser C, Messing A, Heinemann U, Willecke K (2003) Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43. J Neurosci 23:766-776. Medline
23. Torres A., Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, NedergaardM (2012) Extracellular Ca(2)() acts as a mediator of communication from neurons to glia. Sci Signal 5:ra8. CrossRef Medline